CA2521471A1 - Methods of administering estrogens and progestins - Google Patents
Methods of administering estrogens and progestins Download PDFInfo
- Publication number
- CA2521471A1 CA2521471A1 CA002521471A CA2521471A CA2521471A1 CA 2521471 A1 CA2521471 A1 CA 2521471A1 CA 002521471 A CA002521471 A CA 002521471A CA 2521471 A CA2521471 A CA 2521471A CA 2521471 A1 CA2521471 A1 CA 2521471A1
- Authority
- CA
- Canada
- Prior art keywords
- conjugated
- dose
- acetate
- administering
- therapeutic amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000583 progesterone congener Substances 0.000 title claims abstract description 61
- 238000000034 method Methods 0.000 title claims abstract description 59
- 239000000262 estrogen Substances 0.000 title claims abstract description 45
- 229940011871 estrogen Drugs 0.000 title abstract description 32
- 208000024891 symptom Diseases 0.000 claims abstract description 16
- 230000001457 vasomotor Effects 0.000 claims abstract description 16
- 201000006828 endometrial hyperplasia Diseases 0.000 claims abstract description 11
- 150000001875 compounds Chemical class 0.000 claims description 59
- 239000000203 mixture Substances 0.000 claims description 51
- RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 claims description 49
- 229960004296 megestrol acetate Drugs 0.000 claims description 48
- 230000001076 estrogenic effect Effects 0.000 claims description 46
- 230000001225 therapeutic effect Effects 0.000 claims description 41
- -1 laevo-norgestrel Chemical compound 0.000 claims description 18
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 claims description 16
- DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 claims description 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 11
- 229940035811 conjugated estrogen Drugs 0.000 claims description 11
- VIKNJXKGJWUCNN-XGXHKTLJSA-N norethisterone Chemical compound O=C1CC[C@@H]2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 VIKNJXKGJWUCNN-XGXHKTLJSA-N 0.000 claims description 11
- 150000003839 salts Chemical class 0.000 claims description 11
- DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 claims description 10
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- 230000009245 menopause Effects 0.000 claims description 10
- VOXZDWNPVJITMN-SFFUCWETSA-N 17α-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-SFFUCWETSA-N 0.000 claims description 9
- 208000033830 Hot Flashes Diseases 0.000 claims description 9
- WKRLQDKEXYKHJB-HFTRVMKXSA-N equilin Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4C3=CCC2=C1 WKRLQDKEXYKHJB-HFTRVMKXSA-N 0.000 claims description 9
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- PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 claims description 6
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- 229940022663 acetate Drugs 0.000 claims description 5
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- 239000003098 androgen Substances 0.000 claims description 5
- UWFYSQMTEOIJJG-FDTZYFLXSA-N cyproterone acetate Chemical compound C1=C(Cl)C2=CC(=O)[C@@H]3C[C@@H]3[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 UWFYSQMTEOIJJG-FDTZYFLXSA-N 0.000 claims description 5
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- JGMOKGBVKVMRFX-HQZYFCCVSA-N dydrogesterone Chemical compound C1=CC2=CC(=O)CC[C@@]2(C)[C@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 JGMOKGBVKVMRFX-HQZYFCCVSA-N 0.000 claims description 5
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- CHNXZKVNWQUJIB-CEGNMAFCSA-N ethisterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 CHNXZKVNWQUJIB-CEGNMAFCSA-N 0.000 claims description 5
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- ONKUMRGIYFNPJW-KIEAKMPYSA-N ethynodiol diacetate Chemical compound C1C[C@]2(C)[C@@](C#C)(OC(C)=O)CC[C@H]2[C@@H]2CCC3=C[C@@H](OC(=O)C)CC[C@@H]3[C@H]21 ONKUMRGIYFNPJW-KIEAKMPYSA-N 0.000 claims description 5
- 229940012028 ethynodiol diacetate Drugs 0.000 claims description 5
- HCFSGRMEEXUOSS-JXEXPEPMSA-N medrogestone Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(C)[C@@]1(C)CC2 HCFSGRMEEXUOSS-JXEXPEPMSA-N 0.000 claims description 5
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- SONVSJYKHAWLHA-UHFFFAOYSA-N 3-hydroxy-13-methyl-7,8,12,14,15,16-hexahydro-6h-cyclopenta[a]phenanthren-17-one Chemical compound OC1=CC=C2C3=CCC(C)(C(CC4)=O)C4C3CCC2=C1 SONVSJYKHAWLHA-UHFFFAOYSA-N 0.000 claims description 3
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- NLLMJANWPUQQTA-SPUZQDLCSA-N estra-1,3,5(10),7-tetraene-3,17alpha-diol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@@H](CC4)O)[C@@H]4C3=CCC2=C1 NLLMJANWPUQQTA-SPUZQDLCSA-N 0.000 claims 6
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
- A61K31/566—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol having an oxo group in position 17, e.g. estrone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/30—Oestrogens
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US46228503P | 2003-04-11 | 2003-04-11 | |
| US60/462,285 | 2003-04-11 | ||
| PCT/US2004/011662 WO2004091535A2 (en) | 2003-04-11 | 2004-04-08 | Methods of administering estrogens and progestins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2521471A1 true CA2521471A1 (en) | 2004-10-28 |
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| CA002521471A Abandoned CA2521471A1 (en) | 2003-04-11 | 2004-04-08 | Methods of administering estrogens and progestins |
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|---|---|
| US (1) | US20040259851A1 (enExample) |
| EP (1) | EP1622623A4 (enExample) |
| JP (1) | JP2006522833A (enExample) |
| CA (1) | CA2521471A1 (enExample) |
| MX (1) | MXPA05010871A (enExample) |
| WO (1) | WO2004091535A2 (enExample) |
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| US20060269611A1 (en) * | 2001-11-29 | 2006-11-30 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
| US20040214898A1 (en) * | 2001-11-29 | 2004-10-28 | Steiner Mitchell S. | Methods for treating hot flashes |
| US20070197664A1 (en) * | 2001-11-29 | 2007-08-23 | Steiner Mitchell S | Prevention and treatment of androgen-deprivation induced osteoporosis |
| US20080249183A1 (en) * | 2001-11-29 | 2008-10-09 | Steiner Mitchell S | Treatment of androgen-deprivation induced osteoporosis |
| US7556150B2 (en) * | 2004-06-07 | 2009-07-07 | Duramed Pharmaceuticals, Inc. | Dispenser for progestin used for acute and maintenance treatment of DUB |
| US20060040904A1 (en) * | 2004-08-17 | 2006-02-23 | Ahmed Salah U | Vaginal cream compositions, kits thereof and methods of using thereof |
| US8663681B2 (en) * | 2005-05-26 | 2014-03-04 | Teva Women's Health, Inc. | Oral dosage forms comprising progesterone and methods of making and using the same |
| EP1971325A2 (en) * | 2005-12-27 | 2008-09-24 | Duramed Pharmaceuticals, Inc. | Conjugated estrogen compositions, applicators, kits, and methods of making and use thereof |
| US20080021003A1 (en) * | 2006-06-13 | 2008-01-24 | Vladimir Hanes | Extended step-down estrogen regimen |
| US8617597B2 (en) | 2006-07-06 | 2013-12-31 | Bayer Intellectual Property Gmbh | Pharmaceutical composition containing a tetrahydrofolic acid |
| AU2007336255B2 (en) | 2006-12-19 | 2013-09-12 | Leonardo UK Ltd | Optical parametric oscillator |
