CA2497333A1 - Derives de pyrazole utilises en tant qu'inhibiteurs de la transcriptase inverse - Google Patents

Derives de pyrazole utilises en tant qu'inhibiteurs de la transcriptase inverse Download PDF

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Publication number
CA2497333A1
CA2497333A1 CA002497333A CA2497333A CA2497333A1 CA 2497333 A1 CA2497333 A1 CA 2497333A1 CA 002497333 A CA002497333 A CA 002497333A CA 2497333 A CA2497333 A CA 2497333A CA 2497333 A1 CA2497333 A1 CA 2497333A1
Authority
CA
Canada
Prior art keywords
alkyl
formula
cycloalkyl
compound
halo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002497333A
Other languages
English (en)
Inventor
Oscar Barba
Lyn Howard Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0222374A external-priority patent/GB0222374D0/en
Priority claimed from GB0223356A external-priority patent/GB0223356D0/en
Application filed by Individual filed Critical Individual
Publication of CA2497333A1 publication Critical patent/CA2497333A1/fr
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/28—Two oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention concerne des dérivés de pyrazole représentés par la formule (I) ou des sels, des solvates, ou des dérivés pharmaceutiquement acceptables de ceux-ci; dans la formule, R' à R4 sont tels que définis dans la description. Cette invention concerne également des procédés de préparation, des produits intermédiaires utilisés lors de la préparation de ces dérivés de pyrazole, des compositions les contenant ainsi que les utilisations de tels dérivés. Les composés décrits dans cette invention se fixent à la transcriptase inverse, et sont des modulateurs, plus spécifiquement des inhibiteurs. Ces composés sont utilisés pour le traitement de divers troubles, y compris ceux impliquant l'inhibition de la transcriptase inverse. Entre autres troubles concernés, figurent ceux causés par le virus de l'immunodéficience humaine (VIH) et des rétrovirus génétiquement associés, tels que le syndrome d'immunodéficience acquise (SIDA).
CA002497333A 2002-09-26 2003-09-15 Derives de pyrazole utilises en tant qu'inhibiteurs de la transcriptase inverse Abandoned CA2497333A1 (fr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB0222374A GB0222374D0 (en) 2002-09-26 2002-09-26 Chemical compounds
GB0222374.1 2002-09-26
GB0223356.7 2002-10-08
GB0223356A GB0223356D0 (en) 2002-10-08 2002-10-08 Chemical compounds
PCT/IB2003/004158 WO2004029042A1 (fr) 2002-09-26 2003-09-15 Derives de pyrazole utilises en tant qu'inhibiteurs de la transcriptase inverse

Publications (1)

Publication Number Publication Date
CA2497333A1 true CA2497333A1 (fr) 2004-04-08

Family

ID=32044462

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002497333A Abandoned CA2497333A1 (fr) 2002-09-26 2003-09-15 Derives de pyrazole utilises en tant qu'inhibiteurs de la transcriptase inverse

Country Status (7)

Country Link
EP (1) EP1546132A1 (fr)
JP (1) JP2006504803A (fr)
AU (1) AU2003260908A1 (fr)
BR (1) BR0314709A (fr)
CA (1) CA2497333A1 (fr)
MX (1) MXPA05003195A (fr)
WO (1) WO2004029042A1 (fr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2658984C (fr) 2006-08-16 2014-12-02 Joshua Kennedy-Smith Inhibiteurs de la transcriptase inverse non nucleoside
KR20100039348A (ko) 2007-06-22 2010-04-15 에프. 호프만-라 로슈 아게 비-뉴클레오사이드 역 전사효소 억제제로서 우레아 및 카바메이트 유도체
ES2526649T3 (es) 2007-12-21 2015-01-14 F. Hoffmann-La Roche Ag Compuestos heterocíclicos antivíricos
JO3637B1 (ar) 2015-04-28 2020-08-27 Janssen Sciences Ireland Uc مركبات بيرازولو- وترايازولو- بيريميدين مضادة للفيروسات rsv
TW201932470A (zh) 2017-11-29 2019-08-16 愛爾蘭商健生科學愛爾蘭無限公司 具有抗ｒｓｖ活性之吡唑并嘧啶
CA3087926A1 (fr) 2018-01-31 2019-08-08 Janssen Sciences Ireland Unlimited Company Pyrazolopyrimidines substituees par cycloalkyle ayant une activite contre le vrs
SG11202010323QA (en) 2018-04-23 2020-11-27 Janssen Sciences Ireland Unlimited Co Heteroaromatic compounds having activity against rsv

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3419391A (en) * 1965-05-24 1968-12-31 Eastman Kodak Co Silver halide color photography utilizing magenta-dye-forming couplers
DK169672B1 (da) * 1985-05-20 1995-01-09 Mitsubishi Chem Ind Farmaceutiske præparater indeholdende pyrazolonderivater som aktiv bestanddel og anvendelsen af pyrazolonderivater til fremstilling af farmaceutiske præparater
JPH0667838B2 (ja) * 1985-12-25 1994-08-31 三菱化成株式会社 過酸化脂質生成抑制剤
JPH01125379A (ja) * 1987-11-10 1989-05-17 Sumitomo Chem Co Ltd 置換ピラゾール誘導体、その製造方法およびそれを有効成分とする農園芸用殺菌剤
JPH03500542A (ja) * 1988-05-09 1991-02-07 ビーチャム　グループ　ピーエルシー 新規な化合物及び治療法
JPH03141276A (ja) * 1989-10-24 1991-06-17 Nissan Chem Ind Ltd 置換ピラゾール誘導体および農園芸用殺菌剤
US5189040A (en) * 1990-05-28 1993-02-23 Sumitomo Chemical Company, Limited Pyrazole derivatives, method for producing the same and agricultural and/or horticultural fungicides containing the same as active ingredient
US5447831A (en) * 1993-10-19 1995-09-05 Eastman Kodak Company Photographic element employing hue correction couplers
US6365334B1 (en) * 1993-10-22 2002-04-02 Eastman Kodak Company Photographic elements containing aryloxypyrazolone couplers and sulfur containing stabilizers
GB0024795D0 (en) * 2000-10-10 2000-11-22 Hoffmann La Roche Pyrazole derivatives for the treatment of viral diseases

Also Published As

Publication number Publication date
AU2003260908A1 (en) 2004-04-19
JP2006504803A (ja) 2006-02-09
EP1546132A1 (fr) 2005-06-29
WO2004029042A1 (fr) 2004-04-08
MXPA05003195A (es) 2005-06-08
BR0314709A (pt) 2005-07-26

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FZDE Dead