CA2492685A1 - Mutants de paroi cellulaire pour la delivrance de composes biologiquement actifs - Google Patents
Mutants de paroi cellulaire pour la delivrance de composes biologiquement actifs Download PDFInfo
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- CA2492685A1 CA2492685A1 CA002492685A CA2492685A CA2492685A1 CA 2492685 A1 CA2492685 A1 CA 2492685A1 CA 002492685 A CA002492685 A CA 002492685A CA 2492685 A CA2492685 A CA 2492685A CA 2492685 A1 CA2492685 A1 CA 2492685A1
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- lactobacillus
- recombinant
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- bacterium
- cell wall
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/104—Aminoacyltransferases (2.3.2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
- A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1051—Hexosyltransferases (2.4.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/90—Isomerases (5.)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5156—Animal cells expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pathology (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Toxicology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
La présente invention a trait à un micro-organisme recombinant comportant une mutation modulant l'expression d'un gène impliqué dans la biosynthèse, la modification ou la dégradation d'un constituant de paroi cellulaire ou exprimant un gène étranger perturbant la biosynthèse, la modification ou la dégradation d'un constituant de paroi cellulaire et comportant un vecteur d'expression conduisant à la production d'un polypeptide présentant une activité prophylactique ou thérapeutique. L'invention a également trait à un procédé permettant la délivrance de polypeptides à des muqueuses, comprenant l'administration à une muqueuse d'un sujet (humain ou animal) d'une composition comportant un micro-organisme recombinant comportant une mutation modulant l'expression d'un gène impliqué dans la biosynthèse, la modification ou la dégradation d'un constituant de paroi cellulaire ou exprimant un gène étranger perturbant la biosynthèse, la modification ou la dégradation d'un constituant de paroi cellulaire et dans lequel le polypeptide à délivrer est produit par ledit micro-organisme recombinant.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP02447119.5 | 2002-06-18 | ||
| EP02447119 | 2002-06-18 | ||
| PCT/EP2003/006523 WO2003106685A1 (fr) | 2002-06-18 | 2003-06-18 | Mutants de paroi cellulaire pour la delivrance de composes biologiquement actifs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2492685A1 true CA2492685A1 (fr) | 2003-12-24 |
Family
ID=29724619
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002492685A Abandoned CA2492685A1 (fr) | 2002-06-18 | 2003-06-18 | Mutants de paroi cellulaire pour la delivrance de composes biologiquement actifs |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1523559A1 (fr) |
| AU (1) | AU2003249855B2 (fr) |
| CA (1) | CA2492685A1 (fr) |
| WO (1) | WO2003106685A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006304382A1 (en) * | 2005-10-14 | 2007-04-26 | The Johns Hopkins School Of Medicine | Reduction and prevention of cell-associated HIV transepithelial migration, microbides and other formulations and methods |
| CN114958896B (zh) * | 2021-11-12 | 2023-06-27 | 淮阴师范学院 | 一种提高乳酸片球菌的电转化效率的方法 |
| CN114558125B (zh) * | 2021-12-30 | 2024-02-20 | 厦门大学附属心血管病医院 | 一种尿素酶驱动中性粒细胞递药系统及其合成方法 |
| CN114836458B (zh) * | 2022-05-12 | 2024-04-02 | 天津大学 | 增强鲫希瓦氏菌核黄素合成促进mo降解和电能回收方法 |
| CN117746994B (zh) * | 2024-02-20 | 2024-04-26 | 济宁职业技术学院 | 一种基于数据分析的菌棒成熟度判定方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1084709A1 (fr) * | 1999-09-17 | 2001-03-21 | Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek Tno | Vaccin oral contenant des Lactobacilli recombinés |
| US6929799B2 (en) * | 2001-12-18 | 2005-08-16 | Board Of Regents University Of Nebraska-Lincoln | D-alanine racemase mutants of mycobacteria and uses therefore |
-
2003
- 2003-06-18 AU AU2003249855A patent/AU2003249855B2/en not_active Ceased
- 2003-06-18 WO PCT/EP2003/006523 patent/WO2003106685A1/fr active Search and Examination
- 2003-06-18 EP EP03759974A patent/EP1523559A1/fr not_active Ceased
- 2003-06-18 CA CA002492685A patent/CA2492685A1/fr not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003106685A1 (fr) | 2003-12-24 |
| AU2003249855A1 (en) | 2003-12-31 |
| EP1523559A1 (fr) | 2005-04-20 |
| AU2003249855B2 (en) | 2008-07-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| FZDE | Discontinued |