CN107184559B - 一种盐酸二甲双胍缓释片及其制备方法 - Google Patents
一种盐酸二甲双胍缓释片及其制备方法 Download PDFInfo
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- CN107184559B CN107184559B CN201710407540.5A CN201710407540A CN107184559B CN 107184559 B CN107184559 B CN 107184559B CN 201710407540 A CN201710407540 A CN 201710407540A CN 107184559 B CN107184559 B CN 107184559B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Description
时间(h) | 1 | 2 | 4 | 6 | 8 | 10 | 12 |
实施例1 | 12% | 28% | 46% | 63% | 74% | 84% | 95% |
实施例2 | 14% | 32% | 51% | 67% | 78% | 89% | 99% |
实施例3 | 10% | 25% | 43% | 60% | 69% | 79% | 90% |
实施例4 | 13% | 27% | 47% | 62% | 75% | 86% | 97% |
实施例5 | 13% | 27% | 42% | 64% | 74% | 85% | 96% |
对比例1 | 20% | 38% | 54% | 76% | 86% | 96% | 99% |
对比例2 | 23% | 40% | 55% | 79% | 88% | 98% | 99% |
对比例3 | 37% | 54% | 71% | 84% | 93% | 99% | 99% |
对比例4 | 30% | 47% | 65% | 80% | 95% | 98% | 99% |
对比例5 | 18% | 34% | 45% | 72% | 81% | 94% | 97% |
对比例6 | 19% | 32% | 50% | 75% | 83% | 95% | 98% |
对比例7 | 22% | 40% | 55% | 78% | 90% | 96% | 99% |
对比例8 | 35% | 52% | 70% | 82% | 94% | 98% | 100% |
上市产品 | 28% | 43% | 65% | 76% | 88% | 95% | 96% |
Claims (2)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
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CN201710407540.5A CN107184559B (zh) | 2017-06-02 | 2017-06-02 | 一种盐酸二甲双胍缓释片及其制备方法 |
Applications Claiming Priority (1)
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CN201710407540.5A CN107184559B (zh) | 2017-06-02 | 2017-06-02 | 一种盐酸二甲双胍缓释片及其制备方法 |
Publications (2)
Publication Number | Publication Date |
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CN107184559A CN107184559A (zh) | 2017-09-22 |
CN107184559B true CN107184559B (zh) | 2018-07-31 |
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CN201710407540.5A Active CN107184559B (zh) | 2017-06-02 | 2017-06-02 | 一种盐酸二甲双胍缓释片及其制备方法 |
Country Status (1)
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CN (1) | CN107184559B (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110354090A (zh) * | 2019-07-29 | 2019-10-22 | 石药集团欧意药业有限公司 | 一种盐酸二甲双胍缓释片及其制备方法 |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111544409B (zh) * | 2020-05-27 | 2021-02-19 | 广东赛康药业有限公司 | 一种盐酸二甲双胍与甲钴胺的药物组合物及其制备方法 |
WO2022184981A1 (en) * | 2021-03-03 | 2022-09-09 | Orion Corporation | Stable pharmaceutical compositions of metformin |
CN113057947A (zh) * | 2021-04-01 | 2021-07-02 | 广东赛康制药厂有限公司 | 一种低ndma、小骨架盐酸二甲双胍缓释片及制备方法 |
CN113081973A (zh) * | 2021-05-07 | 2021-07-09 | 郑州泰丰制药有限公司 | 一种盐酸二甲双胍组合物及其制备方法 |
CN114948891A (zh) * | 2021-06-07 | 2022-08-30 | 南通联亚药业股份有限公司 | 药物组合物 |
CN114404376A (zh) * | 2022-03-16 | 2022-04-29 | 成都恒瑞制药有限公司 | 一种盐酸二甲双胍缓释片剂及其制备方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1635894A (zh) * | 2001-09-28 | 2005-07-06 | 太阳医药工业有限公司 | 糖尿病治疗剂型 |
TWI248815B (en) * | 2003-11-05 | 2006-02-11 | Pei Li Pharmaceutical Ind Co L | The controlled release formulation of metformin HCl |
CN101951891A (zh) * | 2008-01-11 | 2011-01-19 | 希普拉有限公司 | 固态药物剂型 |
CN102247343A (zh) * | 2011-05-18 | 2011-11-23 | 四川晖瑞医药科技有限公司 | 一种复方吡格列酮二甲双胍缓释片制备工艺 |
-
2017
- 2017-06-02 CN CN201710407540.5A patent/CN107184559B/zh active Active
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1635894A (zh) * | 2001-09-28 | 2005-07-06 | 太阳医药工业有限公司 | 糖尿病治疗剂型 |
TWI248815B (en) * | 2003-11-05 | 2006-02-11 | Pei Li Pharmaceutical Ind Co L | The controlled release formulation of metformin HCl |
CN101951891A (zh) * | 2008-01-11 | 2011-01-19 | 希普拉有限公司 | 固态药物剂型 |
CN102247343A (zh) * | 2011-05-18 | 2011-11-23 | 四川晖瑞医药科技有限公司 | 一种复方吡格列酮二甲双胍缓释片制备工艺 |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110354090A (zh) * | 2019-07-29 | 2019-10-22 | 石药集团欧意药业有限公司 | 一种盐酸二甲双胍缓释片及其制备方法 |
CN110354090B (zh) * | 2019-07-29 | 2021-10-01 | 石药集团欧意药业有限公司 | 一种盐酸二甲双胍缓释片及其制备方法 |
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CN107184559A (zh) | 2017-09-22 |
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Effective date of registration: 20190424 Address after: 510000 Building 601, B5, 11 Kaiyuan Avenue, Science City, East District, Huangpu District, Guangzhou City, Guangdong Province Co-patentee after: Saikang (Guangzhou) Pharmaceutical Co.,Ltd. Patentee after: Guangdong Saikang Pharmaceutical Co.,Ltd. Co-patentee after: GUANGDONG SINOCORP PHARMACEUTICAL FACTORY CO.,LTD. Address before: 516800 Xiang2 Road, Huizhou Industrial Transfer Park, Huizhou City, Guangdong Province Patentee before: GUANGDONG SINOCORP PHARMACEUTICAL FACTORY CO.,LTD. |
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Effective date of registration: 20220307 Address after: 510000 Building 601, B5, 11 Kaiyuan Avenue, Science City, East District, Huangpu District, Guangzhou City, Guangdong Province Patentee after: Guangdong Saikang Pharmaceutical Co.,Ltd. Patentee after: GUANGDONG SINOCORP PHARMACEUTICAL FACTORY CO.,LTD. Address before: 510000 Building 601, B5, 11 Kaiyuan Avenue, Science City, East District, Huangpu District, Guangzhou City, Guangdong Province Patentee before: Guangdong Saikang Pharmaceutical Co.,Ltd. Patentee before: Saikang (Guangzhou) Pharmaceutical Co.,Ltd. Patentee before: GUANGDONG SINOCORP PHARMACEUTICAL FACTORY CO.,LTD. |
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CP02 | Change in the address of a patent holder |
Address after: Room 01 and Room 02 (for office use only), Room 1701, No. 31, Tianshou Road, Tianhe District, Guangzhou, Guangdong 510000 Patentee after: Guangdong Saikang Pharmaceutical Co.,Ltd. Patentee after: GUANGDONG SINOCORP PHARMACEUTICAL FACTORY CO.,LTD. Address before: 510000 Building 601, B5, 11 Kaiyuan Avenue, Science City, East District, Huangpu District, Guangzhou City, Guangdong Province Patentee before: Guangdong Saikang Pharmaceutical Co.,Ltd. Patentee before: GUANGDONG SINOCORP PHARMACEUTICAL FACTORY CO.,LTD. |