CA2463323C - Nanoparticles having oligonucleotides attached thereto and uses therefor - Google Patents

Nanoparticles having oligonucleotides attached thereto and uses therefor Download PDF

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Publication number
CA2463323C
CA2463323C CA2463323A CA2463323A CA2463323C CA 2463323 C CA2463323 C CA 2463323C CA 2463323 A CA2463323 A CA 2463323A CA 2463323 A CA2463323 A CA 2463323A CA 2463323 C CA2463323 C CA 2463323C
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CA
Canada
Prior art keywords
oligonucleotides
nanoparticles
nucleic acid
sequence
oligonucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2463323A
Other languages
English (en)
French (fr)
Other versions
CA2463323A1 (en
Inventor
So-Jung Park
Thomas A. Taton
Chad A. Mirkin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nanosphere LLC
Original Assignee
Nanosphere LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/008,978 external-priority patent/US6984491B2/en
Application filed by Nanosphere LLC filed Critical Nanosphere LLC
Publication of CA2463323A1 publication Critical patent/CA2463323A1/en
Application granted granted Critical
Publication of CA2463323C publication Critical patent/CA2463323C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6816—Hybridisation assays characterised by the detection means

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA2463323A 2001-10-09 2002-10-08 Nanoparticles having oligonucleotides attached thereto and uses therefor Expired - Fee Related CA2463323C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32786401P 2001-10-09 2001-10-09
US60/327,864 2001-10-09
US10/008,978 US6984491B2 (en) 1996-07-29 2001-12-07 Nanoparticles having oligonucleotides attached thereto and uses therefor
US10/008,978 2001-12-07
PCT/US2002/032088 WO2003035829A2 (en) 2001-10-09 2002-10-08 Nanoparticles having oligonucleotides attached thereto and uses therefor

Publications (2)

Publication Number Publication Date
CA2463323A1 CA2463323A1 (en) 2003-05-01
CA2463323C true CA2463323C (en) 2010-12-21

Family

ID=32684383

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2463323A Expired - Fee Related CA2463323C (en) 2001-10-09 2002-10-08 Nanoparticles having oligonucleotides attached thereto and uses therefor

Country Status (5)

Country Link
EP (1) EP1478774A4 (ja)
JP (1) JP4347049B2 (ja)
AU (1) AU2002363062B2 (ja)
CA (1) CA2463323C (ja)
WO (1) WO2003035829A2 (ja)

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JP5398982B2 (ja) * 2004-05-24 2014-01-29 ミダテック リミテッド Ｒｎａリガンドを含むナノ粒子
JP4822753B2 (ja) * 2005-07-11 2011-11-24 一般社団法人オンチップ・セロミクス・コンソーシアム 細胞構成物質分取チップならびに細胞構成物質解析システム及びこれらを用いる細胞構成物質解析法
KR100816419B1 (ko) * 2005-10-14 2008-03-27 래플진(주) 핵산의 등온증폭 방법 및 핵산과 신호 프로브의 동시등온증폭을 이용한 핵산의 검출방법
EP1801593A1 (en) * 2005-12-22 2007-06-27 Koninklijke Philips Electronics N.V. A method of imaging biological specimens using inorganic nanoparticles as label agents
WO2007092941A2 (en) * 2006-02-08 2007-08-16 Oxonica, Inc. Sers nanotag assays
JP5391744B2 (ja) * 2009-03-09 2014-01-15 住友ベークライト株式会社 アレイ用基板
US8835358B2 (en) 2009-12-15 2014-09-16 Cellular Research, Inc. Digital counting of individual molecules by stochastic attachment of diverse labels
JP5200069B2 (ja) * 2010-07-27 2013-05-15 トヨタ自動車株式会社 三次元ｄｎａネットワーク
KR101792262B1 (ko) * 2011-10-10 2017-11-02 삼성전기주식회사 도전성 페이스트, 이의 제조방법 및 이를 이용한 적층 세라믹 전자부품
US9335292B2 (en) 2011-10-13 2016-05-10 Auburn University Electrochemical proximity assay
CN104364392B (zh) 2012-02-27 2018-05-25 赛卢拉研究公司 用于分子计数的组合物和试剂盒
KR102536833B1 (ko) 2013-08-28 2023-05-26 벡톤 디킨슨 앤드 컴퍼니 대량의 동시 단일 세포 분석
CN106062210A (zh) * 2013-12-23 2016-10-26 昆士兰大学 核酸检测方法和试剂盒
JPWO2015159535A1 (ja) * 2014-04-16 2017-04-13 富士フイルム株式会社 検出液とその調製方法、バイオセンシング方法
EP3262192B1 (en) 2015-02-27 2020-09-16 Becton, Dickinson and Company Spatially addressable molecular barcoding
US11535882B2 (en) 2015-03-30 2022-12-27 Becton, Dickinson And Company Methods and compositions for combinatorial barcoding
WO2016172373A1 (en) 2015-04-23 2016-10-27 Cellular Research, Inc. Methods and compositions for whole transcriptome amplification
EP3303635B1 (en) 2015-06-01 2021-09-01 California Institute of Technology Compositions and methods for screening t cells with antigens for specific populations
US10619186B2 (en) 2015-09-11 2020-04-14 Cellular Research, Inc. Methods and compositions for library normalization
AU2017268369B2 (en) * 2016-05-18 2022-09-01 Integrated Nano-Technologies, Inc. Method for detection of a PCR product
US10301677B2 (en) 2016-05-25 2019-05-28 Cellular Research, Inc. Normalization of nucleic acid libraries
US10202641B2 (en) 2016-05-31 2019-02-12 Cellular Research, Inc. Error correction in amplification of samples
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US11505799B2 (en) 2017-07-07 2022-11-22 Innamed, Inc. Aptamers for measuring lipoprotein levels
KR20190011117A (ko) * 2017-07-24 2019-02-01 사회복지법인 삼성생명공익재단 금 나노입자의 응집을 이용한 유전자의 변이를 검출하는 방법
US11365409B2 (en) 2018-05-03 2022-06-21 Becton, Dickinson And Company Molecular barcoding on opposite transcript ends
ES2945191T3 (es) 2018-05-03 2023-06-29 Becton Dickinson Co Análisis de muestras multiómicas de alto rendimiento
US11560565B2 (en) 2018-06-13 2023-01-24 Auburn University Electrochemical detection nanostructure, systems, and uses thereof
CN112654346B (zh) * 2018-07-10 2024-06-07 加利福尼亚大学董事会 生物分子包覆颗粒和薄膜及其用途
WO2020072380A1 (en) 2018-10-01 2020-04-09 Cellular Research, Inc. Determining 5' transcript sequences
WO2020097315A1 (en) 2018-11-08 2020-05-14 Cellular Research, Inc. Whole transcriptome analysis of single cells using random priming
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CN115244184A (zh) 2020-01-13 2022-10-25 贝克顿迪金森公司 用于定量蛋白和rna的方法和组合物
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CN116635533A (zh) 2020-11-20 2023-08-22 贝克顿迪金森公司 高表达的蛋白和低表达的蛋白的谱分析
CN113088517B (zh) * 2021-03-15 2023-10-03 华南师范大学 一种纳米探针构建方法
CN115178746B (zh) * 2022-07-13 2024-03-01 宁波大学 用于检测化妆水中汞离子的金纳米粒子的制备方法与用途
CN115369153B (zh) * 2022-10-25 2023-03-10 中国医学科学院北京协和医院 一种Smad4基因检测生物传感器及制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
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US6025202A (en) * 1995-02-09 2000-02-15 The Penn State Research Foundation Self-assembled metal colloid monolayers and detection methods therewith
JP2000510582A (ja) * 1996-04-25 2000-08-15 ゼニコン・サイエンシーズ・コーポレーション 微粒子標識を使用した分析物アッセイ
AU2001255203A1 (en) * 2000-03-28 2001-10-08 Nanosphere Inc. Nanoparticles having oligonucleotides attached thereto and uses therefor

Also Published As

Publication number Publication date
WO2003035829A3 (en) 2004-08-26
JP4347049B2 (ja) 2009-10-21
AU2002363062B2 (en) 2007-03-22
EP1478774A4 (en) 2006-11-29
EP1478774A2 (en) 2004-11-24
CA2463323A1 (en) 2003-05-01
JP2005525084A (ja) 2005-08-25
WO2003035829A2 (en) 2003-05-01

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