WO2005045035A3 - Inhibition mediee par interference arn de l'expression genique de nogo et du recepteur nogo au moyen d'un petit acide nucleique interferent (sina) - Google Patents

Inhibition mediee par interference arn de l'expression genique de nogo et du recepteur nogo au moyen d'un petit acide nucleique interferent (sina) Download PDF

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WO2005045035A3
WO2005045035A3 PCT/US2004/026930 US2004026930W WO2005045035A3 WO 2005045035 A3 WO2005045035 A3 WO 2005045035A3 US 2004026930 W US2004026930 W US 2004026930W WO 2005045035 A3 WO2005045035 A3 WO 2005045035A3
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Prior art keywords
nogo
nucleic acid
short interfering
sina
gene expression
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PCT/US2004/026930
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English (en)
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WO2005045035A2 (fr
Inventor
James Mcswiggen
Bharat M Chowrira
Peter Haeberli
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Sirna Therapeutics Inc
James Mcswiggen
Bharat M Chowrira
Peter Haeberli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Priority claimed from US10/693,059 external-priority patent/US20080039414A1/en
Priority claimed from US10/720,448 external-priority patent/US8273866B2/en
Priority claimed from US10/727,780 external-priority patent/US20050233329A1/en
Priority claimed from US10/757,803 external-priority patent/US20050020525A1/en
Priority claimed from US10/780,447 external-priority patent/US7491805B2/en
Priority claimed from US10/826,966 external-priority patent/US20050032733A1/en
Priority claimed from PCT/US2004/013456 external-priority patent/WO2005041859A2/fr
Priority claimed from PCT/US2004/016390 external-priority patent/WO2005019453A2/fr
Priority to US10/576,690 priority Critical patent/US20070185043A1/en
Priority to CA002543013A priority patent/CA2543013A1/fr
Application filed by Sirna Therapeutics Inc, James Mcswiggen, Bharat M Chowrira, Peter Haeberli filed Critical Sirna Therapeutics Inc
Priority to EP04781588A priority patent/EP1675949A2/fr
Priority to JP2006536609A priority patent/JP2007522793A/ja
Publication of WO2005045035A2 publication Critical patent/WO2005045035A2/fr
Publication of WO2005045035A3 publication Critical patent/WO2005045035A3/fr

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Abstract

L'invention concerne des composés, des compositions et des méthodes utiles pour moduler l'expression génique de NOGO et/ou du récepteur NOGO au moyen de molécules d'un petit acide nucléique interférent (siNA). L'invention concerne également des composés, des compositions et des méthodes utiles pour moduler l'expression et l'activité d'autres gènes impliqués dans les voies de l'expression et/ou de l'activité génique de NOGO et/ou du récepteur NOGO par interférence ARN (RNAi) au moyen de petites molécules d'acide nucléique. Plus particulièrement, la présente invention concerne des petites molécules d'acide nucléique, telles que des molécules d'un petit acide nucléique interférent (siNA), d'un petit ARN interférent (siRNA), d'un ARN bicaténaire (dsRNA), d'un micro-ARN (miRNA) et d'un petit ARN en épingle à cheveux (shRNA), ainsi que des méthodes utilisées pour moduler l'expression génique de NOGO et/ou du récepteur NOGO, y compris NOGO-A, NOGO-B, NOGO-C, le récepteur NOGO-66, NI-35, NI-220, NI-250, la glycoprotéine associée à la myéline, la ténascine-R et NG-2.
PCT/US2004/026930 2003-10-23 2004-08-20 Inhibition mediee par interference arn de l'expression genique de nogo et du recepteur nogo au moyen d'un petit acide nucleique interferent (sina) WO2005045035A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2006536609A JP2007522793A (ja) 2003-10-23 2004-08-20 短鎖干渉核酸（ｓｉＮＡ）を用いた、ＲＮＡ干渉を介したＮＯＧＯ及び／又はＮＯＧＯ受容体遺伝子発現の阻害
EP04781588A EP1675949A2 (fr) 2003-10-23 2004-08-20 INHIBITION MEDIEE PAR INTERFERENCE ARN DE L'EXPRESSION GENIQUE DE NOGO ET DU RECEPTEUR NOGO AU MOYEN D'UN PETIT ACIDE NUCLEIQUE INTERFERENT (siNA)
US10/576,690 US20070185043A1 (en) 2003-10-23 2004-08-20 Rna interference mediated inhibition of nogo and nogo receptor gene expression using short interfering nucleic acid (sina)
CA002543013A CA2543013A1 (fr) 2003-10-23 2004-08-20 Inhibition mediee par interference arn de l'expression genique de nogo et du recepteur nogo au moyen d'un petit acide nucleique interferent (sina)

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US10/693,059 US20080039414A1 (en) 2002-02-20 2003-10-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/693,059 2003-10-23
US10/720,448 2003-11-24
US10/720,448 US8273866B2 (en) 2002-02-20 2003-11-24 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US10/727,780 US20050233329A1 (en) 2002-02-20 2003-12-03 Inhibition of gene expression using duplex forming oligonucleotides
US10/727,780 2003-12-03
US10/757,803 US20050020525A1 (en) 2002-02-20 2004-01-14 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/757,803 2004-01-14
US54348004P 2004-02-10 2004-02-10
US60/543,480 2004-02-10
US10/780,447 US7491805B2 (en) 2001-05-18 2004-02-13 Conjugates and compositions for cellular delivery
US10/780,447 2004-02-13
US10/826,966 US20050032733A1 (en) 2001-05-18 2004-04-16 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
US10/826,966 2004-04-16
PCT/US2004/013456 WO2005041859A2 (fr) 2003-04-30 2004-04-30 Conjugues et compositions
USPCT/US04/13456 2004-04-30
USPCT/US04/16390 2004-05-24
PCT/US2004/016390 WO2005019453A2 (fr) 2001-05-18 2004-05-24 Interference arn a mediation assuree par l'inhibition de genes au moyen de petit acide nucleique interferent (ansi) modifie chimiquement

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PCT/US2004/027333 WO2005040379A2 (fr) 2003-10-23 2004-08-20 Inhibition induite par interference d'arn de l'expression genique ras au moyen de petit acide nucleique interferent (sina)
PCT/US2004/027403 WO2005044981A2 (fr) 2003-10-23 2004-08-20 Inhibition a mediation d'interference d'arn de l'expression genetique a l'aide d'acide nucleique d'interference court (sina)

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PCT/US2004/027403 WO2005044981A2 (fr) 2003-10-23 2004-08-20 Inhibition a mediation d'interference d'arn de l'expression genetique a l'aide d'acide nucleique d'interference court (sina)

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WO2005044981A3 (fr) 2005-09-22
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WO2005040379A2 (fr) 2005-05-06
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