CA2551877A1 - Neutralizing epitope-based growth enhancing vaccine - Google Patents
Neutralizing epitope-based growth enhancing vaccine Download PDFInfo
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- CA2551877A1 CA2551877A1 CA002551877A CA2551877A CA2551877A1 CA 2551877 A1 CA2551877 A1 CA 2551877A1 CA 002551877 A CA002551877 A CA 002551877A CA 2551877 A CA2551877 A CA 2551877A CA 2551877 A1 CA2551877 A1 CA 2551877A1
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A61P37/00—Drugs for immunological or allergic disorders
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- Diabetes (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| CA2514184C (en) * | 2003-01-21 | 2016-04-12 | Ptc Therapeutics, Inc. | Methods for identifying compounds that modulate untranslated region-dependent gene expression and methods of using same |
| US9068234B2 (en) | 2003-01-21 | 2015-06-30 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating gene expression |
| US8426194B2 (en) * | 2003-01-21 | 2013-04-23 | Ptc Therapeutics, Inc. | Methods and agents for screening for compounds capable of modulating VEGF expression |
| WO2005066204A2 (en) * | 2003-12-31 | 2005-07-21 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| JP5335239B2 (ja) | 2004-09-30 | 2013-11-06 | マイオスティン・セラピューティクス・プロプライエタリー・リミテッド | ミオスタチンアイソフォーム |
| TW200634156A (en) * | 2004-12-30 | 2006-10-01 | Schering Plough Ltd | Neutralizing epitope-based growth enhancing vaccine |
| JP5052517B2 (ja) * | 2005-10-06 | 2012-10-17 | イーライ リリー アンド カンパニー | 抗ミオスタチン抗体 |
| UA92504C2 (en) | 2005-10-12 | 2010-11-10 | Эли Лилли Энд Компани | Anti-myostatin monoclonal antibody |
| EP2006381B1 (en) | 2006-03-31 | 2016-02-03 | Chugai Seiyaku Kabushiki Kaisha | Method for controlling blood pharmacokinetics of antibodies |
| AU2013231037B2 (en) * | 2006-08-03 | 2016-05-12 | Myostin Therapeutics Pty Ltd | Myostatin antagonists |
| JP2009545313A (ja) * | 2006-08-03 | 2009-12-24 | オリコ・リミテッド | ミオスタチンアンタゴニスト |
| CA2661836A1 (en) | 2006-09-05 | 2008-03-13 | Eli Lilly And Company | Anti-myostatin antibodies |
| US8283115B1 (en) | 2007-06-20 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating muscular dystrophy using UTRN mRNA translation regulation |
| US8283116B1 (en) | 2007-06-22 | 2012-10-09 | Ptc Therapeutics, Inc. | Methods of screening for compounds for treating spinal muscular atrophy using SMN mRNA translation regulation |
| CA2700701C (en) | 2007-09-26 | 2020-12-29 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
| NZ717429A (en) | 2008-04-11 | 2018-07-27 | Chugai Pharmaceutical Co Ltd | Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly |
| JO3340B1 (ar) | 2010-05-26 | 2019-03-13 | Regeneron Pharma | مضادات حيوية لـعامل تمايز النمو 8 البشري |
| UY33421A (es) * | 2010-06-03 | 2011-12-30 | Glaxo Wellcome House | Proteinas de union al antígeno humanizados |
| SG10201506405YA (en) | 2010-08-16 | 2015-10-29 | Amgen Inc | Polypeptides That Bind Myostatin, Compositions And Methods |
| CN108715614A (zh) | 2010-11-30 | 2018-10-30 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| EP2780368B1 (en) | 2011-11-14 | 2018-01-03 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for increasing muscle mass and muscle strength by specifically antagonizing gdf8 and/or activin a |
| JP6774164B2 (ja) | 2012-08-24 | 2020-10-21 | 中外製薬株式会社 | マウスＦｃγＲＩＩ特異的Ｆｃ抗体 |
| KR102318483B1 (ko) | 2013-04-02 | 2021-10-27 | 추가이 세이야쿠 가부시키가이샤 | Ｆｃ영역 개변체 |
| EP2981822B1 (en) | 2013-05-06 | 2020-09-02 | Scholar Rock, Inc. | Compositions and methods for growth factor modulation |
| TW201920262A (zh) | 2013-07-30 | 2019-06-01 | 美商再生元醫藥公司 | 抗活化素ａ之抗體及其用途 |
| WO2016073853A1 (en) | 2014-11-06 | 2016-05-12 | Scholar Rock, Inc. | Anti-pro/latent-myostatin antibodies and uses thereof |
| KR102650420B1 (ko) | 2014-12-19 | 2024-03-21 | 추가이 세이야쿠 가부시키가이샤 | 항-마이오스타틴 항체, 변이체 Fc 영역을 함유하는 폴리펩타이드, 및 사용 방법 |
| KR102605798B1 (ko) | 2015-02-05 | 2023-11-23 | 추가이 세이야쿠 가부시키가이샤 | 이온 농도 의존적 항원 결합 도메인을 포함하는 항체, Fc 영역 개변체, IL-8에 결합하는 항체, 및 그들의 사용 |
| IL255010B2 (en) | 2015-04-15 | 2024-01-01 | Regeneron Pharma | Methods of increasing strength and functionality with gdf8 inhibitors |
| PT3922645T (pt) * | 2015-09-15 | 2025-05-29 | Scholar Rock Inc | ¿anticorpos anti-pró-miostatina/miostatina latente e suas utilizações |
| JP7141336B2 (ja) | 2015-12-25 | 2022-09-22 | 中外製薬株式会社 | 抗ミオスタチン抗体および使用方法 |
| JP2019504064A (ja) | 2016-01-08 | 2019-02-14 | スカラー ロック インコーポレイテッドＳｃｈｏｌａｒ Ｒｏｃｋ，Ｉｎｃ． | 抗プロ／潜在型ミオスタチン抗体およびその使用方法 |
| LT3368069T (lt) | 2016-06-13 | 2020-12-10 | Scholar Rock, Inc. | Miostatino inhibitorių naudojimas, ir kombinuotas gydymas |
| TW202300168A (zh) | 2016-08-05 | 2023-01-01 | 日商中外製藥股份有限公司 | Il-8相關疾病之治療用或預防用組成物 |
| DK3565592T5 (da) | 2017-01-06 | 2024-09-02 | Scholar Rock Inc | Behandling af stofskiftesygdomme ved inhibering af myostatinaktivering |
| MA52417A (fr) | 2018-03-01 | 2021-01-06 | Regeneron Pharma | Procédés de modification de composition corporelle |
| EP4638496A1 (en) | 2022-12-22 | 2025-10-29 | Scholar Rock, Inc. | Selective and potent inhibitory antibodies of myostatin activation |
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| US5977438A (en) | 1988-02-26 | 1999-11-02 | Biosource Technologies, Inc. | Production of peptides in plants as viral coat protein fusions |
| CA2014033C (en) * | 1989-04-07 | 1993-02-09 | Stephen D. Acres | Compositions and treatments for pneumonia in animals |
| AU2699192A (en) * | 1991-10-16 | 1993-05-21 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
| US5422110A (en) * | 1991-10-16 | 1995-06-06 | University Of Saskatchewan | Enhanced immunogenicity using leukotoxin chimeras |
| US20030074680A1 (en) * | 1993-03-19 | 2003-04-17 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| EP0690873B1 (en) * | 1993-03-19 | 2003-06-11 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| US6607884B1 (en) * | 1993-03-19 | 2003-08-19 | The Johns Hopkins University School Of Medicine | Methods of detecting growth differentiation factor-8 |
| US5994618A (en) * | 1997-02-05 | 1999-11-30 | Johns Hopkins University School Of Medicine | Growth differentiation factor-8 transgenic mice |
| US6042832A (en) | 1996-08-28 | 2000-03-28 | Thomas Jefferson University | Polypeptides fused with alfalfa mosaic virus or ilarvirus capsid proteins |
| WO1998033887A1 (en) | 1997-02-05 | 1998-08-06 | The Johns Hopkins University School Of Medicine | Growth differentiation factor-8 |
| WO1998034639A1 (en) * | 1997-02-05 | 1998-08-13 | Biostar Inc. | Immunization against endogenous molecules |
| US6656475B1 (en) * | 1997-08-01 | 2003-12-02 | The Johns Hopkins University School Of Medicine | Growth differentiation factor receptors, agonists and antagonists thereof, and methods of using same |
| GB2333706A (en) | 1998-02-02 | 1999-08-04 | Merck & Co Inc | Method for increasing muscle mass in animals |
| US6369201B1 (en) * | 1998-02-19 | 2002-04-09 | Metamorphix International, Inc. | Myostatin multimers |
| US6004937A (en) * | 1998-03-09 | 1999-12-21 | Genetics Institute, Inc. | Use of follistatin to modulate growth and differentiation factor 8 [GDF-8] and bone morphogenic protein 11 [BMP-11] |
| DE69941116D1 (de) * | 1998-05-06 | 2009-08-27 | Metamorphix Inc | G von gdf-8 |
| US6284882B1 (en) * | 1999-06-10 | 2001-09-04 | Abbott Laboratories | Myostatin gene promoter and inhibition of activation thereof |
| JP2003506325A (ja) * | 1999-07-20 | 2003-02-18 | ファーメクサ エイ／エス | Ｇｄｆ−８活性のダウン−レギュレート方法 |
| EP1072680A1 (en) * | 1999-07-30 | 2001-01-31 | Pfizer Products Inc. | Myostatin regulatory region, nucleotide sequence determination and methods for its use |
| EP1221961A4 (en) | 1999-10-13 | 2004-03-31 | Roswell Park Memorial Inst | INDUCTION OF A STRONG IMMUNE RESPONSE TO A TUMOR-RELATED SELF-ANTIGEN |
| US6730306B1 (en) * | 2000-03-08 | 2004-05-04 | Large Scale Biology Corporation | Parvovirus vaccine as viral coat protein fusions |
| US7037501B2 (en) * | 2001-01-04 | 2006-05-02 | Regents Of The University Of Minnesota | Myostatin immnoconjugate |
| US7320789B2 (en) | 2001-09-26 | 2008-01-22 | Wyeth | Antibody inhibitors of GDF-8 and uses thereof |
| WO2004052930A2 (en) | 2002-12-11 | 2004-06-24 | Pharmexa A/S | Targeting single epitopes |
| WO2004058988A2 (en) | 2002-12-20 | 2004-07-15 | Amgen, Inc. | Binding agents which inhibit myostatin |
| WO2005066204A2 (en) * | 2003-12-31 | 2005-07-21 | Schering-Plough Ltd. | Neutralizing epitope-based growth enhancing vaccine |
| US20060281075A1 (en) * | 2004-12-22 | 2006-12-14 | Large Scale Biology Corporation | Purification of viruses, proteins and nucleic acids |
| TW200634156A (en) | 2004-12-30 | 2006-10-01 | Schering Plough Ltd | Neutralizing epitope-based growth enhancing vaccine |
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- 2004-12-21 CA CA002551877A patent/CA2551877A1/en not_active Abandoned
- 2004-12-21 UA UAA200608516A patent/UA93855C2/ru unknown
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| NO20063478L (no) | 2006-08-28 |
| US7585648B2 (en) | 2009-09-08 |
| KR20060120229A (ko) | 2006-11-24 |
| UA93855C2 (ru) | 2011-03-25 |
| US20050143306A1 (en) | 2005-06-30 |
| IL176494A0 (en) | 2006-10-05 |
| AU2004312411B2 (en) | 2011-11-03 |
| RU2422460C2 (ru) | 2011-06-27 |
| PE20051050A1 (es) | 2005-12-12 |
| BRPI0418317A (pt) | 2007-05-02 |
| TW200526683A (en) | 2005-08-16 |
| JP2011083290A (ja) | 2011-04-28 |
| ECSP066683A (es) | 2006-10-25 |
| TWI357906B (en) | 2012-02-11 |
| EP1699820A2 (en) | 2006-09-13 |
| JP2007535912A (ja) | 2007-12-13 |
| MXPA06007514A (es) | 2006-08-31 |
| AR047345A1 (es) | 2006-01-18 |
| WO2005066204A2 (en) | 2005-07-21 |
| US20090311282A1 (en) | 2009-12-17 |
| WO2005066204A3 (en) | 2005-08-11 |
| US20080227156A1 (en) | 2008-09-18 |
| NZ547593A (en) | 2009-09-25 |
| US7892561B2 (en) | 2011-02-22 |
| CN1902221A (zh) | 2007-01-24 |
| US7371726B2 (en) | 2008-05-13 |
| ZA200605227B (en) | 2007-03-28 |
| AU2004312411B8 (en) | 2011-11-24 |
| RU2006127314A (ru) | 2008-02-10 |
| SG153874A1 (en) | 2009-07-29 |
| AU2004312411A1 (en) | 2005-07-21 |
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