CA2457753A1 - Mesure d'une substance dans un echantillon biologique - Google Patents
Mesure d'une substance dans un echantillon biologique Download PDFInfo
- Publication number
- CA2457753A1 CA2457753A1 CA002457753A CA2457753A CA2457753A1 CA 2457753 A1 CA2457753 A1 CA 2457753A1 CA 002457753 A CA002457753 A CA 002457753A CA 2457753 A CA2457753 A CA 2457753A CA 2457753 A1 CA2457753 A1 CA 2457753A1
- Authority
- CA
- Canada
- Prior art keywords
- wavelength bands
- electromagnetic radiation
- organic substance
- infrared
- wavelength
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000000126 substance Substances 0.000 title claims abstract description 133
- 239000012472 biological sample Substances 0.000 title claims abstract description 66
- 238000000034 method Methods 0.000 claims abstract description 136
- 230000005670 electromagnetic radiation Effects 0.000 claims abstract description 108
- 239000008103 glucose Substances 0.000 claims description 148
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 146
- 238000010521 absorption reaction Methods 0.000 claims description 74
- 238000002835 absorbance Methods 0.000 claims description 64
- 238000005259 measurement Methods 0.000 claims description 47
- 238000000862 absorption spectrum Methods 0.000 claims description 45
- 238000001514 detection method Methods 0.000 claims description 45
- 239000013060 biological fluid Substances 0.000 claims description 43
- 239000012530 fluid Substances 0.000 claims description 40
- 239000000523 sample Substances 0.000 claims description 36
- 238000011002 quantification Methods 0.000 claims description 26
- 238000013178 mathematical model Methods 0.000 claims description 22
- 230000008569 process Effects 0.000 claims description 20
- 238000012545 processing Methods 0.000 claims description 15
- 230000004044 response Effects 0.000 claims description 15
- 230000003595 spectral effect Effects 0.000 claims description 15
- 238000002834 transmittance Methods 0.000 claims description 11
- 239000000706 filtrate Substances 0.000 claims description 10
- 241000124008 Mammalia Species 0.000 claims 3
- 210000001124 body fluid Anatomy 0.000 claims 1
- 239000010839 body fluid Substances 0.000 claims 1
- 238000004891 communication Methods 0.000 claims 1
- 239000000243 solution Substances 0.000 description 39
- 238000005102 attenuated total reflection Methods 0.000 description 23
- 238000012417 linear regression Methods 0.000 description 19
- 230000005855 radiation Effects 0.000 description 19
- 238000001228 spectrum Methods 0.000 description 19
- 210000004369 blood Anatomy 0.000 description 16
- 239000008280 blood Substances 0.000 description 16
- 239000000835 fiber Substances 0.000 description 16
- 239000013078 crystal Substances 0.000 description 12
- 230000003993 interaction Effects 0.000 description 12
- 241000700159 Rattus Species 0.000 description 10
- 206010012601 diabetes mellitus Diseases 0.000 description 10
- 230000000694 effects Effects 0.000 description 9
- 239000013307 optical fiber Substances 0.000 description 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 8
- 238000002790 cross-validation Methods 0.000 description 8
- 238000010200 validation analysis Methods 0.000 description 8
- 239000012153 distilled water Substances 0.000 description 7
- 230000002452 interceptive effect Effects 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- 239000000306 component Substances 0.000 description 6
- 238000004458 analytical method Methods 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 101150084411 crn1 gene Proteins 0.000 description 5
- ORQBXQOJMQIAOY-UHFFFAOYSA-N nobelium Chemical compound [No] ORQBXQOJMQIAOY-UHFFFAOYSA-N 0.000 description 5
- 230000003287 optical effect Effects 0.000 description 5
- 101100328486 Caenorhabditis elegans cni-1 gene Proteins 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 230000010354 integration Effects 0.000 description 4
- 238000012986 modification Methods 0.000 description 4
- 230000004048 modification Effects 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- 230000001105 regulatory effect Effects 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- -1 LRS Chemical compound 0.000 description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 2
- 229920005372 Plexiglas® Polymers 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 239000011575 calcium Substances 0.000 description 2
- 229910052791 calcium Inorganic materials 0.000 description 2
- 230000001427 coherent effect Effects 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 230000003750 conditioning effect Effects 0.000 description 2
- 238000012937 correction Methods 0.000 description 2
- 238000001914 filtration Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 150000002500 ions Chemical class 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 238000000513 principal component analysis Methods 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 238000004611 spectroscopical analysis Methods 0.000 description 2
- 201000004569 Blindness Diseases 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
- 229930006000 Sucrose Natural products 0.000 description 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
- 239000012042 active reagent Substances 0.000 description 1
- GZCGUPFRVQAUEE-SLPGGIOYSA-N aldehydo-D-glucose Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O GZCGUPFRVQAUEE-SLPGGIOYSA-N 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- 235000013405 beer Nutrition 0.000 description 1
- 239000012503 blood component Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000001508 eye Anatomy 0.000 description 1
- 210000002216 heart Anatomy 0.000 description 1
- 238000002513 implantation Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 150000002484 inorganic compounds Chemical class 0.000 description 1
- 229910010272 inorganic material Inorganic materials 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000000491 multivariate analysis Methods 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 238000010238 partial least squares regression Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000002310 reflectometry Methods 0.000 description 1
- 238000005057 refrigeration Methods 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000009528 severe injury Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 1
- 229960001052 streptozocin Drugs 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 210000001138 tear Anatomy 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1495—Calibrating or testing of in-vivo probes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
- A61B5/14514—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid using means for aiding extraction of interstitial fluid, e.g. microneedles or suction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
Abstract
L'invention concerne un procédé permettant de mesurer la quantité d'une substance organique dans un échantillon biologique par rayonnement électromagnétique infrarouge.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31216501P | 2001-08-14 | 2001-08-14 | |
US60/312,165 | 2001-08-14 | ||
PCT/US2002/022899 WO2003016882A1 (fr) | 2001-08-14 | 2002-07-18 | Mesure d'une substance dans un echantillon biologique |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2457753A1 true CA2457753A1 (fr) | 2003-02-27 |
Family
ID=23210165
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002457753A Abandoned CA2457753A1 (fr) | 2001-08-14 | 2002-07-18 | Mesure d'une substance dans un echantillon biologique |
Country Status (3)
Country | Link |
---|---|
EP (1) | EP1428013A4 (fr) |
CA (1) | CA2457753A1 (fr) |
WO (1) | WO2003016882A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102042967A (zh) * | 2010-11-18 | 2011-05-04 | 上海衡伟信息技术有限公司 | 一种基于近红外光谱技术的葡萄糖水溶液快速识别方法 |
Families Citing this family (58)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040147034A1 (en) * | 2001-08-14 | 2004-07-29 | Gore Jay Prabhakar | Method and apparatus for measuring a substance in a biological sample |
US7050157B2 (en) | 2001-11-08 | 2006-05-23 | Optiscan Biomedical Corp. | Reagent-less whole-blood glucose meter |
US7061593B2 (en) | 2001-11-08 | 2006-06-13 | Optiscan Biomedical Corp. | Device and method for in vitro determination of analyte concentrations within body fluids |
US6958809B2 (en) | 2001-11-08 | 2005-10-25 | Optiscan Biomedical Corporation | Reagent-less whole-blood glucose meter |
US6989891B2 (en) | 2001-11-08 | 2006-01-24 | Optiscan Biomedical Corporation | Device and method for in vitro determination of analyte concentrations within body fluids |
US7288768B2 (en) | 2002-07-18 | 2007-10-30 | Purdue Research Foundation | Method for measuring the amount of an organic substance in a food product with infrared electromagnetic radiation |
DE602004003414T2 (de) * | 2003-04-03 | 2007-09-27 | Matsushita Electric Industrial Co., Ltd., Kadoma | Methode und Gerät zur Konzentrationmessung einer spezifischen Komponente |
US20080119703A1 (en) | 2006-10-04 | 2008-05-22 | Mark Brister | Analyte sensor |
US8761856B2 (en) | 2003-08-01 | 2014-06-24 | Dexcom, Inc. | System and methods for processing analyte sensor data |
US8626257B2 (en) | 2003-08-01 | 2014-01-07 | Dexcom, Inc. | Analyte sensor |
US20190357827A1 (en) | 2003-08-01 | 2019-11-28 | Dexcom, Inc. | Analyte sensor |
US8060173B2 (en) * | 2003-08-01 | 2011-11-15 | Dexcom, Inc. | System and methods for processing analyte sensor data |
DE10351160B3 (de) * | 2003-11-03 | 2005-03-31 | Roche Diagnostics Gmbh | Durchfluß-Meßküvette und Transmissionsspektrometer zur Untersuchung biologischer Flüssigkeiten |
EP1805499A4 (fr) | 2004-10-21 | 2010-07-21 | Optiscan Biomedical Corp | Procede et appareil permettant de determiner la concentration d'une substance a analyser dans un echantillon comprenant une substance interferente |
US20060189925A1 (en) | 2005-02-14 | 2006-08-24 | Gable Jennifer H | Methods and apparatus for extracting and analyzing a component of a bodily fluid |
US20060216209A1 (en) | 2005-02-14 | 2006-09-28 | Braig James R | Analyte detection system with distributed sensing |
US8936755B2 (en) | 2005-03-02 | 2015-01-20 | Optiscan Biomedical Corporation | Bodily fluid composition analyzer with disposable cassette |
US7722537B2 (en) | 2005-02-14 | 2010-05-25 | Optiscan Biomedical Corp. | Method and apparatus for detection of multiple analytes |
US7785258B2 (en) | 2005-10-06 | 2010-08-31 | Optiscan Biomedical Corporation | System and method for determining a treatment dose for a patient |
US8251907B2 (en) | 2005-02-14 | 2012-08-28 | Optiscan Biomedical Corporation | System and method for determining a treatment dose for a patient |
US9561001B2 (en) | 2005-10-06 | 2017-02-07 | Optiscan Biomedical Corporation | Fluid handling cassette system for body fluid analyzer |
US8417311B2 (en) | 2008-09-12 | 2013-04-09 | Optiscan Biomedical Corporation | Fluid component analysis system and method for glucose monitoring and control |
US8412293B2 (en) | 2007-07-16 | 2013-04-02 | Optiscan Biomedical Corporation | Systems and methods for determining physiological parameters using measured analyte values |
WO2008144575A2 (fr) | 2007-05-18 | 2008-11-27 | Optiscan Biomedical Corporation | Système d'injection de fluide et de sécurité |
US8597190B2 (en) | 2007-05-18 | 2013-12-03 | Optiscan Biomedical Corporation | Monitoring systems and methods with fast initialization |
EP2205147A1 (fr) | 2007-10-10 | 2010-07-14 | Optiscan Biomedical Corporation | Système d'analyse de composant de fluide et procédé pour contrôler et réguler le glucose |
US8417312B2 (en) | 2007-10-25 | 2013-04-09 | Dexcom, Inc. | Systems and methods for processing sensor data |
US7959598B2 (en) | 2008-08-20 | 2011-06-14 | Asante Solutions, Inc. | Infusion pump systems and methods |
US10475529B2 (en) | 2011-07-19 | 2019-11-12 | Optiscan Biomedical Corporation | Method and apparatus for analyte measurements using calibration sets |
WO2011011462A1 (fr) | 2009-07-20 | 2011-01-27 | Optiscan Biomedical Corporation | Connecteur réglable à espace mort réduit |
US9554742B2 (en) | 2009-07-20 | 2017-01-31 | Optiscan Biomedical Corporation | Fluid analysis system |
EP2585165B1 (fr) | 2010-05-03 | 2017-06-21 | Optiscan Biomedical Corporation | Raccord réglable, écoulement amélioré de fluide et risque réduit de coagulation |
