CA2523291A1 - Tricyclic indole derivatives and their use in the treatment of alzheimer`s disease - Google Patents

Info

Publication number

CA2523291A1

CA2523291A1 CA002523291A CA2523291A CA2523291A1 CA 2523291 A1 CA2523291 A1 CA 2523291A1 CA 002523291 A CA002523291 A CA 002523291A CA 2523291 A CA2523291 A CA 2523291A CA 2523291 A1 CA2523291 A1 CA 2523291A1

Authority

CA

Canada

Prior art keywords

methyl

ethyl

indole

propyl

hydroxy

Prior art date

2003-04-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Abandoned

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract description 23
• 201000010099 disease Diseases 0.000 title claims abstract description 21
• 238000011282 treatment Methods 0.000 title claims abstract description 21
• 229940054051 antipsychotic indole derivative Drugs 0.000 title description 2
• 150000002475 indoles Chemical class 0.000 title 1
• 208000037259 Amyloid Plaque Diseases 0.000 claims abstract description 21
• 208000024827 Alzheimer disease Diseases 0.000 claims abstract description 14
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 132
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 120
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 120
• -1 cyano, hydroxy, carboxy Chemical group 0.000 claims description 116
• 125000000217 alkyl group Chemical group 0.000 claims description 85
• 150000001875 compounds Chemical class 0.000 claims description 84
• 150000003839 salts Chemical class 0.000 claims description 36
• 229910052739 hydrogen Inorganic materials 0.000 claims description 35
• 239000001257 hydrogen Substances 0.000 claims description 34
• 125000000753 cycloalkyl group Chemical group 0.000 claims description 23
• 229910052757 nitrogen Inorganic materials 0.000 claims description 23
• 125000003118 aryl group Chemical group 0.000 claims description 22
• 125000003545 alkoxy group Chemical group 0.000 claims description 19
• 229910052736 halogen Inorganic materials 0.000 claims description 17
• 150000002367 halogens Chemical class 0.000 claims description 17
• 239000012453 solvate Substances 0.000 claims description 17
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 16
• 125000000623 heterocyclic group Chemical group 0.000 claims description 15
• 125000002877 alkyl aryl group Chemical group 0.000 claims description 13
• 125000001072 heteroaryl group Chemical group 0.000 claims description 12
• 125000005843 halogen group Chemical group 0.000 claims description 11
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 11
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 10
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 10
• 229910052701 rubidium Inorganic materials 0.000 claims description 10
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 9
• 125000005213 alkyl heteroaryl group Chemical group 0.000 claims description 9
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 9
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 9
• 125000000304 alkynyl group Chemical group 0.000 claims description 8
• 239000003814 drug Substances 0.000 claims description 8
• 229910052799 carbon Inorganic materials 0.000 claims description 7
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 7
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
• 125000003342 alkenyl group Chemical group 0.000 claims description 6
• 150000001721 carbon Chemical group 0.000 claims description 6
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 6
• 239000008194 pharmaceutical composition Substances 0.000 claims description 6
• 125000004367 cycloalkylaryl group Chemical group 0.000 claims description 5
• 238000004519 manufacturing process Methods 0.000 claims description 5
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 5
• 125000001589 carboacyl group Chemical group 0.000 claims description 4
• 125000004433 nitrogen atom Chemical group N* 0.000 claims description 4
• 125000000392 cycloalkenyl group Chemical group 0.000 claims description 3
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 3
• 238000011321 prophylaxis Methods 0.000 claims description 3
• 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims description 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 2
• 239000000969 carrier Substances 0.000 claims description 2
• 239000003085 diluting agent Substances 0.000 claims description 2
• 125000000040 m-tolyl group Chemical group [H]C1=C([H])C(*)=C([H])C(=C1[H])C([H])([H])[H] 0.000 claims description 2
• 125000004043 oxo group Chemical group O=* 0.000 claims description 2
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 21
• 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims 5
• 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 1
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 1
• 125000006274 (C1-C3)alkoxy group Chemical group 0.000 claims 1
• 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
• 125000006656 (C2-C4) alkenyl group Chemical group 0.000 claims 1
• VKSBUPOUUDVIJI-LMSSTIIKSA-N 2-[3-ethyl-6-[[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]carbamoyl]-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraen-9-yl]acetic acid Chemical compound C([C@H](NC(=O)C=1C=C2N(CC(O)=O)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 VKSBUPOUUDVIJI-LMSSTIIKSA-N 0.000 claims 1
• FFOYVHXUAYQKKC-UKILVPOCSA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-(propan-2-ylamino)butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC(C)C)C1=CC=CC=C1 FFOYVHXUAYQKKC-UKILVPOCSA-N 0.000 claims 1
• KZSWFBYGEHXBKH-XTEPFMGCSA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-(pyridin-2-ylmethylamino)butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1N=CC=CC=1)C1=CC=CC=C1 KZSWFBYGEHXBKH-XTEPFMGCSA-N 0.000 claims 1
• RFDDXKUWIRIUMP-XTEPFMGCSA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-(pyridin-4-ylmethylamino)butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=CN=CC=1)C1=CC=CC=C1 RFDDXKUWIRIUMP-XTEPFMGCSA-N 0.000 claims 1
• FYFXGPATXSURAK-XDFJSJKPSA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-(quinolin-3-ylmethylamino)butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=C2C=CC=CC2=NC=1)C1=CC=CC=C1 FYFXGPATXSURAK-XDFJSJKPSA-N 0.000 claims 1
