CA2467455C - Method of detection of prostate cancer - Google Patents

Method of detection of prostate cancer Download PDF

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Publication number
CA2467455C
CA2467455C CA 2467455 CA2467455A CA2467455C CA 2467455 C CA2467455 C CA 2467455C CA 2467455 CA2467455 CA 2467455 CA 2467455 A CA2467455 A CA 2467455A CA 2467455 C CA2467455 C CA 2467455C
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Prior art keywords
methylation
prostate
subject
sample
level
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Expired - Lifetime
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CA 2467455
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English (en)
French (fr)
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CA2467455A1 (en
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David Sidransky
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Johns Hopkins University
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Johns Hopkins University
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813Hybridisation assays
    • C12Q1/6827Hybridisation assays for detection of mutation or polymorphism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/6851Quantitative amplification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2523/00Reactions characterised by treatment of reaction samples
    • C12Q2523/10Characterised by chemical treatment
    • C12Q2523/125Bisulfite(s)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/154Methylation markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
CA 2467455 2001-11-16 2002-11-15 Method of detection of prostate cancer Expired - Lifetime CA2467455C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33329601P 2001-11-16 2001-11-16
US60/333,296 2001-11-16
PCT/US2002/036784 WO2003044232A1 (en) 2001-11-16 2002-11-15 Method of detection of prostate cancer

Publications (2)

Publication Number Publication Date
CA2467455A1 CA2467455A1 (en) 2003-05-30
CA2467455C true CA2467455C (en) 2013-03-19

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Family Applications (1)

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CA 2467455 Expired - Lifetime CA2467455C (en) 2001-11-16 2002-11-15 Method of detection of prostate cancer

Country Status (9)

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US (3) US7252935B2 (enExample)
EP (1) EP1456413B1 (enExample)
JP (1) JP4381142B2 (enExample)
AT (1) ATE393240T1 (enExample)
AU (1) AU2002352745A1 (enExample)
CA (1) CA2467455C (enExample)
DE (1) DE60226271T2 (enExample)
ES (1) ES2304462T3 (enExample)
WO (1) WO2003044232A1 (enExample)

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US11105808B2 (en) 2004-11-12 2021-08-31 Health Discovery Corporation Methods for screening, predicting and monitoring prostate cancer
US8268549B2 (en) * 2005-04-15 2012-09-18 University Of Maryland, Baltimore Method and assay for determining methylation of GAL3 promoter for early diagnosis of prostate cancer
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US7851154B2 (en) * 2005-07-22 2010-12-14 Simon Daniel Spivack GC tag-modified bisulfite genomic DNA sequencing for continuous methylation spectra
US20070059753A1 (en) * 2005-09-15 2007-03-15 Tatiana Vener Detecting gene methylation
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JP2008202978A (ja) * 2007-02-16 2008-09-04 Hirosaki Univ 前立腺癌の診断方法
US20080254455A1 (en) * 2007-04-12 2008-10-16 Haiying Wang Detecting prostate cancer
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Also Published As

Publication number Publication date
US7524633B2 (en) 2009-04-28
DE60226271T2 (de) 2009-07-16
EP1456413A4 (en) 2005-05-18
US20090181400A1 (en) 2009-07-16
AU2002352745A1 (en) 2003-06-10
ES2304462T3 (es) 2008-10-16
JP4381142B2 (ja) 2009-12-09
ATE393240T1 (de) 2008-05-15
DE60226271D1 (de) 2008-06-05
EP1456413A1 (en) 2004-09-15
US20080026395A1 (en) 2008-01-31
CA2467455A1 (en) 2003-05-30
US7252935B2 (en) 2007-08-07
EP1456413B1 (en) 2008-04-23
US20030124600A1 (en) 2003-07-03
JP2005509445A (ja) 2005-04-14
WO2003044232A1 (en) 2003-05-30

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