CA2513064C - Nanoparticulate topiramate formulations - Google Patents
Nanoparticulate topiramate formulations Download PDFInfo
- Publication number
- CA2513064C CA2513064C CA002513064A CA2513064A CA2513064C CA 2513064 C CA2513064 C CA 2513064C CA 002513064 A CA002513064 A CA 002513064A CA 2513064 A CA2513064 A CA 2513064A CA 2513064 C CA2513064 C CA 2513064C
- Authority
- CA
- Canada
- Prior art keywords
- less
- chloride
- topiramate
- composition
- ammonium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Molecular Biology (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US44437703P | 2003-01-31 | 2003-01-31 | |
| US60/444,377 | 2003-01-31 | ||
| US47778903P | 2003-06-12 | 2003-06-12 | |
| US60/477,789 | 2003-06-12 | ||
| US51131803P | 2003-10-16 | 2003-10-16 | |
| US60/511,318 | 2003-10-16 | ||
| PCT/US2004/002548 WO2004078162A1 (en) | 2003-01-31 | 2004-01-30 | Nanoparticulate topiramate formulations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2513064A1 CA2513064A1 (en) | 2004-09-16 |
| CA2513064C true CA2513064C (en) | 2009-11-10 |
Family
ID=32966444
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002513064A Expired - Fee Related CA2513064C (en) | 2003-01-31 | 2004-01-30 | Nanoparticulate topiramate formulations |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US7390505B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1587499A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP4469846B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2513064C (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004078162A1 (cg-RX-API-DMAC7.html) |
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| US20080102121A1 (en) * | 1998-11-02 | 2008-05-01 | Elan Pharma International Limited | Compositions comprising nanoparticulate meloxicam and controlled release hydrocodone |
| US7763663B2 (en) * | 2001-12-19 | 2010-07-27 | University Of Massachusetts | Polysaccharide-containing block copolymer particles and uses thereof |
| PT1471887E (pt) | 2002-02-04 | 2010-07-16 | Elan Pharma Int Ltd | Composiães de nanopartculas com lisozima como um estabilizador superficial |
| US20060088886A1 (en) * | 2004-10-25 | 2006-04-27 | Anlong Ouyang | Topiramate analogs |
| US7638291B2 (en) | 2004-10-25 | 2009-12-29 | Seradyn, Inc. | Immunoassays for topiramate |
| JP2008535924A (ja) * | 2005-04-12 | 2008-09-04 | エラン ファーマ インターナショナル リミテッド | ナノ粒子キナゾリン誘導体製剤 |
| EP1954253A4 (en) | 2005-06-08 | 2011-07-27 | Elan Pharma Int Ltd | NANOTEILIC AND CONTROLLED RELEASED COMPOSITIONS WITH CEFDITORS |
| AU2006346369B2 (en) | 2005-07-18 | 2013-02-21 | University Of Massachusetts Lowell | Compositions and methods for making and using nanoemulsions |
| JP2009505976A (ja) * | 2005-08-12 | 2009-02-12 | アストラゼネカ・アクチエボラーグ | 方法 |
| WO2007035348A2 (en) | 2005-09-15 | 2007-03-29 | Elan Pharma International, Limited | Nanoparticulate aripiprazole formulations |
| DE202005016250U1 (de) * | 2005-10-17 | 2006-01-26 | Helm Ag | Topiramat und pharmazeutische Formulierungen davon |
| PL3144013T3 (pl) | 2005-12-01 | 2019-04-30 | Univ Of Massachusetts Lowell | Nanoemulsje botulinowe |
| US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
| CN101495096A (zh) | 2006-05-30 | 2009-07-29 | 伊兰制药国际有限公司 | 纳米微粒泊沙康唑制剂 |
| JP2009543803A (ja) * | 2006-07-12 | 2009-12-10 | エラン・ファルマ・インターナショナル・リミテッド | モダフィニルのナノ粒子製剤 |
| WO2008027557A2 (en) | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| EP2394643B1 (en) | 2006-11-17 | 2015-09-02 | Supernus Pharmaceuticals, Inc. | Sustained-release formulations of topiramate |
| CN101848702B (zh) | 2006-12-01 | 2013-07-17 | 安特里奥公司 | 两亲实体纳米粒子 |
| SG10201607909WA (en) | 2006-12-01 | 2016-11-29 | Anterios Inc | Peptide nanoparticles and uses therefor |
| EP2363113B1 (en) * | 2006-12-04 | 2017-08-02 | Supernus Pharmaceuticals, Inc. | Enhanced immediate release formulations of topiramate |
| WO2008095221A1 (en) | 2007-02-07 | 2008-08-14 | Gosforth Centre (Holdings) Pty Ltd | Treatment of adhd |
| TW200848039A (en) * | 2007-02-09 | 2008-12-16 | Astrazeneca Ab | Pharmaceutical compositions |
| JP2010517759A (ja) * | 2007-02-09 | 2010-05-27 | アストラゼネカ・アクチエボラーグ | 水性媒体中における固体非晶質サブミクロン粒子の安定な分散体を製造する方法 |
| JP5424571B2 (ja) * | 2007-04-12 | 2014-02-26 | 協和発酵キリン株式会社 | トピラマート含有固形製剤 |
| WO2008151022A2 (en) | 2007-05-31 | 2008-12-11 | Anterios, Inc. | Nucleic acid nanoparticles and uses therefor |
| TW200918099A (en) | 2007-09-14 | 2009-05-01 | Nitto Denko Corp | Drug carriers |
| MX2011001384A (es) | 2008-08-06 | 2011-09-27 | Gosforth Ct Holdings Pty Ltd | Composiciones y metodos para tratar trastornos psiquiatricos. |
| US20100055187A1 (en) * | 2008-08-28 | 2010-03-04 | Dong June Ahn | Nanovitamin synthesis |
| US20100055246A1 (en) * | 2008-08-28 | 2010-03-04 | Dong June Ahn | Nutrition delivery capsules for functional foods |
| WO2010042203A1 (en) * | 2008-10-10 | 2010-04-15 | Alvine Pharmaceuticals, Inc. | Dosage forms that facilitate rapid activation of zymogen |
| EP2177215A1 (en) | 2008-10-17 | 2010-04-21 | Laboratorios Del. Dr. Esteve, S.A. | Co-crystals of tramadol and NSAIDs |
| RU2011135958A (ru) * | 2009-01-30 | 2013-03-10 | Мейдзи Сейка Фарма Ко., Лтд. | Тонко измельченная фармацевтическая композиция |
| JP6072539B2 (ja) | 2009-05-27 | 2017-02-01 | アルカーメス ファーマ アイルランド リミテッド | ナノ粒子活性物質組成物におけるフレーク状凝集の軽減 |
| US9012511B2 (en) | 2010-05-19 | 2015-04-21 | Alkermes Pharma Ireland Limited | Nanoparticulate cinacalcet compositions |
| US8962662B2 (en) | 2011-11-15 | 2015-02-24 | Byocoat Enterprises, Inc. | Antimicrobial compositions and methods of use thereof |
| US8652527B1 (en) | 2013-03-13 | 2014-02-18 | Upsher-Smith Laboratories, Inc | Extended-release topiramate capsules |
| US9101545B2 (en) | 2013-03-15 | 2015-08-11 | Upsher-Smith Laboratories, Inc. | Extended-release topiramate capsules |
| US10278948B1 (en) | 2015-09-03 | 2019-05-07 | Tian Xia | Method for transnasal delivery of anticonvulsant and therapeutic treatments |
| EP3541358A1 (en) | 2016-11-21 | 2019-09-25 | Eirion Therapeutics, Inc. | Transdermal delivery of large agents |
| WO2020056191A1 (en) | 2018-09-13 | 2020-03-19 | Eirion Therapeutics, Inc. | Uses of plasminogen activator inhibitor 1 (pai-1) inhibitors |
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| CN114748670B (zh) * | 2022-04-11 | 2023-04-21 | 武汉诺薇生物科技有限公司 | 一种非织造止血纱布及其制备方法和应用 |
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| US6375986B1 (en) | 2000-09-21 | 2002-04-23 | Elan Pharma International Ltd. | Solid dose nanoparticulate compositions comprising a synergistic combination of a polymeric surface stabilizer and dioctyl sodium sulfosuccinate |
| US6428814B1 (en) * | 1999-10-08 | 2002-08-06 | Elan Pharma International Ltd. | Bioadhesive nanoparticulate compositions having cationic surface stabilizers |
| US6270806B1 (en) | 1999-03-03 | 2001-08-07 | Elan Pharma International Limited | Use of peg-derivatized lipids as surface stabilizers for nanoparticulate compositions |
| US6267989B1 (en) | 1999-03-08 | 2001-07-31 | Klan Pharma International Ltd. | Methods for preventing crystal growth and particle aggregation in nanoparticulate compositions |
| CA2393195C (en) | 1999-06-01 | 2007-02-20 | Elan Pharma International Limited | Small-scale mill and method thereof |
| US6656504B1 (en) | 1999-09-09 | 2003-12-02 | Elan Pharma International Ltd. | Nanoparticulate compositions comprising amorphous cyclosporine and methods of making and using such compositions |
| ATE453454T1 (de) | 2000-04-26 | 2010-01-15 | Elan Pharma Int Ltd | Vorrichtung zur sanitären nassvermahlung |
| US6316029B1 (en) | 2000-05-18 | 2001-11-13 | Flak Pharma International, Ltd. | Rapidly disintegrating solid oral dosage form |
| EP1392441B1 (en) | 2001-06-05 | 2008-07-23 | Elan Pharma International Limited | System and method for milling materials |
| EP2283864A1 (en) * | 2002-07-16 | 2011-02-16 | Elan Pharma International Ltd. | Liquid dosage compositions fo stable nanoparticulate active agents |
| AU2004240640A1 (en) | 2003-05-19 | 2004-12-02 | Baxter International Inc. | Solid particles comprising an anticonvulsant or an immunosuppressive coated with one or more surface modifiers |
-
2004
- 2004-01-30 US US10/766,960 patent/US7390505B2/en not_active Expired - Fee Related
- 2004-01-30 JP JP2006508639A patent/JP4469846B2/ja not_active Expired - Lifetime
- 2004-01-30 WO PCT/US2004/002548 patent/WO2004078162A1/en not_active Ceased
- 2004-01-30 EP EP04706953A patent/EP1587499A1/en not_active Withdrawn
- 2004-01-30 CA CA002513064A patent/CA2513064C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US7390505B2 (en) | 2008-06-24 |
| JP2006520814A (ja) | 2006-09-14 |
| EP1587499A1 (en) | 2005-10-26 |
| US20040258758A1 (en) | 2004-12-23 |
| WO2004078162A1 (en) | 2004-09-16 |
| CA2513064A1 (en) | 2004-09-16 |
| JP4469846B2 (ja) | 2010-06-02 |
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| EEER | Examination request | ||
| MKLA | Lapsed |
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