CA2542835A1 - Inhibition a mediation d'interference d'arn de l'expression genetique a l'aide d'acide nucleique d'interference court (sina) - Google Patents
Inhibition a mediation d'interference d'arn de l'expression genetique a l'aide d'acide nucleique d'interference court (sina) Download PDFInfo
- Publication number
- CA2542835A1 CA2542835A1 CA002542835A CA2542835A CA2542835A1 CA 2542835 A1 CA2542835 A1 CA 2542835A1 CA 002542835 A CA002542835 A CA 002542835A CA 2542835 A CA2542835 A CA 2542835A CA 2542835 A1 CA2542835 A1 CA 2542835A1
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- CA
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- Prior art keywords
- nucleotides
- sina
- sina molecule
- molecule
- rna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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- C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/11—Antisense
- C12N2310/111—Antisense spanning the whole gene, or a large part of it
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Applications Claiming Priority (19)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/693,059 US20080039414A1 (en) | 2002-02-20 | 2003-10-23 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US10/693,059 | 2003-10-23 | ||
US10/720,448 | 2003-11-24 | ||
US10/720,448 US8273866B2 (en) | 2002-02-20 | 2003-11-24 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA) |
US10/727,780 US20050233329A1 (en) | 2002-02-20 | 2003-12-03 | Inhibition of gene expression using duplex forming oligonucleotides |
US10/727,780 | 2003-12-03 | ||
US10/757,803 US20050020525A1 (en) | 2002-02-20 | 2004-01-14 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US10/757,803 | 2004-01-14 | ||
US54348004P | 2004-02-10 | 2004-02-10 | |
US60/543,480 | 2004-02-10 | ||
US10/780,447 | 2004-02-13 | ||
US10/780,447 US7491805B2 (en) | 2001-05-18 | 2004-02-13 | Conjugates and compositions for cellular delivery |
US10/826,966 US20050032733A1 (en) | 2001-05-18 | 2004-04-16 | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA) |
US10/826,966 | 2004-04-16 | ||
USPCT/US04/13456 | 2004-04-30 | ||
PCT/US2004/013456 WO2005041859A2 (fr) | 2003-04-30 | 2004-04-30 | Conjugues et compositions |
USPCT/US04/16390 | 2004-05-24 | ||
PCT/US2004/016390 WO2005019453A2 (fr) | 2001-05-18 | 2004-05-24 | Interference arn a mediation assuree par l'inhibition de genes au moyen de petit acide nucleique interferent (ansi) modifie chimiquement |
PCT/US2004/027403 WO2005044981A2 (fr) | 2003-10-23 | 2004-08-20 | Inhibition a mediation d'interference d'arn de l'expression genetique a l'aide d'acide nucleique d'interference court (sina) |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2542835A1 true CA2542835A1 (fr) | 2005-05-19 |
Family
ID=56290593
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002542835A Abandoned CA2542835A1 (fr) | 2003-10-23 | 2004-08-20 | Inhibition a mediation d'interference d'arn de l'expression genetique a l'aide d'acide nucleique d'interference court (sina) |
CA002543013A Abandoned CA2543013A1 (fr) | 2003-10-23 | 2004-08-20 | Inhibition mediee par interference arn de l'expression genique de nogo et du recepteur nogo au moyen d'un petit acide nucleique interferent (sina) |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002543013A Abandoned CA2543013A1 (fr) | 2003-10-23 | 2004-08-20 | Inhibition mediee par interference arn de l'expression genique de nogo et du recepteur nogo au moyen d'un petit acide nucleique interferent (sina) |
Country Status (4)
Country | Link |
---|---|
EP (3) | EP1675949A2 (fr) |
JP (2) | JP2008506351A (fr) |
CA (2) | CA2542835A1 (fr) |
WO (3) | WO2005044981A2 (fr) |
Families Citing this family (62)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9657294B2 (en) | 2002-02-20 | 2017-05-23 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
US9181551B2 (en) | 2002-02-20 | 2015-11-10 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA) |
WO2005066363A2 (fr) * | 2004-01-09 | 2005-07-21 | Medigen Biotechnology Corporation | Gene mg20 specifique du cancer |
ES2384940T3 (es) | 2004-01-16 | 2012-07-16 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Inmunoquinasas |
CA2572439A1 (fr) | 2004-07-02 | 2006-01-12 | Protiva Biotherapeutics, Inc. | Molecules sirna immunostimulatrices et utilisations de celles-ci |
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WO2002081628A2 (fr) * | 2001-04-05 | 2002-10-17 | Ribozyme Pharmaceuticals, Incorporated | Modulation de l'expression genique associee a la proliferation inflammatoire et a la croissance de neurites, par des procedes faisant intervenir l'acide nucleique |
WO2002044321A2 (fr) * | 2000-12-01 | 2002-06-06 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Petites molecules d'arn mediant l'interference arn |
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AU2003219781A1 (en) * | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc | RNA INTERFERENCE MEDIATED INHIBITION OF PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
EP1472265A4 (fr) * | 2002-02-20 | 2005-06-15 | Sirna Therapeutics Inc | Inhibition mediee par interference d'arn de l'expression du gene de la proteine ezh2 du groupe polycomb a l'aide d'un acide nucleique court interferent (sina) |
AU2003207708A1 (en) * | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | Rna interference mediated inhibition of map kinase genes |
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2004
- 2004-08-20 WO PCT/US2004/027403 patent/WO2005044981A2/fr active Application Filing
- 2004-08-20 WO PCT/US2004/026930 patent/WO2005045035A2/fr not_active Application Discontinuation
- 2004-08-20 CA CA002542835A patent/CA2542835A1/fr not_active Abandoned
- 2004-08-20 EP EP04781588A patent/EP1675949A2/fr not_active Withdrawn
- 2004-08-20 CA CA002543013A patent/CA2543013A1/fr not_active Abandoned
- 2004-08-20 WO PCT/US2004/027333 patent/WO2005040379A2/fr active Application Filing
- 2004-08-20 JP JP2006536613A patent/JP2008506351A/ja not_active Withdrawn
- 2004-08-20 JP JP2006536609A patent/JP2007522793A/ja active Pending
- 2004-08-20 EP EP04816819A patent/EP1675953A2/fr not_active Withdrawn
- 2004-08-20 EP EP04781982A patent/EP1682661A2/fr not_active Withdrawn
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JP2007522793A (ja) | 2007-08-16 |
WO2005044981A2 (fr) | 2005-05-19 |
EP1682661A2 (fr) | 2006-07-26 |
WO2005040379A3 (fr) | 2006-03-02 |
WO2005045035A2 (fr) | 2005-05-19 |
WO2005040379A2 (fr) | 2005-05-06 |
EP1675949A2 (fr) | 2006-07-05 |
CA2543013A1 (fr) | 2005-05-19 |
WO2005044981A3 (fr) | 2005-09-22 |
EP1675953A2 (fr) | 2006-07-05 |
WO2005045035A3 (fr) | 2005-12-08 |
JP2008506351A (ja) | 2008-03-06 |
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