CA2537837A1

CA2537837A1 - Treating and/or preventing urinary incontinence using prodrugs of gaba analogs

Treating and/or preventing urinary incontinence using prodrugs of gaba analogs Download PDF

Info

Publication number: CA2537837A1
Authority: CA; Canada
Prior art keywords: substituted; butyl; cycloalkyl; prodrug; alkyl
Prior art date: 2003-09-11
Legal status : Abandoned

Application number

CA002537837A

Other languages

English (en)

French (fr)

Inventor

Ronald W. Barrett

Current Assignee

XenoPort Inc

Original Assignee

Individual

Priority date

2003-09-11

Filing date

2004-09-13

Publication date

2005-03-24

2004-09-13 Application filed by Individual filed Critical Individual

2005-03-24 Publication of CA2537837A1 publication Critical patent/CA2537837A1/en

Status Abandoned legal-status Critical Current

Links

229940002612 prodrug Drugs 0.000 title claims abstract description 134
239000000651 prodrug Substances 0.000 title claims abstract description 134
206010046543 Urinary incontinence Diseases 0.000 title claims abstract description 60
BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical class NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims abstract description 83
238000000034 method Methods 0.000 claims abstract description 79
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 30
-1 4-imidazolylmethyl Chemical group 0.000 claims description 736
229910052739 hydrogen Inorganic materials 0.000 claims description 105
239000001257 hydrogen Substances 0.000 claims description 105
UGJMXCAKCUNAIE-UHFFFAOYSA-N Gabapentin Chemical compound OC(=O)CC1(CN)CCCCC1 UGJMXCAKCUNAIE-UHFFFAOYSA-N 0.000 claims description 103
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 101
125000001072 heteroaryl group Chemical group 0.000 claims description 100
125000003710 aryl alkyl group Chemical group 0.000 claims description 94
125000000753 cycloalkyl group Chemical group 0.000 claims description 83
125000000217 alkyl group Chemical group 0.000 claims description 75
125000003118 aryl group Chemical group 0.000 claims description 73
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 67
125000000547 substituted alkyl group Chemical group 0.000 claims description 58
239000003814 drug Substances 0.000 claims description 57
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 56
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 56
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125000004453 alkoxycarbonyl group Chemical group 0.000 claims description 55
125000002252 acyl group Chemical group 0.000 claims description 54
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239000002552 dosage form Substances 0.000 claims description 52
229940079593 drug Drugs 0.000 claims description 52
125000004446 heteroarylalkyl group Chemical group 0.000 claims description 52
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 52
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229960002870 gabapentin Drugs 0.000 claims description 51
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 49
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125000004429 atom Chemical group 0.000 claims description 17
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