CA2520027C - Derives de 2,3,6-trisubstitue 4-pyrimidone - Google Patents
Derives de 2,3,6-trisubstitue 4-pyrimidone Download PDFInfo
- Publication number
- CA2520027C CA2520027C CA2520027A CA2520027A CA2520027C CA 2520027 C CA2520027 C CA 2520027C CA 2520027 A CA2520027 A CA 2520027A CA 2520027 A CA2520027 A CA 2520027A CA 2520027 C CA2520027 C CA 2520027C
- Authority
- CA
- Canada
- Prior art keywords
- group
- methyl
- pyrimidin
- piperazin
- pyridyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Endocrinology (AREA)
- Cardiology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2003126021 | 2003-03-26 | ||
JP2003-126022 | 2003-03-26 | ||
JP2003-126021 | 2003-03-26 | ||
JP2003126022 | 2003-03-26 | ||
PCT/JP2004/004320 WO2004085408A1 (fr) | 2003-03-26 | 2004-03-26 | Derives de 2,3,6-trisubstitue 4-pyrimidone |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2520027A1 CA2520027A1 (fr) | 2004-10-07 |
CA2520027C true CA2520027C (fr) | 2011-08-09 |
Family
ID=33100427
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2520027A Expired - Fee Related CA2520027C (fr) | 2003-03-26 | 2004-03-26 | Derives de 2,3,6-trisubstitue 4-pyrimidone |
Country Status (16)
Country | Link |
---|---|
US (1) | US7504411B2 (fr) |
EP (3) | EP2308854A1 (fr) |
JP (1) | JP4679509B2 (fr) |
KR (1) | KR100985419B1 (fr) |
CN (1) | CN1764650B (fr) |
AR (1) | AR045677A1 (fr) |
AU (1) | AU2004223987B2 (fr) |
BR (1) | BRPI0409042A (fr) |
CA (1) | CA2520027C (fr) |
EA (1) | EA009620B1 (fr) |
HK (1) | HK1090368A1 (fr) |
IL (1) | IL170877A (fr) |
NO (1) | NO20054952L (fr) |
NZ (1) | NZ543096A (fr) |
TW (1) | TWI357408B (fr) |
WO (1) | WO2004085408A1 (fr) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI241298B (en) | 1998-09-25 | 2005-10-11 | Mitsubishi Chem Corp | Pyrimidone derivatives |
MXPA04002662A (es) * | 2001-09-21 | 2004-11-22 | Sanofi Aventis | Derivados de 3-substituida-4-pirimidona. |
AR036604A1 (es) | 2001-09-21 | 2004-09-22 | Mitsubishi Pharma Corp | Derivados de 4-pirimidona 3-sustituida |
WO2004055007A1 (fr) | 2002-12-16 | 2004-07-01 | Mitsubishi Pharma Corporation | Derives 4-pyrimidones substitues en 3 |
US20040242568A1 (en) | 2003-03-25 | 2004-12-02 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
US7790736B2 (en) | 2003-08-13 | 2010-09-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
US7790734B2 (en) | 2003-09-08 | 2010-09-07 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
CN102134229B (zh) | 2004-03-15 | 2020-08-04 | 武田药品工业株式会社 | 二肽基肽酶抑制剂 |
TW200621760A (en) * | 2004-09-09 | 2006-07-01 | Mitsubishi Pharma Corp | 2-morpholino-4-pyrimidone compound |
ZA200703383B (en) * | 2004-09-29 | 2009-05-27 | Mitsubishi Pharma Corp | 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors |
CN101084198A (zh) * | 2004-10-15 | 2007-12-05 | 阿斯利康(瑞典)有限公司 | 取代的氨基-嘧啶酮及其用途 |
