CA2550091A1 - Methods of treating a disorder - Google Patents

Info

Publication number

CA2550091A1

CA2550091A1 CA002550091A CA2550091A CA2550091A1 CA 2550091 A1 CA2550091 A1 CA 2550091A1 CA 002550091 A CA002550091 A CA 002550091A CA 2550091 A CA2550091 A CA 2550091A CA 2550091 A1 CA2550091 A1 CA 2550091A1

Authority

CA

Canada

Prior art keywords

alkyl

aminocarbonyl

amino

dialkyl

hydrazinocarbonyl

Prior art date

2003-12-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 238000000034 method Methods 0.000 title claims abstract description 186
• 150000001875 compounds Chemical class 0.000 claims abstract description 291
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract description 160
• 208000035475 disorder Diseases 0.000 claims abstract description 102
• 208000015122 neurodegenerative disease Diseases 0.000 claims abstract description 23
• 230000001613 neoplastic effect Effects 0.000 claims abstract description 16
• 210000001789 adipocyte Anatomy 0.000 claims abstract description 9
• -1 cyano, nitro, amino Chemical group 0.000 claims description 221
• 125000000392 cycloalkenyl group Chemical group 0.000 claims description 82
• 125000000475 sulfinyl group Chemical group [*:2]S([*:1])=O 0.000 claims description 63
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 59
• 125000004366 heterocycloalkenyl group Chemical group 0.000 claims description 59
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 58
• 125000000623 heterocyclic group Chemical group 0.000 claims description 57
• 125000000217 alkyl group Chemical group 0.000 claims description 52
• 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims description 52
• 125000005309 thioalkoxy group Chemical group 0.000 claims description 51
• 102000011990 Sirtuin Human genes 0.000 claims description 48
• 108050002485 Sirtuin Proteins 0.000 claims description 48
• 125000002252 acyl group Chemical group 0.000 claims description 46
• 125000003118 aryl group Chemical group 0.000 claims description 40
• 206010028980 Neoplasm Diseases 0.000 claims description 39
• 125000005296 thioaryloxy group Chemical group 0.000 claims description 39
• 125000003710 aryl alkyl group Chemical group 0.000 claims description 37
• 125000005404 thioheteroaryloxy group Chemical group 0.000 claims description 36
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 35
• 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims description 33
• 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims description 33
• 208000024827 Alzheimer disease Diseases 0.000 claims description 33
• 125000003368 amide group Chemical group 0.000 claims description 33
• 229910019142 PO4 Inorganic materials 0.000 claims description 32
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims description 32
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 31
• 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims description 31
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims description 31
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 31
• 239000010452 phosphate Substances 0.000 claims description 31
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 30
• 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims description 29
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 27
• 125000004694 alkoxyaminocarbonyl group Chemical group 0.000 claims description 24
• 206010012601 diabetes mellitus Diseases 0.000 claims description 24
• 125000001424 substituent group Chemical group 0.000 claims description 23
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 23
• 125000003545 alkoxy group Chemical group 0.000 claims description 21
• 125000004475 heteroaralkyl group Chemical group 0.000 claims description 21
• 125000001188 haloalkyl group Chemical group 0.000 claims description 20
• 125000004737 (C1-C6) haloalkoxy group Chemical group 0.000 claims description 19
• 201000011510 cancer Diseases 0.000 claims description 19
• 229910052799 carbon Inorganic materials 0.000 claims description 18
• 125000005530 alkylenedioxy group Chemical group 0.000 claims description 17
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 17
• 125000004663 dialkyl amino group Chemical group 0.000 claims description 17
• 125000003342 alkenyl group Chemical group 0.000 claims description 16
• 125000000747 amidyl group Chemical group [H][N-]* 0.000 claims description 14
• 125000004104 aryloxy group Chemical group 0.000 claims description 14
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 13
• 229910052760 oxygen Inorganic materials 0.000 claims description 13
• 125000005553 heteroaryloxy group Chemical group 0.000 claims description 12
• 125000004043 oxo group Chemical group O=* 0.000 claims description 12
• 208000018737 Parkinson disease Diseases 0.000 claims description 11
• 125000004122 cyclic group Chemical group 0.000 claims description 11
• 125000005097 aminocarbonylalkyl group Chemical group 0.000 claims description 10
• 206010022489 Insulin Resistance Diseases 0.000 claims description 9
• 208000001145 Metabolic Syndrome Diseases 0.000 claims description 7
• 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims description 7
• 208000002705 Glucose Intolerance Diseases 0.000 claims description 6
• 206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 6
• SQERDRRMCKKWIL-UHFFFAOYSA-N 2-hydroperoxy-2-oxoacetic acid Chemical group OOC(=O)C(O)=O SQERDRRMCKKWIL-UHFFFAOYSA-N 0.000 claims description 5
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 5
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 5
• PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical group [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 claims description 5
• 229910052717 sulfur Inorganic materials 0.000 claims description 5
• 201000009104 prediabetes syndrome Diseases 0.000 claims description 4
• 206010020772 Hypertension Diseases 0.000 claims description 3
• 208000017170 Lipid metabolism disease Diseases 0.000 claims description 3
• 201000001421 hyperglycemia Diseases 0.000 claims description 3
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 3
• 235000001508 sulfur Nutrition 0.000 claims description 3
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 2
• 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 2
• 208000032928 Dyslipidaemia Diseases 0.000 claims description 2
• 206010018429 Glucose tolerance impaired Diseases 0.000 claims description 2
• 230000011759 adipose tissue development Effects 0.000 claims description 2
• 125000002102 aryl alkyloxo group Chemical group 0.000 claims description 2
• 230000000923 atherogenic effect Effects 0.000 claims description 2
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 2
• 230000001771 impaired effect Effects 0.000 claims description 2
• 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 45
• 125000000041 C6-C10 aryl group Chemical group 0.000 claims 39
• 125000001313 C5-C10 heteroaryl group Chemical group 0.000 claims 33
• 125000001475 halogen functional group Chemical group 0.000 claims 30
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 20
• 125000000027 (C1-C10) alkoxy group Chemical group 0.000 claims 14
• 229910006069 SO3H Inorganic materials 0.000 claims 9
• 125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims 9
• 125000001831 (C6-C10) heteroaryl group Chemical group 0.000 claims 6
• AKEJUJNQAAGONA-UHFFFAOYSA-N sulfur trioxide Chemical compound O=S(=O)=O AKEJUJNQAAGONA-UHFFFAOYSA-N 0.000 claims 3
• 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 1
• 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 1
• 125000005114 heteroarylalkoxy group Chemical group 0.000 claims 1
• 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
• 208000030159 metabolic disease Diseases 0.000 abstract description 12
• 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
• 108090000623 proteins and genes Proteins 0.000 description 95
• 102000004169 proteins and genes Human genes 0.000 description 74
• 235000018102 proteins Nutrition 0.000 description 68
• 102100031455 NAD-dependent protein deacetylase sirtuin-1 Human genes 0.000 description 62
• 108010041191 Sirtuin 1 Proteins 0.000 description 60
• 210000004027 cell Anatomy 0.000 description 56
• 201000010099 disease Diseases 0.000 description 55
• 239000000203 mixture Substances 0.000 description 50
• 230000000694 effects Effects 0.000 description 49
• 241000282414 Homo sapiens Species 0.000 description 46
• 208000024891 symptom Diseases 0.000 description 41
• 238000012360 testing method Methods 0.000 description 39
• 125000005843 halogen group Chemical group 0.000 description 35
• 238000003556 assay Methods 0.000 description 34
• 125000001072 heteroaryl group Chemical group 0.000 description 33
• 241001465754 Metazoa Species 0.000 description 28
• 239000000758 substrate Substances 0.000 description 23
• 238000009739 binding Methods 0.000 description 22
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 22
• 230000003993 interaction Effects 0.000 description 22
• 230000027455 binding Effects 0.000 description 21
• 125000004356 hydroxy functional group Chemical group O* 0.000 description 21
• 239000000463 material Substances 0.000 description 21
• 235000021317 phosphate Nutrition 0.000 description 19
• 239000000126 substance Substances 0.000 description 19
• 208000023105 Huntington disease Diseases 0.000 description 18
• 125000000304 alkynyl group Chemical group 0.000 description 18
• 239000003795 chemical substances by application Substances 0.000 description 18
• 108090000765 processed proteins & peptides Proteins 0.000 description 18
• 238000011282 treatment Methods 0.000 description 18
• 230000002068 genetic effect Effects 0.000 description 17
• 125000005842 heteroatom Chemical group 0.000 description 17
• 229920000155 polyglutamine Polymers 0.000 description 17
• 210000001519 tissue Anatomy 0.000 description 17
• 101001030705 Homo sapiens Huntingtin Proteins 0.000 description 16
• 208000009415 Spinocerebellar Ataxias Diseases 0.000 description 16
• 206010002026 amyotrophic lateral sclerosis Diseases 0.000 description 16
• 239000008194 pharmaceutical composition Substances 0.000 description 16
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 15
• 208000012902 Nervous system disease Diseases 0.000 description 15
• 235000002639 sodium chloride Nutrition 0.000 description 15
• 102100025064 Cellular tumor antigen p53 Human genes 0.000 description 14
• 101000721661 Homo sapiens Cellular tumor antigen p53 Proteins 0.000 description 14
• 101000654471 Mus musculus NAD-dependent protein deacetylase sirtuin-1 Proteins 0.000 description 14
• 108091023040 Transcription factor Proteins 0.000 description 14
• 102000040945 Transcription factor Human genes 0.000 description 14
• 239000005090 green fluorescent protein Substances 0.000 description 14
• 102000054185 human HTT Human genes 0.000 description 14
• 230000004770 neurodegeneration Effects 0.000 description 14
• 108010040003 polyglutamine Proteins 0.000 description 14
• 230000000750 progressive effect Effects 0.000 description 14
• 238000011830 transgenic mouse model Methods 0.000 description 14
• 239000003814 drug Substances 0.000 description 13
• 230000001404 mediated effect Effects 0.000 description 13
• 201000006417 multiple sclerosis Diseases 0.000 description 13
• 208000008589 Obesity Diseases 0.000 description 12
• 125000002619 bicyclic group Chemical group 0.000 description 12
• 230000001419 dependent effect Effects 0.000 description 12
• 210000002569 neuron Anatomy 0.000 description 12
• 235000020824 obesity Nutrition 0.000 description 12
• 239000007787 solid Substances 0.000 description 12
• 230000009261 transgenic effect Effects 0.000 description 12
• 102000004877 Insulin Human genes 0.000 description 11
• 108090001061 Insulin Proteins 0.000 description 11
• 206010064930 age-related macular degeneration Diseases 0.000 description 11
• 238000010171 animal model Methods 0.000 description 11
• 239000003153 chemical reaction reagent Substances 0.000 description 11
• 108020001507 fusion proteins Proteins 0.000 description 11
• 102000037865 fusion proteins Human genes 0.000 description 11
• 229940125396 insulin Drugs 0.000 description 11
• 201000001119 neuropathy Diseases 0.000 description 11
• 230000007823 neuropathy Effects 0.000 description 11
• 150000003839 salts Chemical class 0.000 description 11
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 11
• 108010043121 Green Fluorescent Proteins Proteins 0.000 description 10
• 102000004144 Green Fluorescent Proteins Human genes 0.000 description 10
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 10
• 102100022913 NAD-dependent protein deacetylase sirtuin-2 Human genes 0.000 description 10
• DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 10
• 239000000853 adhesive Substances 0.000 description 10
• 230000001070 adhesive effect Effects 0.000 description 10
• 230000002776 aggregation Effects 0.000 description 10
• 238000004220 aggregation Methods 0.000 description 10
• 210000004369 blood Anatomy 0.000 description 10
• 239000008280 blood Substances 0.000 description 10
• 239000002552 dosage form Substances 0.000 description 10
• 208000033808 peripheral neuropathy Diseases 0.000 description 10
• 201000009030 Carcinoma Diseases 0.000 description 9
• KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 9
• 241000700159 Rattus Species 0.000 description 9
• 230000005856 abnormality Effects 0.000 description 9
• 210000004556 brain Anatomy 0.000 description 9
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 9
• 125000004438 haloalkoxy group Chemical group 0.000 description 9
• 125000002950 monocyclic group Chemical group 0.000 description 9
• 238000002360 preparation method Methods 0.000 description 9
• 102000004196 processed proteins & peptides Human genes 0.000 description 9
• 239000000047 product Substances 0.000 description 9
• 230000002829 reductive effect Effects 0.000 description 9
• 239000002904 solvent Substances 0.000 description 9
• 108010033040 Histones Proteins 0.000 description 8
• 102100030710 NAD-dependent protein deacetylase sirtuin-3, mitochondrial Human genes 0.000 description 8
• 108010041216 Sirtuin 2 Proteins 0.000 description 8
• 102000004243 Tubulin Human genes 0.000 description 8
• 108090000704 Tubulin Proteins 0.000 description 8
• 230000002159 abnormal effect Effects 0.000 description 8
• 125000003275 alpha amino acid group Chemical group 0.000 description 8
• 235000001014 amino acid Nutrition 0.000 description 8
• 229940024606 amino acid Drugs 0.000 description 8
• 238000004519 manufacturing process Methods 0.000 description 8
• 210000003205 muscle Anatomy 0.000 description 8
