CA2485268A1 - Formulation pharmaceutique resorbable destinee a la liberation continue de thrombine - Google Patents

Formulation pharmaceutique resorbable destinee a la liberation continue de thrombine Download PDF

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Publication number
CA2485268A1
CA2485268A1 CA002485268A CA2485268A CA2485268A1 CA 2485268 A1 CA2485268 A1 CA 2485268A1 CA 002485268 A CA002485268 A CA 002485268A CA 2485268 A CA2485268 A CA 2485268A CA 2485268 A1 CA2485268 A1 CA 2485268A1
Authority
CA
Canada
Prior art keywords
resorbable
pharmaceutical formulation
thrombin
formulation according
collagen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002485268A
Other languages
English (en)
Inventor
Frank Gerhards
Rui-Miguel Pereira-Paz
Doris Klee
Hartwig Hoecker
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Rheinisch Westlische Technische Hochschuke RWTH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rheinisch Westlische Technische Hochschuke RWTH filed Critical Rheinisch Westlische Technische Hochschuke RWTH
Publication of CA2485268A1 publication Critical patent/CA2485268A1/fr
Abandoned legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A61L15/325—Collagen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Materials Engineering (AREA)
  • Dispersion Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des formulations pharmaceutiques résorbables destinées à la libération continue locale de thrombine. La thrombine est enrobée dans des sphères en polymère résorbable, les sphères étant incorporées dans une éponge de collagène. La formulation selon l'invention propose un hémostyptique résorbable destiné à être utilisé en chirurgie, notamment en chirurgie dentaire dans le cas d'interventions dento-alvéolaires.
CA002485268A 2002-05-08 2003-05-05 Formulation pharmaceutique resorbable destinee a la liberation continue de thrombine Abandoned CA2485268A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10220030.0 2002-05-08
DE10220030 2002-05-08
PCT/EP2003/004680 WO2003094983A1 (fr) 2002-05-08 2003-05-05 Formulation pharmaceutique resorbable destinee a la liberation continue de thrombine

Publications (1)

Publication Number Publication Date
CA2485268A1 true CA2485268A1 (fr) 2003-11-20

Family

ID=29413701

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002485268A Abandoned CA2485268A1 (fr) 2002-05-08 2003-05-05 Formulation pharmaceutique resorbable destinee a la liberation continue de thrombine

Country Status (4)

Country Link
EP (1) EP1501558A1 (fr)
AU (1) AU2003232257A1 (fr)
CA (1) CA2485268A1 (fr)
WO (1) WO2003094983A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104163779A (zh) * 2014-06-06 2014-11-26 浙江工业大学 一种管式连续化制备亚硫酸氢钠甲萘醌的方法
US9283187B2 (en) 2011-04-27 2016-03-15 Biom'up Hemostatic compositions
CN111053944A (zh) * 2019-11-28 2020-04-24 中国科学院大学温州研究院(温州生物材料与工程研究所) 一种载凝血酶微球-膨胀海绵复合止血材料及其制备方法及应用
US11052172B2 (en) 2016-08-12 2021-07-06 Biom'up France SAS Hemostatic flowable

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2259803B2 (fr) 2008-02-29 2019-03-13 Ferrosan Medical Devices A/S Dispositif pour la promotion de l homéostasie et/ou la cicatrisation des plaies
CA2865349C (fr) 2012-03-06 2021-07-06 Ferrosan Medical Devices A/S Recipient mis sous pression contenant de la pate hemostatique
CA2874290C (fr) 2012-06-12 2020-02-25 Ferrosan Medical Devices A/S Composition hemostatique seche
US9724078B2 (en) 2013-06-21 2017-08-08 Ferrosan Medical Devices A/S Vacuum expanded dry composition and syringe for retaining same
CA2928963C (fr) 2013-12-11 2020-10-27 Ferrosan Medical Devices A/S Composition seche comprenant un ameliorateur d'extrusion
CN106999621B (zh) 2014-10-13 2020-07-03 弗罗桑医疗设备公司 用于止血和伤口愈合的干组合物
US10653837B2 (en) 2014-12-24 2020-05-19 Ferrosan Medical Devices A/S Syringe for retaining and mixing first and second substances
EP3316930B1 (fr) 2015-07-03 2019-07-31 Ferrosan Medical Devices A/S Seringue destinée à mélanger deux composants et à maintenir un vide dans une condition de stockage
KR20210008479A (ko) 2018-05-09 2021-01-22 훼로산 메디칼 디바이스 에이/에스 지혈 조성물을 제조하는 방법
CN114159623B (zh) * 2020-12-12 2022-11-08 复旦大学 一种自抗凝弹性体材料及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4515637A (en) * 1983-11-16 1985-05-07 Seton Company Collagen-thrombin compositions
DE69724243T2 (de) * 1996-04-04 2004-06-17 Baxter Ag Blutstillender schwamm auf kollagenbasis
EP1053753A1 (fr) * 1999-05-19 2000-11-22 Resorba Chirurgisches Nahtmaterial Franz Hiltner GmbH & Co. Support de médicaments à utilisation locale

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9283187B2 (en) 2011-04-27 2016-03-15 Biom'up Hemostatic compositions
US9662374B2 (en) 2011-04-27 2017-05-30 Biom'up Hemostatic compositions
US10046034B2 (en) 2011-04-27 2018-08-14 Biom'up Hemostatic compositions
US10342856B2 (en) 2011-04-27 2019-07-09 Biom'up Hemostatic compostions
CN104163779A (zh) * 2014-06-06 2014-11-26 浙江工业大学 一种管式连续化制备亚硫酸氢钠甲萘醌的方法
CN104163779B (zh) * 2014-06-06 2016-04-13 浙江工业大学 一种管式连续化制备亚硫酸氢钠甲萘醌的方法
US11052172B2 (en) 2016-08-12 2021-07-06 Biom'up France SAS Hemostatic flowable
CN111053944A (zh) * 2019-11-28 2020-04-24 中国科学院大学温州研究院(温州生物材料与工程研究所) 一种载凝血酶微球-膨胀海绵复合止血材料及其制备方法及应用

Also Published As

Publication number Publication date
EP1501558A1 (fr) 2005-02-02
WO2003094983A1 (fr) 2003-11-20
AU2003232257A1 (en) 2003-11-11

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Legal Events

Date Code Title Description
FZDE Discontinued