US20090221579A1 (en) * | 2004-10-15 | 2009-09-03 | Jeffrey Scott Albert | Substituted Amino-Compounds and Uses Thereof |
ES2435790T3 (es) * | 2004-12-03 | 2013-12-23 | Intervet International B.V. | Piperazinas sustituidas como antagonistas de CB1 |
WO2006068978A2 (fr) | 2004-12-21 | 2006-06-29 | Takeda Pharmaceutial Company Limited | Inhibiteurs de dipeptidyle peptidase |
TW200740779A (en) | 2005-07-22 | 2007-11-01 | Mitsubishi Pharma Corp | Intermediate compound for synthesizing pharmaceutical agent and production method thereof |
PL1942898T5 (pl) | 2005-09-14 | 2014-10-31 | Takeda Pharmaceuticals Co | Inhibitory peptydazy dipeptydylowej do leczenia cukrzycy |
CN102675221A (zh) | 2005-09-16 | 2012-09-19 | 武田药品工业株式会社 | 用于制备嘧啶二酮衍生物的方法中的中间体 |
TW200813015A (en) * | 2006-03-15 | 2008-03-16 | Mitsubishi Pharma Corp | 2-(cyclic amino)-pyrimidone derivatives |
WO2008023239A1 (fr) * | 2006-08-23 | 2008-02-28 | Pfizer Products Inc. | Composés de pyrimidone en tant qu'inhibiteurs de gsk-3 |
US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
TW200838536A (en) | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
AR064660A1 (es) * | 2006-12-26 | 2009-04-15 | Mitsubishi Tanabe Pharma Corp | Derivados de pirimidinona 6-heterociclica 2-sustituida, medicamentos que los contienen y usos para prevenir y/o tratar enfermedades neurodegenerativas entre otras |
JP5438976B2 (ja) | 2007-02-09 | 2014-03-12 | 株式会社カネカ | 光学活性2−アリールピペラジン誘導体の製造法 |
US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
KR20100051625A (ko) * | 2007-06-28 | 2010-05-17 | 인터벳 인터내셔널 비.브이. | Cb1 길항제로서의 치환된 피페라진 |
US20100249144A1 (en) * | 2007-06-28 | 2010-09-30 | Demong Duane Eugene | Substituted piperazines as cb1 antagonists |
MX2010002765A (es) * | 2007-09-14 | 2010-05-19 | Mitsubishi Tanabe Pharma Corp | Derivado de 6-pirimidinil-pirimid-4-ona. |
WO2011019089A1 (fr) * | 2009-08-13 | 2011-02-17 | Mitsubishi Tanabe Pharma Corporation | Dérivés du pyrimidone utilisés comme inhibiteurs de la protéine kinase tau 1 |
EP2464632A1 (fr) | 2009-08-13 | 2012-06-20 | Mitsubishi Tanabe Pharma Corporation | Dérivés de pyrimidone utilisés en tant qu'inhibiteurs de la protéine kinase tau 1 |
CN104211635A (zh) * | 2013-06-03 | 2014-12-17 | 中国科学院上海药物研究所 | 一类哌啶类化合物及其制备方法、药物组合物和用途 |
US10246463B2 (en) | 2015-04-07 | 2019-04-02 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Hypoxia-inducible factor 1 (HIF-1) inhibitors |
CN105130904B (zh) * | 2015-08-24 | 2017-10-13 | 如东众意化工有限公司 | 一种2‑氰基‑4‑氯‑5‑(4‑甲基苯基)咪唑的合成方法 |
CN106854189A (zh) * | 2015-12-08 | 2017-06-16 | 湖南华腾制药有限公司 | 一种哌嗪化合物的合成方法 |
Family Cites Families (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US187004A (en) * | 1877-02-06 | Improvement in water-wheels | ||
US90490A (en) * | 1869-05-25 | Improved washing-machine | ||