• 230000035772 mutation Effects 0.000 description 8
• 150000007523 nucleic acids Chemical class 0.000 description 8
• 125000003367 polycyclic group Chemical group 0.000 description 8
• 239000000243 solution Substances 0.000 description 8
• 229940124597 therapeutic agent Drugs 0.000 description 8
• 101710137189 Amyloid-beta A4 protein Proteins 0.000 description 7
• 101710151993 Amyloid-beta precursor protein Proteins 0.000 description 7
• 208000024172 Cardiovascular disease Diseases 0.000 description 7
• 102000004190 Enzymes Human genes 0.000 description 7
• 108090000790 Enzymes Proteins 0.000 description 7
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
• 241000699670 Mus sp. Species 0.000 description 7
• 239000002253 acid Substances 0.000 description 7
• 230000006907 apoptotic process Effects 0.000 description 7
• 125000004429 atom Chemical group 0.000 description 7
• 150000001721 carbon Chemical group 0.000 description 7
• 125000004432 carbon atom Chemical group C* 0.000 description 7
• 230000006196 deacetylation Effects 0.000 description 7
• 238000003381 deacetylation reaction Methods 0.000 description 7
• 238000009472 formulation Methods 0.000 description 7
• 239000008103 glucose Substances 0.000 description 7
• 101150113725 hd gene Proteins 0.000 description 7
• 238000000338 in vitro Methods 0.000 description 7
• 238000002347 injection Methods 0.000 description 7
• 239000007924 injection Substances 0.000 description 7
• 210000002161 motor neuron Anatomy 0.000 description 7
• 230000008685 targeting Effects 0.000 description 7
• DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical compound CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 description 6
• 102100022704 Amyloid-beta precursor protein Human genes 0.000 description 6
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 6
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 6
• 208000027747 Kennedy disease Diseases 0.000 description 6
• 208000002569 Machado-Joseph Disease Diseases 0.000 description 6
• 241000124008 Mammalia Species 0.000 description 6
• 206010028289 Muscle atrophy Diseases 0.000 description 6
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 6
• 208000036834 Spinocerebellar ataxia type 3 Diseases 0.000 description 6
• 208000009956 adenocarcinoma Diseases 0.000 description 6
• 150000001413 amino acids Chemical group 0.000 description 6
• DZHSAHHDTRWUTF-SIQRNXPUSA-N amyloid-beta polypeptide 42 Chemical compound C([C@@H](C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C)C(O)=O)[C@@H](C)CC)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(O)=O)C(C)C)C(C)C)C1=CC=CC=C1 DZHSAHHDTRWUTF-SIQRNXPUSA-N 0.000 description 6
• 239000005557 antagonist Substances 0.000 description 6
• 239000012131 assay buffer Substances 0.000 description 6
• 238000013461 design Methods 0.000 description 6
• 239000003937 drug carrier Substances 0.000 description 6
• 239000012634 fragment Substances 0.000 description 6
• 125000001183 hydrocarbyl group Chemical group 0.000 description 6
• 230000001965 increasing effect Effects 0.000 description 6
• 208000002780 macular degeneration Diseases 0.000 description 6
• 230000036210 malignancy Effects 0.000 description 6
• 230000020763 muscle atrophy Effects 0.000 description 6
• 201000000585 muscular atrophy Diseases 0.000 description 6
• 229960003966 nicotinamide Drugs 0.000 description 6
• 239000011570 nicotinamide Substances 0.000 description 6
• 102000039446 nucleic acids Human genes 0.000 description 6
• 108020004707 nucleic acids Proteins 0.000 description 6
• 239000002773 nucleotide Substances 0.000 description 6
• 125000003729 nucleotide group Chemical group 0.000 description 6
• 229920001184 polypeptide Polymers 0.000 description 6
• 125000006413 ring segment Chemical group 0.000 description 6
• 239000000523 sample Substances 0.000 description 6
• 239000000725 suspension Substances 0.000 description 6
• 108700028369 Alleles Proteins 0.000 description 5
• 101000654472 Homo sapiens NAD-dependent protein deacetylase sirtuin-1 Proteins 0.000 description 5
• 206010060862 Prostate cancer Diseases 0.000 description 5
• 208000026214 Skeletal muscle atrophy Diseases 0.000 description 5
• 102000019197 Superoxide Dismutase Human genes 0.000 description 5
• 108010012715 Superoxide dismutase Proteins 0.000 description 5
• 230000021736 acetylation Effects 0.000 description 5
• 238000006640 acetylation reaction Methods 0.000 description 5
• 230000032683 aging Effects 0.000 description 5
• 125000003282 alkyl amino group Chemical group 0.000 description 5
• 230000015572 biosynthetic process Effects 0.000 description 5
• 239000000872 buffer Substances 0.000 description 5
• 230000008859 change Effects 0.000 description 5
• 238000006243 chemical reaction Methods 0.000 description 5
• 239000000460 chlorine Substances 0.000 description 5
• 230000007423 decrease Effects 0.000 description 5
• 108010048367 enhanced green fluorescent protein Proteins 0.000 description 5
• 230000002255 enzymatic effect Effects 0.000 description 5
• 238000002875 fluorescence polarization Methods 0.000 description 5
• 230000006870 function Effects 0.000 description 5
• 230000012010 growth Effects 0.000 description 5
• 238000001727 in vivo Methods 0.000 description 5
• 210000003141 lower extremity Anatomy 0.000 description 5
• 235000018977 lysine Nutrition 0.000 description 5
• 239000011159 matrix material Substances 0.000 description 5
• 235000005152 nicotinamide Nutrition 0.000 description 5
• 229910052757 nitrogen Inorganic materials 0.000 description 5
• 150000003254 radicals Chemical class 0.000 description 5
• 230000025185 skeletal muscle atrophy Effects 0.000 description 5
• 238000003786 synthesis reaction Methods 0.000 description 5
• QXJDOADTRZGPJZ-UHFFFAOYSA-N 1-benzothiophene-3-carboxamide Chemical compound C1=CC=C2C(C(=O)N)=CSC2=C1 QXJDOADTRZGPJZ-UHFFFAOYSA-N 0.000 description 4
• PLRACCBDVIHHLZ-UHFFFAOYSA-N 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Chemical compound C1N(C)CCC(C=2C=CC=CC=2)=C1 PLRACCBDVIHHLZ-UHFFFAOYSA-N 0.000 description 4
• KFXATFHYDIVAOC-UHFFFAOYSA-N 2,3,3a,4-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=CCC2C(C(=O)N)CSC2=C1 KFXATFHYDIVAOC-UHFFFAOYSA-N 0.000 description 4
• SMNDYUVBFMFKNZ-UHFFFAOYSA-N 2-furoic acid Chemical compound OC(=O)C1=CC=CO1 SMNDYUVBFMFKNZ-UHFFFAOYSA-N 0.000 description 4
• 208000037259 Amyloid Plaque Diseases 0.000 description 4
• 102000007371 Ataxin-3 Human genes 0.000 description 4
• 102000007368 Ataxin-7 Human genes 0.000 description 4
• 108010032953 Ataxin-7 Proteins 0.000 description 4
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
• 208000029402 Bulbospinal muscular atrophy Diseases 0.000 description 4
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 4
• 201000008163 Dentatorubral pallidoluysian atrophy Diseases 0.000 description 4
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 4
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 4
• 102000006947 Histones Human genes 0.000 description 4
• 101000915806 Homo sapiens Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Proteins 0.000 description 4
• TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
• 238000005481 NMR spectroscopy Methods 0.000 description 4
• 108091005770 SIRT3 Proteins 0.000 description 4
• 102100029014 Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform Human genes 0.000 description 4
• 239000002671 adjuvant Substances 0.000 description 4
• VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 4
• 238000004458 analytical method Methods 0.000 description 4
• 239000011324 bead Substances 0.000 description 4
• 210000001175 cerebrospinal fluid Anatomy 0.000 description 4
• 210000004978 chinese hamster ovary cell Anatomy 0.000 description 4
• 230000001684 chronic effect Effects 0.000 description 4
• 230000001149 cognitive effect Effects 0.000 description 4
• 230000002950 deficient Effects 0.000 description 4
• 230000006735 deficit Effects 0.000 description 4
• 230000007850 degeneration Effects 0.000 description 4
• 238000001514 detection method Methods 0.000 description 4
• 235000005911 diet Nutrition 0.000 description 4
• 230000037213 diet Effects 0.000 description 4
• 239000003085 diluting agent Substances 0.000 description 4
• 238000010790 dilution Methods 0.000 description 4
• 239000012895 dilution Substances 0.000 description 4
• 239000002270 dispersing agent Substances 0.000 description 4
• VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 description 4
• 238000005516 engineering process Methods 0.000 description 4
• 235000019197 fats Nutrition 0.000 description 4
• MHMNJMPURVTYEJ-UHFFFAOYSA-N fluorescein-5-isothiocyanate Chemical compound O1C(=O)C2=CC(N=C=S)=CC=C2C21C1=CC=C(O)C=C1OC1=CC(O)=CC=C21 MHMNJMPURVTYEJ-UHFFFAOYSA-N 0.000 description 4
• 230000030279 gene silencing Effects 0.000 description 4
• 235000004554 glutamine Nutrition 0.000 description 4
• 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 4
• RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 4
• 102000056482 human SIRT1 Human genes 0.000 description 4
• 206010020718 hyperplasia Diseases 0.000 description 4
• 238000003384 imaging method Methods 0.000 description 4
• 239000004615 ingredient Substances 0.000 description 4
• 230000002401 inhibitory effect Effects 0.000 description 4
• 230000003902 lesion Effects 0.000 description 4
• 239000007788 liquid Substances 0.000 description 4
• 210000004072 lung Anatomy 0.000 description 4
• 230000007257 malfunction Effects 0.000 description 4
• 239000003550 marker Substances 0.000 description 4
• 230000015654 memory Effects 0.000 description 4
• 230000004060 metabolic process Effects 0.000 description 4
• 230000009826 neoplastic cell growth Effects 0.000 description 4
• 239000012071 phase Substances 0.000 description 4
• 239000002243 precursor Substances 0.000 description 4
• 125000006239 protecting group Chemical group 0.000 description 4
• 239000011541 reaction mixture Substances 0.000 description 4
• 210000002027 skeletal muscle Anatomy 0.000 description 4
• 238000005556 structure-activity relationship Methods 0.000 description 4
• 238000006467 substitution reaction Methods 0.000 description 4
• 208000011580 syndromic disease Diseases 0.000 description 4
• RTKIYFITIVXBLE-QEQCGCAPSA-N trichostatin A Chemical compound ONC(=O)/C=C/C(/C)=C/[C@@H](C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-QEQCGCAPSA-N 0.000 description 4
• 238000013293 zucker diabetic fatty rat Methods 0.000 description 4
• WUYMUVBIVVABRN-UHFFFAOYSA-N 1-[[4-[4-amino-5-(3-methoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]methyl]piperidin-4-ol Chemical compound COC1=CC=CC(C=2C3=C(N)N=CN=C3N(C=3C=CC(CN4CCC(O)CC4)=CC=3)C=2)=C1 WUYMUVBIVVABRN-UHFFFAOYSA-N 0.000 description 3
• ZKXSEMXZKAQARN-UHFFFAOYSA-N 2-amino-4,5-dimethylthiophene-3-carboxamide Chemical compound CC=1SC(N)=C(C(N)=O)C=1C ZKXSEMXZKAQARN-UHFFFAOYSA-N 0.000 description 3
• STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 3
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 3
• 206010061666 Autonomic neuropathy Diseases 0.000 description 3
• 201000004569 Blindness Diseases 0.000 description 3
• 208000026310 Breast neoplasm Diseases 0.000 description 3
• 206010008748 Chorea Diseases 0.000 description 3
• 229920000858 Cyclodextrin Polymers 0.000 description 3
• 102100030497 Cytochrome c Human genes 0.000 description 3
• 108010092160 Dactinomycin Proteins 0.000 description 3
• 102100031814 EGF-containing fibulin-like extracellular matrix protein 1 Human genes 0.000 description 3
• 101000863566 Homo sapiens NAD-dependent protein deacetylase sirtuin-3, mitochondrial Proteins 0.000 description 3
• 101001035259 Homo sapiens Probable E3 ubiquitin-protein ligase HERC4 Proteins 0.000 description 3
• 239000004472 Lysine Substances 0.000 description 3
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
• 241000699666 Mus <mouse, genus> Species 0.000 description 3
• 208000010428 Muscle Weakness Diseases 0.000 description 3
• 206010028372 Muscular weakness Diseases 0.000 description 3
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 3
• 102100021840 NAD-dependent protein deacetylase sirtuin-6 Human genes 0.000 description 3
• 102100034376 NAD-dependent protein deacetylase sirtuin-7 Human genes 0.000 description 3
• 102100030709 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Human genes 0.000 description 3
• 208000025966 Neurological disease Diseases 0.000 description 3
• 206010033307 Overweight Diseases 0.000 description 3
• 102100039913 Probable E3 ubiquitin-protein ligase HERC4 Human genes 0.000 description 3
• DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
• 208000000236 Prostatic Neoplasms Diseases 0.000 description 3
• 208000006265 Renal cell carcinoma Diseases 0.000 description 3
• ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 3
• 208000025865 Ulcer Diseases 0.000 description 3
• 230000001154 acute effect Effects 0.000 description 3
• 239000000556 agonist Substances 0.000 description 3
• 239000002246 antineoplastic agent Substances 0.000 description 3
• 239000002585 base Substances 0.000 description 3
• 230000004071 biological effect Effects 0.000 description 3
• 230000036772 blood pressure Effects 0.000 description 3
• 230000037396 body weight Effects 0.000 description 3
• 210000005013 brain tissue Anatomy 0.000 description 3
• 210000000481 breast Anatomy 0.000 description 3
• 239000000969 carrier Substances 0.000 description 3
• 230000003197 catalytic effect Effects 0.000 description 3
• 230000010261 cell growth Effects 0.000 description 3
• 230000001413 cellular effect Effects 0.000 description 3
• 125000003636 chemical group Chemical group 0.000 description 3
• 208000012601 choreatic disease Diseases 0.000 description 3
• 238000004587 chromatography analysis Methods 0.000 description 3
• 210000001072 colon Anatomy 0.000 description 3
• 208000029078 coronary artery disease Diseases 0.000 description 3
• 230000006378 damage Effects 0.000 description 3
• STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 3
• 230000003247 decreasing effect Effects 0.000 description 3
• 238000011161 development Methods 0.000 description 3
• 230000018109 developmental process Effects 0.000 description 3
• 238000003745 diagnosis Methods 0.000 description 3
• 235000014113 dietary fatty acids Nutrition 0.000 description 3
• 230000003292 diminished effect Effects 0.000 description 3
• 208000016097 disease of metabolism Diseases 0.000 description 3
• 230000003291 dopaminomimetic effect Effects 0.000 description 3
• 229940079593 drug Drugs 0.000 description 3
• 239000003995 emulsifying agent Substances 0.000 description 3
• 239000000839 emulsion Substances 0.000 description 3