• OJCGTUUAJINADL-CQTOTRCISA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[(6-pyridin-2-ylpyridin-2-yl)methylamino]butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1N=C(C=CC=1)C=1N=CC=CC=1)C1=CC=CC=C1 OJCGTUUAJINADL-CQTOTRCISA-N 0.000 claims 1
• JENWYAOLLKXDLO-MFMCTBQISA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[2-[3-(trifluoromethyl)phenyl]propan-2-ylamino]butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC(C)(C)C=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 JENWYAOLLKXDLO-MFMCTBQISA-N 0.000 claims 1
• IFVAVALDLOSTLO-AHKZPQOWSA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[1-(2,2,2-trifluoroethyl)pyrazol-4-yl]methylamino]butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC1=CN(CC(F)(F)F)N=C1)C1=CC=CC=C1 IFVAVALDLOSTLO-AHKZPQOWSA-N 0.000 claims 1
• ZTJGSTVSUDFSMO-LMSSTIIKSA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethoxy)phenyl]methylamino]butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=C(OC(F)(F)F)C=CC=1)C1=CC=CC=C1 ZTJGSTVSUDFSMO-LMSSTIIKSA-N 0.000 claims 1
• RYDQNNZIERLVEQ-BBVCVYGMSA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-9,11-dimethyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)C(C)N3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 RYDQNNZIERLVEQ-BBVCVYGMSA-N 0.000 claims 1
• FDBMWJPRLCCERS-XTEPFMGCSA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 FDBMWJPRLCCERS-XTEPFMGCSA-N 0.000 claims 1
• LUOVVGBKHGGZOU-LMSSTIIKSA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-4-[(3-methoxyphenyl)methylamino]-1-phenylbutan-2-yl]-10-oxo-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2NC(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=C(OC)C=CC=1)C1=CC=CC=C1 LUOVVGBKHGGZOU-LMSSTIIKSA-N 0.000 claims 1
• DHMUWFLOJWNFRP-XTEPFMGCSA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-4-[(5-methylpyrazin-2-yl)methylamino]-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1N=CC(C)=NC=1)C1=CC=CC=C1 DHMUWFLOJWNFRP-XTEPFMGCSA-N 0.000 claims 1
• FABRCIKGOOMRBB-LMSSTIIKSA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-4-[(6-methylpyridin-2-yl)methylamino]-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1N=C(C)C=CC=1)C1=CC=CC=C1 FABRCIKGOOMRBB-LMSSTIIKSA-N 0.000 claims 1
• OQEVWBUOQBCUIZ-LMSSTIIKSA-N 3-ethyl-N-[(2S,3R)-3-hydroxy-4-[[5-(methylcarbamoyl)pyridin-3-yl]methylamino]-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=C(C=NC=1)C(=O)NC)C1=CC=CC=C1 OQEVWBUOQBCUIZ-LMSSTIIKSA-N 0.000 claims 1
• SNTCTRGDVFKQPC-AHKZPQOWSA-N 3-ethyl-N-[(2S,3R)-4-[(1-ethylpyrazol-4-yl)methylamino]-3-hydroxy-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC1=CN(CC)N=C1)C1=CC=CC=C1 SNTCTRGDVFKQPC-AHKZPQOWSA-N 0.000 claims 1
• KZBAKEHPWOCZMR-XTEPFMGCSA-N 3-ethyl-N-[(2S,3R)-4-[(1-ethylpyrazol-4-yl)methylamino]-3-hydroxy-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC1=CN(CC)N=C1)C1=CC=CC=C1 KZBAKEHPWOCZMR-XTEPFMGCSA-N 0.000 claims 1
• WLNRSNILOZRUHQ-XTEPFMGCSA-N 3-ethyl-N-[(2S,3R)-4-[(3-ethyl-1,2-oxazol-5-yl)methylamino]-3-hydroxy-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound O1N=C(CC)C=C1CNC[C@@H](O)[C@@H](NC(=O)C=1C=C2C(CC)=CN3CCS(=O)(=O)N(C)C(=C23)C=1)CC1=CC=CC=C1 WLNRSNILOZRUHQ-XTEPFMGCSA-N 0.000 claims 1
