CA2483102C - Treatment and prevention of pulmonary conditions - Google Patents
Treatment and prevention of pulmonary conditions Download PDFInfo
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- CA2483102C CA2483102C CA2483102A CA2483102A CA2483102C CA 2483102 C CA2483102 C CA 2483102C CA 2483102 A CA2483102 A CA 2483102A CA 2483102 A CA2483102 A CA 2483102A CA 2483102 C CA2483102 C CA 2483102C
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Classifications
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- A61K38/55—Protease inhibitors
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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Landscapes
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| AU2004296206A1 (en) * | 2003-12-04 | 2005-06-23 | The Scripps Research Institute | Treatment and preventions of asthma |
| WO2005073246A2 (en) * | 2004-01-20 | 2005-08-11 | Discovery Laboratories, Inc. | Method for preparing kl4 lung surfactant |
| WO2005087249A1 (ja) * | 2004-03-11 | 2005-09-22 | Kurume University | プロテアーゼ阻害剤及び疾患の予防又は治療剤 |
| US7553810B2 (en) | 2004-06-16 | 2009-06-30 | Pneumrx, Inc. | Lung volume reduction using glue composition |
| US7608579B2 (en) | 2004-06-16 | 2009-10-27 | Pneumrx, Inc. | Lung volume reduction using glue compositions |
| US7678767B2 (en) | 2004-06-16 | 2010-03-16 | Pneumrx, Inc. | Glue compositions for lung volume reduction |
| US7468350B2 (en) | 2004-06-16 | 2008-12-23 | Pneumrx, Inc. | Glue composition for lung volume reduction |
| CA2570261C (en) | 2004-07-08 | 2014-06-10 | Pneumrx, Inc. | Pleural effusion treatment device, method and material |
| KR101241434B1 (ko) * | 2004-09-10 | 2013-03-12 | 파마오리진 에이피에스 | 국소 기관, 기관지 또는 폐포의 출혈 또는 객혈의 치료방법 |
| US8337815B2 (en) * | 2004-12-23 | 2012-12-25 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations |
| CN101094651B (zh) * | 2004-12-30 | 2011-03-09 | 多贝尔有限公司 | 含有胶原凝集素家族蛋白质或者其变体的喷雾干燥的组合物和其制备方法 |
| GB0510463D0 (en) * | 2005-05-23 | 2005-06-29 | Britania Pharmaceuticals Ltd | Improvements in or relating to organic materials |
| CN101262880A (zh) * | 2005-06-24 | 2008-09-10 | 德拉格雷丘尔公司 | 在影响呼吸道的炎症病状中气道施用组织因子途径抑制物 |
| WO2007005672A2 (en) * | 2005-06-30 | 2007-01-11 | The Scripps Research Institute | Treatment and prevention of respiratory diseases and conditions |
| EP2142196A4 (en) | 2007-03-29 | 2010-06-30 | Nat Jewish Health | SURFACTANTLIPIDS, COMPOSITIONS AND THEIR USE |
| EP1997502A1 (en) * | 2007-06-01 | 2008-12-03 | CHIESI FARMACEUTICI S.p.A. | Reconstituted surfactants having improved properties |
| EP2170270B1 (en) * | 2007-06-05 | 2016-01-13 | Paka Pulmonary Pharmaceuticals, Inc. | Compositions for delivering medicaments into the lungs, uses thereof |
| EP2227085A4 (en) * | 2007-12-06 | 2013-10-09 | Berg Pharma Llc | INGREDIBLE COMPOSITIONS WITH INCREASED BIOLOGICAL AVAILABILITY |
| GB0724772D0 (en) * | 2007-12-19 | 2008-01-30 | Ucl Business Plc | Carrier |
| EP2370068A4 (en) | 2008-12-10 | 2015-09-23 | Paka Pulmonary Pharmaceuticals Inc | METHOD AND COMPOSITIONS FOR DELIVERING MEDICAMENTS TO THE LUNG |
| CN102300582A (zh) | 2009-01-30 | 2011-12-28 | 阿尔法贝塔公司 | 用于治疗阿尔茨海默病的化合物和方法 |
| US8434479B2 (en) | 2009-02-27 | 2013-05-07 | Covidien Lp | Flow rate compensation for transient thermal response of hot-wire anemometers |
| JP5622728B2 (ja) * | 2009-08-06 | 2014-11-12 | 一般財団法人化学及血清療法研究所 | 咳嗽抑制効果を持つ血漿タンパク質 |
| EP2308489B1 (en) | 2009-10-05 | 2014-01-01 | Nutri-Fit GmbH & Co. KG | Compositions for use in treating or preventing metabolic stress-induced lung injury and methods for increasing physical capacity of mammalian livestock |
| NZ599783A (en) * | 2009-11-03 | 2013-10-25 | Grifols Therapeutics Inc | Composition and use for alpha-1 proteinase inhibitor |
| KR101567901B1 (ko) | 2009-11-24 | 2015-11-10 | 그리폴스 테라퓨틱스 인코포레이티드 | 동결건조 방법, 조성물, 및 키트 |
| GB201003559D0 (en) * | 2010-03-03 | 2010-04-21 | Proteo Biotech Ag | Novel use of elafin |
| US11400058B2 (en) | 2010-03-12 | 2022-08-02 | Berg Llc | Intravenous formulations of coenzyme Q10 (CoQ10) and methods of use thereof |
| WO2011162655A1 (en) | 2010-06-24 | 2011-12-29 | Alphabeta Ab | Compound and method for treatment of alzheimer's disease and familial dementia |
| CN101897720B (zh) * | 2010-07-27 | 2015-09-09 | 北京华禧联合科技发展有限公司 | 一种治疗呼吸道疾病的药物组合物 |
| WO2012061750A2 (en) * | 2010-11-04 | 2012-05-10 | The Board Of Regents Of The University Of Oklahoma | Peptide compositions that downregulate tlr-4 signaling pathway and methods of producing and using same |
| US20130184202A1 (en) * | 2011-02-08 | 2013-07-18 | Changjiang Guo | Peptide Inhibitors and Methods of Use Thereof |
| EP2694977B1 (en) | 2011-04-05 | 2016-06-29 | Alphabeta AB | Amyloidosis target useful in methods of screening of compounds |
| ES2711670T3 (es) | 2011-04-12 | 2019-05-06 | Moerae Matrix Inc | Composiciones y métodos para la prevención o tratamiento de la fibrosis pulmonar |
| US9890200B2 (en) | 2011-04-12 | 2018-02-13 | Moerae Matrix, Inc. | Compositions and methods for preventing or treating diseases, conditions, or processes characterized by aberrant fibroblast proliferation and extracellular matrix deposition |
| EA201490047A1 (ru) | 2011-06-17 | 2014-08-29 | Берг Ллк | Ингаляционные фармацевтические композиции |
| US9089657B2 (en) | 2011-10-31 | 2015-07-28 | Covidien Lp | Methods and systems for gating user initiated increases in oxygen concentration during ventilation |
| WO2013188016A2 (en) * | 2012-05-04 | 2013-12-19 | Discovery Laboratories, Inc. | Surfactant therapy for exposure to ionizing radiation |
| CN105745223A (zh) | 2013-09-18 | 2016-07-06 | 詹姆斯库克大学 | 修饰的抗炎蛋白及使用方法 |
| AU2014324093A1 (en) * | 2013-09-18 | 2016-04-28 | James Cook University | Anti-inflammatory proteins and methods of use |
| WO2015061412A1 (en) * | 2013-10-22 | 2015-04-30 | The Scripps Research Institute | Methods and compositions for promoting bronchioli dilatation |
| WO2016030323A1 (en) * | 2014-08-26 | 2016-03-03 | Proteo Biotech Ag | Use of elafin for disorders associated with elastase independent increase in troponin |
| US10568846B2 (en) | 2015-04-27 | 2020-02-25 | Omniactive Health Technologies Limited | Betacryptoxanthin compositions, processes for preparation and uses thereof |
| US10239847B1 (en) | 2016-03-03 | 2019-03-26 | Cellactin | Method for 2-oxothiazolidine-4-carboxylic acid for cellular glutathione |
| EP3512539A4 (en) * | 2016-09-13 | 2020-07-29 | Prothera Biologics, Inc. | METHODS FOR TREATING LUNG DISEASE USING INTER-ALPHA INHIBITOR PROTEINS |
| AU2018241248B2 (en) * | 2017-03-31 | 2025-01-23 | Ena Respiratory Pty Ltd | Treatment of respiratory infection with a TLR2 agonist |
| EP3727353A4 (en) * | 2017-12-21 | 2021-10-13 | Civitas Therapeutics, Inc. | SURFACTANT FORMULATIONS FOR INHALATION |
| CN112654344A (zh) * | 2018-04-17 | 2021-04-13 | 板层小体生物医学有限公司 | 抗纤维化组合物 |
| JP7483684B2 (ja) * | 2018-08-17 | 2024-05-15 | ザ トラスティーズ オブ ザ ユニバーシティ オブ ペンシルバニア | 急性肺損傷の処置のための組成物および方法 |
| AU2019361193B2 (en) | 2018-10-19 | 2025-06-26 | Ohio State Innovation Foundation | Nanocarriers for lung inflammation therapy |
| CA3117213A1 (en) * | 2018-10-23 | 2020-04-30 | George Edward Hoag | Composition and method for treating the lungs |
| AU2019370363B2 (en) * | 2018-10-30 | 2025-07-10 | University Of Florida Research Foundation, Incorporated | Amino acid compositions and methods for treating cystic fibrosis |
| CA3145702A1 (en) * | 2019-08-01 | 2021-02-04 | Philip A. Pemberton | Oxidation-resistant serpins |
| KR102276935B1 (ko) * | 2020-02-06 | 2021-07-12 | 한양대학교 산학협력단 | 신규한 비올라크산틴 고생산 클로렐라 불가리스 균주 및 이로부터 비올라크산틴을 생산하는 방법 |
| CN115379828A (zh) * | 2020-04-08 | 2022-11-22 | 代表亚利桑那大学的亚利桑那校董会 | 用于治疗和预防肺病的组合物和方法 |
| CN115245559A (zh) * | 2021-04-25 | 2022-10-28 | 上海萨美细胞技术有限公司 | 一种用于治疗肺损伤的药物 |
| WO2024097169A1 (en) * | 2022-11-01 | 2024-05-10 | National Jewish Health | Treatment of coronavirus infections with antimicrobial phospholipid compositions |
| CN116421704A (zh) * | 2023-02-20 | 2023-07-14 | 成都佩德生物医药有限公司 | 多肽pd-dp-005在制备治疗肺部疾病药物中的应用及其药物 |
| CN120000688B (zh) * | 2025-04-16 | 2025-08-05 | 山东杰凯生物科技有限公司 | 基于干细胞外囊泡的雾化吸入组合物及其制备方法、应用 |
Family Cites Families (34)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57144224A (en) * | 1981-03-02 | 1982-09-06 | Mochida Pharmaceut Co Ltd | Remedy for respiratory dieseases |
| US4916117A (en) * | 1986-12-24 | 1990-04-10 | John Lezdey | Treatment of inflammation using alpha 1-antichymotrypsin |
| US5260273A (en) * | 1988-01-06 | 1993-11-09 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| US5164369A (en) * | 1988-01-06 | 1992-11-17 | The Scripps Research Institute | Pulmonary surfactant protein and related polypeptide |
| US6013619A (en) * | 1988-01-06 | 2000-01-11 | The Scripps Research Institute | Pulmonary surfactants and therapeutic uses, including pulmonary lavage |
| US4938949A (en) | 1988-09-12 | 1990-07-03 | University Of New York | Treatment of damaged bone marrow and dosage units therefor |
| US5707634A (en) | 1988-10-05 | 1998-01-13 | Pharmacia & Upjohn Company | Finely divided solid crystalline powders via precipitation into an anti-solvent |
| NO177716C (no) * | 1989-06-09 | 1995-11-08 | Zeneca Ltd | Fremgangsmåte for fremstilling av terapeutisk aktive polypeptider, DNA-sekvens, ekspresjonsvektor og antistoff |
| WO1991000871A1 (en) * | 1989-07-11 | 1991-01-24 | Genentech, Inc. | Surfactant compositions and methods |
| US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
| US5272252A (en) * | 1991-11-04 | 1993-12-21 | Merrell Dow Pharmaceuticals Inc. | Synthetic lung surfactant having antioxidant properties |
| ES2107048T3 (es) * | 1992-07-31 | 1997-11-16 | Merrell Pharma Inc | Tensioactivos pulmonares peptidicos sinteticos con antioxidantes covalentemente unidos. |
| US5734014A (en) * | 1992-08-11 | 1998-03-31 | Tsumura & Co. | Elafin derivative |
| WO1994008599A1 (en) | 1992-10-14 | 1994-04-28 | The Regents Of The University Of Colorado | Ion-pairing of drugs for improved efficacy and delivery |
| US5301644A (en) | 1993-06-16 | 1994-04-12 | Kohler Co. | Fuel shut-off mechanism for internal combustion engines |
| US5961970A (en) | 1993-10-29 | 1999-10-05 | Pharmos Corporation | Submicron emulsions as vaccine adjuvants |
| EP0763055B1 (en) * | 1994-06-02 | 1999-11-03 | Merrell Pharmaceuticals Inc. | Perfluoroalkyl ketone inhibitors of elastase and processes for making the same |
| GB9413202D0 (en) | 1994-06-30 | 1994-08-24 | Univ Bradford | Method and apparatus for the formation of particles |
| US5878912A (en) | 1995-12-26 | 1999-03-09 | Stein; Myron | Duct disinfecting method and apparatus |
| US5874029A (en) | 1996-10-09 | 1999-02-23 | The University Of Kansas | Methods for particle micronization and nanonization by recrystallization from organic solutions sprayed into a compressed antisolvent |
| US5833891A (en) | 1996-10-09 | 1998-11-10 | The University Of Kansas | Methods for a particle precipitation and coating using near-critical and supercritical antisolvents |
| US5780440A (en) * | 1996-06-17 | 1998-07-14 | Protease Sciences Inc. | Treatment of pulmonary disease with protease inhibitors |
| WO1998029098A1 (en) | 1996-12-31 | 1998-07-09 | Inhale Therapeutic Systems, Inc. | Processes for spray drying aqueous suspensions of hydrophobic drugs with hydrophilic excipients and compositions prepared by such processes |
| US6051257A (en) | 1997-02-24 | 2000-04-18 | Superior Micropowders, Llc | Powder batch of pharmaceutically-active particles and methods for making same |
| JP3796340B2 (ja) * | 1997-11-18 | 2006-07-12 | 株式会社ノエビア | セリンプロテアーゼ阻害剤 |
| JPH11147832A (ja) * | 1997-11-18 | 1999-06-02 | Noevir Co Ltd | 好中球エラスターゼ阻害剤 |
| US6284282B1 (en) | 1998-04-29 | 2001-09-04 | Genentech, Inc. | Method of spray freeze drying proteins for pharmaceutical administration |
| US5883084A (en) * | 1998-06-08 | 1999-03-16 | Clarion Pharmaceuticals Inc. | Treatment of respiratory diseases utilizing α-tocopheryl-phosphocholine |
| US6223455B1 (en) | 1999-05-03 | 2001-05-01 | Acusphere, Inc. | Spray drying apparatus and methods of use |
| EP1216052A1 (en) | 1999-09-16 | 2002-06-26 | Byk Gulden Lomberg Chemische Fabrik GmbH | Combination of c1-inh and lung surfactant for the treatment of respiratory disorders |
| WO2001048231A2 (en) * | 1999-12-28 | 2001-07-05 | Novartis Ag | Method of achieving persistent transgene expression |
| AU2908501A (en) * | 2000-01-06 | 2001-07-16 | Eli Lilly And Company | Combination therapy for the treatment of inflammatory and respiratory diseases |
| AU2003223718B2 (en) | 2002-04-25 | 2007-08-16 | The Scripps Research Institute | Treatment and prevention of pulmonary conditions |
| US6819898B2 (en) * | 2002-11-22 | 2004-11-16 | Kabushiki Kaisha Toshiba | Image forming apparatus including stopping member and backstop member to stop rotation of revolver type developing unit |
-
2003
- 2003-04-25 AU AU2003223718A patent/AU2003223718B2/en not_active Ceased
- 2003-04-25 AT AT03719918T patent/ATE520411T1/de not_active IP Right Cessation
- 2003-04-25 WO PCT/US2003/012731 patent/WO2003090682A2/en not_active Ceased
- 2003-04-25 KR KR1020047017208A patent/KR101036058B1/ko not_active Expired - Fee Related
- 2003-04-25 CA CA2483102A patent/CA2483102C/en not_active Expired - Fee Related
- 2003-04-25 JP JP2003587321A patent/JP4651946B2/ja not_active Expired - Fee Related
- 2003-04-25 NZ NZ536796A patent/NZ536796A/en not_active IP Right Cessation
- 2003-04-25 KR KR1020117002442A patent/KR20110017465A/ko not_active Ceased
- 2003-04-25 CN CNA038145170A patent/CN1838964A/zh active Pending
- 2003-04-25 EP EP03719918A patent/EP1558273B1/en not_active Expired - Lifetime
- 2003-04-25 MX MXPA04010560A patent/MXPA04010560A/es not_active Application Discontinuation
- 2003-04-25 IL IL16479503A patent/IL164795A0/xx active IP Right Grant
-
2004
- 2004-10-22 ZA ZA200408573A patent/ZA200408573B/en unknown
- 2004-10-22 US US10/971,461 patent/US7863241B2/en not_active Expired - Lifetime
- 2004-10-24 IL IL164795A patent/IL164795A/en not_active IP Right Cessation
-
2010
- 2010-10-01 JP JP2010224369A patent/JP2011001383A/ja not_active Withdrawn
-
2011
- 2011-01-04 US US12/930,336 patent/US20120189602A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US7863241B2 (en) | 2011-01-04 |
| JP2005529885A (ja) | 2005-10-06 |
| JP2011001383A (ja) | 2011-01-06 |
| ZA200408573B (en) | 2006-03-29 |
| CA2483102A1 (en) | 2003-11-06 |
| AU2003223718C1 (en) | 2003-11-10 |
| KR101036058B1 (ko) | 2011-05-19 |
| JP4651946B2 (ja) | 2011-03-16 |
| EP1558273B1 (en) | 2011-08-17 |
| NZ536796A (en) | 2007-03-30 |
| EP1558273A2 (en) | 2005-08-03 |
| US20120189602A1 (en) | 2012-07-26 |
| EP1558273A4 (en) | 2008-07-16 |
| WO2003090682A3 (en) | 2004-09-16 |
| AU2003223718A1 (en) | 2003-11-10 |
| WO2003090682A2 (en) | 2003-11-06 |
| ATE520411T1 (de) | 2011-09-15 |
| IL164795A (en) | 2011-02-28 |
| MXPA04010560A (es) | 2005-08-15 |
| AU2003223718B2 (en) | 2007-08-16 |
| KR20110017465A (ko) | 2011-02-21 |
| KR20050019073A (ko) | 2005-02-28 |
| US20050070477A1 (en) | 2005-03-31 |
| IL164795A0 (en) | 2005-12-18 |
| CN1838964A (zh) | 2006-09-27 |
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