CA2504259A1 - Medical devices having antimicrobial coatings thereon - Google Patents
Medical devices having antimicrobial coatings thereon Download PDFInfo
- Publication number
- CA2504259A1 CA2504259A1 CA002504259A CA2504259A CA2504259A1 CA 2504259 A1 CA2504259 A1 CA 2504259A1 CA 002504259 A CA002504259 A CA 002504259A CA 2504259 A CA2504259 A CA 2504259A CA 2504259 A1 CA2504259 A1 CA 2504259A1
- Authority
- CA
- Canada
- Prior art keywords
- medical device
- antimicrobial
- layer
- poly
- coating
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/25—Peptides having up to 20 amino acids in a defined sequence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
- A61L2300/608—Coatings having two or more layers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Surgery (AREA)
- Vascular Medicine (AREA)
- Materials For Medical Uses (AREA)
- Eyeglasses (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Paints Or Removers (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43063502P | 2002-12-03 | 2002-12-03 | |
| US60/430,635 | 2002-12-03 | ||
| PCT/EP2003/013598 WO2004050132A2 (en) | 2002-12-03 | 2003-12-02 | Medical devices having antimicrobial coatings thereon |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2504259A1 true CA2504259A1 (en) | 2004-06-17 |
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ID=32469502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002504259A Abandoned CA2504259A1 (en) | 2002-12-03 | 2003-12-02 | Medical devices having antimicrobial coatings thereon |
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| US (1) | US8172395B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP1569700B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2006508720A (cg-RX-API-DMAC7.html) |
| AT (1) | ATE348640T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2003298164A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2504259A1 (cg-RX-API-DMAC7.html) |
| DE (1) | DE60310611T2 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2004050132A2 (cg-RX-API-DMAC7.html) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103611181A (zh) * | 2013-10-25 | 2014-03-05 | 无锡灵锡医疗器械科技有限公司 | 一种抗菌肽水凝胶及其制备方法 |
Families Citing this family (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7282214B2 (en) * | 2002-12-19 | 2007-10-16 | Johnson & Johnson Vision Care, Inc. | Biomedical devices with antimicrobial coatings |
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| AU2005308920B2 (en) | 2004-11-29 | 2010-04-15 | Dsm Ip Assets B.V. | Method for reducing the amount of migrateables of polymer coatings |
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| TWI441835B (zh) | 2006-07-12 | 2014-06-21 | Novartis Ag | 新穎聚合物 |
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| US8809411B2 (en) * | 2007-02-28 | 2014-08-19 | Dsm Ip Assets B.V. | Hydrophilic coating |
| US7858337B2 (en) * | 2007-03-08 | 2010-12-28 | Novartis Ag | Process for the manufacture of a composite material |
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| US20090258045A1 (en) * | 2008-03-18 | 2009-10-15 | Massachusetts Institute Of Technology | Structures including antimicrobial peptides |
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| EP2318584A1 (en) * | 2008-08-13 | 2011-05-11 | Dow Global Technologies LLC | Process of fabricating peptide-coated fibers |
| US20100040879A1 (en) * | 2008-08-13 | 2010-02-18 | Koopmans Rudolf J | Peptide-coated fibers |
| JP5417843B2 (ja) * | 2008-12-26 | 2014-02-19 | 東レ株式会社 | 医療用材料 |
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| KR101413390B1 (ko) | 2010-07-30 | 2014-06-27 | 노파르티스 아게 | 수분이 풍부한 표면을 갖는 실리콘 히드로겔 렌즈 |
| US8672476B2 (en) * | 2011-03-24 | 2014-03-18 | Johnson & Johnson Vision Care, Inc. | Contact lenses with improved movement |
| CN103917899B (zh) | 2011-10-12 | 2018-04-03 | 诺华股份有限公司 | 通过涂布制备uv吸收性眼用透镜的方法 |
| EP2785296B1 (en) | 2011-12-02 | 2018-06-20 | AcuFocus, Inc. | Ocular mask having selective spectral transmission |
| US9395468B2 (en) | 2012-08-27 | 2016-07-19 | Ocular Dynamics, Llc | Contact lens with a hydrophilic layer |
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| US9204962B2 (en) | 2013-03-13 | 2015-12-08 | Acufocus, Inc. | In situ adjustable optical mask |
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| JP6338715B2 (ja) * | 2017-02-06 | 2018-06-06 | ナンヤン テクノロジカル ユニヴァーシティー | 眼用及び医療用の重合性組成物及びそれを重合して得られる抗菌性組成物 |
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| WO2019210414A1 (en) * | 2018-05-02 | 2019-11-07 | Arc Medical Devices Inc. | Fucan-based compounds and complexes |
| CN110585482B (zh) * | 2019-08-02 | 2022-03-01 | 大连理工大学 | 一种具有抗菌性能的杂萘联苯聚芳醚腈及其表面改性方法 |
