CA2461693A1 - Dosage form for treatment of diabetes mellitus - Google Patents
Dosage form for treatment of diabetes mellitus Download PDFInfo
- Publication number
- CA2461693A1 CA2461693A1 CA002461693A CA2461693A CA2461693A1 CA 2461693 A1 CA2461693 A1 CA 2461693A1 CA 002461693 A CA002461693 A CA 002461693A CA 2461693 A CA2461693 A CA 2461693A CA 2461693 A1 CA2461693 A1 CA 2461693A1
- Authority
- CA
- Canada
- Prior art keywords
- dosage form
- metformin
- cellulose
- hpmc
- core
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000002552 dosage form Substances 0.000 title claims abstract description 63
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 25
- 239000000203 mixture Substances 0.000 claims abstract description 79
- XZWYZXLIPXDOLR-UHFFFAOYSA-N metformin Chemical compound CN(C)C(=N)NC(N)=N XZWYZXLIPXDOLR-UHFFFAOYSA-N 0.000 claims abstract description 61
- 229960003105 metformin Drugs 0.000 claims abstract description 50
- 229940100389 Sulfonylurea Drugs 0.000 claims abstract description 39
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical compound OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229940123208 Biguanide Drugs 0.000 claims abstract description 34
- XNCOSPRUTUOJCJ-UHFFFAOYSA-N Biguanide Chemical compound NC(N)=NC(N)=N XNCOSPRUTUOJCJ-UHFFFAOYSA-N 0.000 claims abstract description 30
- 238000013270 controlled release Methods 0.000 claims abstract description 28
- 150000003839 salts Chemical class 0.000 claims abstract description 26
- 239000012729 immediate-release (IR) formulation Substances 0.000 claims abstract description 12
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- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 51
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 51
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 51
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- FSBVERYRVPGNGG-UHFFFAOYSA-N dimagnesium dioxido-bis[[oxido(oxo)silyl]oxy]silane hydrate Chemical compound O.[Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O FSBVERYRVPGNGG-UHFFFAOYSA-N 0.000 claims description 3
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- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN941/MUM/2001 | 2001-09-28 | ||
| IN941MU2001 | 2001-09-28 | ||
| IN942/MUM/2001 | 2001-09-28 | ||
| IN942MU2001 | 2001-09-28 | ||
| PCT/IN2002/000194 WO2003026637A2 (en) | 2001-09-28 | 2002-09-27 | Dosage form for treatment of diabetes mellitus |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2461693A1 true CA2461693A1 (en) | 2003-04-03 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002461693A Abandoned CA2461693A1 (en) | 2001-09-28 | 2002-09-27 | Dosage form for treatment of diabetes mellitus |
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| Country | Link |
|---|---|
| US (1) | US20040202718A1 (enExample) |
| EP (1) | EP1435931A2 (enExample) |
| JP (1) | JP2005508331A (enExample) |
| KR (1) | KR20040044992A (enExample) |
| CN (1) | CN1635894A (enExample) |
| BR (1) | BR0213079A (enExample) |
| CA (1) | CA2461693A1 (enExample) |
| HU (1) | HUP0402328A2 (enExample) |
| MX (1) | MXPA04002702A (enExample) |
| PL (1) | PL370818A1 (enExample) |
| RU (1) | RU2004108219A (enExample) |
| WO (1) | WO2003026637A2 (enExample) |
| ZA (1) | ZA200402369B (enExample) |
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| US6682759B2 (en) * | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
| WO2003105809A1 (en) | 2002-06-17 | 2003-12-24 | Themis Laboratories Private Limited | Multilayer tablets containing thiazolidinedione and biguanides and methods for producing them |
| EP1562607A1 (en) * | 2002-11-15 | 2005-08-17 | Ranbaxy Laboratories, Ltd. | Pharmaceutical dosage forms of biguanide-sulfonylurea combinations |
| FR2853831A1 (fr) * | 2003-03-05 | 2004-10-22 | Usv Ltd | Forme posologique solide a usage oral de metformine et de glyburide et son procede de preparation |
| EP1646374A1 (en) * | 2003-06-16 | 2006-04-19 | Ranbaxy Laboratories, Ltd. | Extended-release tablets of metformin |