• BIFXFADRRVXKMW-LMSSTIIKSA-N 6,6,5 tricyclic sulfonamide, 21 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=C(OC)C=CC=1)C1=CC=CC=C1 BIFXFADRRVXKMW-LMSSTIIKSA-N 0.000 claims 1
• GPAVTBALSLYNRZ-LMSSTIIKSA-N 6,6,5 tricyclic sulfonamide, 23 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNC(C)(C)CCCC(C)C)C1=CC=CC=C1 GPAVTBALSLYNRZ-LMSSTIIKSA-N 0.000 claims 1
• JFEIECKPYMIBAC-AHKZPQOWSA-N 6,6,5 tricyclic sulfonamide, 25 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CCCCC1)C1=CC=CC=C1 JFEIECKPYMIBAC-AHKZPQOWSA-N 0.000 claims 1
• POGMNGBOVVGHGD-RBBKRZOGSA-N 6,6,5 tricyclic sulfonamide, 27 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNC)C1=CC=CC=C1 POGMNGBOVVGHGD-RBBKRZOGSA-N 0.000 claims 1
• FBCAWJXDTWUBGJ-AHKZPQOWSA-N 7,6,5 tricyclic sulfonamide, 13 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CCOCC1)C1=CC=CC=C1 FBCAWJXDTWUBGJ-AHKZPQOWSA-N 0.000 claims 1
• VHIKANGIVZQCPI-XTEPFMGCSA-N 7,6,5 tricyclic sulfonamide, 35 Chemical compound C([C@H](NC(=O)C=1C=C2N(S(CCN3C=C(CC)C(=C23)C=1)(=O)=O)CC)[C@H](O)CNC1CCOCC1)C1=CC=CC=C1 VHIKANGIVZQCPI-XTEPFMGCSA-N 0.000 claims 1
• GLEZETRPRUIAGJ-AHKZPQOWSA-N 7,6,5 tricyclic sulfonamide, 37 Chemical compound C([C@H](NC(=O)C=1C=C2N(CC(F)(F)F)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CCOCC1)C1=CC=CC=C1 GLEZETRPRUIAGJ-AHKZPQOWSA-N 0.000 claims 1
• XBSGWVTXAJRWKB-LMSSTIIKSA-N 7,6,5 tricyclic sulfonamide, 38 Chemical compound C([C@H](NC(=O)C=1C=C2N(S(CCN3C=C(CC)C(=C23)C=1)(=O)=O)CC)[C@H](O)CNC1CCCCC1)C1=CC=CC=C1 XBSGWVTXAJRWKB-LMSSTIIKSA-N 0.000 claims 1
• IBCUBWFCCFTHOX-IGYGKHONSA-N 9-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-[[3-(trifluoromethyl)phenyl]methylamino]butan-2-yl]-10,10-dioxo-3-propyl-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(CC)S(=O)(=O)CCN3C=C(C(C=1)=C32)CCC)[C@H](O)CNCC=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 IBCUBWFCCFTHOX-IGYGKHONSA-N 0.000 claims 1
• FYACSYJEEVPJRT-AHKZPQOWSA-N C([C@H](NC(=O)C1=CC2=C3N(C(S(=O)(=O)N2C)(C)C)C=C(C3=C1)CC)[C@H](O)CNC1CCOCC1)C1=CC=CC=C1 Chemical compound C([C@H](NC(=O)C1=CC2=C3N(C(S(=O)(=O)N2C)(C)C)C=C(C3=C1)CC)[C@H](O)CNC1CCOCC1)C1=CC=CC=C1 FYACSYJEEVPJRT-AHKZPQOWSA-N 0.000 claims 1
• AFMRBRUYHBVKCH-JFVQPPLISA-N C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)C(C)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNC(C)(C)CCCC(C)C)C1=CC=CC=C1 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)C(C)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNC(C)(C)CCCC(C)C)C1=CC=CC=C1 AFMRBRUYHBVKCH-JFVQPPLISA-N 0.000 claims 1
• NVTKGNKFONWMJJ-PJGYDLQESA-N C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)C(C)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC1=CN(CC)N=C1)C1=CC=CC=C1 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)C(C)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC1=CN(CC)N=C1)C1=CC=CC=C1 NVTKGNKFONWMJJ-PJGYDLQESA-N 0.000 claims 1
• ICJKHVNKPKGIFE-RPPQISJBSA-N C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)C(C)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)C(C)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 ICJKHVNKPKGIFE-RPPQISJBSA-N 0.000 claims 1