• 210000003414 extremity Anatomy 0.000 description 3
• 239000000194 fatty acid Substances 0.000 description 3
• 229930195729 fatty acid Natural products 0.000 description 3
• 150000004665 fatty acids Chemical class 0.000 description 3
• 230000004927 fusion Effects 0.000 description 3
• 238000012226 gene silencing method Methods 0.000 description 3
• 125000004446 heteroarylalkyl group Chemical group 0.000 description 3
• 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
• 230000009878 intermolecular interaction Effects 0.000 description 3
• 150000002500 ions Chemical class 0.000 description 3
• 150000002669 lysines Chemical class 0.000 description 3
• 239000011777 magnesium Substances 0.000 description 3
• 229910052749 magnesium Inorganic materials 0.000 description 3
• 239000002609 medium Substances 0.000 description 3
• 230000002503 metabolic effect Effects 0.000 description 3
• 230000001394 metastastic effect Effects 0.000 description 3
• 206010061289 metastatic neoplasm Diseases 0.000 description 3
• 238000000386 microscopy Methods 0.000 description 3
• 230000004048 modification Effects 0.000 description 3
• 238000012986 modification Methods 0.000 description 3
• 238000010172 mouse model Methods 0.000 description 3
• 210000005170 neoplastic cell Anatomy 0.000 description 3
• 210000002682 neurofibrillary tangle Anatomy 0.000 description 3
• 208000002154 non-small cell lung carcinoma Diseases 0.000 description 3
• 231100000252 nontoxic Toxicity 0.000 description 3
• 230000003000 nontoxic effect Effects 0.000 description 3
• 238000003499 nucleic acid array Methods 0.000 description 3
• 210000000056 organ Anatomy 0.000 description 3
• 210000001672 ovary Anatomy 0.000 description 3
• 235000020825 overweight Nutrition 0.000 description 3
• 208000035824 paresthesia Diseases 0.000 description 3
• 230000001575 pathological effect Effects 0.000 description 3
• 229920001223 polyethylene glycol Polymers 0.000 description 3
• 239000013641 positive control Substances 0.000 description 3
• 210000002307 prostate Anatomy 0.000 description 3
• 230000004845 protein aggregation Effects 0.000 description 3
• 238000000746 purification Methods 0.000 description 3
• 230000009467 reduction Effects 0.000 description 3
• 238000011160 research Methods 0.000 description 3
• 229920006395 saturated elastomer Polymers 0.000 description 3
• 239000011780 sodium chloride Substances 0.000 description 3
• 239000007790 solid phase Substances 0.000 description 3
• 238000003860 storage Methods 0.000 description 3
• 229960001052 streptozocin Drugs 0.000 description 3
• ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 3
• 238000002198 surface plasmon resonance spectroscopy Methods 0.000 description 3
• 230000001225 therapeutic effect Effects 0.000 description 3
• DAUYIKBTMNZABP-UHFFFAOYSA-N thiophene-3-carboxamide Chemical compound NC(=O)C=1C=CSC=1 DAUYIKBTMNZABP-UHFFFAOYSA-N 0.000 description 3
• 230000017423 tissue regeneration Effects 0.000 description 3
• 238000012546 transfer Methods 0.000 description 3
• 210000004881 tumor cell Anatomy 0.000 description 3
• 210000001364 upper extremity Anatomy 0.000 description 3
• 239000013598 vector Substances 0.000 description 3
• 239000003981 vehicle Substances 0.000 description 3
• OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 3
• 229960004528 vincristine Drugs 0.000 description 3
• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 3
• YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
• PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
• NMQPIBPZSLMCFI-UHFFFAOYSA-N 2-(4-methylphenyl)acetamide Chemical compound CC1=CC=C(CC(N)=O)C=C1 NMQPIBPZSLMCFI-UHFFFAOYSA-N 0.000 description 2
• VTJUDAHMLJPMOG-UHFFFAOYSA-N 4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1CCCC2=C1SC=C2C(=O)N VTJUDAHMLJPMOG-UHFFFAOYSA-N 0.000 description 2
• YVTQHZDUDUCGRD-UHFFFAOYSA-N 5-bromofuran-2-carboxylic acid Chemical compound OC(=O)C1=CC=C(Br)O1 YVTQHZDUDUCGRD-UHFFFAOYSA-N 0.000 description 2
• XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 2
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 2
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 2
• 208000031261 Acute myeloid leukaemia Diseases 0.000 description 2
• QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
• 208000000044 Amnesia Diseases 0.000 description 2
• 206010003694 Atrophy Diseases 0.000 description 2
• 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 description 2
• 208000032791 BCR-ABL1 positive chronic myelogenous leukemia Diseases 0.000 description 2
• 206010006187 Breast cancer Diseases 0.000 description 2
• 206010068597 Bulbospinal muscular atrophy congenital Diseases 0.000 description 2
• COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 2
• 206010007559 Cardiac failure congestive Diseases 0.000 description 2
• 208000031229 Cardiomyopathies Diseases 0.000 description 2
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
• 208000028698 Cognitive impairment Diseases 0.000 description 2
• 206010009944 Colon cancer Diseases 0.000 description 2
• 229920002261 Corn starch Polymers 0.000 description 2
• 108010075031 Cytochromes c Proteins 0.000 description 2
• 108020004414 DNA Proteins 0.000 description 2
• 206010012289 Dementia Diseases 0.000 description 2
• 208000014094 Dystonic disease Diseases 0.000 description 2
• 206010017577 Gait disturbance Diseases 0.000 description 2
• 206010018341 Gliosis Diseases 0.000 description 2
• 108010024636 Glutathione Proteins 0.000 description 2
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
• 206010019280 Heart failures Diseases 0.000 description 2
• 108700014808 Homeobox Protein Nkx-2.2 Proteins 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 101001065272 Homo sapiens EGF-containing fibulin-like extracellular matrix protein 1 Proteins 0.000 description 2
• 101000616738 Homo sapiens NAD-dependent protein deacetylase sirtuin-6 Proteins 0.000 description 2
• 101000709248 Homo sapiens NAD-dependent protein deacetylase sirtuin-7 Proteins 0.000 description 2
• 101000863629 Homo sapiens NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Proteins 0.000 description 2
• 102000016252 Huntingtin Human genes 0.000 description 2
• 108050004784 Huntingtin Proteins 0.000 description 2
• 208000031226 Hyperlipidaemia Diseases 0.000 description 2
• 208000006083 Hypokinesia Diseases 0.000 description 2
• 108010031794 IGF Type 1 Receptor Proteins 0.000 description 2
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
• 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 description 2
• 102000000589 Interleukin-1 Human genes 0.000 description 2
• 108010002352 Interleukin-1 Proteins 0.000 description 2
• 208000032382 Ischaemic stroke Diseases 0.000 description 2
• ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
• GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 description 2
• 241000282560 Macaca mulatta Species 0.000 description 2
• 206010027476 Metastases Diseases 0.000 description 2
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
• 208000016285 Movement disease Diseases 0.000 description 2
• LRJUYAVTHIEHAI-LHBNDURVSA-N Muristerone Chemical compound C1[C@@H](O)[C@@H](O)C[C@]2(C)[C@@H]([C@H](O)C[C@@]3([C@@H]([C@@](C)(O)[C@H](O)CCC(C)C)CC[C@]33O)C)C3=CC(=O)[C@@]21O LRJUYAVTHIEHAI-LHBNDURVSA-N 0.000 description 2
• 241000699660 Mus musculus Species 0.000 description 2
• 101100460498 Mus musculus Nkx2-2 gene Proteins 0.000 description 2
• 208000002740 Muscle Rigidity Diseases 0.000 description 2
• 208000033776 Myeloid Acute Leukemia Diseases 0.000 description 2
• WPWFMRDPTDEJJA-FAXVYDRBSA-N N-retinylidene-N-retinylethanolamine Chemical compound C=1C(\C=C\C=C(/C)\C=C\C=2C(CCCC=2C)(C)C)=CC=[N+](CCO)C=1\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C WPWFMRDPTDEJJA-FAXVYDRBSA-N 0.000 description 2
• 102100021839 NAD-dependent protein deacylase sirtuin-5, mitochondrial Human genes 0.000 description 2
• 229910002651 NO3 Inorganic materials 0.000 description 2
• 101710138657 Neurotoxin Proteins 0.000 description 2
• 102000004108 Neurotransmitter Receptors Human genes 0.000 description 2
• 108090000590 Neurotransmitter Receptors Proteins 0.000 description 2
• NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 2
• 102000007999 Nuclear Proteins Human genes 0.000 description 2
• 108010089610 Nuclear Proteins Proteins 0.000 description 2
• 108091028043 Nucleic acid sequence Proteins 0.000 description 2
• 241000283973 Oryctolagus cuniculus Species 0.000 description 2
• 206010033128 Ovarian cancer Diseases 0.000 description 2
• 229930012538 Paclitaxel Natural products 0.000 description 2
• 206010033799 Paralysis Diseases 0.000 description 2
• 206010034620 Peripheral sensory neuropathy Diseases 0.000 description 2
• 206010035664 Pneumonia Diseases 0.000 description 2
• 239000002202 Polyethylene glycol Substances 0.000 description 2
• 229920001213 Polysorbate 20 Polymers 0.000 description 2
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 2
• 208000032319 Primary lateral sclerosis Diseases 0.000 description 2
• 241000288906 Primates Species 0.000 description 2
• 208000033766 Prolymphocytic Leukemia Diseases 0.000 description 2
• 208000017442 Retinal disease Diseases 0.000 description 2
• 206010038923 Retinopathy Diseases 0.000 description 2
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
• 206010039491 Sarcoma Diseases 0.000 description 2
• 108010090804 Streptavidin Proteins 0.000 description 2
• 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 description 2
• 210000001744 T-lymphocyte Anatomy 0.000 description 2
• 208000024313 Testicular Neoplasms Diseases 0.000 description 2
• 206010044565 Tremor Diseases 0.000 description 2
• RTKIYFITIVXBLE-UHFFFAOYSA-N Trichostatin A Natural products ONC(=O)C=CC(C)=CC(C)C(=O)C1=CC=C(N(C)C)C=C1 RTKIYFITIVXBLE-UHFFFAOYSA-N 0.000 description 2
• VGQOVCHZGQWAOI-UHFFFAOYSA-N UNPD55612 Natural products N1C(O)C2CC(C=CC(N)=O)=CN2C(=O)C2=CC=C(C)C(O)=C12 VGQOVCHZGQWAOI-UHFFFAOYSA-N 0.000 description 2
• 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 description 2
• 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 description 2
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 2
• 206010047513 Vision blurred Diseases 0.000 description 2
• 208000033559 Waldenström macroglobulinemia Diseases 0.000 description 2
• 208000006269 X-Linked Bulbo-Spinal Atrophy Diseases 0.000 description 2
• 238000009825 accumulation Methods 0.000 description 2
• QTBSBXVTEAMEQO-UHFFFAOYSA-N acetic acid Substances CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
• 150000007513 acids Chemical class 0.000 description 2
• 229930183665 actinomycin Natural products 0.000 description 2
• RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 2
• 239000004480 active ingredient Substances 0.000 description 2
• 125000004457 alkyl amino carbonyl group Chemical group 0.000 description 2
• 230000029936 alkylation Effects 0.000 description 2
• 238000005804 alkylation reaction Methods 0.000 description 2
• 108010004469 allophycocyanin Proteins 0.000 description 2
• 150000001408 amides Chemical class 0.000 description 2
• 125000000539 amino acid group Chemical group 0.000 description 2
• 150000001450 anions Chemical class 0.000 description 2
• VGQOVCHZGQWAOI-HYUHUPJXSA-N anthramycin Chemical compound N1[C@@H](O)[C@@H]2CC(\C=C\C(N)=O)=CN2C(=O)C2=CC=C(C)C(O)=C12 VGQOVCHZGQWAOI-HYUHUPJXSA-N 0.000 description 2
• 239000000427 antigen Substances 0.000 description 2
• 108091007433 antigens Proteins 0.000 description 2
• 102000036639 antigens Human genes 0.000 description 2
• 238000013459 approach Methods 0.000 description 2
• 239000007864 aqueous solution Substances 0.000 description 2
• 239000007900 aqueous suspension Substances 0.000 description 2
• 206010003119 arrhythmia Diseases 0.000 description 2
• 210000001367 artery Anatomy 0.000 description 2
• 230000037444 atrophy Effects 0.000 description 2
• 235000019445 benzyl alcohol Nutrition 0.000 description 2
• XMIIGOLPHOKFCH-UHFFFAOYSA-N beta-phenylpropanoic acid Natural products OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 2
• 238000001574 biopsy Methods 0.000 description 2
• 229960002092 busulfan Drugs 0.000 description 2
• 239000002775 capsule Substances 0.000 description 2
• 239000001768 carboxy methyl cellulose Substances 0.000 description 2
• 230000000747 cardiac effect Effects 0.000 description 2
• 238000000423 cell based assay Methods 0.000 description 2
• 238000004113 cell culture Methods 0.000 description 2
• 230000004663 cell proliferation Effects 0.000 description 2
• 210000003169 central nervous system Anatomy 0.000 description 2
• 239000007795 chemical reaction product Substances 0.000 description 2
• 230000000973 chemotherapeutic effect Effects 0.000 description 2
• 229960004630 chlorambucil Drugs 0.000 description 2
• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 2
• HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
• 229960004316 cisplatin Drugs 0.000 description 2
• 208000010877 cognitive disease Diseases 0.000 description 2
• 208000029742 colonic neoplasm Diseases 0.000 description 2
• 230000009918 complex formation Effects 0.000 description 2
• 238000003271 compound fluorescence assay Methods 0.000 description 2
• 239000012141 concentrate Substances 0.000 description 2
• 230000021615 conjugation Effects 0.000 description 2
• 239000000470 constituent Substances 0.000 description 2
• 239000008120 corn starch Substances 0.000 description 2
• CVSVTCORWBXHQV-UHFFFAOYSA-N creatine Chemical compound NC(=[NH2+])N(C)CC([O-])=O CVSVTCORWBXHQV-UHFFFAOYSA-N 0.000 description 2
• 239000013078 crystal Substances 0.000 description 2
• 201000007241 cutaneous T cell lymphoma Diseases 0.000 description 2
• 229940097362 cyclodextrins Drugs 0.000 description 2
• 210000000805 cytoplasm Anatomy 0.000 description 2
• 229940127089 cytotoxic agent Drugs 0.000 description 2
• 229960000975 daunorubicin Drugs 0.000 description 2
• CFCUWKMKBJTWLW-UHFFFAOYSA-N deoliosyl-3C-alpha-L-digitoxosyl-MTM Natural products CC=1C(O)=C2C(O)=C3C(=O)C(OC4OC(C)C(O)C(OC5OC(C)C(O)C(OC6OC(C)C(O)C(C)(O)C6)C5)C4)C(C(OC)C(=O)C(O)C(C)O)CC3=CC2=CC=1OC(OC(C)C1O)CC1OC1CC(O)C(O)C(C)O1 CFCUWKMKBJTWLW-UHFFFAOYSA-N 0.000 description 2
• 229960003638 dopamine Drugs 0.000 description 2
• 229960004679 doxorubicin Drugs 0.000 description 2
• 238000009510 drug design Methods 0.000 description 2
• 208000010118 dystonia Diseases 0.000 description 2
• 238000001962 electrophoresis Methods 0.000 description 2
• 230000001804 emulsifying effect Effects 0.000 description 2
• 201000002491 encephalomyelitis Diseases 0.000 description 2