| US12022583B2 (en) | 2020-07-10 | 2024-06-25 | Asiatelco Technologies, Inc. | Portable devices, systems and methods with automated heat control assembly |
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| US12416073B2 (en) | 2023-01-19 | 2025-09-16 | Institute For Plasma Research | Plasma based system for generating antimicrobial coating on flexible polymeric substrates and process thereof |
| CN118406273B (zh) * | 2024-05-29 | 2024-11-19 | 广东安拓普聚合物科技股份有限公司 | 一种医用导管用tpu材料及其生产工艺 |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1980002840A1 (en) | 1979-06-20 | 1980-12-24 | W Foley | Contact lenses with polymer bound asepticizing agents |
| US5171318A (en) * | 1987-11-09 | 1992-12-15 | Chiron Ophthalmics, Inc. | Treated corneal prosthetic device |
| US4933410A (en) * | 1989-03-29 | 1990-06-12 | Applied Immunesciences, Inc. | Covalent attachment of macromolecules on substrate surfaces |
| JPH0476518A (ja) * | 1990-07-19 | 1992-03-11 | Sangi Co Ltd | 抗菌性コンタクトレンズ |
| AU1259892A (en) | 1991-03-01 | 1992-10-06 | Warner-Lambert Company | Oral and personal hygiene articles containing active agents bonded to the surface thereof |
| EP0537774B1 (en) | 1991-10-18 | 1998-01-07 | Kuraray Co., Ltd. | Antimicrobial polymerizable composition, the polymer and article obtained from the same |
| TW243455B (cg-RX-API-DMAC7.html) | 1993-02-09 | 1995-03-21 | Ciba Geigy | |
| US6054504A (en) * | 1997-12-31 | 2000-04-25 | Hydromer, Inc. | Biostatic coatings for the reduction and prevention of bacterial adhesion |
| ES2200496T3 (es) * | 1998-01-09 | 2004-03-01 | Novartis Ag | Recubrimiento de polimeros. |
| MXPA00011767A (es) * | 1998-05-29 | 2002-10-17 | Lawrence A Lynn | Receptor luer y metodos para transferir fluidos. |
| US6482799B1 (en) | 1999-05-25 | 2002-11-19 | The Regents Of The University Of California | Self-preserving multipurpose ophthalmic solutions incorporating a polypeptide antimicrobial |
| WO2001056627A1 (en) | 2000-01-12 | 2001-08-09 | Am-Pharma B.V. | Medical device coated with antimicrobial peptides |
| US6719929B2 (en) * | 2000-02-04 | 2004-04-13 | Novartis Ag | Method for modifying a surface |
| US6793973B2 (en) | 2000-02-04 | 2004-09-21 | Novartis Ag | Single-dip process for achieving a layer-by-layer-like coating |
| AUPQ681200A0 (en) * | 2000-04-10 | 2000-05-11 | Unisearch Limited | Antimicrobial coatings |
| AR030282A1 (es) | 2000-05-30 | 2003-08-20 | Novartis Ag | Material compuesto, proceso para su fabricacion, dispositivo biomedico, y uso del material compuesto para la fabricacion de un dispositivo oftalmico |
| EP1294740A2 (en) * | 2000-06-16 | 2003-03-26 | Hercules Incorporated | Chemically-modified antimicrobial peptides, compositions and methods of production and use |
| WO2002040536A2 (en) | 2000-11-15 | 2002-05-23 | Emory University | Acylated antimicrobial peptides |
| EP1357954A1 (en) | 2001-02-09 | 2003-11-05 | Johnson & Johnson Vision Care, Inc. | Biomedical devices with antimicrobial cationic peptide coatings |
| EP1368050B1 (en) * | 2001-02-16 | 2008-08-20 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Virus derived antimicrobial peptides |
| WO2002085542A1 (en) * | 2001-04-23 | 2002-10-31 | Massachusetts Institute Of Technology | Antimicrobial polymeric surfaces |
| US6702983B2 (en) | 2001-05-15 | 2004-03-09 | Bausch & Lomb Incorporated | Low ionic strength method and composition for reducing bacterial attachment to biomaterials |
| US6835410B2 (en) | 2001-05-21 | 2004-12-28 | Novartis Ag | Bottle-brush type coatings with entangled hydrophilic polymer |
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- 2003-12-02 DE DE60310611T patent/DE60310611T2/de not_active Expired - Lifetime
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- 2003-12-02 AU AU2003298164A patent/AU2003298164A1/en not_active Abandoned
- 2003-12-02 WO PCT/EP2003/013598 patent/WO2004050132A2/en not_active Ceased
- 2003-12-02 JP JP2004556275A patent/JP2006508720A/ja active Pending
- 2003-12-02 EP EP03795870A patent/EP1569700B1/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103611181A (zh) * | 2013-10-25 | 2014-03-05 | 无锡灵锡医疗器械科技有限公司 | 一种抗菌肽水凝胶及其制备方法 |
| CN103611181B (zh) * | 2013-10-25 | 2015-06-17 | 无锡灵锡医疗器械科技有限公司 | 一种抗菌肽水凝胶及其制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| DE60310611D1 (de) | 2007-02-01 |
| JP2006508720A (ja) | 2006-03-16 |
| US20040135967A1 (en) | 2004-07-15 |
| EP1569700A2 (en) | 2005-09-07 |
| WO2004050132A2 (en) | 2004-06-17 |
| US8172395B2 (en) | 2012-05-08 |
| AU2003298164A1 (en) | 2004-06-23 |
| AU2003298164A8 (en) | 2004-06-23 |
| ATE348640T1 (de) | 2007-01-15 |
| EP1569700B1 (en) | 2006-12-20 |
| WO2004050132A3 (en) | 2004-10-14 |
| DE60310611T2 (de) | 2007-10-25 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |