CA2457814A1 - Disulfide and thiosulfonate ligands and libraries comprising these ligands - Google Patents

Disulfide and thiosulfonate ligands and libraries comprising these ligands Download PDF

Info

Publication number
CA2457814A1
CA2457814A1 CA002457814A CA2457814A CA2457814A1 CA 2457814 A1 CA2457814 A1 CA 2457814A1 CA 002457814 A CA002457814 A CA 002457814A CA 2457814 A CA2457814 A CA 2457814A CA 2457814 A1 CA2457814 A1 CA 2457814A1
Authority
CA
Canada
Prior art keywords
aryl
aliphatic
heteroaryl
heteroaliphatic
library
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002457814A
Other languages
English (en)
French (fr)
Inventor
Andrew C. Braisted
Daniel A. Erlanson
Jeffrey W. Jacobs
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Viracta Therapeutics Inc
Original Assignee
Sunesis Pharmaceuticals, Inc.
Andrew C. Braisted
Daniel A. Erlanson
Jeffrey W. Jacobs
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/990,421 external-priority patent/US6919178B2/en
Priority claimed from US10/121,216 external-priority patent/US6998233B2/en
Application filed by Sunesis Pharmaceuticals, Inc., Andrew C. Braisted, Daniel A. Erlanson, Jeffrey W. Jacobs filed Critical Sunesis Pharmaceuticals, Inc.
Publication of CA2457814A1 publication Critical patent/CA2457814A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
CA002457814A 2001-08-07 2002-05-10 Disulfide and thiosulfonate ligands and libraries comprising these ligands Abandoned CA2457814A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US31072501P 2001-08-07 2001-08-07
US60/310,725 2001-08-07
US09/990,421 2001-11-21
US09/990,421 US6919178B2 (en) 2000-11-21 2001-11-21 Extended tethering approach for rapid identification of ligands
US10/121,216 US6998233B2 (en) 1998-06-26 2002-04-10 Methods for ligand discovery
US10/121,216 2002-04-10
PCT/US2002/014778 WO2003014072A1 (en) 2001-08-07 2002-05-10 Disulfide and thiosulfonate ligands and libraries comprising these ligands

Publications (1)

Publication Number Publication Date
CA2457814A1 true CA2457814A1 (en) 2003-02-20

Family

ID=27382591

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002457814A Abandoned CA2457814A1 (en) 2001-08-07 2002-05-10 Disulfide and thiosulfonate ligands and libraries comprising these ligands

Country Status (7)

Country Link
EP (1) EP1421063A1 (ja)
JP (1) JP2004537594A (ja)
CA (1) CA2457814A1 (ja)
IL (1) IL159983A0 (ja)
MX (1) MXPA04001074A (ja)
NZ (1) NZ530811A (ja)
WO (1) WO2003014072A1 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7214487B2 (en) 1998-06-26 2007-05-08 Sunesis Pharmaceuticals, Inc. Methods for identifying compounds that modulate enzymatic activities by employing covalently bonded target-extender complexes with ligand candidates
CA2478981A1 (en) 2002-03-21 2003-10-02 Sunesis Pharmaceuticals, Inc. Identification of kinase inhibitors
MX2007002210A (es) * 2004-08-26 2007-05-07 Nicholas Piramal India Ltd Profarmacos que contienen enlazantes bioescindibles novedosos.
US7544754B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544755B2 (en) 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups
US7544756B2 (en) * 2005-09-30 2009-06-09 3M Innovative Properties Company Crosslinked polymers with amine binding groups

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU509899B2 (en) * 1976-02-13 1980-05-29 E.R. Squibb & Sons, Inc. Proline derivatives and related compounds
US4614712A (en) * 1983-02-25 1986-09-30 The Upjohn Company Immunoassays with luciferase labeled ligands or receptors
JPH08201958A (ja) * 1995-01-24 1996-08-09 Konica Corp ハロゲン化銀写真感光材料及び画像形成方法
PL337019A1 (en) * 1997-05-22 2000-07-31 Merck Patent Gmbh Peptide-coated implants and method of obtaining them
US6344330B1 (en) * 1998-03-27 2002-02-05 The Regents Of The University Of California Pharmacophore recombination for the identification of small molecule drug lead compounds
US6335155B1 (en) * 1998-06-26 2002-01-01 Sunesis Pharmaceuticals, Inc. Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules
JP3836791B2 (ja) * 2000-11-21 2006-10-25 サネシス ファーマシューティカルズ， インコーポレイテッド リガンドの迅速な同定のための拡張されたテザー化アプローチ

Also Published As

Publication number Publication date
NZ530811A (en) 2005-07-29
WO2003014072A1 (en) 2003-02-20
IL159983A0 (en) 2004-06-20
JP2004537594A (ja) 2004-12-16
EP1421063A1 (en) 2004-05-26
MXPA04001074A (es) 2004-07-08

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Legal Events

Date Code Title Description
FZDE Discontinued