CA2553630A1 - Dehydrophenylahistines et leurs analogues et la synthese des dehydrophenylahistines et de leurs analogues - Google Patents
Dehydrophenylahistines et leurs analogues et la synthese des dehydrophenylahistines et de leurs analogues Download PDFInfo
- Publication number
- CA2553630A1 CA2553630A1 CA002553630A CA2553630A CA2553630A1 CA 2553630 A1 CA2553630 A1 CA 2553630A1 CA 002553630 A CA002553630 A CA 002553630A CA 2553630 A CA2553630 A CA 2553630A CA 2553630 A1 CA2553630 A1 CA 2553630A1
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- Prior art keywords
- substituted
- kpu
- atom
- nitro
- heteroaryl
- Prior art date
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- Abandoned
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
- C07D407/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54207304P | 2004-02-04 | 2004-02-04 | |
| US60/542,073 | 2004-02-04 | ||
| US62426204P | 2004-11-01 | 2004-11-01 | |
| US60/624,262 | 2004-11-01 | ||
| PCT/US2005/003636 WO2005077940A1 (fr) | 2004-02-04 | 2005-02-04 | Dehydrophenylahistines et leurs analogues et la synthese des dehydrophenylahistines et de leurs analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2553630A1 true CA2553630A1 (fr) | 2005-08-25 |
Family
ID=34864489
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002553630A Abandoned CA2553630A1 (fr) | 2004-02-04 | 2005-02-04 | Dehydrophenylahistines et leurs analogues et la synthese des dehydrophenylahistines et de leurs analogues |
Country Status (9)
| Country | Link |
|---|---|
| EP (1) | EP1711487A1 (fr) |
| JP (1) | JP2007520565A (fr) |
| KR (1) | KR101228104B1 (fr) |
| AU (1) | AU2005212399B2 (fr) |
| BR (1) | BRPI0506655A (fr) |
| CA (1) | CA2553630A1 (fr) |
| IL (1) | IL176932A0 (fr) |
| NZ (1) | NZ548659A (fr) |
| WO (1) | WO2005077940A1 (fr) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7919497B2 (en) | 2002-08-02 | 2011-04-05 | Nereus Pharmaceuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| CN100540548C (zh) | 2002-08-02 | 2009-09-16 | 尼瑞斯药品公司 | 脱氢苯基阿夕斯丁及其类似物以及脱氢苯基阿夕斯丁及其类似物的合成 |
| US7935704B2 (en) | 2003-08-01 | 2011-05-03 | Nereus Pharmaceuticals, Inc. | Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof |
| WO2007035841A1 (fr) * | 2005-09-21 | 2007-03-29 | Nereus Pharmaceuticals, Inc. | Analogues de deshydrophenylahistines et utilisation therapeutique de ceux-ci |
| US8129527B2 (en) | 2006-11-03 | 2012-03-06 | Nereus Pharmacuticals, Inc. | Analogs of dehydrophenylahistins and their therapeutic use |
| MY185650A (en) * | 2013-10-11 | 2021-05-27 | Beyondspring Inc | Cancer treatment with combinantion of plinabulin and taxane |
| MY193968A (en) * | 2015-02-12 | 2022-11-03 | Beyondspring Pharmaceuticals Inc | Use of plinabulin in combination with immune checkpoint inhibitors |
| MX2017011375A (es) * | 2015-03-06 | 2018-01-23 | Beyondspring Pharmaceuticals Inc | Método para tratar un tumor cerebral. |
| KR102626155B1 (ko) | 2015-03-06 | 2024-01-17 | 비욘드스프링 파마수티컬스, 인코포레이티드. | Ras 돌연변이와 관련된 암의 치료 방법 |
| EP4011878A1 (fr) | 2015-07-13 | 2022-06-15 | Beyondspring Pharmaceuticals, Inc. | Compositions de plinabuline |
| CA3013467A1 (fr) | 2016-02-08 | 2017-08-17 | Beyondspring Pharmaceuticals, Inc. | Compositions contenant du tucaresol ou ses analogues |
| KR20230018545A (ko) | 2016-06-06 | 2023-02-07 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 호중구감소증을 줄이는 조성물 및 방법 |
| WO2018028420A1 (fr) * | 2016-08-12 | 2018-02-15 | 青岛海洋生物医药研究院股份有限公司 | Forme polycristalline de composé de type déhydrophénylahistine, son procédé de fabrication et de purification et son application. |
| JP2020503363A (ja) | 2017-01-06 | 2020-01-30 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | チューブリン結合化合物およびその治療的使用 |
| KR20190109479A (ko) | 2017-02-01 | 2019-09-25 | 비욘드스프링 파마수티컬스, 인코포레이티드. | 호중구감소증의 감소 방법 |
| CN110603037A (zh) * | 2017-03-13 | 2019-12-20 | 大连万春布林医药有限公司 | 普那布林的组合物及其用途 |
| JP7350015B2 (ja) | 2018-01-24 | 2023-09-25 | ビヨンドスプリング ファーマシューティカルズ，インコーポレイテッド | プリナブリンの投与による血小板減少症を軽減するための組成物および方法 |
| CN108524442B (zh) * | 2018-06-05 | 2022-01-28 | 深圳海王医药科技研究院有限公司 | 一种抗肿瘤药物的注射剂及其制备方法 |
| JP2018199726A (ja) * | 2018-09-26 | 2018-12-20 | ビヨンドスプリング インコーポレイテッド | プリナブリン及びタキサンの組合せがん治療 |
| CA3234699A1 (fr) * | 2021-10-07 | 2023-04-13 | Beyondspring Pharmaceuticals, Inc. | Methodes de traitement de cancers et de tumeurs |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3318789A1 (de) * | 1983-05-24 | 1984-11-29 | Eduard Gerlach GmbH Chemische Fabrik, 4990 Lübbecke | Deodorant |
| GB9402807D0 (en) * | 1994-02-14 | 1994-04-06 | Xenova Ltd | Pharmaceutical compounds |
| US6069146A (en) * | 1998-03-25 | 2000-05-30 | The Regents Of The University Of California | Halimide, a cytotoxic marine natural product, and derivatives thereof |
| US6358957B1 (en) * | 1998-11-12 | 2002-03-19 | Nereus Pharmaceuticals, Inc. | Phenylahistin and the phenylahistin analogs, a new class of anti-tumor compounds |
| MXPA02006826A (es) * | 2000-01-18 | 2004-04-05 | Nereus Phamraceuticals Inc | Un inhibidor de division celular y un metodo de produccion del mismo. |
| CZ301743B6 (cs) * | 2000-05-09 | 2010-06-09 | Angiorx Corporation | Piperazindionové slouceniny a protinádorové využití |
| CN100540548C (zh) * | 2002-08-02 | 2009-09-16 | 尼瑞斯药品公司 | 脱氢苯基阿夕斯丁及其类似物以及脱氢苯基阿夕斯丁及其类似物的合成 |
-
2005
- 2005-02-04 NZ NZ548659A patent/NZ548659A/en unknown
- 2005-02-04 CA CA002553630A patent/CA2553630A1/fr not_active Abandoned
- 2005-02-04 BR BRPI0506655-7A patent/BRPI0506655A/pt not_active IP Right Cessation
- 2005-02-04 WO PCT/US2005/003636 patent/WO2005077940A1/fr active Application Filing
- 2005-02-04 KR KR1020067017883A patent/KR101228104B1/ko active IP Right Grant
- 2005-02-04 AU AU2005212399A patent/AU2005212399B2/en not_active Ceased
- 2005-02-04 JP JP2006552282A patent/JP2007520565A/ja active Pending
- 2005-02-04 EP EP05712910A patent/EP1711487A1/fr not_active Withdrawn
-
2006
- 2006-07-18 IL IL176932A patent/IL176932A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR101228104B1 (ko) | 2013-02-01 |
| IL176932A0 (en) | 2006-12-10 |
| KR20060124743A (ko) | 2006-12-05 |
| AU2005212399B2 (en) | 2011-09-22 |
| WO2005077940A1 (fr) | 2005-08-25 |
| AU2005212399A1 (en) | 2005-08-25 |
| BRPI0506655A (pt) | 2007-05-08 |
| EP1711487A1 (fr) | 2006-10-18 |
| JP2007520565A (ja) | 2007-07-26 |
| NZ548659A (en) | 2011-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |
Effective date: 20130204 |