CA2495784A1 - Furanone derivatives and methods of making same - Google Patents

Furanone derivatives and methods of making same Download PDF

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Publication number
CA2495784A1
CA2495784A1 CA002495784A CA2495784A CA2495784A1 CA 2495784 A1 CA2495784 A1 CA 2495784A1 CA 002495784 A CA002495784 A CA 002495784A CA 2495784 A CA2495784 A CA 2495784A CA 2495784 A1 CA2495784 A1 CA 2495784A1
Authority
CA
Canada
Prior art keywords
substituted
unsubstituted
compound
halogen
arylalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002495784A
Other languages
English (en)
French (fr)
Inventor
Naresh Kumar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Biosignal Australia Pty Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2495784A1 publication Critical patent/CA2495784A1/en
Abandoned legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
    • A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
    • A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
    • A01N43/08—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings with oxygen as the ring hetero atom
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
    • A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
    • A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Disinfection or sterilisation of materials or objects, in general; Accessories therefor
    • A61L2/16—Disinfection or sterilisation of materials or objects, in general; Accessories therefor using chemical substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/38—2-Pyrrolones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/60—Two oxygen atoms, e.g. succinic anhydride
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/66—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Environmental Sciences (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Absorbent Articles And Supports Therefor (AREA)
  • Pyrrole Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Furan Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Cultivation Of Plants (AREA)
  • Pretreatment Of Seeds And Plants (AREA)
CA002495784A 2002-08-19 2003-08-19 Furanone derivatives and methods of making same Abandoned CA2495784A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2002950862A AU2002950862A0 (en) 2002-08-19 2002-08-19 Furanone derivatives and methods of making same
AU2002950862 2002-08-19
PCT/AU2003/001053 WO2004016588A1 (en) 2002-08-19 2003-08-19 Furanone derivatives and methods of making same

Publications (1)

Publication Number Publication Date
CA2495784A1 true CA2495784A1 (en) 2004-02-26

Family

ID=27809947

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002495784A Abandoned CA2495784A1 (en) 2002-08-19 2003-08-19 Furanone derivatives and methods of making same

Country Status (7)

Country Link
US (1) US20050215772A1 (https=)
EP (1) EP1539692A4 (https=)
JP (1) JP2006514610A (https=)
CN (1) CN1688543A (https=)
AU (1) AU2002950862A0 (https=)
CA (1) CA2495784A1 (https=)
WO (1) WO2004016588A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007133777A1 (en) * 2006-05-15 2007-11-22 Tyco Healthcare Group Lp Furanone endcapped polymers
WO2007133781A3 (en) * 2006-05-15 2008-05-08 Tyco Healthcare Furanone-initiated polymers