Family Cites Families (89)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3230142A (en) * | 1963-03-25 | 1966-01-18 | Upjohn Co | Oral contraceptive compositions and methods |
| NL6615481A (enExample) * | 1966-11-02 | 1968-05-03 | ||
| US3487152A (en) * | 1967-02-07 | 1969-12-30 | Hoffmann La Roche | Tablets containing 7 - chloro - 2 - methylamino - 5 - phenyl - 3h - 1,4 - benzodiazepine-4-oxide and conjugated estrogenic substances |
| US3568828A (en) * | 1967-03-01 | 1971-03-09 | Squibb & Sons Inc | Modified sequential oral contraceptive |
| US3591688A (en) * | 1969-08-22 | 1971-07-06 | American Home Prod | Method of preventing ovulation and composition therefor |
| US3639600A (en) * | 1969-08-28 | 1972-02-01 | Upjohn Co | Process of establishing cyclicity in a human female |
| US3795734A (en) * | 1970-04-20 | 1974-03-05 | American Home Prod | Cyclic regimen of hormone administration for contraception |
| US3733407A (en) * | 1971-08-25 | 1973-05-15 | Syntex Corp | Menopause treatment |
| US3836651A (en) * | 1972-02-22 | 1974-09-17 | Biolog Concepts Inc | Novel oral contraceptive combination |
| DE2310963A1 (de) * | 1972-04-14 | 1974-09-05 | Schering Ag | Methode zur kontrazeption durch verabfolgung von stufenkombinationspraeparaten |
| US3969502A (en) * | 1972-04-14 | 1976-07-13 | Schering Aktiengesellschaft | Method for contraception by the administration of sequential contraceptive preparations |
| US3932635A (en) * | 1972-04-24 | 1976-01-13 | Syntex Corporation | Novel cyclic progestogen-interrupted estrogen oral contraceptive regimens |
| US3942641A (en) * | 1972-05-05 | 1976-03-09 | Syntex Corporation | Dispensing packages containing novel cyclic progestogen-interrupted estrogen oral contraceptive regimens |
| GB1399162A (en) * | 1972-06-29 | 1975-06-25 | Schering Ag | 6-keto-delta1,3,5-10-steroids and process for the manufacture of 6-keto-delta1,3,5-10-steroids |
| US4066757A (en) * | 1973-03-26 | 1978-01-03 | Ortho Pharmaceutical Corporation | Oral contraceptive regimen |
| DE2365103C3 (de) * | 1973-12-21 | 1980-08-28 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | V erwendung von Hormonen zur Kontrazeption |
| US4147783A (en) * | 1974-02-28 | 1979-04-03 | Akzona Incorporated | Oral pharmaceutical preparation |
| NL7506407A (nl) * | 1975-05-30 | 1976-12-02 | Akzo Nv | Werkwijze ter bereiding van een oraal werkzaam far- maceutisch preparaat. |
| US4027019A (en) * | 1975-07-24 | 1977-05-31 | Ortho Pharmaceutical Corporation | 3-Oximes of D-17α-ethynyl-19-nortestosterone esters and method |
| US4154820A (en) * | 1976-02-23 | 1979-05-15 | Akzona Incorporated | Compositions containing alkali metal sulfate salts of conjugated estrogens and antioxidants as stabilizers |
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-
2004
- 2004-04-08 WO PCT/US2004/011662 patent/WO2004091535A2/en not_active Ceased
- 2004-04-08 EP EP04750182A patent/EP1622623A4/en not_active Withdrawn
- 2004-04-08 MX MXPA05010871A patent/MXPA05010871A/es active IP Right Grant
- 2004-04-08 JP JP2006510080A patent/JP2006522833A/ja not_active Withdrawn
- 2004-04-08 CA CA002521471A patent/CA2521471A1/en not_active Abandoned
- 2004-04-08 US US10/821,278 patent/US20040259851A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2004091535A3 (en) | 2005-03-24 |
| US20040259851A1 (en) | 2004-12-23 |
| EP1622623A4 (en) | 2009-03-18 |
| JP2006522833A (ja) | 2006-10-05 |
| EP1622623A2 (en) | 2006-02-08 |
| MXPA05010871A (es) | 2005-11-25 |
| AU2004229565A1 (en) | 2004-10-28 |
| WO2004091535A2 (en) | 2004-10-28 |
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| FZDE | Discontinued |
Effective date: 20130408 |