| US20050013863A1 (en) * | 2003-07-18 | 2005-01-20 | Depomed, Inc., A Corporation Of The State Of California | Dual drug dosage forms with improved separation of drugs |
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| ITFI20130184A1 (it) * | 2013-08-01 | 2015-02-02 | Valpharma Internat S P A | Una formulazione farmaceutica di gliclazide a rilascio modificato, somministrabile per via orale, e suo metodo di produzione. |
| CN104906115A (zh) * | 2015-06-18 | 2015-09-16 | 青岛海之星生物科技有限公司 | 一种二甲双胍格列喹酮复方缓释片及制备方法 |
| CN104906114A (zh) * | 2015-06-18 | 2015-09-16 | 青岛海之星生物科技有限公司 | 一种二甲双胍格列喹酮复方缓释胶囊及制备方法 |
| CN106389446A (zh) * | 2016-11-07 | 2017-02-15 | 华中药业股份有限公司 | 一种降糖药物组合物及其制备方法 |
| CN107184559B (zh) * | 2017-06-02 | 2018-07-31 | 广东赛康制药厂有限公司 | 一种盐酸二甲双胍缓释片及其制备方法 |
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| DE3320582A1 (de) * | 1983-06-08 | 1984-12-13 | Dr. Karl Thomae Gmbh, 7950 Biberach | Gliquidonhaltige zubereitungsformen und verfahren zu ihrer herstellung |
| US5024843A (en) * | 1989-09-05 | 1991-06-18 | Alza Corporation | Oral hypoglycemic glipizide granulation |
| US5576306A (en) * | 1991-03-01 | 1996-11-19 | Dow Chemical Company | Pharmaceutical compositions and uses of water-soluble, high-viscosity grade cellulose ethers |
| DE4432757A1 (de) * | 1994-09-14 | 1996-03-21 | Boehringer Mannheim Gmbh | Pharmazeutische Zubereitung enthaltend Metformin und Verfahren zu deren Herstellung |
| IT1276130B1 (it) * | 1995-11-14 | 1997-10-27 | Gentili Ist Spa | Associazione glibenclamide-metformina, composizioni farmaceutiche che la contengono e loro uso nel trattamento del diabete mellito di tipo |
| WO1999029314A1 (en) * | 1997-12-08 | 1999-06-17 | Bristol-Myers Squibb Company | Novel salts of metformin and method |
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| US6586438B2 (en) * | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| ATE340563T1 (de) * | 2000-02-04 | 2006-10-15 | Depomed Inc | DOSIERUNGSFORM DES TYPS ßHÜLLE UND KERNß MIT EINER WIRKSTOFFFREISETZUNG, DIE SICH DER NULLTEN ORDNUNG ANNÄHERT |
| DE20023135U1 (de) * | 2000-04-03 | 2003-04-03 | Beisel, Günther, 40789 Monheim | Mittel mit verbesserter Retardwirkung |
| US6451342B2 (en) * | 2000-05-01 | 2002-09-17 | Aeropharm Technology Incorporated | Core formulation comprised of troglitazone and a biguanide |
-
2002
- 2002-09-27 PL PL02370818A patent/PL370818A1/xx not_active Application Discontinuation
- 2002-09-27 JP JP2003530274A patent/JP2005508331A/ja active Pending
- 2002-09-27 WO PCT/IN2002/000194 patent/WO2003026637A2/en not_active Ceased
- 2002-09-27 BR BR0213079-3A patent/BR0213079A/pt not_active IP Right Cessation
- 2002-09-27 MX MXPA04002702A patent/MXPA04002702A/es unknown
- 2002-09-27 RU RU2004108219/15A patent/RU2004108219A/ru not_active Application Discontinuation
- 2002-09-27 HU HU0402328A patent/HUP0402328A2/hu unknown
- 2002-09-27 US US10/491,305 patent/US20040202718A1/en not_active Abandoned
- 2002-09-27 KR KR10-2004-7004387A patent/KR20040044992A/ko not_active Withdrawn
- 2002-09-27 CN CNA028188349A patent/CN1635894A/zh active Pending
- 2002-09-27 EP EP02781737A patent/EP1435931A2/en not_active Withdrawn
- 2002-09-27 CA CA002461693A patent/CA2461693A1/en not_active Abandoned
-
2004
- 2004-03-25 ZA ZA2004/02369A patent/ZA200402369B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20040044992A (ko) | 2004-05-31 |
| US20040202718A1 (en) | 2004-10-14 |
| EP1435931A2 (en) | 2004-07-14 |
| ZA200402369B (en) | 2005-02-23 |
| BR0213079A (pt) | 2004-11-09 |
| WO2003026637A2 (en) | 2003-04-03 |
| MXPA04002702A (es) | 2004-07-05 |
| WO2003026637A3 (en) | 2003-05-01 |
| PL370818A1 (en) | 2005-05-30 |
| HUP0402328A2 (hu) | 2005-02-28 |
| JP2005508331A (ja) | 2005-03-31 |
| CN1635894A (zh) | 2005-07-06 |
| RU2004108219A (ru) | 2005-03-10 |
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| Date | Code | Title | Description |
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| FZDE | Discontinued |