CA2540986A1 - Utilisation therapeutique du facteur xi - Google Patents

Utilisation therapeutique du facteur xi Download PDF

Info

Publication number
CA2540986A1
CA2540986A1 CA002540986A CA2540986A CA2540986A1 CA 2540986 A1 CA2540986 A1 CA 2540986A1 CA 002540986 A CA002540986 A CA 002540986A CA 2540986 A CA2540986 A CA 2540986A CA 2540986 A1 CA2540986 A1 CA 2540986A1
Authority
CA
Canada
Prior art keywords
fxi
polypeptide
patient
factor
buffer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002540986A
Other languages
English (en)
Inventor
Rasmus Roejkjaer
Dorthe Viuff
Soeren Oestergaard
Simon Bjerregaard Jensen
Jens Jacob Hansen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk Health Care AG
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2540986A1 publication Critical patent/CA2540986A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • A61K38/48Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482Serine endopeptidases (3.4.21)
    • A61K38/4846Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12YENZYMES
    • C12Y304/00Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21Serine endopeptidases (3.4.21)
    • C12Y304/21027Coagulation factor XIa (3.4.21.27)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CA002540986A 2003-11-20 2004-11-22 Utilisation therapeutique du facteur xi Abandoned CA2540986A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200301721 2003-11-20
DKPA200301721 2003-11-20
DKPA200401141 2004-07-23
DKPA200401141 2004-07-23
PCT/DK2004/000810 WO2005049070A1 (fr) 2003-11-20 2004-11-22 Utilisation therapeutique du facteur xi

Publications (1)

Publication Number Publication Date
CA2540986A1 true CA2540986A1 (fr) 2005-06-02

Family

ID=34621448

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002540986A Abandoned CA2540986A1 (fr) 2003-11-20 2004-11-22 Utilisation therapeutique du facteur xi

Country Status (9)

Country Link
EP (1) EP1687020A1 (fr)
JP (1) JP2007513881A (fr)
KR (1) KR20060118486A (fr)
AU (1) AU2004290869A1 (fr)
BR (1) BRPI0416461A (fr)
CA (1) CA2540986A1 (fr)
RU (1) RU2006115783A (fr)
TW (1) TW200529870A (fr)
WO (1) WO2005049070A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006008266A2 (fr) * 2004-07-23 2006-01-26 Novo Nordisk Health Care Ag Proteines de liaison au facteur xi
WO2006128497A1 (fr) * 2005-06-01 2006-12-07 Novo Nordisk A/S Formule pharmaceutique de facteur xi
US8450275B2 (en) 2010-03-19 2013-05-28 Baxter International Inc. TFPI inhibitors and methods of use
DK2379096T3 (da) 2008-12-19 2019-11-25 Baxalta GmbH TFPI-inhibitorer og fremgangsmåder til anvendelse
EP2305289A1 (fr) * 2009-09-16 2011-04-06 Bio-Products & Bio-Engineering Aktiengesellschaft Produits médicinaux pour le traitement de troubles de la coagulation sanguine
HUE046572T2 (hu) 2012-03-21 2020-03-30 Baxalta GmbH TFPI inhibitorok és alkalmazási eljárások
DE102012022234A1 (de) 2012-11-14 2014-05-15 Instraction Gmbh Einstufiges Verfahren zur Reinigung von (Blut)Plasmaproteinen wie Albumin aus Gemischen
DE102012022233A1 (de) 2012-11-14 2014-05-15 Instraction Gmbh Verfahren zur Reinigung eines (Blut)plasmaproteins
EP3953361A1 (fr) 2020-04-05 2022-02-16 Pfizer Inc. Composés et méthodes destinés au traitement de la covid-19

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2676231A1 (fr) * 1991-05-07 1992-11-13 Aetsrn Concentre de facteur xi de la coagulation sanguine a haute activite specifique, approprie a usage therapeutique et son procede de preparation.
ATE348161T1 (de) * 2000-03-03 2007-01-15 Curagen Corp Fctrx genannte proteine und dafür kodierende nuklein säure
JP2004534855A (ja) * 2001-07-20 2004-11-18 ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト 第vii因子ポリペプチドおよび第xi因子ポリペプチドを含んでなる医薬組成物

Also Published As

Publication number Publication date
EP1687020A1 (fr) 2006-08-09
BRPI0416461A (pt) 2007-03-06
WO2005049070A1 (fr) 2005-06-02
JP2007513881A (ja) 2007-05-31
KR20060118486A (ko) 2006-11-23
AU2004290869A1 (en) 2005-06-02
RU2006115783A (ru) 2007-12-27
TW200529870A (en) 2005-09-16

Similar Documents

Publication Publication Date Title
US20050181978A1 (en) Therapeutic use of factor XI
JP5037331B2 (ja) 出血性障害の処置のための第ixa因子
JP6029826B2 (ja) 補因子の非存在下において凝固活性を有する第ix因子変異体および出血性疾患の処置のためのその使用
WO2006128497A1 (fr) Formule pharmaceutique de facteur xi
JP2011517951A (ja) 修飾された第ix因子ポリペプチドおよびそれらの使用
US8697844B2 (en) Method of purifying pegylated proteins
US8383776B2 (en) Purification of factor XIII polypeptides from biological materials
JP7273918B2 (ja) 第xa因子誘導体の調製
EP1651252B1 (fr) Variants de proteine c activee avec activite cytoprotectrice normale mais avec activite anticoagulante reduite
ES2481420T3 (es) Variantes de proteína C activada con actividad citoprotectora pero con actividad anticoagulante reducida
CA2540986A1 (fr) Utilisation therapeutique du facteur xi
AU2008341008A1 (en) Haemostasis- modulating compositions and uses therefor
JP5236952B2 (ja) 改善された特性を有するfxiiiバリアント
EP2948168B1 (fr) Inhibition d'inhibiteur de la voie du facteur tissulaire a l'aide de derives de facteur xa
JP2016536368A (ja) 第Xa因子の半減期を延ばす組成物および方法
MXPA06005477A (en) Therapeutic use of factor xi
KR20110017359A (ko) 폴리펩티드 변형 반응의 제어 방법
Wu Characterization of TAFI activation by the thrombin-thrombomodulin complex
KR20180089439A (ko) 재조합 세린 프로테아제
WO2009123573A1 (fr) Anticoagulants dérivés de venin de serpent naja nigricollis

Legal Events

Date Code Title Description
FZDE Discontinued