• OENNVAYYRUALCN-JTHBVZDNSA-N C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC)C1=CC=CC(Cl)=C1 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC)C1=CC=CC(Cl)=C1 OENNVAYYRUALCN-JTHBVZDNSA-N 0.000 claims 1
• DTLMIJUEOADSOV-JTHBVZDNSA-N C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC)C1=CC=CC(F)=C1 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC)C1=CC=CC(F)=C1 DTLMIJUEOADSOV-JTHBVZDNSA-N 0.000 claims 1
• POXZPNDRDGMUOM-JTHBVZDNSA-N C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC(F)(F)C(F)(F)F)C1=CC=CC=C1 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC(F)(F)C(F)(F)F)C1=CC=CC=C1 POXZPNDRDGMUOM-JTHBVZDNSA-N 0.000 claims 1
• NPLLWQSCEDKDLI-XTEPFMGCSA-N C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=NC=CC=1)C1=CC=CC=C1 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=NC=CC=1)C1=CC=CC=C1 NPLLWQSCEDKDLI-XTEPFMGCSA-N 0.000 claims 1
• WJPFSIOHUCRTFZ-MFMCTBQISA-N C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCCC=1C=CC=CC=1)C1=CC=CC=C1 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCCC=1C=CC=CC=1)C1=CC=CC=C1 WJPFSIOHUCRTFZ-MFMCTBQISA-N 0.000 claims 1
• XMCMDMBYAJTCKE-MFMCTBQISA-N C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CCC)[C@H](O)CNCC=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CCC)[C@H](O)CNCC=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 XMCMDMBYAJTCKE-MFMCTBQISA-N 0.000 claims 1
• RUAWEOGDECXJLX-LMSSTIIKSA-N C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNC(C)(C)C=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNC(C)(C)C=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 RUAWEOGDECXJLX-LMSSTIIKSA-N 0.000 claims 1
• MMHWDMAMGWVXDB-MFMCTBQISA-N C([C@H](NC(=O)C=1C=C2N(CC)S(=O)(=O)CCN3C=C(C(C=1)=C32)CCC)[C@H](O)CNCC1=CN(CC)N=C1)C1=CC=CC=C1 Chemical compound C([C@H](NC(=O)C=1C=C2N(CC)S(=O)(=O)CCN3C=C(C(C=1)=C32)CCC)[C@H](O)CNCC1=CN(CC)N=C1)C1=CC=CC=C1 MMHWDMAMGWVXDB-MFMCTBQISA-N 0.000 claims 1
• GSDXFBHPGSKZOB-AZGAKELHSA-N C([C@H](NC(=O)C=1C=C2NS(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CCCCC1)C1=CC=CC=C1 Chemical compound C([C@H](NC(=O)C=1C=C2NS(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CCCCC1)C1=CC=CC=C1 GSDXFBHPGSKZOB-AZGAKELHSA-N 0.000 claims 1
• XEIKHRYVIXSAFH-AHKZPQOWSA-N C([C@H](NC(=O)C=1C=C2NS(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 Chemical compound C([C@H](NC(=O)C=1C=C2NS(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=C(C=CC=1)C(F)(F)F)C1=CC=CC=C1 XEIKHRYVIXSAFH-AHKZPQOWSA-N 0.000 claims 1
• VKFYMKFLRVMTFI-QWOOXDRHSA-N C=12C3=CC(C(=O)N[C@@H](CC=4C=CC=CC=4)[C@H](O)CNCC=4C=C(C=CC=4)C(F)(F)F)=CC=1C(CC)=CN2CCS(=O)(=O)N3CC1=CC=CC=C1 Chemical compound C=12C3=CC(C(=O)N[C@@H](CC=4C=CC=CC=4)[C@H](O)CNCC=4C=C(C=CC=4)C(F)(F)F)=CC=1C(CC)=CN2CCS(=O)(=O)N3CC1=CC=CC=C1 VKFYMKFLRVMTFI-QWOOXDRHSA-N 0.000 claims 1
• PVWVCMPJBNIWQR-LADGPHEKSA-N N-[(2S,3R)-3-hydroxy-4-(methylamino)-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-3-propan-2-yl-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@@H]([C@H](O)CNC)NC(=O)C=1C=C2C(C(C)C)=CN3CCS(=O)(=O)N(C)C(=C23)C=1)C1=CC=CC=C1 PVWVCMPJBNIWQR-LADGPHEKSA-N 0.000 claims 1
