CA2540986A1 - Utilisation therapeutique du facteur xi - Google Patents
Utilisation therapeutique du facteur xi Download PDFInfo
- Publication number
- CA2540986A1 CA2540986A1 CA002540986A CA2540986A CA2540986A1 CA 2540986 A1 CA2540986 A1 CA 2540986A1 CA 002540986 A CA002540986 A CA 002540986A CA 2540986 A CA2540986 A CA 2540986A CA 2540986 A1 CA2540986 A1 CA 2540986A1
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- Prior art keywords
- fxi
- polypeptide
- patient
- factor
- buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 229910000406 trisodium phosphate Inorganic materials 0.000 description 1
- 235000019801 trisodium phosphate Nutrition 0.000 description 1
- 230000001810 trypsinlike Effects 0.000 description 1
- RUDATBOHQWOJDD-UZVSRGJWSA-N ursodeoxycholic acid Chemical compound C([C@H]1C[C@@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-UZVSRGJWSA-N 0.000 description 1
- 229960001661 ursodiol Drugs 0.000 description 1
- 239000006213 vaginal ring Substances 0.000 description 1
- 239000004474 valine Substances 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 235000008979 vitamin B4 Nutrition 0.000 description 1
- 229940019333 vitamin k antagonists Drugs 0.000 description 1
- 208000012137 von Willebrand disease (hereditary or acquired) Diseases 0.000 description 1
- 229960005080 warfarin Drugs 0.000 description 1
- PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
- 210000005253 yeast cell Anatomy 0.000 description 1
- 239000002888 zwitterionic surfactant Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21027—Coagulation factor XIa (3.4.21.27)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DKPA200301721 | 2003-11-20 | ||
DKPA200301721 | 2003-11-20 | ||
DKPA200401141 | 2004-07-23 | ||
DKPA200401141 | 2004-07-23 | ||
PCT/DK2004/000810 WO2005049070A1 (fr) | 2003-11-20 | 2004-11-22 | Utilisation therapeutique du facteur xi |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2540986A1 true CA2540986A1 (fr) | 2005-06-02 |
Family
ID=34621448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002540986A Abandoned CA2540986A1 (fr) | 2003-11-20 | 2004-11-22 | Utilisation therapeutique du facteur xi |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1687020A1 (fr) |
JP (1) | JP2007513881A (fr) |
KR (1) | KR20060118486A (fr) |
AU (1) | AU2004290869A1 (fr) |
BR (1) | BRPI0416461A (fr) |
CA (1) | CA2540986A1 (fr) |
RU (1) | RU2006115783A (fr) |
TW (1) | TW200529870A (fr) |
WO (1) | WO2005049070A1 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2006008266A2 (fr) * | 2004-07-23 | 2006-01-26 | Novo Nordisk Health Care Ag | Proteines de liaison au facteur xi |
WO2006128497A1 (fr) * | 2005-06-01 | 2006-12-07 | Novo Nordisk A/S | Formule pharmaceutique de facteur xi |
US8450275B2 (en) | 2010-03-19 | 2013-05-28 | Baxter International Inc. | TFPI inhibitors and methods of use |
DK2379096T3 (da) | 2008-12-19 | 2019-11-25 | Baxalta GmbH | TFPI-inhibitorer og fremgangsmåder til anvendelse |
EP2305289A1 (fr) * | 2009-09-16 | 2011-04-06 | Bio-Products & Bio-Engineering Aktiengesellschaft | Produits médicinaux pour le traitement de troubles de la coagulation sanguine |
HUE046572T2 (hu) | 2012-03-21 | 2020-03-30 | Baxalta GmbH | TFPI inhibitorok és alkalmazási eljárások |
DE102012022234A1 (de) | 2012-11-14 | 2014-05-15 | Instraction Gmbh | Einstufiges Verfahren zur Reinigung von (Blut)Plasmaproteinen wie Albumin aus Gemischen |
DE102012022233A1 (de) | 2012-11-14 | 2014-05-15 | Instraction Gmbh | Verfahren zur Reinigung eines (Blut)plasmaproteins |
EP3953361A1 (fr) | 2020-04-05 | 2022-02-16 | Pfizer Inc. | Composés et méthodes destinés au traitement de la covid-19 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2676231A1 (fr) * | 1991-05-07 | 1992-11-13 | Aetsrn | Concentre de facteur xi de la coagulation sanguine a haute activite specifique, approprie a usage therapeutique et son procede de preparation. |
ATE348161T1 (de) * | 2000-03-03 | 2007-01-15 | Curagen Corp | Fctrx genannte proteine und dafür kodierende nuklein säure |
JP2004534855A (ja) * | 2001-07-20 | 2004-11-18 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第vii因子ポリペプチドおよび第xi因子ポリペプチドを含んでなる医薬組成物 |
-
2004
- 2004-11-22 TW TW093135827A patent/TW200529870A/zh unknown
- 2004-11-22 EP EP04797471A patent/EP1687020A1/fr not_active Withdrawn
- 2004-11-22 CA CA002540986A patent/CA2540986A1/fr not_active Abandoned
- 2004-11-22 BR BRPI0416461-0A patent/BRPI0416461A/pt not_active IP Right Cessation
- 2004-11-22 AU AU2004290869A patent/AU2004290869A1/en not_active Abandoned
- 2004-11-22 RU RU2006115783/14A patent/RU2006115783A/ru not_active Application Discontinuation
- 2004-11-22 JP JP2006540175A patent/JP2007513881A/ja not_active Withdrawn
- 2004-11-22 KR KR1020067009406A patent/KR20060118486A/ko not_active Application Discontinuation
- 2004-11-22 WO PCT/DK2004/000810 patent/WO2005049070A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
EP1687020A1 (fr) | 2006-08-09 |
BRPI0416461A (pt) | 2007-03-06 |
WO2005049070A1 (fr) | 2005-06-02 |
JP2007513881A (ja) | 2007-05-31 |
KR20060118486A (ko) | 2006-11-23 |
AU2004290869A1 (en) | 2005-06-02 |
RU2006115783A (ru) | 2007-12-27 |
TW200529870A (en) | 2005-09-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued |