CA2474468C - Amplifying repetitive nucleic acid sequences - Google Patents
Amplifying repetitive nucleic acid sequences Download PDFInfo
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- CA2474468C CA2474468C CA2474468A CA2474468A CA2474468C CA 2474468 C CA2474468 C CA 2474468C CA 2474468 A CA2474468 A CA 2474468A CA 2474468 A CA2474468 A CA 2474468A CA 2474468 C CA2474468 C CA 2474468C
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- primer
- repetitive
- nucleotide
- primers
- nucleic acid
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- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
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| US8097419B2 (en) | 2006-09-12 | 2012-01-17 | Longhorn Vaccines & Diagnostics Llc | Compositions and method for rapid, real-time detection of influenza A virus (H1N1) swine 2009 |
| US9481912B2 (en) | 2006-09-12 | 2016-11-01 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and identifying nucleic acid sequences in biological samples |
| US8080645B2 (en) | 2007-10-01 | 2011-12-20 | Longhorn Vaccines & Diagnostics Llc | Biological specimen collection/transport compositions and methods |
| US8652782B2 (en) * | 2006-09-12 | 2014-02-18 | Longhorn Vaccines & Diagnostics, Llc | Compositions and methods for detecting, identifying and quantitating mycobacterial-specific nucleic acids |
| US11041215B2 (en) | 2007-08-24 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | PCR ready compositions and methods for detecting and identifying nucleic acid sequences |
| US9683256B2 (en) | 2007-10-01 | 2017-06-20 | Longhorn Vaccines And Diagnostics, Llc | Biological specimen collection and transport system |
| WO2009029686A1 (en) | 2007-08-27 | 2009-03-05 | Longhorn Vaccines & Diagnostics Llc | Immunogenic compositions and methods |
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| DK2195466T3 (da) | 2007-10-01 | 2013-01-14 | Longhorn Vaccines & Diagnostics Llc | Fremgangsmåde til opbevaring af biologiske prøver |
| US11041216B2 (en) | 2007-10-01 | 2021-06-22 | Longhorn Vaccines And Diagnostics, Llc | Compositions and methods for detecting and quantifying nucleic acid sequences in blood samples |
| CN101230403B (zh) * | 2008-02-21 | 2010-12-29 | 浙江理工大学 | 解析染色体端粒g-末端序列的方法 |
| WO2010045245A1 (en) | 2008-10-17 | 2010-04-22 | Geron Corporation | Method for identification of sensitivity of a patient to telomerase inhibition therapy |
| CA2748265C (en) * | 2008-12-22 | 2018-04-03 | University Of Utah Research Foundation | Monochrome multiplex quantitative pcr |
| US20110207128A1 (en) * | 2010-02-16 | 2011-08-25 | Cawthon Richard M | Methods and kits for determining biological age and longevity based on gene expression profiles |
| JP2011223940A (ja) * | 2010-04-21 | 2011-11-10 | Asahi Breweries Ltd | 偽陰性を排除するｐｃｒ検査方法およびそれに使用するプライマー |
| WO2012135125A1 (en) | 2011-03-28 | 2012-10-04 | Geron Corporation | Telomere length measurement in formalin-fixed, paraffin embedded (ffpe) samples by quantitative pcr |
| WO2013054666A1 (ja) * | 2011-10-13 | 2013-04-18 | 学校法人 東京女子医科大学 | テロメア配列増幅用プライマー |
| WO2013101290A1 (en) * | 2011-12-29 | 2013-07-04 | Qiagen | Methods of using telomeres as markers for aging |
| CN104203272A (zh) | 2012-01-26 | 2014-12-10 | 长角牛疫苗和诊断有限责任公司 | 复合抗原序列及疫苗 |
| US20130310269A1 (en) * | 2012-05-04 | 2013-11-21 | Austin So | Hot-start digital pcr |
| CA2892445C (en) | 2012-11-30 | 2022-06-28 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
| US9200327B2 (en) | 2012-11-30 | 2015-12-01 | Geron Corporation | Diagnostic markers for treating cell proliferative disorders with telomerase inhibitors |
| WO2014152937A1 (en) * | 2013-03-14 | 2014-09-25 | Ibis Biosciences, Inc. | Nucleic acid control panels |
| WO2014152676A1 (en) * | 2013-03-15 | 2014-09-25 | New York University | A method for a single cell analysis of telomer length |
| EP2971134B1 (en) * | 2013-03-15 | 2023-10-25 | Aegea Biotechnologies, Inc. | Methods for amplifying fragmented target nucleic acids utilizing an assembler sequence |
| ES2762860T3 (es) * | 2013-05-22 | 2020-05-26 | Telomere Diagnostics Inc | Medidas de abundancia de telómeros cortos |
| GB201418144D0 (en) * | 2014-10-14 | 2014-11-26 | Univ Cardiff | High throughput sequencing |
| CA2971169A1 (en) | 2014-12-30 | 2016-07-07 | Telomere Diagnostics, Inc. | Multiplex quantitative pcr |
| WO2016183292A1 (en) | 2015-05-14 | 2016-11-17 | Longhorn Vaccines And Diagnostics, Llc | Rapid methods for the extraction of nucleic acids from biological samples |
| US10577643B2 (en) * | 2015-10-07 | 2020-03-03 | Illumina, Inc. | Off-target capture reduction in sequencing techniques |
| US10186789B1 (en) | 2018-04-13 | 2019-01-22 | Rustcraft Industries LLC | Keyed cable and connector system |
| CN112029841B (zh) | 2019-06-03 | 2024-02-09 | 香港中文大学 | 定量端粒长度和基因组基序的方法 |
| US12485166B2 (en) | 2020-02-06 | 2025-12-02 | Longhorn Vaccines And Diagnostics, Llc | Vaccines for the treatment and prevention of zoonotic infections |
| KR20230091978A (ko) | 2020-10-20 | 2023-06-23 | 롱혼 백신즈 앤드 다이어그나스틱스, 엘엘씨 | 면역원성 항원 |
| CN113862339B (zh) * | 2021-12-01 | 2022-03-22 | 广州滴纳生物科技有限公司 | 核酸组合产品、检测试剂盒和扩增靶核酸的方法 |
| CN116218893B (zh) * | 2023-03-24 | 2025-07-29 | 哈尔滨医科大学 | 一种通过体外扩增重组质粒在其编码基因上生成短片段串联重复序列的方法 |
| CN117230169B (zh) * | 2023-11-13 | 2024-02-13 | 元码基因科技（北京）股份有限公司 | 用于长片段端粒序列测序的接头、预文库及其构建方法 |
| CN117248003B (zh) * | 2023-11-13 | 2024-04-12 | 元码基因科技（北京）股份有限公司 | 用于完整端粒扩增子测序的组合物、预文库及其构建方法 |
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| US6020124A (en) * | 1992-04-27 | 2000-02-01 | Trustees Of Dartmouth College | Detection of soluble gene sequences in biological fluids |
| US5489508A (en) * | 1992-05-13 | 1996-02-06 | University Of Texas System Board Of Regents | Therapy and diagnosis of conditions related to telomere length and/or telomerase activity |
| US5512441A (en) * | 1994-11-15 | 1996-04-30 | American Health Foundation | Quantative method for early detection of mutant alleles and diagnostic kits for carrying out the method |
| US5741677A (en) * | 1995-06-07 | 1998-04-21 | Geron Corporation | Methods for measuring telomere length |
| JP3718892B2 (ja) * | 1996-02-05 | 2005-11-24 | 三菱化学株式会社 | ヒト・テロメラーゼ活性の測定方法 |
| JP4013333B2 (ja) | 1998-06-05 | 2007-11-28 | 株式会社Ｂ＆Ｃラボラトリーズ | 皮膚の老化度の測定方法および測定用キット |
| US6436677B1 (en) * | 2000-03-02 | 2002-08-20 | Promega Corporation | Method of reverse transcription |
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| US7695904B2 (en) | 2010-04-13 |
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| WO2003064615A2 (en) | 2003-08-07 |
| CA2474468A1 (en) | 2003-08-07 |
| EP1476561B1 (en) | 2011-11-23 |
| HK1072275A1 (en) | 2005-08-19 |
| CN1639352A (zh) | 2005-07-13 |
| JP2005515778A (ja) | 2005-06-02 |
| JP4515767B2 (ja) | 2010-08-04 |
| US8048631B2 (en) | 2011-11-01 |
| AU2003208902B2 (en) | 2008-08-07 |
| ES2379375T3 (es) | 2012-04-25 |
| WO2003064615A3 (en) | 2004-02-26 |
| CN100473723C (zh) | 2009-04-01 |
| EP1476561A2 (en) | 2004-11-17 |
| EP1476561A4 (en) | 2006-08-02 |
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