CA2460489C - Pegylated and diglycosylated erythropoietin - Google Patents

Pegylated and diglycosylated erythropoietin Download PDF

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Publication number
CA2460489C
CA2460489C CA2460489A CA2460489A CA2460489C CA 2460489 C CA2460489 C CA 2460489C CA 2460489 A CA2460489 A CA 2460489A CA 2460489 A CA2460489 A CA 2460489A CA 2460489 C CA2460489 C CA 2460489C
Authority
CA
Canada
Prior art keywords
erythropoietin
mutein
terminal
epo
glycosylated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2460489A
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English (en)
French (fr)
Other versions
CA2460489A1 (en
Inventor
Wilhelm Tischer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
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F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of CA2460489A1 publication Critical patent/CA2460489A1/en
Application granted granted Critical
Publication of CA2460489C publication Critical patent/CA2460489C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • C07K14/505Erythropoietin [EPO]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA2460489A 2001-09-25 2002-09-20 Pegylated and diglycosylated erythropoietin Expired - Lifetime CA2460489C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01122555 2001-09-25
EP01122555.4 2001-09-25
PCT/EP2002/010556 WO2003029291A2 (en) 2001-09-25 2002-09-20 Pegylated and diglycosylated erythropoietin

Publications (2)

Publication Number Publication Date
CA2460489A1 CA2460489A1 (en) 2003-04-10
CA2460489C true CA2460489C (en) 2011-12-06

Family

ID=8178675

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2460489A Expired - Lifetime CA2460489C (en) 2001-09-25 2002-09-20 Pegylated and diglycosylated erythropoietin

Country Status (10)

Country Link
US (1) US6930086B2 (cg-RX-API-DMAC7.html)
EP (1) EP1432802B1 (cg-RX-API-DMAC7.html)
JP (1) JP4025727B2 (cg-RX-API-DMAC7.html)
CN (1) CN100365117C (cg-RX-API-DMAC7.html)
AR (1) AR036575A1 (cg-RX-API-DMAC7.html)
AU (1) AU2002338743A1 (cg-RX-API-DMAC7.html)
CA (1) CA2460489C (cg-RX-API-DMAC7.html)
DE (1) DE60224415T2 (cg-RX-API-DMAC7.html)
ES (1) ES2298402T3 (cg-RX-API-DMAC7.html)
WO (1) WO2003029291A2 (cg-RX-API-DMAC7.html)

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Also Published As

Publication number Publication date
AU2002338743A1 (en) 2003-04-14
EP1432802B1 (en) 2008-01-02
US6930086B2 (en) 2005-08-16
JP4025727B2 (ja) 2007-12-26
US20030077753A1 (en) 2003-04-24
WO2003029291A2 (en) 2003-04-10
AR036575A1 (es) 2004-09-15
ES2298402T3 (es) 2008-05-16
CN100365117C (zh) 2008-01-30
EP1432802A2 (en) 2004-06-30
DE60224415D1 (de) 2008-02-14
JP2005509609A (ja) 2005-04-14
WO2003029291A3 (en) 2003-07-24
DE60224415T2 (de) 2008-12-18
CA2460489A1 (en) 2003-04-10
CN1558952A (zh) 2004-12-29

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