• 150000002148 esters Chemical class 0.000 description 2
• 238000011156 evaluation Methods 0.000 description 2
• 230000005284 excitation Effects 0.000 description 2
• 238000000695 excitation spectrum Methods 0.000 description 2
• 230000029142 excretion Effects 0.000 description 2
• 208000012997 experimental autoimmune encephalomyelitis Diseases 0.000 description 2
• 238000002474 experimental method Methods 0.000 description 2
• 239000000796 flavoring agent Substances 0.000 description 2
• 238000002866 fluorescence resonance energy transfer Methods 0.000 description 2
• 108010021843 fluorescent protein 583 Proteins 0.000 description 2
• 230000037406 food intake Effects 0.000 description 2
• 210000002683 foot Anatomy 0.000 description 2
• 230000005021 gait Effects 0.000 description 2
• 230000002496 gastric effect Effects 0.000 description 2
• 102000054766 genetic haplotypes Human genes 0.000 description 2
• 230000000762 glandular Effects 0.000 description 2
• 230000007387 gliosis Effects 0.000 description 2
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
• 229960003180 glutathione Drugs 0.000 description 2
• 125000005456 glyceride group Chemical group 0.000 description 2
• 229940121372 histone deacetylase inhibitor Drugs 0.000 description 2
• 239000003276 histone deacetylase inhibitor Substances 0.000 description 2
• XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 2
• 230000000910 hyperinsulinemic effect Effects 0.000 description 2
• 230000003463 hyperproliferative effect Effects 0.000 description 2
• 230000001900 immune effect Effects 0.000 description 2
• 230000001976 improved effect Effects 0.000 description 2
• 238000000126 in silico method Methods 0.000 description 2
• 238000011534 incubation Methods 0.000 description 2
• 208000015181 infectious disease Diseases 0.000 description 2
• 238000001802 infusion Methods 0.000 description 2
• 239000003112 inhibitor Substances 0.000 description 2
• 230000005764 inhibitory process Effects 0.000 description 2
• 230000000977 initiatory effect Effects 0.000 description 2
• 238000003780 insertion Methods 0.000 description 2
• 230000037431 insertion Effects 0.000 description 2
• 230000003914 insulin secretion Effects 0.000 description 2
• 239000000543 intermediate Substances 0.000 description 2
• 230000003907 kidney function Effects 0.000 description 2
• 238000002372 labelling Methods 0.000 description 2
• 239000008101 lactose Substances 0.000 description 2
• 201000010901 lateral sclerosis Diseases 0.000 description 2
• 239000010410 layer Substances 0.000 description 2
• 239000006193 liquid solution Substances 0.000 description 2
• 230000007774 longterm Effects 0.000 description 2
• 229910001629 magnesium chloride Inorganic materials 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• 238000002595 magnetic resonance imaging Methods 0.000 description 2
• 230000003211 malignant effect Effects 0.000 description 2
• 210000004962 mammalian cell Anatomy 0.000 description 2
• 210000001161 mammalian embryo Anatomy 0.000 description 2
• 201000001441 melanoma Diseases 0.000 description 2
• GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 2
• 230000009401 metastasis Effects 0.000 description 2
• 239000002480 mineral oil Substances 0.000 description 2
• 235000010446 mineral oil Nutrition 0.000 description 2
• CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 2
• 229960004857 mitomycin Drugs 0.000 description 2
• 238000012544 monitoring process Methods 0.000 description 2
• 201000005962 mycosis fungoides Diseases 0.000 description 2
• 239000006225 natural substrate Substances 0.000 description 2
• 239000013642 negative control Substances 0.000 description 2
• 210000001577 neostriatum Anatomy 0.000 description 2
• 210000005036 nerve Anatomy 0.000 description 2
• 230000001537 neural effect Effects 0.000 description 2
• 230000002232 neuromuscular Effects 0.000 description 2
• 208000018360 neuromuscular disease Diseases 0.000 description 2
• 230000016273 neuron death Effects 0.000 description 2
• 239000002581 neurotoxin Substances 0.000 description 2
• 231100000618 neurotoxin Toxicity 0.000 description 2
• 239000000346 nonvolatile oil Substances 0.000 description 2
• 210000000633 nuclear envelope Anatomy 0.000 description 2
• 231100000862 numbness Toxicity 0.000 description 2
• 239000003921 oil Substances 0.000 description 2
• 235000019198 oils Nutrition 0.000 description 2
• 210000004789 organ system Anatomy 0.000 description 2
• 229960001592 paclitaxel Drugs 0.000 description 2
• 230000036961 partial effect Effects 0.000 description 2
• 230000007170 pathology Effects 0.000 description 2
• 239000003208 petroleum Substances 0.000 description 2
• 210000003800 pharynx Anatomy 0.000 description 2
• 108091008695 photoreceptors Proteins 0.000 description 2
• 230000010399 physical interaction Effects 0.000 description 2
• 239000000049 pigment Substances 0.000 description 2
• 229960003171 plicamycin Drugs 0.000 description 2
• 229920000642 polymer Polymers 0.000 description 2
• 102000054765 polymorphisms of proteins Human genes 0.000 description 2
• 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
• 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
• 229920000136 polysorbate Polymers 0.000 description 2
• 230000001144 postural effect Effects 0.000 description 2
• 239000011591 potassium Substances 0.000 description 2
• 229910052700 potassium Inorganic materials 0.000 description 2
• 239000003755 preservative agent Substances 0.000 description 2
• 230000002265 prevention Effects 0.000 description 2
• 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 description 2
• 238000011809 primate model Methods 0.000 description 2
• 238000012545 processing Methods 0.000 description 2
• 229940002612 prodrug Drugs 0.000 description 2
• 239000000651 prodrug Substances 0.000 description 2
• 201000008752 progressive muscular atrophy Diseases 0.000 description 2
• 230000035755 proliferation Effects 0.000 description 2
• 230000000069 prophylactic effect Effects 0.000 description 2
• AQHHHDLHHXJYJD-UHFFFAOYSA-N propranolol Chemical compound C1=CC=C2C(OCC(O)CNC(C)C)=CC=CC2=C1 AQHHHDLHHXJYJD-UHFFFAOYSA-N 0.000 description 2
• 230000002797 proteolythic effect Effects 0.000 description 2
• RXWNCPJZOCPEPQ-NVWDDTSBSA-N puromycin Chemical compound C1=CC(OC)=CC=C1C[C@H](N)C(=O)N[C@H]1[C@@H](O)[C@H](N2C3=NC=NC(=C3N=C2)N(C)C)O[C@@H]1CO RXWNCPJZOCPEPQ-NVWDDTSBSA-N 0.000 description 2
• NIPZZXUFJPQHNH-UHFFFAOYSA-N pyrazine-2-carboxylic acid Chemical compound OC(=O)C1=CN=CC=N1 NIPZZXUFJPQHNH-UHFFFAOYSA-N 0.000 description 2
• 238000005956 quaternization reaction Methods 0.000 description 2
• 230000011514 reflex Effects 0.000 description 2
• 230000001105 regulatory effect Effects 0.000 description 2
• 230000010076 replication Effects 0.000 description 2
• 210000003583 retinal pigment epithelium Anatomy 0.000 description 2
• 238000012552 review Methods 0.000 description 2
• 230000004434 saccadic eye movement Effects 0.000 description 2
• 230000035945 sensitivity Effects 0.000 description 2
• 230000001953 sensory effect Effects 0.000 description 2
• 201000005572 sensory peripheral neuropathy Diseases 0.000 description 2
• 238000000926 separation method Methods 0.000 description 2
• 210000000813 small intestine Anatomy 0.000 description 2
• 239000011734 sodium Substances 0.000 description 2
• 229910052708 sodium Inorganic materials 0.000 description 2
• 229940035044 sorbitan monolaurate Drugs 0.000 description 2
• 230000009870 specific binding Effects 0.000 description 2
• ATHGHQPFGPMSJY-UHFFFAOYSA-N spermidine Chemical compound NCCCCNCCCN ATHGHQPFGPMSJY-UHFFFAOYSA-N 0.000 description 2
• PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 description 2
• 238000010561 standard procedure Methods 0.000 description 2
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 2
• 235000000346 sugar Nutrition 0.000 description 2
• 239000004094 surface-active agent Substances 0.000 description 2
• 239000000375 suspending agent Substances 0.000 description 2
• 230000009747 swallowing Effects 0.000 description 2
• 230000002194 synthesizing effect Effects 0.000 description 2
• 239000003826 tablet Substances 0.000 description 2
• 102000013498 tau Proteins Human genes 0.000 description 2
• 108010026424 tau Proteins Proteins 0.000 description 2
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 2
• WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 2
• 238000011200 topical administration Methods 0.000 description 2
• 230000000699 topical effect Effects 0.000 description 2
• VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
• 230000009466 transformation Effects 0.000 description 2
• 238000000844 transformation Methods 0.000 description 2
• 238000011269 treatment regimen Methods 0.000 description 2
• 150000003626 triacylglycerols Chemical class 0.000 description 2
• 150000003852 triazoles Chemical group 0.000 description 2
• 230000004565 tumor cell growth Effects 0.000 description 2
• 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 description 2
• 231100000397 ulcer Toxicity 0.000 description 2
• 229960003048 vinblastine Drugs 0.000 description 2
• JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 2
• 230000004584 weight gain Effects 0.000 description 2
• 235000019786 weight gain Nutrition 0.000 description 2
• 238000001262 western blot Methods 0.000 description 2
• 210000004885 white matter Anatomy 0.000 description 2
• LSPHULWDVZXLIL-UHFFFAOYSA-N (+/-)-Camphoric acid Chemical compound CC1(C)C(C(O)=O)CCC1(C)C(O)=O LSPHULWDVZXLIL-UHFFFAOYSA-N 0.000 description 1
• YMXHPSHLTSZXKH-RVBZMBCESA-N (2,5-dioxopyrrolidin-1-yl) 5-[(3as,4s,6ar)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]pentanoate Chemical compound C([C@H]1[C@H]2NC(=O)N[C@H]2CS1)CCCC(=O)ON1C(=O)CCC1=O YMXHPSHLTSZXKH-RVBZMBCESA-N 0.000 description 1
• VRYALKFFQXWPIH-PBXRRBTRSA-N (3r,4s,5r)-3,4,5,6-tetrahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)CC=O VRYALKFFQXWPIH-PBXRRBTRSA-N 0.000 description 1
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
• FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 1
• IAKHMKGGTNLKSZ-INIZCTEOSA-N (S)-colchicine Chemical compound C1([C@@H](NC(C)=O)CC2)=CC(=O)C(OC)=CC=C1C1=C2C=C(OC)C(OC)=C1OC IAKHMKGGTNLKSZ-INIZCTEOSA-N 0.000 description 1
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 1
• IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
• 101710125124 14-3-3 protein epsilon Proteins 0.000 description 1
• 102100025007 14-3-3 protein epsilon Human genes 0.000 description 1
• YGEPHDCRGZFWQM-UHFFFAOYSA-N 2,3,3a,4,5,6-hexahydrocycloocta[b]thiophene-3-carboxamide Chemical compound C1=CCCCC2C(C(=O)N)CSC2=C1 YGEPHDCRGZFWQM-UHFFFAOYSA-N 0.000 description 1
• CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
• WBJGNXYBEZIOES-UHFFFAOYSA-N 2-(2-chlorophenyl)acetamide Chemical compound NC(=O)CC1=CC=CC=C1Cl WBJGNXYBEZIOES-UHFFFAOYSA-N 0.000 description 1
• OLKQIWCQICCYQS-UHFFFAOYSA-N 2-(4-methoxyphenyl)acetamide Chemical compound COC1=CC=C(CC(N)=O)C=C1 OLKQIWCQICCYQS-UHFFFAOYSA-N 0.000 description 1
• KISWVXRQTGLFGD-UHFFFAOYSA-N 2-[[2-[[6-amino-2-[[2-[[2-[[5-amino-2-[[2-[[1-[2-[[6-amino-2-[(2,5-diamino-5-oxopentanoyl)amino]hexanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-(diaminomethylideneamino)p Chemical compound C1CCN(C(=O)C(CCCN=C(N)N)NC(=O)C(CCCCN)NC(=O)C(N)CCC(N)=O)C1C(=O)NC(CO)C(=O)NC(CCC(N)=O)C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(C(=O)NC(CC(C)C)C(O)=O)CC1=CC=C(O)C=C1 KISWVXRQTGLFGD-UHFFFAOYSA-N 0.000 description 1
• FFAKFORHXDNYEN-UHFFFAOYSA-N 2-amino-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1CCCC2=C1SC(N)=C2C(=O)N FFAKFORHXDNYEN-UHFFFAOYSA-N 0.000 description 1
• 125000004974 2-butenyl group Chemical group C(C=CC)* 0.000 description 1
• 229940080296 2-naphthalenesulfonate Drugs 0.000 description 1
• LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
• 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 description 1
• 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 description 1
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
• PIDCVSWVTBWNOK-UHFFFAOYSA-N 3,3a,4,5-tetrahydro-2H-cyclohepta[b]thiophene-3-carboxamide Chemical compound S1C=2C(C(C1)C(=O)N)CCC=CC2 PIDCVSWVTBWNOK-UHFFFAOYSA-N 0.000 description 1
• AUUIARVPJHGTSA-UHFFFAOYSA-N 3-(aminomethyl)chromen-2-one Chemical compound C1=CC=C2OC(=O)C(CN)=CC2=C1 AUUIARVPJHGTSA-UHFFFAOYSA-N 0.000 description 1
• BRMWTNUJHUMWMS-UHFFFAOYSA-N 3-Methylhistidine Natural products CN1C=NC(CC(N)C(O)=O)=C1 BRMWTNUJHUMWMS-UHFFFAOYSA-N 0.000 description 1
• 125000006041 3-hexenyl group Chemical group 0.000 description 1
• XMIIGOLPHOKFCH-UHFFFAOYSA-M 3-phenylpropionate Chemical compound [O-]C(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-M 0.000 description 1
• 125000006201 3-phenylpropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• UYOWQFWKDDJSLV-UHFFFAOYSA-N 5-hydroxypentanamide Chemical compound NC(=O)CCCCO UYOWQFWKDDJSLV-UHFFFAOYSA-N 0.000 description 1
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 1
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
• HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 1
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
• 101150037123 APOE gene Proteins 0.000 description 1
• 208000004611 Abdominal Obesity Diseases 0.000 description 1
• 108010085238 Actins Proteins 0.000 description 1
• 102000007469 Actins Human genes 0.000 description 1
• 241000242764 Aequorea victoria Species 0.000 description 1
• 206010001541 Akinesia Diseases 0.000 description 1
• 108010088751 Albumins Proteins 0.000 description 1
• 102000009027 Albumins Human genes 0.000 description 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
• 102100026882 Alpha-synuclein Human genes 0.000 description 1
• 201000003076 Angiosarcoma Diseases 0.000 description 1
• 206010002942 Apathy Diseases 0.000 description 1
• 102100029470 Apolipoprotein E Human genes 0.000 description 1
• 102000003823 Aromatic-L-amino-acid decarboxylases Human genes 0.000 description 1
• 108090000121 Aromatic-L-amino-acid decarboxylases Proteins 0.000 description 1
• 206010003571 Astrocytoma Diseases 0.000 description 1
• 201000001320 Atherosclerosis Diseases 0.000 description 1
• 208000023275 Autoimmune disease Diseases 0.000 description 1
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
• 210000002237 B-cell of pancreatic islet Anatomy 0.000 description 1
• 206010004146 Basal cell carcinoma Diseases 0.000 description 1
• 208000006373 Bell palsy Diseases 0.000 description 1
• 206010004593 Bile duct cancer Diseases 0.000 description 1
• 206010005003 Bladder cancer Diseases 0.000 description 1
• 108010006654 Bleomycin Proteins 0.000 description 1
