CA2458611C - Aminobenzophenones as interleukin 1-beta and tumour necrosis factor-alpha inhibitors - Google Patents

Aminobenzophenones as interleukin 1-beta and tumour necrosis factor-alpha inhibitors Download PDF

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CA2458611C
CA2458611C CA2458611A CA2458611A CA2458611C CA 2458611 C CA2458611 C CA 2458611C CA 2458611 A CA2458611 A CA 2458611A CA 2458611 A CA2458611 A CA 2458611A CA 2458611 C CA2458611 C CA 2458611C
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phenyl
amino
chloro
methylphenyl
compound
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French (fr)
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CA2458611A1 (en
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Erik Rytter Ottosen
Anne Marie Horneman
Xifu Liang
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Leo Pharma AS
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Leo Pharma AS
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    • C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/40—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
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    • C07C233/42—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/43—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of a saturated carbon skeleton
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    • C07D309/10—Oxygen atoms
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    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
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    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/28—Radicals substituted by nitrogen atoms
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    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
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    • C07C2601/00—Systems containing only non-condensed rings
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CA2458611A 2001-08-28 2002-08-26 Aminobenzophenones as interleukin 1-beta and tumour necrosis factor-alpha inhibitors Expired - Fee Related CA2458611C (en)

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KR100896667B1 (ko) * 2001-08-28 2009-05-14 레오 파마 에이/에스 신규한 아미노벤조페논 및 이를 포함하는 약제학적 조성물
PL377377A1 (pl) * 2002-12-20 2006-02-06 Leo Pharma A/S Nowe związki aminobenzofenonu
DK1658263T3 (da) * 2003-07-24 2010-09-27 Leo Pharma As Aminobenzophenonforbindelser
KR101260236B1 (ko) 2004-12-13 2013-05-06 레오 파마 에이/에스 트리아졸 치환된 아미노벤조페논 화합물
DE102005022020A1 (de) * 2005-05-12 2006-11-23 Merckle Gmbh Dibenzocycloheptanverbindungen und pharmazeutische Mittel, welche diese Verbindungen enthalten
EP2206534A1 (de) 2008-10-09 2010-07-14 c-a-i-r biosciences GmbH Dibenzocycloheptanonderivate und pharmazeutische Mittel, welche diese Verbindungen enthalten
AU2010301449B2 (en) * 2009-09-30 2013-03-14 Toray Industries, Inc. 2,3-dihydro-1H-indene-2-ylurea derivative and pharmaceutical application of same
KR102098606B1 (ko) * 2012-10-31 2020-04-09 후지필름 도야마 케미컬 가부시키가이샤 신규 아민 유도체 또는 그 염
US9758445B2 (en) * 2013-04-09 2017-09-12 Materia, Inc. Preparation of surfactants via cross-metathesis
WO2015126462A1 (en) * 2014-02-19 2015-08-27 Materia, Inc. Preparation of surfactants via cross-metathesis

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JPS57177058A (en) 1981-04-24 1982-10-30 Hodogaya Chem Co Ltd Novel fluoran compound
EP0859771A4 (en) * 1995-10-31 2000-03-15 Merck & Co Inc SUBSTITUTED PYRIDYLPYRROLE, PREPARATIONS CONTAINING SUCH COMPOUNDS AND METHOD FOR THE USE THEREOF
GB9701453D0 (en) * 1997-01-24 1997-03-12 Leo Pharm Prod Ltd Aminobenzophenones
JPH11349568A (ja) * 1998-06-08 1999-12-21 Maruho Co Ltd ラクタム誘導体及びその医薬用途
RU2240995C2 (ru) * 1999-07-16 2004-11-27 Лео Фармасьютикал Продактс Лтд.А/С (Левенс Кемиске Фабрик Продукционсактиесельскаб) Аминобензофеноны в качестве ингибиторов интерлейкина il-1бета и фактора некроза опухолей tnf-альфа
EP1210325B1 (en) * 1999-07-16 2004-10-06 Leo Pharma A/S Aminobenzophenones as inhibitors of il-1beta and tnf-alpha
ES2228555T3 (es) * 1999-07-16 2005-04-16 Leo Pharma A/S Aminobenzofenonas con inhibidores de la il-1beta y tnf-alfa.
AU768473B2 (en) 1999-07-16 2003-12-11 Leo Pharmaceutical Products Ltd. A/S (Lovens Kemiske Fabrik Produktionsaktieselskab) Novel aminobenzophenones
ATE277889T1 (de) 1999-07-16 2004-10-15 Leo Pharma As Aminobenzophenone als inhibitoren von il-1beta und tnf-alpha
MXPA02005604A (es) * 1999-12-06 2004-09-10 Leo Pharma As Aminobenzofenonas como inhibidores de il-1beta y tnf-alfa.
AU2001260081B2 (en) * 2000-05-22 2005-07-28 Leo Pharma A/S Benzophenones as inhibitors of il-1beta and tnf-alpha
US20020165286A1 (en) * 2000-12-08 2002-11-07 Hanne Hedeman Dermal anti-inflammatory composition
KR100896667B1 (ko) * 2001-08-28 2009-05-14 레오 파마 에이/에스 신규한 아미노벤조페논 및 이를 포함하는 약제학적 조성물

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IL160442A (en) 2011-11-30
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WO2003018535A3 (en) 2004-03-18
HUP0401644A2 (hu) 2004-11-29
US7034015B2 (en) 2006-04-25
PL207487B1 (pl) 2010-12-31
KR20040029455A (ko) 2004-04-06
BR0212249A (pt) 2004-10-05
WO2003018535A2 (en) 2003-03-06
CN100347151C (zh) 2007-11-07
KR100896667B1 (ko) 2009-05-14
AU2002331310B2 (en) 2008-07-17
PL368686A1 (en) 2005-04-04
JP2010189410A (ja) 2010-09-02
RU2361855C2 (ru) 2009-07-20
EP1423356A2 (en) 2004-06-02
JP4540984B2 (ja) 2010-09-08
RU2004109142A (ru) 2005-08-20
US20030119902A1 (en) 2003-06-26
HK1068606A1 (zh) 2005-04-29
HUP0401644A3 (en) 2008-03-28
CN1561327A (zh) 2005-01-05

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