WO2005007855A3 - Inhibition induite par interference d'arn de l'expression du gene b7-h1 au moyen d'acide nucleique a interference courte (sina) - Google Patents

Inhibition induite par interference d'arn de l'expression du gene b7-h1 au moyen d'acide nucleique a interference courte (sina) Download PDF

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Publication number
WO2005007855A3
WO2005007855A3 PCT/US2004/022658 US2004022658W WO2005007855A3 WO 2005007855 A3 WO2005007855 A3 WO 2005007855A3 US 2004022658 W US2004022658 W US 2004022658W WO 2005007855 A3 WO2005007855 A3 WO 2005007855A3
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WIPO (PCT)
Prior art keywords
nucleic acid
short interfering
sina
gene expression
rna
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PCT/US2004/022658
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English (en)
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WO2005007855A2 (fr
Inventor
Nassim Usman
James Mcswiggen
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Sirna Therapeutics Inc
Nassim Usman
James Mcswiggen
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Filing date
Publication date
Priority claimed from US10/693,059 external-priority patent/US20080039414A1/en
Priority claimed from US10/720,448 external-priority patent/US8273866B2/en
Priority claimed from US10/727,780 external-priority patent/US20050233329A1/en
Priority claimed from US10/757,803 external-priority patent/US20050020525A1/en
Priority claimed from US10/780,447 external-priority patent/US7491805B2/en
Priority claimed from US10/826,966 external-priority patent/US20050032733A1/en
Priority claimed from PCT/US2004/013456 external-priority patent/WO2005041859A2/fr
Priority claimed from PCT/US2004/016390 external-priority patent/WO2005019453A2/fr
Application filed by Sirna Therapeutics Inc, Nassim Usman, James Mcswiggen filed Critical Sirna Therapeutics Inc
Publication of WO2005007855A2 publication Critical patent/WO2005007855A2/fr
Publication of WO2005007855A3 publication Critical patent/WO2005007855A3/fr
Priority to US11/332,655 priority Critical patent/US20060276422A1/en

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01022—3-Oxo-5alpha-steroid 4-dehydrogenase (NADP+) (1.3.1.22), i.e. cortisone alpha-reductase
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    • C12Y604/01—Ligases forming carbon-carbon bonds (6.4.1)
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract

L'invention concerne des composés, des compositions et des procédés utiles dans la modulation de l'expression du gène B7-H1 (également connu en tant que PD-L1) au moyen de molécules d'acide nucléique à interférence courte (siNA). Cette invention concerne également des composés, des compositions, et des procédés utiles dans la modulation de l'expression et de l'activité d'autres gènes impliqués dans les voies de l'expression du gène B7-H1 et/ou de l'activité de celui-ci par interférence d'ARN (ARNi) au moyen de petites molécules d'acides nucléiques. Plus particulièrement, cette invention concerne de petites molécules d'acides nucléiques, telles que des molécules d'acides nucléiques à interférence courte (siNA), des molécules d'ARN à interférence courte (siARN), des molécules d'ARN à double brin (dsARN), des molécules de micro-ARN (miARN), et des molécules d'ARN à épingle à cheveux courte (shARN) ainsi que des procédés utilisés en vue de moduler l'expression des gènes B7-H1.
PCT/US2004/022658 2001-05-18 2004-07-14 Inhibition induite par interference d'arn de l'expression du gene b7-h1 au moyen d'acide nucleique a interference courte (sina) WO2005007855A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US11/332,655 US20060276422A1 (en) 2001-05-18 2006-01-13 RNA interference mediated inhibition of B7-H1 gene expression using short interfering nucleic acid (siNA)

Applications Claiming Priority (20)

Application Number Priority Date Filing Date Title
US48721403P 2003-07-14 2003-07-14
US60/487,214 2003-07-14
US10/693,059 2003-10-23
US10/693,059 US20080039414A1 (en) 2002-02-20 2003-10-23 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US10/720,448 US8273866B2 (en) 2002-02-20 2003-11-24 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SINA)
US10/720,448 2003-11-24
US10/727,780 US20050233329A1 (en) 2002-02-20 2003-12-03 Inhibition of gene expression using duplex forming oligonucleotides
US10/727,780 2003-12-03
US10/757,803 2004-01-14
US10/757,803 US20050020525A1 (en) 2002-02-20 2004-01-14 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
US54348004P 2004-02-10 2004-02-10
US60/543,480 2004-02-10
US10/780,447 2004-02-13
US10/780,447 US7491805B2 (en) 2001-05-18 2004-02-13 Conjugates and compositions for cellular delivery
US10/826,966 2004-04-16
US10/826,966 US20050032733A1 (en) 2001-05-18 2004-04-16 RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
USPCT/US04/13456 2004-04-30
PCT/US2004/013456 WO2005041859A2 (fr) 2003-04-30 2004-04-30 Conjugues et compositions
USPCT/US04/16390 2004-05-24
PCT/US2004/016390 WO2005019453A2 (fr) 2001-05-18 2004-05-24 Interference arn a mediation assuree par l'inhibition de genes au moyen de petit acide nucleique interferent (ansi) modifie chimiquement

