CA2512797C - Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer - Google Patents

Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer Download PDF

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Publication number
CA2512797C
CA2512797C CA2512797A CA2512797A CA2512797C CA 2512797 C CA2512797 C CA 2512797C CA 2512797 A CA2512797 A CA 2512797A CA 2512797 A CA2512797 A CA 2512797A CA 2512797 C CA2512797 C CA 2512797C
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CA
Canada
Prior art keywords
methyl
group
substituted
use according
unsubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2512797A
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English (en)
French (fr)
Other versions
CA2512797A1 (en
Inventor
Keizo Koya
Lijun Sun
Yaming Wu
Timothy Korbut
Dan Zhou
Zhenjian Du
Shoujun Chen
Noriaki Tatsuta
Guiqing Liang
Mitsunori Ono
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Synta Phamaceuticals Corp
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Synta Phamaceuticals Corp
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Filing date
Publication date
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Publication of CA2512797A1 publication Critical patent/CA2512797A1/en
Application granted granted Critical
Publication of CA2512797C publication Critical patent/CA2512797C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/275—Nitriles; Isonitriles
    • A61K31/277—Nitriles; Isonitriles having a ring, e.g. verapamil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2512797A 2003-01-15 2004-01-15 Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer Expired - Fee Related CA2512797C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44040603P 2003-01-15 2003-01-15
US60/440,406 2003-01-15
PCT/US2004/001089 WO2004064826A1 (en) 2003-01-15 2004-01-15 Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer

Publications (2)

Publication Number Publication Date
CA2512797A1 CA2512797A1 (en) 2004-08-05
CA2512797C true CA2512797C (en) 2012-02-21

Family

ID=32771813

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2512797A Expired - Fee Related CA2512797C (en) 2003-01-15 2004-01-15 Bis (thio-hydrazide amide) compounds for treating multi-drug resistant cancer

Country Status (13)

Country Link
US (1) US7763658B2 (enExample)
EP (1) EP1583524B1 (enExample)
JP (1) JP4852409B2 (enExample)
AT (1) ATE336991T1 (enExample)
AU (1) AU2004206865B2 (enExample)
CA (1) CA2512797C (enExample)
CY (1) CY1106246T1 (enExample)
DE (1) DE602004002087T2 (enExample)
DK (1) DK1583524T3 (enExample)
ES (1) ES2271839T3 (enExample)
PT (1) PT1583524E (enExample)
TW (1) TWI330079B (enExample)
WO (1) WO2004064826A1 (enExample)

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US8618170B2 (en) * 2007-11-09 2013-12-31 Synta Pharmaceuticals Corp. Oral formulations of bis(thiohydrazide amides)
EP2225201A2 (en) * 2007-11-28 2010-09-08 Synta Pharmaceuticals Corp. Polymorphs of n-malonyl-bis(n'-methyl-n'-thiobenzoylhydrazide)
US8581004B2 (en) 2008-02-21 2013-11-12 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2009123704A2 (en) * 2008-03-31 2009-10-08 Synta Pharmaceuticals Corp. Process for preparing bis(thiohydrazide amides)
US8461199B2 (en) * 2008-10-22 2013-06-11 Synta Pharmaceuticals Corp. Transition metal complexes of a bis[thio-hydrazide amide] compound
KR20110073613A (ko) 2008-10-22 2011-06-29 신타 파마슈티칼스 코프. 비스(티오하이드라자이드 아마이드) 화합물의 전이금속착체
US8525776B2 (en) * 2008-10-27 2013-09-03 Lenovo (Singapore) Pte. Ltd Techniques for controlling operation of a device with a virtual touchscreen
CA2745065A1 (en) 2008-12-01 2010-06-10 Synta Pharmaceuticals Corp. Compounds for treating proliferative disorders
WO2011069159A2 (en) 2009-12-04 2011-06-09 Synta Pharmaceuticals Corp. Bis[thiohydrazide amide] compounds for treating leukemia
WO2011133673A1 (en) 2010-04-20 2011-10-27 Synta Pharmaceuticals Corp. Use of bis [thiohydrazide amide] compounds such as elesclomol for treating cancers
EP2776021A1 (en) * 2011-11-10 2014-09-17 Synta Pharmaceuticals Corp. Administration of a bis(thiohydrazide amide) compound for treating cancers
US20130149392A1 (en) 2011-12-12 2013-06-13 Synta Pharmaceuticals Corp. Method of treating non-small cell lung cancer with bis-(thiohydrazide)amide compounds
KR20160104612A (ko) 2013-07-26 2016-09-05 업데이트 파마 인코포레이트 비산트렌의 치료 효과 개선용 조성물
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Also Published As

Publication number Publication date
PT1583524E (pt) 2006-12-29
AU2004206865B2 (en) 2006-07-13
HK1084024A1 (en) 2006-07-21
TW200418449A (en) 2004-10-01
ES2271839T3 (es) 2007-04-16
WO2004064826A1 (en) 2004-08-05
TWI330079B (en) 2010-09-11
EP1583524B1 (en) 2006-08-23
DE602004002087D1 (de) 2006-10-05
JP4852409B2 (ja) 2012-01-11
US7763658B2 (en) 2010-07-27
AU2004206865A1 (en) 2004-08-05
JP2006515626A (ja) 2006-06-01
EP1583524A1 (en) 2005-10-12
DK1583524T3 (da) 2006-12-27
CY1106246T1 (el) 2011-06-08
CA2512797A1 (en) 2004-08-05
ATE336991T1 (de) 2006-09-15
US20040225016A1 (en) 2004-11-11
DE602004002087T2 (de) 2007-03-08

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