JPS559099B2 (fr) | 1972-08-07 | 1980-03-07 | ||
JPS4935633A (fr) | 1972-08-09 | 1974-04-02 | ||
JPS5124008B2 (fr) | 1972-08-10 | 1976-07-21 | ||
JPS4935632A (fr) | 1972-08-10 | 1974-04-02 | ||
JPS5271481A (en) | 1975-12-10 | 1977-06-14 | Yoshitomi Pharmaceut Ind Ltd | Synthesis of pyridylpyrimidines |
JPS52139085A (en) | 1976-05-13 | 1977-11-19 | Hokuriku Pharmaceutical | 22allylpiperazine derivative and method for its preparation |
US4507302A (en) | 1979-03-19 | 1985-03-26 | The Upjohn Company | Method for treating arthritis with 6-aryl pyrimidine compounds |
US4619933A (en) | 1979-09-28 | 1986-10-28 | The Upjohn Company | 6-aryl pyrimidines for treating aplastic anemia |
US4725600A (en) | 1984-07-13 | 1988-02-16 | Fujisawa Pharmaceutical Co., Ltd. | Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent |
EP0354179B1 (fr) | 1988-07-29 | 1994-08-17 | Ciba-Geigy Ag | Thiouracils comme stabilisants pour des polymères contenant du chlore |
EP0911390B1 (fr) | 1991-12-06 | 2009-08-05 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Protéine kinases comme outils pour le diagnostic et le traitement de la maladie d' Alzheimer |
DE4206145A1 (de) | 1992-02-28 | 1993-09-02 | Basf Ag | Herbizide n-((pyrimidin-2-yl)aminocarbonyl)benzolfulfonamide |
JP3324611B2 (ja) | 1992-07-03 | 2002-09-17 | 三菱化学株式会社 | タウ蛋白質のリン酸化方法 |
JPH06329551A (ja) | 1993-03-22 | 1994-11-29 | Mitsubishi Kasei Corp | アルツハイマー病の予防または治療薬およびそのスクリーニング方法 |
BR9407799A (pt) | 1993-10-12 | 1997-05-06 | Du Pont Merck Pharma | Composição de matéria método de tratamento e composição farmaceutica |
AU735901C (en) | 1996-12-05 | 2004-02-12 | Amgen, Inc. | Substituted pyrimidinone and pyridone compounds and methods of use |
US6096753A (en) | 1996-12-05 | 2000-08-01 | Amgen Inc. | Substituted pyrimidinone and pyridone compounds and methods of use |
CZ296911B6 (cs) | 1996-12-05 | 2006-07-12 | Amgen Inc. | Substituovaný pyrimidin, jeho pouzití a farmaceutický prostredek na jeho bázi |
WO1998024782A2 (fr) | 1996-12-05 | 1998-06-11 | Amgen Inc. | Composes pyrimidines substitues et leur utilisation |
US6410729B1 (en) | 1996-12-05 | 2002-06-25 | Amgen Inc. | Substituted pyrimidine compounds and methods of use |
TWI241298B (en) * | 1998-09-25 | 2005-10-11 | Mitsubishi Chem Corp | Pyrimidone derivatives |
EP1261327B1 (fr) | 2000-02-25 | 2005-04-27 | F.Hoffmann-La Roche Ag | Modulateurs de recepteurs de l'adenosine |
FR2806723B1 (fr) | 2000-03-23 | 2002-05-10 | Sanofi Synthelabo | DERIVES D'ACIDE 8-OXO-5,8-DIHYDRO-6H-DIBENZO [a,g] QUINOLIZINE-13-PROPANOIQUE , LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE |
WO2001070728A1 (fr) | 2000-03-23 | 2001-09-27 | Sanofi-Synthelabo | Derives de la 2-[azote-heterocyclique]pyrimidone |
EP1136482A1 (fr) | 2000-03-23 | 2001-09-26 | Sanofi-Synthelabo | Dérivés de 2-amino-3-(alkyl)-pyrimidone comme inhibiteurs de GSK3bêta |