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200602665B (en) * 2003-12-05 2007-07-25 Biosignal Ltd Association of antimicrobial compounds with surfaces and polymer
CA2596480A1 (en) * 2005-02-04 2006-08-10 Wisconsin Alumni Research Foundation Compounds and methods for modulating communication and virulence in quorum sensing bacteria
JP4969065B2 (ja) * 2005-07-13 2012-07-04 株式会社 メドレックス 常温性イオン性液体を含有する医薬組成物
KR101347278B1 (ko) * 2006-01-24 2014-01-03 바이오시그널 리미티드 신규한 락탐 화합물
AU2015200142B2 (en) * 2006-01-24 2016-07-07 Unilever Plc Novel lactams
WO2008040097A1 (en) * 2006-10-06 2008-04-10 Biosignal Limited Furanone compounds and lactam analogues thereof
US20100209411A1 (en) 2006-12-01 2010-08-19 Laclede, Inc. Use of hydrolytic and oxidative enzymes to dissolve biofilm in ears
EP2136800A4 (en) * 2007-03-19 2011-10-05 Wisconsin Alumni Res Found MODULATION OF BACTERIAL QUORUM DETECTION WITH SYNTHETIC LIGANDS
CN101503397B (zh) * 2009-03-23 2012-07-18 暨南大学 卤代呋喃酮化合物及其在制备抗感染药物上的应用
US8624063B2 (en) 2009-06-30 2014-01-07 Wisconsin Alumni Research Foundation Non-lactone carbocyclic and heterocyclic antagonists and agonists of bacterial quorum sensing
EP2425862B1 (de) * 2010-09-07 2012-08-29 Miele & Cie. KG Verfahren zur Reinigung und thermischen Desinfektion von Spülgut
CN102002024B (zh) * 2010-11-19 2012-10-10 吉首大学 3-芳基-4-芳氨基-2（5h）-呋喃酮型化合物及其制法和用途
EP3345596B1 (en) * 2012-09-21 2021-01-20 Rhode Island Hospital Inhibitors of beta-hydrolase for treatment of cancer
EP2950645B1 (en) * 2013-02-01 2020-10-21 Unilever PLC Antimicrobial composition comprising a lactam and a hydrotrope
WO2014183164A1 (en) * 2013-05-17 2014-11-20 Naresh Kumar Dihydropyrrolones and their use as antimicrobial agents
WO2016176146A1 (en) * 2015-04-26 2016-11-03 The Trustees Of Princeton University Surfaces comprising attached quorum sensing modulators
CN107920977A (zh) * 2015-08-20 2018-04-17 荷兰联合利华有限公司 内酰胺组合物
WO2017029092A1 (en) * 2015-08-20 2017-02-23 Unilever Plc Improved lactam solubility
TR201901410T4 (tr) * 2015-08-20 2019-02-21 Unilever Nv Geliştirilmiş Laktam Çözünürlüğü
CN107920979A (zh) * 2015-08-20 2018-04-17 荷兰联合利华有限公司 改善的内酰胺溶解度
CN108024939B (zh) 2015-08-20 2024-06-07 联合利华知识产权控股有限公司 包封的内酰胺
EP3337454B1 (en) 2015-08-20 2018-12-26 Unilever Plc. Improved lactam solubility
CN109475526A (zh) * 2016-07-21 2019-03-15 荷兰联合利华有限公司 用于治疗呼吸道感染的内酰胺
WO2018015278A1 (en) 2016-07-21 2018-01-25 Unilever Plc Lactams for use in the treatment of skin lesions
EP3487496B1 (en) 2016-07-21 2026-04-08 Unilever IP Holdings B.V. 4-(4-chlorophenyl)-5-methylene-pyrrol-2-one and 5-methylene-4-(p-tolyl)pyrrol-2-one for use in the treatment of gram negative bacterial infections
CN106518818B (zh) * 2016-10-14 2018-07-27 宁波大学 一种呋喃酮类化合物及其制备方法和用途
BR112019010110A2 (pt) 2016-11-17 2019-08-20 Unilever Nv composição de lactama e uso da composição farmacêutica
BR112019010124A2 (pt) 2016-11-17 2019-08-20 Unilever Nv composições de lactama e usos da composição farmacêutica
US10526278B2 (en) 2017-10-19 2020-01-07 Wisconsin Alumni Research Foundation Inhibitors of quorum sensing receptor LasR
RU2691634C2 (ru) * 2017-11-27 2019-06-17 Федеральное Государственное бюджетное научное учреждение Всероссийский научно-исследовательский институт мясного скотоводства СПОСОБ ПРИМЕНЕНИЯ ГАММА-ОКТАЛАКТОНА В КАЧЕСТВЕ ИНГИБИТОРА СИСТЕМЫ "КВОРУМ СЕНСИНГА" LuxI/LuxR ТИПА У БАКТЕРИЙ
CN109705068A (zh) * 2019-02-27 2019-05-03 重庆医药高等专科学校 原白头翁素合成方法
US20230148597A1 (en) * 2020-04-21 2023-05-18 Conopco, Inc., D/B/A Unilever Varnish
WO2021259819A1 (en) * 2020-06-23 2021-12-30 Akzo Nobel Coatings International B.V. Radiation-curable coating composition, method of coating a substrate and coated substrate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3755356A (en) * 1969-11-06 1973-08-28 Zoecon Corp Substituted crotonic amide ypsilon-lactams
AUPM666694A0 (en) * 1994-07-06 1994-07-28 Unisearch Limited Natural antifouling compositions
AUPQ841900A0 (en) * 2000-06-28 2000-07-20 Unisearch Limited Synthesis of cyclic compounds

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007133777A1 (en) * 2006-05-15 2007-11-22 Tyco Healthcare Group Lp Furanone endcapped polymers
WO2007133781A3 (en) * 2006-05-15 2008-05-08 Tyco Healthcare Furanone-initiated polymers
US7851526B2 (en) 2006-05-15 2010-12-14 Tyco Healthcare Group Lp Furanone-initiated polymers
US8071691B2 (en) 2006-05-15 2011-12-06 Tyco Healthcare Group Lp Furanone endcapped polymers
AU2007249766B2 (en) * 2006-05-15 2012-08-23 Covidien Lp Furanone endcapped polymers
AU2007249679B2 (en) * 2006-05-15 2012-11-01 Covidien Lp Furanone-initiated polymers

Also Published As

Publication number Publication date
CN1688543A (zh) 2005-10-26
US20050215772A1 (en) 2005-09-29
AU2002950862A0 (en) 2002-09-12
EP1539692A4 (en) 2005-08-24
JP2006514610A (ja) 2006-05-11
EP1539692A1 (en) 2005-06-15
WO2004016588A1 (en) 2004-02-26

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued