CA2480389C - Modified saccharides having improved stability in water - Google Patents

Modified saccharides having improved stability in water Download PDF

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Publication number
CA2480389C
CA2480389C CA2480389A CA2480389A CA2480389C CA 2480389 C CA2480389 C CA 2480389C CA 2480389 A CA2480389 A CA 2480389A CA 2480389 A CA2480389 A CA 2480389A CA 2480389 C CA2480389 C CA 2480389C
Authority
CA
Canada
Prior art keywords
saccharide
modified
group
capsular saccharide
groups
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2480389A
Other languages
English (en)
French (fr)
Other versions
CA2480389A1 (en
Inventor
Paolo Costantino
Francesco Berti
Francesco Norelli
Antonella Bartoloni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GlaxoSmithKline Biologicals SA
Original Assignee
Novartis Vaccines and Diagnostics SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB0207117A external-priority patent/GB0207117D0/en
Priority claimed from GB0220195A external-priority patent/GB0220195D0/en
Priority claimed from GB0229494A external-priority patent/GB0229494D0/en
Priority claimed from GB0230163A external-priority patent/GB0230163D0/en
Application filed by Novartis Vaccines and Diagnostics SRL filed Critical Novartis Vaccines and Diagnostics SRL
Publication of CA2480389A1 publication Critical patent/CA2480389A1/en
Application granted granted Critical
Publication of CA2480389C publication Critical patent/CA2480389C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Polymers & Plastics (AREA)
  • Immunology (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
CA2480389A 2002-03-26 2003-03-26 Modified saccharides having improved stability in water Expired - Fee Related CA2480389C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
GB0207117.3 2002-03-26
GB0207117A GB0207117D0 (en) 2002-03-26 2002-03-26 Modified saccharides having improved stability in water
GB0220195A GB0220195D0 (en) 2002-08-30 2002-08-30 Modified saccharides having improved stability in water
GB0220195.2 2002-08-30
GB0229494.0 2002-12-18
GB0229494A GB0229494D0 (en) 2002-12-18 2002-12-18 Modified saccharides having improved stability in water
GB0230163A GB0230163D0 (en) 2002-12-24 2002-12-24 Modified saccharides having improved stability in water
GB0230163.8 2002-12-24
PCT/IB2003/001436 WO2003080678A1 (en) 2002-03-26 2003-03-26 Modified saccharides having improved stability in water

Publications (2)

Publication Number Publication Date
CA2480389A1 CA2480389A1 (en) 2003-10-02
CA2480389C true CA2480389C (en) 2012-10-09

Family

ID=28457825

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2480389A Expired - Fee Related CA2480389C (en) 2002-03-26 2003-03-26 Modified saccharides having improved stability in water

Country Status (14)

Country Link
EP (2) EP1777236B8 (OSRAM)
JP (2) JP2005526153A (OSRAM)
AT (1) ATE419278T1 (OSRAM)
BR (1) BR0308768A (OSRAM)
CA (1) CA2480389C (OSRAM)
CY (2) CY1108911T1 (OSRAM)
DE (1) DE60325565D1 (OSRAM)
DK (2) DK1490409T3 (OSRAM)
ES (2) ES2616180T3 (OSRAM)
HU (1) HUE030532T2 (OSRAM)
MX (1) MXPA04009339A (OSRAM)
NZ (1) NZ535968A (OSRAM)
PT (2) PT1490409E (OSRAM)
WO (1) WO2003080678A1 (OSRAM)

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Also Published As

Publication number Publication date
JP2005526153A (ja) 2005-09-02
CY1108911T1 (el) 2014-07-02
JP5361767B2 (ja) 2013-12-04
AU2003216633A1 (en) 2003-10-08
PT1490409E (pt) 2009-04-03
ES2318117T3 (es) 2009-05-01
BR0308768A (pt) 2005-02-15
ES2616180T3 (es) 2017-06-09
DE60325565D1 (de) 2009-02-12
PT1777236T (pt) 2017-02-13
DK1490409T3 (da) 2009-03-23
MXPA04009339A (es) 2005-01-25
EP1777236B8 (en) 2017-02-22
EP1777236B1 (en) 2016-11-30
EP1777236A1 (en) 2007-04-25
ATE419278T1 (de) 2009-01-15
CA2480389A1 (en) 2003-10-02
WO2003080678A1 (en) 2003-10-02
NZ535968A (en) 2006-08-31
JP2010132925A (ja) 2010-06-17
CY1118584T1 (el) 2017-07-12
EP1490409A1 (en) 2004-12-29
DK1777236T3 (en) 2017-02-27
EP1490409B1 (en) 2008-12-31
HUE030532T2 (en) 2017-05-29

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Effective date: 20190326