• VQGIUFBXTIRESV-JTHBVZDNSA-N N-[(2S,3R)-4-(2,2-difluoroethylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC(F)F)C1=CC=CC=C1 VQGIUFBXTIRESV-JTHBVZDNSA-N 0.000 claims 1
• MPOMBANESLHDMN-XTEPFMGCSA-N N-[(2S,3R)-4-(2,6-dimethylheptan-2-ylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.3.1.04,12]dodeca-2,4(12),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2NS(=O)(=O)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNC(C)(C)CCCC(C)C)C1=CC=CC=C1 MPOMBANESLHDMN-XTEPFMGCSA-N 0.000 claims 1
• WRTLNZBVFGEMLY-PJGYDLQESA-N N-[(2S,3R)-4-(cyclohexylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9,11-dimethyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)C(C)CN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CCCCC1)C1=CC=CC=C1 WRTLNZBVFGEMLY-PJGYDLQESA-N 0.000 claims 1
• YGOIWTREGTVYTR-AZGAKELHSA-N N-[(2S,3R)-4-(cyclopropylamino)-3-hydroxy-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-3-propan-2-yl-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)C(C)C)[C@H](O)CNC1CC1)C1=CC=CC=C1 YGOIWTREGTVYTR-AZGAKELHSA-N 0.000 claims 1
• HIWZMBDQVFYGJB-AZGAKELHSA-N N-[(2S,3R)-4-(cyclopropylmethylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC1CC1)C1=CC=CC=C1 HIWZMBDQVFYGJB-AZGAKELHSA-N 0.000 claims 1
• OLVSPYCHSTVYNW-UKILVPOCSA-N N-[(2S,3R)-4-(tert-butylamino)-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC(C)(C)C)C1=CC=CC=C1 OLVSPYCHSTVYNW-UKILVPOCSA-N 0.000 claims 1
• GNFSOMXOFNJZEI-LMSSTIIKSA-N N-[(2S,3R)-4-[(1-ethylpyrazol-4-yl)methylamino]-3-hydroxy-1-phenylbutan-2-yl]-9-methyl-10,10-dioxo-3-propyl-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CCC)[C@H](O)CNCC1=CN(CC)N=C1)C1=CC=CC=C1 GNFSOMXOFNJZEI-LMSSTIIKSA-N 0.000 claims 1
• HJEWSMVXXWSQCI-MAVRLOSYSA-N N-[(2S,3R)-4-[(2,2-dimethyloxan-4-yl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CC(C)(C)OCC1)C1=CC=CC=C1 HJEWSMVXXWSQCI-MAVRLOSYSA-N 0.000 claims 1
• YYIXBJZRVWQLNP-AHKZPQOWSA-N N-[(2S,3R)-4-[(4,4-difluorocyclohexyl)amino]-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CCC(F)(F)CC1)C1=CC=CC=C1 YYIXBJZRVWQLNP-AHKZPQOWSA-N 0.000 claims 1
• PAUPCFXIFYNJAX-AHKZPQOWSA-N N-[(2S,3R)-4-[(6-bromopyridin-2-yl)methylamino]-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1N=C(Br)C=CC=1)C1=CC=CC=C1 PAUPCFXIFYNJAX-AHKZPQOWSA-N 0.000 claims 1
• GNIGRHRGKQELKC-PKIMSIDOSA-N N-[(2S,3R)-4-[[(2S)-1-(cyclohexylamino)-1-oxopropan-2-yl]amino]-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CN[C@@H](C)C(=O)NC1CCCCC1)C1=CC=CC=C1 GNIGRHRGKQELKC-PKIMSIDOSA-N 0.000 claims 1
• JZIBSPMHTXOUJJ-RBBKRZOGSA-N N-[(2S,3R)-4-amino-3-hydroxy-1-phenylbutan-2-yl]-3-ethyl-9-methyl-10,10-dioxo-10lambda6-thia-1,9-diazatricyclo[6.4.1.04,13]trideca-2,4(13),5,7-tetraene-6-carboxamide Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CN)C1=CC=CC=C1 JZIBSPMHTXOUJJ-RBBKRZOGSA-N 0.000 claims 1
• STVPNNWNBWFITL-UKILVPOCSA-N chembl523193 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CC1)C1=CC=CC=C1 STVPNNWNBWFITL-UKILVPOCSA-N 0.000 claims 1
• GPNXPYCGPMEGKY-XTEPFMGCSA-N chembl528010 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CCCCC1)C1=CC(F)=CC(F)=C1 GPNXPYCGPMEGKY-XTEPFMGCSA-N 0.000 claims 1