• 102000004506 Blood Proteins Human genes 0.000 description 1
• 108010017384 Blood Proteins Proteins 0.000 description 1
• 208000006386 Bone Resorption Diseases 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 206010006100 Bradykinesia Diseases 0.000 description 1
• 208000024806 Brain atrophy Diseases 0.000 description 1
• CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 1
• FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 description 1
• FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 1
• 108010074051 C-Reactive Protein Proteins 0.000 description 1
• 229960005532 CC-1065 Drugs 0.000 description 1
• 206010006895 Cachexia Diseases 0.000 description 1
• 101001059929 Caenorhabditis elegans Forkhead box protein O Proteins 0.000 description 1
• BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
• 102100029968 Calreticulin Human genes 0.000 description 1
• 108090000549 Calreticulin Proteins 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• 241000283707 Capra Species 0.000 description 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
• 208000005623 Carcinogenesis Diseases 0.000 description 1
• 208000017897 Carcinoma of esophagus Diseases 0.000 description 1
• 201000000274 Carcinosarcoma Diseases 0.000 description 1
• 208000020446 Cardiac disease Diseases 0.000 description 1
• DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 1
• 102100032616 Caspase-2 Human genes 0.000 description 1
• 108090000552 Caspase-2 Proteins 0.000 description 1
• 208000009132 Catalepsy Diseases 0.000 description 1
• 208000002177 Cataract Diseases 0.000 description 1
• 102000003908 Cathepsin D Human genes 0.000 description 1
• 108090000258 Cathepsin D Proteins 0.000 description 1
• 206010065941 Central obesity Diseases 0.000 description 1
• 241000282693 Cercopithecidae Species 0.000 description 1
• 206010008096 Cerebral atrophy Diseases 0.000 description 1
• 206010008342 Cervix carcinoma Diseases 0.000 description 1
• CCPHAMSKHBDMDS-UHFFFAOYSA-N Chetoseminudin B Natural products C=1NC2=CC=CC=C2C=1CC1(SC)NC(=O)C(CO)(SC)N(C)C1=O CCPHAMSKHBDMDS-UHFFFAOYSA-N 0.000 description 1
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
• 208000005243 Chondrosarcoma Diseases 0.000 description 1
• 201000009047 Chordoma Diseases 0.000 description 1
• 208000006332 Choriocarcinoma Diseases 0.000 description 1
• 108010077544 Chromatin Proteins 0.000 description 1
• 208000010833 Chronic myeloid leukaemia Diseases 0.000 description 1
• 206010009696 Clumsiness Diseases 0.000 description 1
• 102100032887 Clusterin Human genes 0.000 description 1
• 108090000197 Clusterin Proteins 0.000 description 1
• 108020004705 Codon Proteins 0.000 description 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 description 1
• 206010010774 Constipation Diseases 0.000 description 1
• 229920000742 Cotton Polymers 0.000 description 1
• 208000009798 Craniopharyngioma Diseases 0.000 description 1
• 102000004420 Creatine Kinase Human genes 0.000 description 1
• 108010042126 Creatine kinase Proteins 0.000 description 1
• 208000011231 Crohn disease Diseases 0.000 description 1
• XZMCDFZZKTWFGF-UHFFFAOYSA-N Cyanamide Chemical compound NC#N XZMCDFZZKTWFGF-UHFFFAOYSA-N 0.000 description 1
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 101710112752 Cytotoxin Proteins 0.000 description 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
• 230000005778 DNA damage Effects 0.000 description 1
• 231100000277 DNA damage Toxicity 0.000 description 1
• WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 description 1
• 108010093668 Deubiquitinating Enzymes Proteins 0.000 description 1
• FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
• 208000007342 Diabetic Nephropathies Diseases 0.000 description 1
• 208000032131 Diabetic Neuropathies Diseases 0.000 description 1
• 208000008960 Diabetic foot Diseases 0.000 description 1
• 206010051153 Diabetic gastroparesis Diseases 0.000 description 1
• 208000003164 Diplopia Diseases 0.000 description 1
• 241000255925 Diptera Species 0.000 description 1
• 206010013496 Disturbance in attention Diseases 0.000 description 1
• 108700002304 Drosophila can Proteins 0.000 description 1
• 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
• 206010013887 Dysarthria Diseases 0.000 description 1
• 206010050256 Dysstasia Diseases 0.000 description 1
• 108091005941 EBFP Proteins 0.000 description 1
• 101710176517 EGF-containing fibulin-like extracellular matrix protein 1 Proteins 0.000 description 1
• 238000002965 ELISA Methods 0.000 description 1
• 201000009051 Embryonal Carcinoma Diseases 0.000 description 1
• 241000792859 Enema Species 0.000 description 1
• 230000010665 Enzyme Interactions Effects 0.000 description 1
• 206010014967 Ependymoma Diseases 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
• 208000006168 Ewing Sarcoma Diseases 0.000 description 1
• 102000037087 Excitatory amino acid transporters Human genes 0.000 description 1
• 108091006291 Excitatory amino acid transporters Proteins 0.000 description 1
• 102100020903 Ezrin Human genes 0.000 description 1
• 208000001308 Fasciculation Diseases 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 108010049003 Fibrinogen Proteins 0.000 description 1
• 102000008946 Fibrinogen Human genes 0.000 description 1
• 201000008808 Fibrosarcoma Diseases 0.000 description 1
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
• BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 description 1
• VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
• 102000013446 GTP Phosphohydrolases Human genes 0.000 description 1
• 108091006109 GTPases Proteins 0.000 description 1
• 208000008069 Geographic Atrophy Diseases 0.000 description 1
• 208000032612 Glial tumor Diseases 0.000 description 1
• 206010018338 Glioma Diseases 0.000 description 1
• 206010018364 Glomerulonephritis Diseases 0.000 description 1
• 102000005720 Glutathione transferase Human genes 0.000 description 1
• 108010070675 Glutathione transferase Proteins 0.000 description 1
• 239000004471 Glycine Substances 0.000 description 1
• AEMRFAOFKBGASW-UHFFFAOYSA-M Glycolate Chemical compound OCC([O-])=O AEMRFAOFKBGASW-UHFFFAOYSA-M 0.000 description 1
• 108010026389 Gramicidin Proteins 0.000 description 1
• 208000001258 Hemangiosarcoma Diseases 0.000 description 1
• 208000016988 Hemorrhagic Stroke Diseases 0.000 description 1
• 102100039869 Histone H2B type F-S Human genes 0.000 description 1
• 102000003964 Histone deacetylase Human genes 0.000 description 1
• 108090000353 Histone deacetylase Proteins 0.000 description 1
• 208000017604 Hodgkin disease Diseases 0.000 description 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
• 101000619542 Homo sapiens E3 ubiquitin-protein ligase parkin Proteins 0.000 description 1
• 101001035372 Homo sapiens Histone H2B type F-S Proteins 0.000 description 1
• 101000825628 Homo sapiens NAD-dependent protein deacetylase sirtuin-2 Proteins 0.000 description 1
• 101000616727 Homo sapiens NAD-dependent protein deacylase sirtuin-5, mitochondrial Proteins 0.000 description 1
• 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 description 1
• 101000664887 Homo sapiens Superoxide dismutase [Cu-Zn] Proteins 0.000 description 1
• 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
• 102000008100 Human Serum Albumin Human genes 0.000 description 1
• 108091006905 Human Serum Albumin Proteins 0.000 description 1
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 1
• CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
• 208000001953 Hypotension Diseases 0.000 description 1
• 206010052341 Impaired insulin secretion Diseases 0.000 description 1
• 206010061218 Inflammation Diseases 0.000 description 1
• 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
• 240000007049 Juglans regia Species 0.000 description 1
• 102000011782 Keratins Human genes 0.000 description 1
• 108010076876 Keratins Proteins 0.000 description 1
• 229930064664 L-arginine Natural products 0.000 description 1
• 235000014852 L-arginine Nutrition 0.000 description 1
• CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 1
• WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
• JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
• 208000006404 Large Granular Lymphocytic Leukemia Diseases 0.000 description 1
• 208000018142 Leiomyosarcoma Diseases 0.000 description 1
• NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
• 108060001084 Luciferase Proteins 0.000 description 1
• 239000005089 Luciferase Substances 0.000 description 1
• 208000019693 Lung disease Diseases 0.000 description 1
• 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
• 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 description 1
• 206010025323 Lymphomas Diseases 0.000 description 1
• JLVVSXFLKOJNIY-UHFFFAOYSA-N Magnesium ion Chemical compound [Mg+2] JLVVSXFLKOJNIY-UHFFFAOYSA-N 0.000 description 1
• 208000002720 Malnutrition Diseases 0.000 description 1
• OFOBLEOULBTSOW-UHFFFAOYSA-L Malonate Chemical compound [O-]C(=O)CC([O-])=O OFOBLEOULBTSOW-UHFFFAOYSA-L 0.000 description 1
• 229930195725 Mannitol Natural products 0.000 description 1
• 208000007054 Medullary Carcinoma Diseases 0.000 description 1
• 208000000172 Medulloblastoma Diseases 0.000 description 1
• 102000018697 Membrane Proteins Human genes 0.000 description 1
• 108010052285 Membrane Proteins Proteins 0.000 description 1
• 206010027406 Mesothelioma Diseases 0.000 description 1
• 108010020004 Microtubule-Associated Proteins Proteins 0.000 description 1
• 102000009664 Microtubule-Associated Proteins Human genes 0.000 description 1
• 244000294411 Mirabilis expansa Species 0.000 description 1
• 235000015429 Mirabilis expansa Nutrition 0.000 description 1
• VFKZTMPDYBFSTM-KVTDHHQDSA-N Mitobronitol Chemical compound BrC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CBr VFKZTMPDYBFSTM-KVTDHHQDSA-N 0.000 description 1
• 229930192392 Mitomycin Natural products 0.000 description 1
• 206010061296 Motor dysfunction Diseases 0.000 description 1
• 101000863568 Mus musculus NAD-dependent protein deacetylase sirtuin-3 Proteins 0.000 description 1
• 101100365819 Mus musculus Sirt2 gene Proteins 0.000 description 1
• 208000008238 Muscle Spasticity Diseases 0.000 description 1
• 206010028293 Muscle contractions involuntary Diseases 0.000 description 1
• 206010049565 Muscle fatigue Diseases 0.000 description 1
• 206010028347 Muscle twitching Diseases 0.000 description 1
• 208000021642 Muscular disease Diseases 0.000 description 1
• 102000047918 Myelin Basic Human genes 0.000 description 1
• 102000006386 Myelin Proteins Human genes 0.000 description 1
• 108010083674 Myelin Proteins Proteins 0.000 description 1
• 101710107068 Myelin basic protein Proteins 0.000 description 1
• 208000033761 Myelogenous Chronic BCR-ABL Positive Leukemia Diseases 0.000 description 1
• 201000009623 Myopathy Diseases 0.000 description 1
• 108060008487 Myosin Proteins 0.000 description 1
• 102000003505 Myosin Human genes 0.000 description 1
• JDHILDINMRGULE-LURJTMIESA-N N(pros)-methyl-L-histidine Chemical compound CN1C=NC=C1C[C@H](N)C(O)=O JDHILDINMRGULE-LURJTMIESA-N 0.000 description 1
• NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical compound ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 description 1
• OTCCIMWXFLJLIA-UHFFFAOYSA-N N-acetyl-DL-aspartic acid Natural products CC(=O)NC(C(O)=O)CC(O)=O OTCCIMWXFLJLIA-UHFFFAOYSA-N 0.000 description 1
• OTCCIMWXFLJLIA-BYPYZUCNSA-N N-acetyl-L-aspartic acid Chemical compound CC(=O)N[C@H](C(O)=O)CC(O)=O OTCCIMWXFLJLIA-BYPYZUCNSA-N 0.000 description 1
• 150000001204 N-oxides Chemical class 0.000 description 1
• 101710189433 NAD-dependent protein deacetylase SRT1 Proteins 0.000 description 1
• 101710169358 NAD-dependent protein deacetylase sirtuin-1 Proteins 0.000 description 1
• 101710169359 NAD-dependent protein deacetylase sirtuin-2 Proteins 0.000 description 1
• 101710169361 NAD-dependent protein deacetylase sirtuin-6 Proteins 0.000 description 1
• 101710169363 NAD-dependent protein deacetylase sirtuin-7 Proteins 0.000 description 1
• 101710172882 NAD-dependent protein deacylase sirtuin-5, mitochondrial Proteins 0.000 description 1
• 101710142346 NAD-dependent protein lipoamidase sirtuin-4, mitochondrial Proteins 0.000 description 1
• 208000028389 Nerve injury Diseases 0.000 description 1
• 206010029260 Neuroblastoma Diseases 0.000 description 1
• PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
• 208000015914 Non-Hodgkin lymphomas Diseases 0.000 description 1
• 239000005642 Oleic acid Substances 0.000 description 1
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
• 201000010133 Oligodendroglioma Diseases 0.000 description 1
• 102000052812 Ornithine decarboxylases Human genes 0.000 description 1
• 108700005126 Ornithine decarboxylases Proteins 0.000 description 1
• 206010061535 Ovarian neoplasm Diseases 0.000 description 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 229920001774 Perfluoroether Polymers 0.000 description 1
• 208000027190 Peripheral T-cell lymphomas Diseases 0.000 description 1
• 208000018262 Peripheral vascular disease Diseases 0.000 description 1
• 208000007641 Pinealoma Diseases 0.000 description 1
• 102000010752 Plasminogen Inactivators Human genes 0.000 description 1
• 108010077971 Plasminogen Inactivators Proteins 0.000 description 1
• 229920001214 Polysorbate 60 Polymers 0.000 description 1
• NPYPAHLBTDXSSS-UHFFFAOYSA-N Potassium ion Chemical compound [K+] NPYPAHLBTDXSSS-UHFFFAOYSA-N 0.000 description 1
• 102000012412 Presenilin-1 Human genes 0.000 description 1
• 108010036933 Presenilin-1 Proteins 0.000 description 1
• 102000012419 Presenilin-2 Human genes 0.000 description 1
• 108010036908 Presenilin-2 Proteins 0.000 description 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
• XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 1
• 108010007568 Protamines Proteins 0.000 description 1
• 102000007327 Protamines Human genes 0.000 description 1
• 108010029485 Protein Isoforms Proteins 0.000 description 1
• 102000001708 Protein Isoforms Human genes 0.000 description 1
• 108010053763 Pyruvate Carboxylase Proteins 0.000 description 1
• 102100039895 Pyruvate carboxylase, mitochondrial Human genes 0.000 description 1
• 108091030071 RNAI Proteins 0.000 description 1
• 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 description 1
• 208000015634 Rectal Neoplasms Diseases 0.000 description 1
• 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 description 1
• 208000001647 Renal Insufficiency Diseases 0.000 description 1
• 241000242743 Renilla reniformis Species 0.000 description 1
• 206010071390 Resting tremor Diseases 0.000 description 1
• 201000000582 Retinoblastoma Diseases 0.000 description 1
• 241000283984 Rodentia Species 0.000 description 1
• 238000011831 SOD1-G93A transgenic mouse Methods 0.000 description 1
• 101100477602 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) SIR3 gene Proteins 0.000 description 1
• 201000010208 Seminoma Diseases 0.000 description 1
• 229920002684 Sepharose Polymers 0.000 description 1
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
• 108010041218 Sirtuin 3 Proteins 0.000 description 1
• FKNQFGJONOIPTF-UHFFFAOYSA-N Sodium cation Chemical compound [Na+] FKNQFGJONOIPTF-UHFFFAOYSA-N 0.000 description 1
• 206010068771 Soft tissue neoplasm Diseases 0.000 description 1
• HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
• 208000002847 Surgical Wound Diseases 0.000 description 1
• 208000031672 T-Cell Peripheral Lymphoma Diseases 0.000 description 1
• 201000008717 T-cell large granular lymphocyte leukemia Diseases 0.000 description 1
• 208000037063 Thinness Diseases 0.000 description 1
• ZMZDMBWJUHKJPS-UHFFFAOYSA-M Thiocyanate anion Chemical compound [S-]C#N ZMZDMBWJUHKJPS-UHFFFAOYSA-M 0.000 description 1
• 102000004338 Transferrin Human genes 0.000 description 1
• 108090000901 Transferrin Proteins 0.000 description 1
• DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 description 1
• GBOGMAARMMDZGR-UHFFFAOYSA-N UNPD149280 Natural products N1C(=O)C23OC(=O)C=CC(O)CCCC(C)CC=CC3C(O)C(=C)C(C)C2C1CC1=CC=CC=C1 GBOGMAARMMDZGR-UHFFFAOYSA-N 0.000 description 1
• 206010046298 Upper motor neurone lesion Diseases 0.000 description 1
• 206010046543 Urinary incontinence Diseases 0.000 description 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
• 208000036826 VIIth nerve paralysis Diseases 0.000 description 1
• 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 1
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
• 208000014070 Vestibular schwannoma Diseases 0.000 description 1
• 108010031318 Vitronectin Proteins 0.000 description 1
• 102100035140 Vitronectin Human genes 0.000 description 1
• 206010047853 Waxy flexibility Diseases 0.000 description 1
• 208000008383 Wilms tumor Diseases 0.000 description 1
• 108010084455 Zeocin Proteins 0.000 description 1
• UYRDHEJRPVSJFM-VSWVFQEASA-N [(1s,3r)-3-hydroxy-4-[(3e,5e,7e,9e,11z)-11-[4-[(e)-2-[(1r,3s,6s)-3-hydroxy-1,5,5-trimethyl-7-oxabicyclo[4.1.0]heptan-6-yl]ethenyl]-5-oxofuran-2-ylidene]-3,10-dimethylundeca-1,3,5,7,9-pentaenylidene]-3,5,5-trimethylcyclohexyl] acetate Chemical compound C[C@@]1(O)C[C@@H](OC(=O)C)CC(C)(C)C1=C=C\C(C)=C\C=C\C=C\C=C(/C)\C=C/1C=C(\C=C\[C@]23[C@@](O2)(C)C[C@@H](O)CC3(C)C)C(=O)O\1 UYRDHEJRPVSJFM-VSWVFQEASA-N 0.000 description 1
• 210000001015 abdomen Anatomy 0.000 description 1
• 230000001594 aberrant effect Effects 0.000 description 1
• 238000005299 abrasion Methods 0.000 description 1
• 229940124532 absorption promoter Drugs 0.000 description 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
• 208000004064 acoustic neuroma Diseases 0.000 description 1
• RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 description 1
• WNLRTRBMVRJNCN-UHFFFAOYSA-L adipate(2-) Chemical compound [O-]C(=O)CCCCC([O-])=O WNLRTRBMVRJNCN-UHFFFAOYSA-L 0.000 description 1
• 210000000593 adipose tissue white Anatomy 0.000 description 1
• 229940072056 alginate Drugs 0.000 description 1
• 235000010443 alginic acid Nutrition 0.000 description 1
• 229920000615 alginic acid Polymers 0.000 description 1
• 229910052783 alkali metal Inorganic materials 0.000 description 1
• 150000001340 alkali metals Chemical class 0.000 description 1
• 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
• 150000001342 alkaline earth metals Chemical class 0.000 description 1
• 125000000278 alkyl amino alkyl group Chemical group 0.000 description 1
• 125000004448 alkyl carbonyl group Chemical group 0.000 description 1
• 229940100198 alkylating agent Drugs 0.000 description 1
• 239000002168 alkylating agent Substances 0.000 description 1
• 125000002947 alkylene group Chemical group 0.000 description 1
• PMMURAAUARKVCB-UHFFFAOYSA-N alpha-D-ara-dHexp Natural products OCC1OC(O)CC(O)C1O PMMURAAUARKVCB-UHFFFAOYSA-N 0.000 description 1
• 108090000185 alpha-Synuclein Proteins 0.000 description 1
• HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
• 230000004075 alteration Effects 0.000 description 1
• PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
• CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
• 229940063655 aluminum stearate Drugs 0.000 description 1
• 230000001668 ameliorated effect Effects 0.000 description 1
• 150000001412 amines Chemical class 0.000 description 1
• 239000003708 ampul Substances 0.000 description 1
• 238000002266 amputation Methods 0.000 description 1
• 108010064539 amyloid beta-protein (1-42) Proteins 0.000 description 1
• 210000003423 ankle Anatomy 0.000 description 1
• MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 1
• 125000002178 anthracenyl group Chemical group C1(=CC=CC2=CC3=CC=CC=C3C=C12)* 0.000 description 1
• 229940045799 anthracyclines and related substance Drugs 0.000 description 1
• 239000003242 anti bacterial agent Substances 0.000 description 1
• 230000000340 anti-metabolite Effects 0.000 description 1
• 230000000692 anti-sense effect Effects 0.000 description 1
• 229940088710 antibiotic agent Drugs 0.000 description 1
• 229940100197 antimetabolite Drugs 0.000 description 1
• 239000002256 antimetabolite Substances 0.000 description 1
• 239000003080 antimitotic agent Substances 0.000 description 1
• WZSUOQDIYKMPMT-UHFFFAOYSA-N argon krypton Chemical compound [Ar].[Kr] WZSUOQDIYKMPMT-UHFFFAOYSA-N 0.000 description 1
• 238000003491 array Methods 0.000 description 1
• 210000000544 articulatio talocruralis Anatomy 0.000 description 1
• 125000001691 aryl alkyl amino group Chemical group 0.000 description 1
• 125000005129 aryl carbonyl group Chemical group 0.000 description 1
• 230000001174 ascending effect Effects 0.000 description 1
• 229940009098 aspartate Drugs 0.000 description 1
• METKIMKYRPQLGS-UHFFFAOYSA-N atenolol Chemical compound CC(C)NCC(O)COC1=CC=C(CC(N)=O)C=C1 METKIMKYRPQLGS-UHFFFAOYSA-N 0.000 description 1
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
• 230000001363 autoimmune Effects 0.000 description 1
• 210000000467 autonomic pathway Anatomy 0.000 description 1
• 235000013871 bee wax Nutrition 0.000 description 1
• 239000012166 beeswax Substances 0.000 description 1
• 230000006399 behavior Effects 0.000 description 1
• 230000003542 behavioural effect Effects 0.000 description 1
• 230000008901 benefit Effects 0.000 description 1
• 229940077388 benzenesulfonate Drugs 0.000 description 1
• SRSXLGNVWSONIS-UHFFFAOYSA-M benzenesulfonate Chemical compound [O-]S(=O)(=O)C1=CC=CC=C1 SRSXLGNVWSONIS-UHFFFAOYSA-M 0.000 description 1
• 229940050390 benzoate Drugs 0.000 description 1
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 1
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
• 201000007180 bile duct carcinoma Diseases 0.000 description 1
• 239000012620 biological material Substances 0.000 description 1
• 238000010170 biological method Methods 0.000 description 1
• 230000033228 biological regulation Effects 0.000 description 1
• 229960002685 biotin Drugs 0.000 description 1
• 235000020958 biotin Nutrition 0.000 description 1
• 239000011616 biotin Substances 0.000 description 1
• 230000006287 biotinylation Effects 0.000 description 1
• 238000007413 biotinylation Methods 0.000 description 1
• 201000001531 bladder carcinoma Diseases 0.000 description 1
• 229960001561 bleomycin Drugs 0.000 description 1
• OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 1
• 230000017531 blood circulation Effects 0.000 description 1
• 210000004204 blood vessel Anatomy 0.000 description 1
• 230000024279 bone resorption Effects 0.000 description 1
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
• 229910052794 bromium Inorganic materials 0.000 description 1
• 208000003362 bronchogenic carcinoma Diseases 0.000 description 1
• 210000001775 bruch membrane Anatomy 0.000 description 1
• 210000004899 c-terminal region Anatomy 0.000 description 1
• 230000001612 cachectic effect Effects 0.000 description 1
• 229910001424 calcium ion Inorganic materials 0.000 description 1
• 238000004364 calculation method Methods 0.000 description 1
• 235000019577 caloric intake Nutrition 0.000 description 1
• MIOPJNTWMNEORI-UHFFFAOYSA-N camphorsulfonic acid Chemical compound C1CC2(CS(O)(=O)=O)C(=O)CC1C2(C)C MIOPJNTWMNEORI-UHFFFAOYSA-N 0.000 description 1
• 230000036952 cancer formation Effects 0.000 description 1
• 208000035269 cancer or benign tumor Diseases 0.000 description 1
• 230000023852 carbohydrate metabolic process Effects 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 239000011203 carbon fibre reinforced carbon Substances 0.000 description 1
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
• 150000007942 carboxylates Chemical class 0.000 description 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
• 231100000504 carcinogenesis Toxicity 0.000 description 1
• 208000025188 carcinoma of pharynx Diseases 0.000 description 1
• 230000002612 cardiopulmonary effect Effects 0.000 description 1
• 210000000748 cardiovascular system Anatomy 0.000 description 1
• 229960005243 carmustine Drugs 0.000 description 1
• 239000012876 carrier material Substances 0.000 description 1
• 239000004359 castor oil Substances 0.000 description 1
• 235000019438 castor oil Nutrition 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 239000003054 catalyst Substances 0.000 description 1
• 150000001768 cations Chemical class 0.000 description 1
• 230000032677 cell aging Effects 0.000 description 1
• 230000005779 cell damage Effects 0.000 description 1
• 208000037887 cell injury Diseases 0.000 description 1
• 230000033077 cellular process Effects 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 235000010980 cellulose Nutrition 0.000 description 1
• 210000003710 cerebral cortex Anatomy 0.000 description 1
• 230000002490 cerebral effect Effects 0.000 description 1
• 201000010881 cervical cancer Diseases 0.000 description 1
• 210000003679 cervix uteri Anatomy 0.000 description 1
• 229940081733 cetearyl alcohol Drugs 0.000 description 1
• NDAYQJDHGXTBJL-MWWSRJDJSA-N chembl557217 Chemical compound C1=CC=C2C(C[C@H](NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](CC=3C4=CC=CC=C4NC=3)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](C(C)C)NC(=O)[C@H](C)NC(=O)[C@H](NC(=O)CNC(=O)[C@@H](NC=O)C(C)C)CC(C)C)C(=O)NCCO)=CNC2=C1 NDAYQJDHGXTBJL-MWWSRJDJSA-N 0.000 description 1
• 238000001311 chemical methods and process Methods 0.000 description 1
• 230000001055 chewing effect Effects 0.000 description 1
• 229910052801 chlorine Inorganic materials 0.000 description 1
• 229930002875 chlorophyll Natural products 0.000 description 1
• 235000019804 chlorophyll Nutrition 0.000 description 1
• ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 1
• 235000019365 chlortetracycline Nutrition 0.000 description 1
• 235000012000 cholesterol Nutrition 0.000 description 1
• 210000003483 chromatin Anatomy 0.000 description 1
• 210000000349 chromosome Anatomy 0.000 description 1
• 208000020832 chronic kidney disease Diseases 0.000 description 1
• 208000032852 chronic lymphocytic leukemia Diseases 0.000 description 1
• 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
• 230000004087 circulation Effects 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 238000010367 cloning Methods 0.000 description 1
• 229940110456 cocoa butter Drugs 0.000 description 1
• 235000019868 cocoa butter Nutrition 0.000 description 1
• 230000001427 coherent effect Effects 0.000 description 1
• 239000008119 colloidal silica Substances 0.000 description 1
• 239000003086 colorant Substances 0.000 description 1
• 238000004440 column chromatography Methods 0.000 description 1
• 230000024203 complement activation Effects 0.000 description 1
• 238000002591 computed tomography Methods 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 230000036757 core body temperature Effects 0.000 description 1
• 239000002537 cosmetic Substances 0.000 description 1
• 239000008406 cosmetic ingredient Substances 0.000 description 1
• 230000008878 coupling Effects 0.000 description 1
• 238000010168 coupling process Methods 0.000 description 1
• 238000005859 coupling reaction Methods 0.000 description 1
• 239000006059 cover glass Substances 0.000 description 1
• 239000006071 cream Substances 0.000 description 1
• 229960003624 creatine Drugs 0.000 description 1
• 239000006046 creatine Substances 0.000 description 1
• 125000006254 cycloalkyl carbonyl group Chemical group 0.000 description 1
• 125000003678 cyclohexadienyl group Chemical group C1(=CC=CCC1)* 0.000 description 1
• 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 description 1
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 description 1
• 208000002445 cystadenocarcinoma Diseases 0.000 description 1
• 229960000684 cytarabine Drugs 0.000 description 1
• GBOGMAARMMDZGR-JREHFAHYSA-N cytochalasin B Natural products C[C@H]1CCC[C@@H](O)C=CC(=O)O[C@@]23[C@H](C=CC1)[C@H](O)C(=C)[C@@H](C)[C@@H]2[C@H](Cc4ccccc4)NC3=O GBOGMAARMMDZGR-JREHFAHYSA-N 0.000 description 1
• GBOGMAARMMDZGR-TYHYBEHESA-N cytochalasin B Chemical compound C([C@H]1[C@@H]2[C@@H](C([C@@H](O)[C@@H]3/C=C/C[C@H](C)CCC[C@@H](O)/C=C/C(=O)O[C@@]23C(=O)N1)=C)C)C1=CC=CC=C1 GBOGMAARMMDZGR-TYHYBEHESA-N 0.000 description 1
• 231100000599 cytotoxic agent Toxicity 0.000 description 1
• 239000002619 cytotoxin Substances 0.000 description 1
• 229960000640 dactinomycin Drugs 0.000 description 1
• 230000000850 deacetylating effect Effects 0.000 description 1
• 230000007812 deficiency Effects 0.000 description 1
• 238000012217 deletion Methods 0.000 description 1
• 230000037430 deletion Effects 0.000 description 1
• 238000002716 delivery method Methods 0.000 description 1
• 230000002638 denervation Effects 0.000 description 1
• 230000008021 deposition Effects 0.000 description 1
• 238000010511 deprotection reaction Methods 0.000 description 1
• 238000009795 derivation Methods 0.000 description 1
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 1
• 229960003957 dexamethasone Drugs 0.000 description 1
• 208000033679 diabetic kidney disease Diseases 0.000 description 1
• 238000002405 diagnostic procedure Methods 0.000 description 1
• 125000004985 dialkyl amino alkyl group Chemical group 0.000 description 1
• 238000001085 differential centrifugation Methods 0.000 description 1
• 230000004069 differentiation Effects 0.000 description 1
• 208000018554 digestive system carcinoma Diseases 0.000 description 1
• 125000005043 dihydropyranyl group Chemical group O1C(CCC=C1)* 0.000 description 1
• GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
• 238000006471 dimerization reaction Methods 0.000 description 1
• ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical group C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
• ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 description 1
• 229910000396 dipotassium phosphate Inorganic materials 0.000 description 1
• 235000019797 dipotassium phosphate Nutrition 0.000 description 1
• 208000037765 diseases and disorders Diseases 0.000 description 1
• BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
• 239000006185 dispersion Substances 0.000 description 1
• MOTZDAYCYVMXPC-UHFFFAOYSA-N dodecyl hydrogen sulfate Chemical compound CCCCCCCCCCCCOS(O)(=O)=O MOTZDAYCYVMXPC-UHFFFAOYSA-N 0.000 description 1
• 229940043264 dodecyl sulfate Drugs 0.000 description 1
• 210000005064 dopaminergic neuron Anatomy 0.000 description 1
• 208000029444 double vision Diseases 0.000 description 1
• 239000000890 drug combination Substances 0.000 description 1
• 238000012377 drug delivery Methods 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 230000004064 dysfunction Effects 0.000 description 1
• 238000002283 elective surgery Methods 0.000 description 1
• 239000003792 electrolyte Substances 0.000 description 1
• 238000000295 emission spectrum Methods 0.000 description 1
• 239000008387 emulsifying waxe Substances 0.000 description 1
• 150000002081 enamines Chemical class 0.000 description 1
• 238000005538 encapsulation Methods 0.000 description 1
• 230000002124 endocrine Effects 0.000 description 1
• 210000000750 endocrine system Anatomy 0.000 description 1
• 239000007920 enema Substances 0.000 description 1
• 229940095399 enema Drugs 0.000 description 1
• 108010045262 enhanced cyan fluorescent protein Proteins 0.000 description 1
• 239000003623 enhancer Substances 0.000 description 1
• 230000002708 enhancing effect Effects 0.000 description 1
• 238000007824 enzymatic assay Methods 0.000 description 1
• 208000037828 epithelial carcinoma Diseases 0.000 description 1
• 230000000925 erythroid effect Effects 0.000 description 1
• CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
• BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
• 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 1
• 229960005420 etoposide Drugs 0.000 description 1
• 238000001704 evaporation Methods 0.000 description 1
• 230000008020 evaporation Effects 0.000 description 1
• 230000007717 exclusion Effects 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 108010055671 ezrin Proteins 0.000 description 1
• 239000004744 fabric Substances 0.000 description 1
• 230000002349 favourable effect Effects 0.000 description 1
• 229940012952 fibrinogen Drugs 0.000 description 1
• 235000013312 flour Nutrition 0.000 description 1
• 239000012530 fluid Substances 0.000 description 1
• 239000007850 fluorescent dye Substances 0.000 description 1
• 102000034287 fluorescent proteins Human genes 0.000 description 1
• 108091006047 fluorescent proteins Proteins 0.000 description 1
• 239000011737 fluorine Substances 0.000 description 1
• 229910052731 fluorine Inorganic materials 0.000 description 1
• 229960002949 fluorouracil Drugs 0.000 description 1
• 239000011888 foil Substances 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 235000013355 food flavoring agent Nutrition 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 101150046266 foxo gene Proteins 0.000 description 1
• 239000003205 fragrance Substances 0.000 description 1
• 230000007160 gastrointestinal dysfunction Effects 0.000 description 1
• 210000001035 gastrointestinal tract Anatomy 0.000 description 1
• 238000001641 gel filtration chromatography Methods 0.000 description 1
• 229960005277 gemcitabine Drugs 0.000 description 1
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 1
• 230000009368 gene silencing by RNA Effects 0.000 description 1
• 239000003862 glucocorticoid Substances 0.000 description 1
• 230000004110 gluconeogenesis Effects 0.000 description 1
• 230000014101 glucose homeostasis Effects 0.000 description 1
• 229930195712 glutamate Natural products 0.000 description 1
• 230000002641 glycemic effect Effects 0.000 description 1
• ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
• 229960002449 glycine Drugs 0.000 description 1
• 230000013595 glycosylation Effects 0.000 description 1
• 238000006206 glycosylation reaction Methods 0.000 description 1
• PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
• 239000010931 gold Substances 0.000 description 1
• 229910052737 gold Inorganic materials 0.000 description 1
• 230000003394 haemopoietic effect Effects 0.000 description 1
• 201000009277 hairy cell leukemia Diseases 0.000 description 1
• 229910052736 halogen Inorganic materials 0.000 description 1
• 150000002367 halogens Chemical class 0.000 description 1
• 210000003128 head Anatomy 0.000 description 1
• 230000036541 health Effects 0.000 description 1
• 230000003862 health status Effects 0.000 description 1
• 210000002216 heart Anatomy 0.000 description 1
• 208000019622 heart disease Diseases 0.000 description 1
• CPBQJMYROZQQJC-UHFFFAOYSA-N helium neon Chemical compound [He].[Ne] CPBQJMYROZQQJC-UHFFFAOYSA-N 0.000 description 1
• 201000002222 hemangioblastoma Diseases 0.000 description 1
• 206010073071 hepatocellular carcinoma Diseases 0.000 description 1
• MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid Chemical compound CCCCCCC(O)=O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 1
• 125000006517 heterocyclyl carbonyl group Chemical group 0.000 description 1
• 125000004415 heterocyclylalkyl group Chemical group 0.000 description 1
• FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
• 238000004128 high performance liquid chromatography Methods 0.000 description 1
• 230000003118 histopathologic effect Effects 0.000 description 1
• 102000056070 human SOD1 Human genes 0.000 description 1
• 235000003642 hunger Nutrition 0.000 description 1
• 238000009396 hybridization Methods 0.000 description 1
• 229910052739 hydrogen Inorganic materials 0.000 description 1
• ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-M hydrogensulfate Chemical compound OS([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-M 0.000 description 1
• 208000013403 hyperactivity Diseases 0.000 description 1
• 230000003345 hyperglycaemic effect Effects 0.000 description 1
• 230000002390 hyperplastic effect Effects 0.000 description 1
• 230000001969 hypertrophic effect Effects 0.000 description 1
• 230000002396 hypoinsulinemic effect Effects 0.000 description 1
• 230000003483 hypokinetic effect Effects 0.000 description 1
• 208000021822 hypotensive Diseases 0.000 description 1
• 230000001077 hypotensive effect Effects 0.000 description 1
• 125000001841 imino group Chemical group [H]N=* 0.000 description 1
• 230000003100 immobilizing effect Effects 0.000 description 1
• 210000002865 immune cell Anatomy 0.000 description 1
• 208000026278 immune system disease Diseases 0.000 description 1
• 238000001114 immunoprecipitation Methods 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 230000006872 improvement Effects 0.000 description 1
• 230000036540 impulse transmission Effects 0.000 description 1
• 238000000099 in vitro assay Methods 0.000 description 1
• 125000002249 indol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([*])=C([H])C2=C1[H] 0.000 description 1
• 230000006698 induction Effects 0.000 description 1
• 230000001939 inductive effect Effects 0.000 description 1
• 230000008595 infiltration Effects 0.000 description 1
• 238000001764 infiltration Methods 0.000 description 1
• 230000002757 inflammatory effect Effects 0.000 description 1
• 230000004054 inflammatory process Effects 0.000 description 1
• 229940102223 injectable solution Drugs 0.000 description 1
• 229940102213 injectable suspension Drugs 0.000 description 1
• 208000014674 injury Diseases 0.000 description 1
• 238000012482 interaction analysis Methods 0.000 description 1
• 238000001361 intraarterial administration Methods 0.000 description 1
• 230000003834 intracellular effect Effects 0.000 description 1
• 230000006662 intracellular pathway Effects 0.000 description 1
• 208000020658 intracerebral hemorrhage Diseases 0.000 description 1
• 238000007917 intracranial administration Methods 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000007919 intrasynovial administration Methods 0.000 description 1
• 238000007913 intrathecal administration Methods 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• 238000011835 investigation Methods 0.000 description 1
• 239000011630 iodine Substances 0.000 description 1
• 229910052740 iodine Inorganic materials 0.000 description 1
• 238000004255 ion exchange chromatography Methods 0.000 description 1
• 230000002427 irreversible effect Effects 0.000 description 1
• SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical compound OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
• 238000002955 isolation Methods 0.000 description 1
• VFQXVTODMYMSMJ-UHFFFAOYSA-N isonicotinamide Chemical compound NC(=O)C1=CC=NC=C1 VFQXVTODMYMSMJ-UHFFFAOYSA-N 0.000 description 1
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
• 208000017169 kidney disease Diseases 0.000 description 1
• 201000006370 kidney failure Diseases 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 229940067606 lecithin Drugs 0.000 description 1
• 102000005861 leptin receptors Human genes 0.000 description 1
• 108010019813 leptin receptors Proteins 0.000 description 1
• 231100000225 lethality Toxicity 0.000 description 1
• 208000032839 leukemia Diseases 0.000 description 1
• 229960004194 lidocaine Drugs 0.000 description 1
• 239000003446 ligand Substances 0.000 description 1
• 230000037356 lipid metabolism Effects 0.000 description 1
• 150000002632 lipids Chemical class 0.000 description 1
• 206010024627 liposarcoma Diseases 0.000 description 1
• 239000007791 liquid phase Substances 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 201000007270 liver cancer Diseases 0.000 description 1
• 208000014018 liver neoplasm Diseases 0.000 description 1
• 230000033001 locomotion Effects 0.000 description 1
• 230000003137 locomotive effect Effects 0.000 description 1
• 229960002247 lomustine Drugs 0.000 description 1
• 208000018769 loss of vision Diseases 0.000 description 1
• 231100000864 loss of vision Toxicity 0.000 description 1
• 239000006210 lotion Substances 0.000 description 1
• 239000000314 lubricant Substances 0.000 description 1
• 201000005296 lung carcinoma Diseases 0.000 description 1
• 208000037829 lymphangioendotheliosarcoma Diseases 0.000 description 1
• 210000004324 lymphatic system Anatomy 0.000 description 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 description 1
• 210000003712 lysosome Anatomy 0.000 description 1
• 230000001868 lysosomic effect Effects 0.000 description 1
• 210000002540 macrophage Anatomy 0.000 description 1
• 229910001425 magnesium ion Inorganic materials 0.000 description 1
• 239000000391 magnesium silicate Substances 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 229940099273 magnesium trisilicate Drugs 0.000 description 1
• 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
• 235000019793 magnesium trisilicate Nutrition 0.000 description 1
• 238000012423 maintenance Methods 0.000 description 1
• VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
• 239000000594 mannitol Substances 0.000 description 1
• 235000010355 mannitol Nutrition 0.000 description 1
• 230000013011 mating Effects 0.000 description 1
• 238000010297 mechanical methods and process Methods 0.000 description 1
• 229960004961 mechlorethamine Drugs 0.000 description 1
• HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical compound ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 description 1
• 208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 1
• 229960001924 melphalan Drugs 0.000 description 1
• SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 1
• 210000004379 membrane Anatomy 0.000 description 1
• 239000012528 membrane Substances 0.000 description 1
• 206010027191 meningioma Diseases 0.000 description 1
• 229960001428 mercaptopurine Drugs 0.000 description 1
• 108020004999 messenger RNA Proteins 0.000 description 1
• 230000006609 metabolic stress Effects 0.000 description 1
• 239000002207 metabolite Substances 0.000 description 1
• MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 description 1
• 229960000485 methotrexate Drugs 0.000 description 1
• 230000011987 methylation Effects 0.000 description 1
• 238000007069 methylation reaction Methods 0.000 description 1
• 229940042472 mineral oil Drugs 0.000 description 1
• 150000007522 mineralic acids Chemical class 0.000 description 1
• 235000013536 miso Nutrition 0.000 description 1
• 229960005485 mitobronitol Drugs 0.000 description 1
• 210000003470 mitochondria Anatomy 0.000 description 1
• 230000002438 mitochondrial effect Effects 0.000 description 1
• 229960001156 mitoxantrone Drugs 0.000 description 1
• KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• 238000003032 molecular docking Methods 0.000 description 1
• 230000007659 motor function Effects 0.000 description 1
• 208000005264 motor neuron disease Diseases 0.000 description 1
• 201000006938 muscular dystrophy Diseases 0.000 description 1
• 210000005012 myelin Anatomy 0.000 description 1
• 208000001611 myxosarcoma Diseases 0.000 description 1
• SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 description 1
• KVBGVZZKJNLNJU-UHFFFAOYSA-M naphthalene-2-sulfonate Chemical compound C1=CC=CC2=CC(S(=O)(=O)[O-])=CC=C21 KVBGVZZKJNLNJU-UHFFFAOYSA-M 0.000 description 1
• 125000001624 naphthyl group Chemical group 0.000 description 1
• 239000007922 nasal spray Substances 0.000 description 1
• 210000003739 neck Anatomy 0.000 description 1
• 208000025189 neoplasm of testis Diseases 0.000 description 1
• 230000008764 nerve damage Effects 0.000 description 1
• 230000001722 neurochemical effect Effects 0.000 description 1
• 210000004498 neuroglial cell Anatomy 0.000 description 1
• 238000010984 neurological examination Methods 0.000 description 1
• 230000003961 neuronal insult Effects 0.000 description 1
• 230000007991 neuronal integrity Effects 0.000 description 1
• 239000002858 neurotransmitter agent Substances 0.000 description 1
• 208000004235 neutropenia Diseases 0.000 description 1
• 235000001968 nicotinic acid Nutrition 0.000 description 1
• 239000011664 nicotinic acid Substances 0.000 description 1
• 231100000344 non-irritating Toxicity 0.000 description 1
• 125000003518 norbornenyl group Chemical group C12(C=CC(CC1)C2)* 0.000 description 1
