CA2508780A1 - Procede d'utilisation de composes d'aminocyanopyridine en tant qu'inhibiteurs de la proteine mapkap kinase-2 - Google Patents

Procede d'utilisation de composes d'aminocyanopyridine en tant qu'inhibiteurs de la proteine mapkap kinase-2 Download PDF

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Publication number
CA2508780A1
CA2508780A1 CA002508780A CA2508780A CA2508780A1 CA 2508780 A1 CA2508780 A1 CA 2508780A1 CA 002508780 A CA002508780 A CA 002508780A CA 2508780 A CA2508780 A CA 2508780A CA 2508780 A1 CA2508780 A1 CA 2508780A1
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Prior art keywords
amino
carbonitrile
pyridine
chromeno
diamino
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Abandoned
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CA002508780A
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English (en)
Inventor
Emily J. Reinhard
Stephen A. Kolodziej
David R. Anderson
Nathan W. Stehle
William F. Vernier
Len F. Lee
Shridhar G. Hegde
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Pharmacia LLC
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Individual
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Publication of CA2508780A1 publication Critical patent/CA2508780A1/fr
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
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Abstract

La présente invention a trait à un procédé permettant l'inhibition de la protéine MAPKKK chez un sujet qui en a besoin, qui comprend l'administration au sujet d'un composé d'aminocyanopyridine MK-2, ou un de ses sels pharmaceutiquement acceptables.
CA002508780A 2002-12-12 2003-12-09 Procede d'utilisation de composes d'aminocyanopyridine en tant qu'inhibiteurs de la proteine mapkap kinase-2 Abandoned CA2508780A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US43280702P 2002-12-12 2002-12-12
US60/432,807 2002-12-12
PCT/US2003/039166 WO2004054505A2 (fr) 2002-12-12 2003-12-09 Procede d'utilisation de composes d'aminocyanopyridine en tant qu'inhibiteurs de la proteine mapkap kinase-2

Publications (1)

Publication Number Publication Date
CA2508780A1 true CA2508780A1 (fr) 2004-07-01

Family

ID=32595087

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002508780A Abandoned CA2508780A1 (fr) 2002-12-12 2003-12-09 Procede d'utilisation de composes d'aminocyanopyridine en tant qu'inhibiteurs de la proteine mapkap kinase-2

Country Status (7)

Country Link
EP (1) EP1569645A2 (fr)
JP (1) JP2006512338A (fr)
AU (1) AU2003296414A1 (fr)
BR (1) BR0317183A (fr)
CA (1) CA2508780A1 (fr)
MX (1) MXPA05006367A (fr)
WO (1) WO2004054505A2 (fr)

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