• MZFWJFYQYIPXQF-LMSSTIIKSA-N chembl533686 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=CC=CC=1)C1=CC=CC=C1 MZFWJFYQYIPXQF-LMSSTIIKSA-N 0.000 claims 1
• PXWROFUOQDERFO-UKILVPOCSA-N chembl533988 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CC1)C1=CC(F)=CC(F)=C1 PXWROFUOQDERFO-UKILVPOCSA-N 0.000 claims 1
• MBEIKKKHBAEUDD-LADGPHEKSA-N chembl534410 Chemical compound C([C@@H]([C@H](O)CNCC)NC(=O)C=1C=C2C(CC)=CN3CCS(=O)(=O)N(C)C(=C23)C=1)C1=CC=CC=C1 MBEIKKKHBAEUDD-LADGPHEKSA-N 0.000 claims 1
• WICLUVROROXQTO-MFMCTBQISA-N chembl541757 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC(C)(C)CCCC(C)C)C1=CC=CC=C1 WICLUVROROXQTO-MFMCTBQISA-N 0.000 claims 1
• SQUWMGPNENGLQH-AZGAKELHSA-N chembl546091 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CCC1)C1=CC=CC=C1 SQUWMGPNENGLQH-AZGAKELHSA-N 0.000 claims 1
• WOMRPPRIHDQNOD-MFMCTBQISA-N chembl546180 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C(=CC=CC=1)C)C1=CC=CC=C1 WOMRPPRIHDQNOD-MFMCTBQISA-N 0.000 claims 1
• SHZHGXXCSGCUOU-UKILVPOCSA-N chembl546469 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CC1)C1=CC=CC(Cl)=C1 SHZHGXXCSGCUOU-UKILVPOCSA-N 0.000 claims 1
• UKWLYOHWARGLPS-MFMCTBQISA-N chembl546517 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC=1C=CC(C)=CC=1)C1=CC=CC=C1 UKWLYOHWARGLPS-MFMCTBQISA-N 0.000 claims 1
• SXGYJWCJYRBHTI-LMSSTIIKSA-N chembl547343 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CCC)[C@H](O)CNC1CCCCC1)C1=CC=CC=C1 SXGYJWCJYRBHTI-LMSSTIIKSA-N 0.000 claims 1
• VXDWLOITVGHSCA-LMSSTIIKSA-N chembl548055 Chemical compound C([C@H](NC(=O)C=1C=C2N(CC)S(=O)(=O)CCN3C=C(C(C=1)=C32)CCC)[C@H](O)CNC1CCOCC1)C1=CC=CC=C1 VXDWLOITVGHSCA-LMSSTIIKSA-N 0.000 claims 1
• YKBWRXAAWVDSLD-AZGAKELHSA-N chembl549257 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCC(C)C)C1=CC=CC=C1 YKBWRXAAWVDSLD-AZGAKELHSA-N 0.000 claims 1
• WSZHJFHSCUWOJZ-YZXAJQSBSA-N chembl556660 Chemical compound C([C@@H]([C@H](O)CN[C@H](C)CC)NC(=O)C=1C=C2C(CC)=CN3CCS(=O)(=O)N(C)C(=C23)C=1)C1=CC=CC=C1 WSZHJFHSCUWOJZ-YZXAJQSBSA-N 0.000 claims 1
• GXBZBNGARSSJGU-JTHBVZDNSA-N chembl562554 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC)C1=CC=CC=C1 GXBZBNGARSSJGU-JTHBVZDNSA-N 0.000 claims 1
• KDQRIUPZQXCNKH-LADGPHEKSA-N chembl562703 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNCCF)C1=CC=CC=C1 KDQRIUPZQXCNKH-LADGPHEKSA-N 0.000 claims 1
• YFPIYHDYCGUXHF-XTEPFMGCSA-N chembl580117 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CCCCC1)C1=CC=CC(Cl)=C1 YFPIYHDYCGUXHF-XTEPFMGCSA-N 0.000 claims 1
• UOQCRDNYVUQPQD-XTEPFMGCSA-N chembl581363 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)C(C)C)[C@H](O)CNC1CCOCC1)C1=CC=CC=C1 UOQCRDNYVUQPQD-XTEPFMGCSA-N 0.000 claims 1
• ZPFCKDHSMUIEMN-UKILVPOCSA-N chembl581638 Chemical compound C([C@H](NC(=O)C=1C=C2N(C)S(=O)(=O)CCN3C=C(C(C=1)=C32)CC)[C@H](O)CNC1CC1)C1=CC=CC(F)=C1 ZPFCKDHSMUIEMN-UKILVPOCSA-N 0.000 claims 1
• WSZHJFHSCUWOJZ-VFHOHQAYSA-N chembl582426 Chemical compound C([C@@H]([C@H](O)CN[C@@H](C)CC)NC(=O)C=1C=C2C(CC)=CN3CCS(=O)(=O)N(C)C(=C23)C=1)C1=CC=CC=C1 WSZHJFHSCUWOJZ-VFHOHQAYSA-N 0.000 claims 1
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