• 125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 description 1
• 210000004940 nucleus Anatomy 0.000 description 1
• 235000018343 nutrient deficiency Nutrition 0.000 description 1
• GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 1
• 239000002674 ointment Substances 0.000 description 1
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
• 239000004006 olive oil Substances 0.000 description 1
• 235000008390 olive oil Nutrition 0.000 description 1
• 210000000158 ommatidium Anatomy 0.000 description 1
• 231100000590 oncogenic Toxicity 0.000 description 1
• 230000002246 oncogenic effect Effects 0.000 description 1
• 210000000287 oocyte Anatomy 0.000 description 1
• 230000003287 optical effect Effects 0.000 description 1
• 230000008816 organ damage Effects 0.000 description 1
• 150000007524 organic acids Chemical class 0.000 description 1
• 235000005985 organic acids Nutrition 0.000 description 1
• 201000008482 osteoarthritis Diseases 0.000 description 1
• 201000008968 osteosarcoma Diseases 0.000 description 1
• 229940043515 other immunoglobulins in atc Drugs 0.000 description 1
• 239000001301 oxygen Substances 0.000 description 1
• 125000004430 oxygen atom Chemical group O* 0.000 description 1
• 201000002528 pancreatic cancer Diseases 0.000 description 1
• 208000008443 pancreatic carcinoma Diseases 0.000 description 1
• 208000004019 papillary adenocarcinoma Diseases 0.000 description 1
• 201000010198 papillary carcinoma Diseases 0.000 description 1
• 102000045222 parkin Human genes 0.000 description 1
• 244000052769 pathogen Species 0.000 description 1
• 230000037361 pathway Effects 0.000 description 1
• 230000035515 penetration Effects 0.000 description 1
• 125000005010 perfluoroalkyl group Chemical group 0.000 description 1
• UTIQDNPUHSAVDN-UHFFFAOYSA-N peridinin Natural products CC(=O)OC1CC(C)(C)C(=C=CC(=CC=CC=CC=C2/OC(=O)C(=C2)C=CC34OC3(C)CC(O)CC4(C)C)C)C(C)(O)C1 UTIQDNPUHSAVDN-UHFFFAOYSA-N 0.000 description 1
• 210000000578 peripheral nerve Anatomy 0.000 description 1
• 210000001428 peripheral nervous system Anatomy 0.000 description 1
• JRKICGRDRMAZLK-UHFFFAOYSA-L peroxydisulfate Chemical compound [O-]S(=O)(=O)OOS([O-])(=O)=O JRKICGRDRMAZLK-UHFFFAOYSA-L 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1
• 230000000144 pharmacologic effect Effects 0.000 description 1
• CWCMIVBLVUHDHK-ZSNHEYEWSA-N phleomycin D1 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC[C@@H](N=1)C=1SC=C(N=1)C(=O)NCCCCNC(N)=N)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C CWCMIVBLVUHDHK-ZSNHEYEWSA-N 0.000 description 1
• 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
• 230000026731 phosphorylation Effects 0.000 description 1
• 238000006366 phosphorylation reaction Methods 0.000 description 1
• 230000004962 physiological condition Effects 0.000 description 1
• 229940075930 picrate Drugs 0.000 description 1
• OXNIZHLAWKMVMX-UHFFFAOYSA-M picrate anion Chemical compound [O-]C1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-M 0.000 description 1
• 208000024724 pineal body neoplasm Diseases 0.000 description 1
• 201000004123 pineal gland cancer Diseases 0.000 description 1
• 125000003386 piperidinyl group Chemical group 0.000 description 1
• 229950010765 pivalate Drugs 0.000 description 1
• IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
• 239000013612 plasmid Substances 0.000 description 1
• 239000002797 plasminogen activator inhibitor Substances 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• 238000007747 plating Methods 0.000 description 1
• 229920000729 poly(L-lysine) polymer Polymers 0.000 description 1
• 229920000058 polyacrylate Polymers 0.000 description 1
• 229920000768 polyamine Polymers 0.000 description 1
• 229940113116 polyethylene glycol 1000 Drugs 0.000 description 1
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
• 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
• 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
• 229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
• 229940113124 polysorbate 60 Drugs 0.000 description 1
• 229920000053 polysorbate 80 Polymers 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 230000004481 post-translational protein modification Effects 0.000 description 1
• 229910001414 potassium ion Inorganic materials 0.000 description 1
• 239000004302 potassium sorbate Substances 0.000 description 1
• 235000010241 potassium sorbate Nutrition 0.000 description 1
• 229940069338 potassium sorbate Drugs 0.000 description 1
• 230000002335 preservative effect Effects 0.000 description 1
• 206010063401 primary progressive multiple sclerosis Diseases 0.000 description 1
• 229960004919 procaine Drugs 0.000 description 1
• MFDFERRIHVXMIY-UHFFFAOYSA-N procaine Chemical compound CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 MFDFERRIHVXMIY-UHFFFAOYSA-N 0.000 description 1
• 230000008569 process Effects 0.000 description 1
• 201000002241 progressive bulbar palsy Diseases 0.000 description 1
• 230000000770 proinflammatory effect Effects 0.000 description 1
• 230000002062 proliferating effect Effects 0.000 description 1
• 125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
• 229960003712 propranolol Drugs 0.000 description 1
• 201000001514 prostate carcinoma Diseases 0.000 description 1
• 229950008679 protamine sulfate Drugs 0.000 description 1
• 239000011241 protective layer Substances 0.000 description 1
• 238000003498 protein array Methods 0.000 description 1
• 230000022558 protein metabolic process Effects 0.000 description 1
• 230000012743 protein tagging Effects 0.000 description 1
• 230000017854 proteolysis Effects 0.000 description 1
• 230000003331 prothrombotic effect Effects 0.000 description 1
• 229950010131 puromycin Drugs 0.000 description 1
• 125000000714 pyrimidinyl group Chemical group 0.000 description 1
• 125000000719 pyrrolidinyl group Chemical group 0.000 description 1
• 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
• UOWVMDUEMSNCAV-WYENRQIDSA-N rachelmycin Chemical compound C1([C@]23C[C@@H]2CN1C(=O)C=1NC=2C(OC)=C(O)C4=C(C=2C=1)CCN4C(=O)C1=CC=2C=4CCN(C=4C(O)=C(C=2N1)OC)C(N)=O)=CC(=O)C1=C3C(C)=CN1 UOWVMDUEMSNCAV-WYENRQIDSA-N 0.000 description 1
• 239000000376 reactant Substances 0.000 description 1
• 238000001953 recrystallisation Methods 0.000 description 1
• 206010038038 rectal cancer Diseases 0.000 description 1
• 229940100618 rectal suppository Drugs 0.000 description 1
• 239000006215 rectal suppository Substances 0.000 description 1
• 210000000664 rectum Anatomy 0.000 description 1
• 201000001275 rectum cancer Diseases 0.000 description 1
• 238000009877 rendering Methods 0.000 description 1
• 230000008439 repair process Effects 0.000 description 1
• 229920005989 resin Polymers 0.000 description 1
• 239000011347 resin Substances 0.000 description 1
• 230000029058 respiratory gaseous exchange Effects 0.000 description 1
• 210000002345 respiratory system Anatomy 0.000 description 1
• 230000004043 responsiveness Effects 0.000 description 1
• 230000000717 retained effect Effects 0.000 description 1
• 239000000790 retinal pigment Substances 0.000 description 1
• 230000001177 retroviral effect Effects 0.000 description 1
• 238000003757 reverse transcription PCR Methods 0.000 description 1
• 201000009410 rhabdomyosarcoma Diseases 0.000 description 1
• 206010039073 rheumatoid arthritis Diseases 0.000 description 1
• 102220225613 rs945135468 Human genes 0.000 description 1
• 235000002020 sage Nutrition 0.000 description 1
• YGSDEFSMJLZEOE-UHFFFAOYSA-M salicylate Chemical compound OC1=CC=CC=C1C([O-])=O YGSDEFSMJLZEOE-UHFFFAOYSA-M 0.000 description 1
• 229960001860 salicylate Drugs 0.000 description 1
• 238000005070 sampling Methods 0.000 description 1
• 210000003497 sciatic nerve Anatomy 0.000 description 1
• 238000003345 scintillation counting Methods 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 238000007789 sealing Methods 0.000 description 1
• 201000008407 sebaceous adenocarcinoma Diseases 0.000 description 1
• 230000009758 senescence Effects 0.000 description 1
• 230000035807 sensation Effects 0.000 description 1
• 210000002966 serum Anatomy 0.000 description 1
• 230000035939 shock Effects 0.000 description 1
• 238000009097 single-agent therapy Methods 0.000 description 1
• 101150026756 sir1 gene Proteins 0.000 description 1
• 101150089009 sir2 gene Proteins 0.000 description 1
• 238000002741 site-directed mutagenesis Methods 0.000 description 1
• 208000000587 small cell lung carcinoma Diseases 0.000 description 1
• 101150017120 sod gene Proteins 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
• 229910001415 sodium ion Inorganic materials 0.000 description 1
• 239000006104 solid solution Substances 0.000 description 1
• 230000003381 solubilizing effect Effects 0.000 description 1
• 239000004334 sorbic acid Substances 0.000 description 1
• 235000010199 sorbic acid Nutrition 0.000 description 1
• 229940075582 sorbic acid Drugs 0.000 description 1
• 239000001587 sorbitan monostearate Substances 0.000 description 1
• 235000011076 sorbitan monostearate Nutrition 0.000 description 1
• 229940035048 sorbitan monostearate Drugs 0.000 description 1
• 241000894007 species Species 0.000 description 1
• 238000004611 spectroscopical analysis Methods 0.000 description 1
• 229940063673 spermidine Drugs 0.000 description 1
• 229940063675 spermine Drugs 0.000 description 1
• 210000000278 spinal cord Anatomy 0.000 description 1
• 208000002320 spinal muscular atrophy Diseases 0.000 description 1
• 230000002269 spontaneous effect Effects 0.000 description 1
• 239000007921 spray Substances 0.000 description 1
• 206010041823 squamous cell carcinoma Diseases 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 238000010186 staining Methods 0.000 description 1
• 230000037351 starvation Effects 0.000 description 1
• 239000008223 sterile water Substances 0.000 description 1
• 208000023516 stroke disease Diseases 0.000 description 1
• 238000002899 structure database search Methods 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 210000003523 substantia nigra Anatomy 0.000 description 1
• 150000001420 substituted heterocyclic compounds Chemical class 0.000 description 1
• 229940124530 sulfonamide Drugs 0.000 description 1
• 150000003456 sulfonamides Chemical class 0.000 description 1
• 150000003457 sulfones Chemical class 0.000 description 1
• 150000003462 sulfoxides Chemical class 0.000 description 1
• 239000011593 sulfur Substances 0.000 description 1
• 125000004434 sulfur atom Chemical group 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1
• 238000013268 sustained release Methods 0.000 description 1
• 239000012730 sustained-release form Substances 0.000 description 1
• 201000010965 sweat gland carcinoma Diseases 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 206010042863 synovial sarcoma Diseases 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 229940095064 tartrate Drugs 0.000 description 1
• 210000003411 telomere Anatomy 0.000 description 1
• 108091035539 telomere Proteins 0.000 description 1
• 102000055501 telomere Human genes 0.000 description 1
• NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 1
• 229960001278 teniposide Drugs 0.000 description 1
• 238000010998 test method Methods 0.000 description 1
• 230000002381 testicular Effects 0.000 description 1
• 201000003120 testicular cancer Diseases 0.000 description 1
• 229960002372 tetracaine Drugs 0.000 description 1
• GKCBAIGFKIBETG-UHFFFAOYSA-N tetracaine Chemical compound CCCCNC1=CC=C(C(=O)OCCN(C)C)C=C1 GKCBAIGFKIBETG-UHFFFAOYSA-N 0.000 description 1
• TUGDLVFMIQZYPA-UHFFFAOYSA-N tetracopper;tetrazinc Chemical compound [Cu+2].[Cu+2].[Cu+2].[Cu+2].[Zn+2].[Zn+2].[Zn+2].[Zn+2] TUGDLVFMIQZYPA-UHFFFAOYSA-N 0.000 description 1
• MHXBHWLGRWOABW-UHFFFAOYSA-N tetradecyl octadecanoate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCCCC MHXBHWLGRWOABW-UHFFFAOYSA-N 0.000 description 1
• UJJLJRQIPMGXEZ-UHFFFAOYSA-N tetrahydro-2-furoic acid Chemical compound OC(=O)C1CCCO1 UJJLJRQIPMGXEZ-UHFFFAOYSA-N 0.000 description 1
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 description 1
• 125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
• 125000005942 tetrahydropyridyl group Chemical group 0.000 description 1
• QEMXHQIAXOOASZ-UHFFFAOYSA-N tetramethylammonium Chemical compound C[N+](C)(C)C QEMXHQIAXOOASZ-UHFFFAOYSA-N 0.000 description 1
• MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
• 238000002560 therapeutic procedure Methods 0.000 description 1
• 238000011285 therapeutic regimen Methods 0.000 description 1
• 125000000464 thioxo group Chemical group S=* 0.000 description 1
• 229960003087 tioguanine Drugs 0.000 description 1
• 229960001295 tocopherol Drugs 0.000 description 1
• 239000011732 tocopherol Substances 0.000 description 1
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
• 231100000167 toxic agent Toxicity 0.000 description 1
• 239000003440 toxic substance Substances 0.000 description 1
• 238000013518 transcription Methods 0.000 description 1
• 230000035897 transcription Effects 0.000 description 1
• 238000001890 transfection Methods 0.000 description 1
• 230000001052 transient effect Effects 0.000 description 1
• 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 1
• 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
• 125000000430 tryptophan group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C2=C([H])C([H])=C([H])C([H])=C12 0.000 description 1
• 230000004614 tumor growth Effects 0.000 description 1
• 238000010798 ubiquitination Methods 0.000 description 1
• 230000034512 ubiquitination Effects 0.000 description 1
• 230000036269 ulceration Effects 0.000 description 1
• ZDPHROOEEOARMN-UHFFFAOYSA-N undecanoic acid Chemical compound CCCCCCCCCCC(O)=O ZDPHROOEEOARMN-UHFFFAOYSA-N 0.000 description 1
• 206010048828 underweight Diseases 0.000 description 1
• 230000003827 upregulation Effects 0.000 description 1
• 208000010570 urinary bladder carcinoma Diseases 0.000 description 1
• 210000002229 urogenital system Anatomy 0.000 description 1
• 235000013311 vegetables Nutrition 0.000 description 1
• 230000003612 virological effect Effects 0.000 description 1
• 230000004393 visual impairment Effects 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 239000002699 waste material Substances 0.000 description 1
• 239000001993 wax Substances 0.000 description 1
• 239000000080 wetting agent Substances 0.000 description 1
• 210000002268 wool Anatomy 0.000 description 1
• 230000029663 wound healing Effects 0.000 description 1
• 108091005957 yellow fluorescent proteins Proteins 0.000 description 1
• 239000011701 zinc Substances 0.000 description 1
• 150000003751 zinc Chemical class 0.000 description 1