EP3156796A1 (fr) | 2010-06-09 | 2017-04-19 | Optiscan Biomedical Corporation | Mesure d'analytes dans un échantillon de liquide prélevé chez un patient |
ES2847578T3 (es) | 2011-04-15 | 2021-08-03 | Dexcom Inc | Calibración avanzada de sensor de analito y detección de errores |
EP2729784A4 (fr) | 2011-07-06 | 2015-05-13 | Optiscan Biomedical Corp | Cellule échantillon pour système d'analyse de fluide |
WO2015095239A1 (fr) | 2013-12-18 | 2015-06-25 | Optiscan Biomedical Corporation | Systèmes et procédés de détection de fuites |
GB2523989B (en) | 2014-01-30 | 2020-07-29 | Insulet Netherlands B V | Therapeutic product delivery system and method of pairing |
CN111905188B (zh) | 2015-02-18 | 2022-07-22 | 英赛罗公司 | 流体输送和输注装置及其使用方法 |
EP3374905A1 (fr) | 2016-01-13 | 2018-09-19 | Bigfoot Biomedical, Inc. | Interface utilisateur pour système de gestion du diabète |
CN112933333B (zh) | 2016-01-14 | 2023-03-28 | 比格福特生物医药公司 | 调整胰岛素输送速率 |
US10765807B2 (en) | 2016-09-23 | 2020-09-08 | Insulet Corporation | Fluid delivery device with sensor |
USD928199S1 (en) | 2018-04-02 | 2021-08-17 | Bigfoot Biomedical, Inc. | Medication delivery device with icons |
AU2019263490A1 (en) | 2018-05-04 | 2020-11-26 | Insulet Corporation | Safety constraints for a control algorithm-based drug delivery system |
CN112789070A (zh) | 2018-09-28 | 2021-05-11 | 英赛罗公司 | 人造胰腺系统的活动模式 |
WO2020077223A1 (fr) | 2018-10-11 | 2020-04-16 | Insulet Corporation | Détection d'événement pour système d'administration de médicament |
USD920343S1 (en) | 2019-01-09 | 2021-05-25 | Bigfoot Biomedical, Inc. | Display screen or portion thereof with graphical user interface associated with insulin delivery |
US11801344B2 (en) | 2019-09-13 | 2023-10-31 | Insulet Corporation | Blood glucose rate of change modulation of meal and correction insulin bolus quantity |
US11935637B2 (en) | 2019-09-27 | 2024-03-19 | Insulet Corporation | Onboarding and total daily insulin adaptivity |
US11957875B2 (en) | 2019-12-06 | 2024-04-16 | Insulet Corporation | Techniques and devices providing adaptivity and personalization in diabetes treatment |
US11833329B2 (en) | 2019-12-20 | 2023-12-05 | Insulet Corporation | Techniques for improved automatic drug delivery performance using delivery tendencies from past delivery history and use patterns |
US11551802B2 (en) | 2020-02-11 | 2023-01-10 | Insulet Corporation | Early meal detection and calorie intake detection |
US11547800B2 (en) | 2020-02-12 | 2023-01-10 | Insulet Corporation | User parameter dependent cost function for personalized reduction of hypoglycemia and/or hyperglycemia in a closed loop artificial pancreas system |
US11324889B2 (en) | 2020-02-14 | 2022-05-10 | Insulet Corporation | Compensation for missing readings from a glucose monitor in an automated insulin delivery system |
US11607493B2 (en) | 2020-04-06 | 2023-03-21 | Insulet Corporation | Initial total daily insulin setting for user onboarding |
US11684716B2 (en) | 2020-07-31 | 2023-06-27 | Insulet Corporation | Techniques to reduce risk of occlusions in drug delivery systems |
US11904140B2 (en) | 2021-03-10 | 2024-02-20 | Insulet Corporation | Adaptable asymmetric medicament cost component in a control system for medicament delivery |
US11738144B2 (en) | 2021-09-27 | 2023-08-29 | Insulet Corporation | Techniques enabling adaptation of parameters in aid systems by user input |
US11439754B1 (en) | 2021-12-01 | 2022-09-13 | Insulet Corporation | Optimizing embedded formulations for drug delivery |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2934190A1 (de) * | 1979-08-23 | 1981-03-19 | Müller, Gerhard, Prof. Dr.-Ing., 7080 Aalen | Verfahren und vorrichtung zur molekuelspektroskopie, insbesondere zur bestimmung von stoffwechselprodukten |
US4777953A (en) * | 1987-02-25 | 1988-10-18 | Ash Medical Systems, Inc. | Capillary filtration and collection method for long-term monitoring of blood constituents |
AU7302991A (en) * | 1990-02-02 | 1991-08-21 | Boston Advanced Technologies, Inc. | Systems for material analysis based on reflectance ratio detection |
