CA2507774C - Avermectin b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position - Google Patents

Avermectin b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position Download PDF

Info

Publication number
CA2507774C
CA2507774C CA2507774A CA2507774A CA2507774C CA 2507774 C CA2507774 C CA 2507774C CA 2507774 A CA2507774 A CA 2507774A CA 2507774 A CA2507774 A CA 2507774A CA 2507774 C CA2507774 C CA 2507774C
Authority
CA
Canada
Prior art keywords
spp
alkyl
aryl
heterocyclyl
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2507774A
Other languages
English (en)
French (fr)
Other versions
CA2507774A1 (en
Inventor
Peter Maienfisch
Fiona Murphy Kessabi
Jerome Cassayre
Laura Quaranta
Thomas Pitterna
Ottmar Franz Hueter
Pierre Jung
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Animal Health USA Inc
Original Assignee
Merial LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merial LLC filed Critical Merial LLC
Publication of CA2507774A1 publication Critical patent/CA2507774A1/en
Application granted granted Critical
Publication of CA2507774C publication Critical patent/CA2507774C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/22—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom rings with more than six members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/10—Anthelmintics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA2507774A 2002-12-20 2003-12-19 Avermectin b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position Expired - Fee Related CA2507774C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB0229804.0 2002-12-20
GBGB0229804.0A GB0229804D0 (en) 2002-12-20 2002-12-20 Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
PCT/EP2003/014613 WO2004056844A1 (en) 2002-12-20 2003-12-19 Avermectin b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4”- or 4’-position

Publications (2)

Publication Number Publication Date
CA2507774A1 CA2507774A1 (en) 2004-07-08
CA2507774C true CA2507774C (en) 2011-06-14

Family

ID=9950151

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2507774A Expired - Fee Related CA2507774C (en) 2002-12-20 2003-12-19 Avermectin b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position

Country Status (22)

Country Link
US (3) US7737261B2 (https=)
EP (1) EP1581546B1 (https=)
JP (2) JP4851094B2 (https=)
KR (1) KR101109500B1 (https=)
CN (1) CN1738828B (https=)
AR (1) AR042533A1 (https=)
AU (1) AU2003302284B2 (https=)
BR (1) BR0317601A (https=)
CA (1) CA2507774C (https=)
CO (1) CO5690647A1 (https=)
ES (1) ES2742899T3 (https=)
GB (1) GB0229804D0 (https=)
IL (1) IL169092A (https=)
MA (1) MA27646A1 (https=)
MX (1) MXPA05006036A (https=)
PE (1) PE20040713A1 (https=)
PL (1) PL211483B1 (https=)
RU (1) RU2330857C2 (https=)
TW (1) TW200512214A (https=)
UA (1) UA81281C2 (https=)
WO (1) WO2004056844A1 (https=)
ZA (1) ZA200504353B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0229804D0 (en) * 2002-12-20 2003-01-29 Syngenta Participations Ag Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position
JP2010006703A (ja) * 2006-11-07 2010-01-14 Hokko Chem Ind Co Ltd アベルメクチンモノ配糖体誘導体
RU2453553C1 (ru) * 2011-05-11 2012-06-20 Игорь Викторович Заварзин 5-о-сукциноилавермектин, способ его получения и антипаразитарное средство на его основе
RU2472801C1 (ru) * 2011-05-11 2013-01-20 Игорь Викторович Заварзин 5-о-производные авермектина, способ их получения и антипаразитарные средства на их основе
CN103613625B (zh) * 2013-12-02 2016-03-02 兰州大学 一种阿维菌素类化合物及其制备方法和在农药中的用途
CN104402953B (zh) * 2014-11-28 2017-07-28 大庆志飞生物化工有限公司 阿维菌素单糖化合物及其制备方法和用途
CN104402954A (zh) * 2014-11-28 2015-03-11 大庆志飞生物化工有限公司 甲胺基阿维菌素单糖化合物及其制备方法和用途
JP6577184B2 (ja) 2014-12-24 2019-09-18 Ntn株式会社 転がり軸受
CN107501368B (zh) * 2017-09-30 2020-02-21 中国科学院成都生物研究所 一种多拉菌素衍生物的合成及其杀虫应用
CN113150053B (zh) * 2020-01-22 2024-10-01 华东理工大学 偶氮苯类阿维菌素衍生物及其制备方法和应用
CN113817008B (zh) * 2021-07-15 2023-05-23 湖州师范学院 新型琥珀酰基十六元大环内酯的制备方法及用途

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US87519A (en) * 1869-03-02 Improvement in furnace-stoves and registers
US18993A (en) * 1857-12-29 Cider-mill
US148520A (en) * 1874-03-10 Improvement in faucets
SE434277B (sv) 1976-04-19 1984-07-16 Merck & Co Inc Sett att framstella nya antihelmintiskt verkande foreningar genom odling av streptomyces avermitilis
US4874749A (en) * 1987-07-31 1989-10-17 Merck & Co., Inc. 4"-Deoxy-4-N-methylamino avermectin Bla/Blb
GB8811037D0 (en) 1988-05-10 1988-06-15 Glaxo Group Ltd Chemical compounds
EP0353959A2 (en) 1988-08-02 1990-02-07 Beecham Group Plc Antihelmintic macrolide antibiotics
SE465605B (sv) * 1990-02-26 1991-10-07 Harry Nilsson Skivfilter
JP2622197B2 (ja) 1990-03-01 1997-06-18 三共株式会社 １３−エーテル置換ミルベマイシン誘導体
US5169839A (en) * 1990-05-11 1992-12-08 Merck & Co., Inc. Derivatives of 3'- and 3"-o-desmethyl avermectin compounds, compositions and methods of treating melmintic and parasitic infections
US5262400A (en) * 1991-06-20 1993-11-16 Merck & Co., Inc. 4α-substituted avermectin derivatives
US5411737A (en) 1991-10-15 1995-05-02 Merck & Co., Inc. Slow release syneresing polymeric drug delivery device
US5602107A (en) 1993-05-10 1997-02-11 Merck & Co., Inc. Pour-on formulations consisting of gylcols, glycerides and avermectin compounds
PL174488B1 (pl) 1993-05-10 1998-08-31 Merck & Co Inc Preparat do zwalczania pasożytów zwierząt oraz sposób wytwarzania preparatu do zwalczania pasożytów zwierząt
CA2168843C (en) * 1993-08-19 2004-10-19 Raymond Cvetovich Thermodynamically stable crystal form of 4"-deoxy-4"-epi-methylamino avermectin b1a/b1b benzoic acid salt and processes for its preparation
US5436355A (en) 1994-02-03 1995-07-25 Merck & Co., Inc. Process for making avermectin/zein compositions
TW327125B (en) 1994-02-07 1998-02-21 Merck & Co Inc Composition and method for protecting against pine exhausted
WO2002012248A1 (en) 2000-08-09 2002-02-14 The Kitasato Institute Avermectin derivatives
JPWO2002012261A1 (ja) 2000-08-09 2004-01-15 社団法人北里研究所 エバーメクチン誘導体
EP1483580A4 (en) * 2002-03-05 2006-10-11 Merck & Co Inc BIOMARKERS FOR THE EFFICACY OF APPETIZERS
GB0229804D0 (en) 2002-12-20 2003-01-29 Syngenta Participations Ag Avermection b1 and avermectin b1 monosaccharide derivatives having an alkoxymethyl substituent in the 4"- or 4'-position

Also Published As

Publication number Publication date
MA27646A1 (fr) 2005-12-01
US7737261B2 (en) 2010-06-15
IL169092A0 (en) 2007-07-04
IL169092A (en) 2010-12-30
AU2003302284B2 (en) 2009-07-23
US20100210574A1 (en) 2010-08-19
US8263566B2 (en) 2012-09-11
KR101109500B1 (ko) 2012-01-31
RU2330857C2 (ru) 2008-08-10
WO2004056844A1 (en) 2004-07-08
PE20040713A1 (es) 2004-12-02
GB0229804D0 (en) 2003-01-29
PL377497A1 (pl) 2006-02-06
RU2005122943A (ru) 2006-01-20
JP2011102303A (ja) 2011-05-26
CN1738828A (zh) 2006-02-22
AU2003302284A1 (en) 2004-07-14
UA81281C2 (en) 2007-12-25
US20110230429A1 (en) 2011-09-22
US20060148729A1 (en) 2006-07-06
EP1581546A1 (en) 2005-10-05
CN1738828B (zh) 2012-09-05
JP4851094B2 (ja) 2012-01-11
JP5302297B2 (ja) 2013-10-02
CA2507774A1 (en) 2004-07-08
US8017589B2 (en) 2011-09-13
TW200512214A (en) 2005-04-01
AR042533A1 (es) 2005-06-22
EP1581546B1 (en) 2019-03-20
ZA200504353B (en) 2006-03-29
JP2006515849A (ja) 2006-06-08
KR20050088133A (ko) 2005-09-01
PL211483B1 (pl) 2012-05-31
CO5690647A1 (es) 2006-10-31
ES2742899T3 (es) 2020-02-17
MXPA05006036A (es) 2005-08-18
BR0317601A (pt) 2005-11-29

Similar Documents

Publication Publication Date Title
US8263566B2 (en) Avermectin B1 and avermectin B1 monosaccharide derivatives having an alkoxymethyl substituent in the 4″-or 4′-position
EP1594878B1 (en) Avermectin monosaccharide derivatives having pesticidal properties
EP1613639B1 (en) Avermectins substituted in the 4'' and 4´-positions having pesticidal properties
EP1592700B1 (en) Avermectin- and avermectin monosaccharide derivatives substituted in the 4''- or 4'- position having pesticidal properties
EP1660510B1 (en) Avermectins and avermectin monosaccharides substituted in the 4'- and 4'' position having pesticidal properties
EP1638984B1 (en) Avermectin b1 monosaccharide derivatives
EP1592701B1 (en) Avermectins and avermectin monosaccharides substituted in the 4'- and 4''- position having pesticidal properties

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20211220