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US11/332,655 Continuation-In-Part US20060276422A1 (en) 2001-05-18 2006-01-13 RNA interference mediated inhibition of B7-H1 gene expression using short interfering nucleic acid (siNA)

Publications (2)

Publication Number Publication Date
WO2005007855A2 WO2005007855A2 (fr) 2005-01-27
WO2005007855A3 true WO2005007855A3 (fr) 2005-03-24

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PCT/US2004/022658 WO2005007855A2 (fr) 2001-05-18 2004-07-14 Inhibition induite par interference d'arn de l'expression du gene b7-h1 au moyen d'acide nucleique a interference courte (sina)

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Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060276422A1 (en) * 2001-05-18 2006-12-07 Nassim Usman RNA interference mediated inhibition of B7-H1 gene expression using short interfering nucleic acid (siNA)
HUE039237T2 (hu) 2004-10-06 2018-12-28 Mayo Found Medical Education & Res B7-H1 és PD-1 vesesejt karcinoma kezelésében
JPWO2010101249A1 (ja) * 2009-03-06 2012-09-10 国立大学法人三重大学 Ｔ細胞の機能増強方法
AU2015268740B2 (en) * 2010-04-06 2017-08-03 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of cd274/pd-l1 gene
US8507663B2 (en) * 2010-04-06 2013-08-13 Alnylam Pharmaceuticals, Inc. Compositions and methods for inhibiting expression of CD274/PD-L1 gene
CN101887530B (zh) 2010-07-07 2013-11-06 中兴通讯股份有限公司 一种带电池数据卡的开关装置及其节电的实现方法
LT2929031T (lt) 2012-12-05 2018-02-12 Alnylam Pharmaceuticals, Inc. Pcsk9 irna kompozicijos ir jų naudojimo būdai
CA2996701C (fr) 2015-08-25 2024-05-28 Alnylam Pharmaceuticals, Inc. Procedes et compositions pour le traitement d'un trouble associe a un gene de proproteine convertase subtilisine kexine (pcsk9)
CN108368507B (zh) * 2015-09-02 2022-03-22 阿尔尼拉姆医药品有限公司 程序性细胞死亡1配体1(PD-L1)的iRNA组合物及其使用方法
WO2017100127A1 (fr) * 2015-12-06 2017-06-15 Boston Biomedical, Inc. Arn interférents asymétriques, ainsi que compositions, utilisation ou préparation associées
TWI794662B (zh) 2016-03-14 2023-03-01 瑞士商赫孚孟拉羅股份公司 用於降低pd-l1表現之寡核苷酸
US10988763B2 (en) 2016-06-22 2021-04-27 Proqr Therapeutics Ii B.V. Single-stranded RNA-editing oligonucleotides
US20180193270A1 (en) 2016-11-29 2018-07-12 PureTech Health LLC Exosomes for delivery of therapeutic agents
WO2018160887A1 (fr) * 2017-03-01 2018-09-07 Boston Biomedical, Inc. Compositions d'arn interférents asymétriques spécifiques de la bêta-caténine et spécifiques de pdl1, utilisations ou préparation associées
CN109576231B (zh) * 2017-09-28 2022-03-25 北京康万达医药科技有限公司 分离的重组溶瘤腺病毒、药物组合物及其在治疗肿瘤和/或癌症的药物中的用途
AU2020254929A1 (en) 2019-04-02 2021-11-11 Proqr Therapeutics Ii B.V. Antisense oligonucleotides for immunotherapy
WO2021173811A1 (fr) * 2020-02-28 2021-09-02 Aligos Therapeutics, Inc. Procédés et compositions pour le ciblage de pd-l1
WO2023233290A1 (fr) * 2022-05-31 2023-12-07 Janssen Sciences Ireland Unlimited Company Agents d'arni ciblant pd-l1

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WO2003104456A1 (fr) * 2002-06-10 2003-12-18 London Health Sciences Centre Research Inc. Immunomodulation a l'aide de cellules dendritiques alterees

Patent Citations (2)

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WO2002097114A2 (fr) * 2001-05-29 2002-12-05 Sirna Therapeutics, Inc. Traitement a l'acide nucleique de maladies ou d'affections associees aux taux de ras, her2 et hiv
WO2003104456A1 (fr) * 2002-06-10 2003-12-18 London Health Sciences Centre Research Inc. Immunomodulation a l'aide de cellules dendritiques alterees

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FREEMAN G ET AL: "ENGAGEMENT OF THE PD-1 IMMUNOINHIBITORY RECEPTOR BY A NOVEL B7 FAMILY MEMBER LEADS TO NEGATIVE REGULATION OF LYMPHOCYTE ACTIVATION", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 192, no. 7, 2 October 2000 (2000-10-02), pages 1027 - 1034, XP000971650, ISSN: 0022-1007 *
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SCHWARZ D S ET AL: "EVIDENCE THAT SIRNAS FUNCTION AS GUIDES, NOT PRIMERS, IN THE DROSOPHILA AND HUMAN RNAI PATHWAYS", MOLECULAR CELL, vol. 10, no. 3, September 2002 (2002-09-01), pages 537 - 548, XP009019083, ISSN: 1097-2765 *

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