MXPA04002662A (es) | 2001-09-21 | 2004-11-22 | Sanofi Aventis | Derivados de 3-substituida-4-pirimidona. |
AR036604A1 (es) * | 2001-09-21 | 2004-09-22 | Mitsubishi Pharma Corp | Derivados de 4-pirimidona 3-sustituida |
JP4653915B2 (ja) * | 2001-10-29 | 2011-03-16 | 独立行政法人科学技術振興機構 | 全身性エリテマトーデスモデル非ヒト動物 |
WO2004055007A1 (fr) | 2002-12-16 | 2004-07-01 | Mitsubishi Pharma Corporation | Derives 4-pyrimidones substitues en 3 |
-
2004
- 2004-03-25 TW TW093108174A patent/TWI357408B/zh not_active IP Right Cessation
- 2004-03-26 KR KR1020057017840A patent/KR100985419B1/ko not_active IP Right Cessation
- 2004-03-26 EP EP10192283A patent/EP2308854A1/fr not_active Withdrawn
- 2004-03-26 WO PCT/JP2004/004320 patent/WO2004085408A1/fr active Application Filing
- 2004-03-26 US US10/550,299 patent/US7504411B2/en not_active Expired - Fee Related
- 2004-03-26 EA EA200501516A patent/EA009620B1/ru not_active IP Right Cessation
- 2004-03-26 AR ARP040101028A patent/AR045677A1/es not_active Application Discontinuation
- 2004-03-26 CN CN2004800080655A patent/CN1764650B/zh not_active Expired - Fee Related
- 2004-03-26 BR BRPI0409042-0A patent/BRPI0409042A/pt not_active IP Right Cessation
- 2004-03-26 NZ NZ543096A patent/NZ543096A/en not_active IP Right Cessation
- 2004-03-26 JP JP2006507692A patent/JP4679509B2/ja not_active Expired - Fee Related
- 2004-03-26 EP EP10192295A patent/EP2305651A1/fr not_active Withdrawn
- 2004-03-26 EP EP04723777A patent/EP1608630A1/fr not_active Withdrawn
- 2004-03-26 AU AU2004223987A patent/AU2004223987B2/en not_active Ceased
- 2004-03-26 CA CA2520027A patent/CA2520027C/fr not_active Expired - Fee Related
-
2005
- 2005-09-15 IL IL170877A patent/IL170877A/en not_active IP Right Cessation
- 2005-10-25 NO NO20054952A patent/NO20054952L/no not_active Application Discontinuation
-
2006
- 2006-10-10 HK HK06111095.5A patent/HK1090368A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
AR045677A1 (es) | 2005-11-09 |
AU2004223987B2 (en) | 2010-02-18 |
TWI357408B (en) | 2012-02-01 |
CN1764650A (zh) | 2006-04-26 |
HK1090368A1 (en) | 2006-12-22 |
BRPI0409042A (pt) | 2006-03-28 |
CN1764650B (zh) | 2010-06-16 |
IL170877A (en) | 2011-02-28 |
US20060252768A1 (en) | 2006-11-09 |
JP2006521370A (ja) | 2006-09-21 |
NO20054952L (no) | 2005-10-25 |
KR100985419B1 (ko) | 2010-10-05 |
EA200501516A1 (ru) | 2006-04-28 |
EA009620B1 (ru) | 2008-02-28 |
EP1608630A1 (fr) | 2005-12-28 |
EP2308854A1 (fr) | 2011-04-13 |
CA2520027A1 (fr) | 2004-10-07 |
JP4679509B2 (ja) | 2011-04-27 |
AU2004223987A1 (en) | 2004-10-07 |
EP2305651A1 (fr) | 2011-04-06 |
US7504411B2 (en) | 2009-03-17 |
NZ543096A (en) | 2008-07-31 |
TW200510338A (en) | 2005-03-16 |
WO2004085408A1 (fr) | 2004-10-07 |
KR20050111613A (ko) | 2005-11-25 |
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