US5321265A (en) * | 1992-07-15 | 1994-06-14 | Block Myron J | Non-invasive testing |
US5533509A (en) * | 1993-08-12 | 1996-07-09 | Kurashiki Boseki Kabushiki Kaisha | Method and apparatus for non-invasive measurement of blood sugar level |
US5743262A (en) * | 1995-06-07 | 1998-04-28 | Masimo Corporation | Blood glucose monitoring system |
US6025597A (en) * | 1995-10-17 | 2000-02-15 | Optiscan Biomedical Corporation | Non-invasive infrared absorption spectrometer for measuring glucose or other constituents in a human or other body |
IL127213A (en) * | 1996-07-08 | 2003-09-17 | Animas Corp | Implantable sensor and system for in vivo measurement and control of fluid constituent levels |
US6157041A (en) * | 1998-10-13 | 2000-12-05 | Rio Grande Medical Technologies, Inc. | Methods and apparatus for tailoring spectroscopic calibration models |
-
2002
- 2002-07-18 CA CA002457753A patent/CA2457753A1/fr not_active Abandoned
- 2002-07-18 EP EP02756523A patent/EP1428013A4/fr not_active Withdrawn
- 2002-07-18 WO PCT/US2002/022899 patent/WO2003016882A1/fr not_active Application Discontinuation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102042967A (zh) * | 2010-11-18 | 2011-05-04 | 上海衡伟信息技术有限公司 | 一种基于近红外光谱技术的葡萄糖水溶液快速识别方法 |
CN102042967B (zh) * | 2010-11-18 | 2012-07-04 | 上海衡伟信息技术有限公司 | 一种基于近红外光谱技术的葡萄糖水溶液快速识别方法 |
Also Published As
Publication number | Publication date |
---|---|
WO2003016882A1 (fr) | 2003-02-27 |
EP1428013A4 (fr) | 2007-10-31 |
EP1428013A1 (fr) | 2004-06-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2457753A1 (fr) | Mesure d'une substance dans un echantillon biologique | |
US20040147034A1 (en) | Method and apparatus for measuring a substance in a biological sample | |
US4882492A (en) | Non-invasive near infrared measurement of blood analyte concentrations | |
EP0404562B1 (fr) | Procédé et appareil pour déterminer la ressemblance d'un analyte biologique, à partir d'un modèle construit de fluides biologiques connus | |
US20110009720A1 (en) | Continuous whole blood glucose monitor | |
US7277740B2 (en) | Analysis system for reagent-free determination of the concentration of an analyte in living tissue | |
US6741875B1 (en) | Method for determination of analytes using near infrared, adjacent visible spectrum and an array of longer near infrared wavelengths | |
EP3737938B1 (fr) | Systèmes et procédés de détection et de quantification d'ammoniac et d'ammonium dans des liquides | |
CA2383727A1 (fr) | Procede de determination d'analytes au moyen d'un spectre visible adjacent, a infrarouge proche et reseau de longueurs d'onde plus longues a infrarouge proche | |
WO2004075734A2 (fr) | Determination du ph et de la concentration de l'hemoglobine | |
WO2000070350A1 (fr) | Procede et dispositif de mesure rapide de hba¿1c? | |
US20050203356A1 (en) | Joint-diagnostic in vivo & in vitro apparatus | |
WO2011116006A2 (fr) | Procédé rapide pour mesurer le cyanure dans des échantillons biologiques | |
CA2383725A1 (fr) | Procede de determination d'analytes au moyen d'un spectre en proche infrarouge, d'un spectre visible adjacent et de longueurs d'ondes distinctes de spectre en proche infrarouge | |
CN1314368C (zh) | 测量待测物中成分浓度的方法和设备 | |
Fogt | Continuous ex vivo and in vivo monitoring with chemical sensors | |
EP0282505A1 (fr) | Procede et dispositif permettant de determiner le niveau d'un analyte dans un echantillon de sang total | |
WO2009071102A1 (fr) | Procédé et dispositif optique pour mesurer des concentrations de substances dans des fluides biologiques | |
US8523785B2 (en) | Method and apparatus for measuring analytes | |
WO1993009421A1 (fr) | Appareil pour la mesure ex-vivo des niveaux de sucre dans le sang | |
JP2002514758A (ja) | 光学的化学検出のためのシステムおよび方法 | |
JP3642602B2 (ja) | 尿中成分の測定装置 | |
Scheggi et al. | Optical Fibre Sensors And Applications With Particular Reference To Chemical Sensing | |
Shih et al. | Introduction to spectroscopy for noninvasive glucose sensing | |
Bronzino | Optical Sensors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |