EP0282505A1 - Procede et dispositif permettant de determiner le niveau d'un analyte dans un echantillon de sang total - Google Patents

Procede et dispositif permettant de determiner le niveau d'un analyte dans un echantillon de sang total

Info

Publication number
EP0282505A1
EP0282505A1 EP87905244A EP87905244A EP0282505A1 EP 0282505 A1 EP0282505 A1 EP 0282505A1 EP 87905244 A EP87905244 A EP 87905244A EP 87905244 A EP87905244 A EP 87905244A EP 0282505 A1 EP0282505 A1 EP 0282505A1
Authority
EP
European Patent Office
Prior art keywords
sample
light
reflection element
analyte
reflection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP87905244A
Other languages
German (de)
English (en)
Inventor
Brendan M. Buckley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Radiometer AS
Original Assignee
Radiometer AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Radiometer AS filed Critical Radiometer AS
Publication of EP0282505A1 publication Critical patent/EP0282505A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection

Definitions

  • the object of the present invention is to provide an improved, analysis method for use on whole blood.
  • FIG. 3 shows diagrammatically an analyzer 21 according to the invention for analyzing samples of whole blood.
  • a sampling device in the present case a syringe 22
  • a sample is introduced in the analyzer 1 through sample inlet means 23.
  • the sample is drawn through a sample conduit 24 of analyzer 1 by means of pump means shown as 25.
  • pump means shown as 25.
  • the sample reaches particular measuring locations or cuvettes 26 and 27 in conduit 24 the sample transport is stopped.
  • the sample is contacted with a potassium measuring electrode 28 and a reference electrode 29.
  • a reflection element 30 forms part of the upper wall of cuvette 27, reflection element 30 further being connected to light source means 31 and light detector means 32 via light guides 33, 34, respectively.

Landscapes

  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)

Abstract

Sont décrits un procédé de détermination du niveau d'un analyte dans un échantillon de sang total par une technique de spectroscopie à réflexion interne et un dispositif indiqué pour cette technique. Ce procédé est particulièremnt utile pour détecter l'atténuation de la lumière entièrement réfléchie, suite à l'absorption de l'onde évanescente, p. ex. par les hémoglobines. Dans le dispositif (1) la lumière incidente est dirigée par un guide de lumière (7) vers l'élément de réflexion (3) et la lumière atténuée entièrement réfléchie est dirigée à l'extérieur de l'élément vers un photodétecteur (12) par un guide de lumière (11). Dans le sang total contenu dans la cuvette (18), les celleules sont extraites de l'interface (8) par la force de gravité et laissent un plasma (4) exempt de cellules sanguines à proximité de l'interface (8). Il est ainsi possible de détecter les analytes présents dans le plasma et d'évaluer l'étendue de l'hémolyse.
EP87905244A 1986-08-14 1987-08-14 Procede et dispositif permettant de determiner le niveau d'un analyte dans un echantillon de sang total Withdrawn EP0282505A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868619823A GB8619823D0 (en) 1986-08-14 1986-08-14 Determining level of analyte
GB8619823 1986-08-14

Publications (1)

Publication Number Publication Date
EP0282505A1 true EP0282505A1 (fr) 1988-09-21

Family

ID=10602715

Family Applications (1)

Application Number Title Priority Date Filing Date
EP87905244A Withdrawn EP0282505A1 (fr) 1986-08-14 1987-08-14 Procede et dispositif permettant de determiner le niveau d'un analyte dans un echantillon de sang total

Country Status (6)

Country Link
EP (1) EP0282505A1 (fr)
JP (1) JPH01500928A (fr)
DK (1) DK201088A (fr)
FI (1) FI881704A (fr)
GB (1) GB8619823D0 (fr)
WO (1) WO1988001376A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK163194C (da) * 1988-12-22 1992-06-22 Radiometer As Fremgangsmaade ved fotometrisk in vitro bestemmelse af en blodgasparameter i en blodproeve
GB8818690D0 (en) * 1988-08-05 1988-09-07 Red Kite Technology Ltd Refractive index measurement
GB9008261D0 (en) * 1990-04-11 1990-06-13 Ares Serono Res & Dev Ltd Method of improving assay sensitivity
DE4124920C2 (de) * 1990-07-27 1993-12-23 Hitachi Ltd Biochemischer Analysator mit einer Prismenzelle für abgeschwächte Totalreflexion und einer Kühleinrichtung
EP0488947B1 (fr) * 1990-11-26 1995-02-15 Ciba-Geigy Ag Cellule détectrice
DE4128846C2 (de) * 1991-08-30 1994-07-14 Rainer Dr Klein Integriert optischer Stoffsensor
DE9110757U1 (de) * 1991-08-30 1992-02-13 Klein, Rainer, 5840 Schwerte Integriert-optischer Stoffsensor
DE4333560A1 (de) * 1993-10-01 1995-04-06 Bayer Ag Vorrichtung zur kontinuierlichen spektroskopischen Analyse nach dem Prinzip der abgeschwächten Totalreflexion
DE10030920C2 (de) * 2000-06-24 2003-01-02 Glukomeditech Ag Messvorrichtung zur gleichzeitigen refraktrometrischen und ATR-spektrometrischen Messung der Konzentration flüssiger Medien und Verwendung dieser Vorrichtung s
SE0104443D0 (sv) 2001-12-28 2001-12-28 Hemocue Ab Analysis method and cuvette therefor
CA2446328C (fr) 2002-10-29 2013-12-31 Bayer Healthcare Llc Dispositif d'essai optique avec reactif pour petits volumes d'echantillons
US8377381B2 (en) 2003-01-21 2013-02-19 Bayer Healthcare Llc Optical format
US7221440B2 (en) 2004-07-22 2007-05-22 Eastman Kodak Company System and method for controlling ink concentration using a refractometer
US7375813B2 (en) 2004-10-21 2008-05-20 Eastman Kodak Company Method and system for diffusion attenuated total reflection based concentration sensing
JP5268981B2 (ja) * 2010-03-24 2013-08-21 株式会社東芝 光学式センサ
JP5901012B2 (ja) * 2012-02-13 2016-04-06 国立大学法人 東京医科歯科大学 血液情報の測定方法及び装置
US10288600B2 (en) 2016-05-20 2019-05-14 Instrumentation Laboratory Company Evanescent hemolysis detection
EP3526587B1 (fr) 2016-10-13 2024-05-01 Instrumentation Laboratory Company Mesure de protéine totale à l'aide de la réfractométrie de sang entier
EP3370058A1 (fr) * 2017-03-01 2018-09-05 Danmarks Tekniske Universitet Dispositif de guide d'onde planaire avec filtre de taille nanométrique
EP3775845B1 (fr) * 2018-04-12 2023-08-30 Radiometer Medical ApS Élément capteur à membrane poreuse

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3480490D1 (en) * 1984-12-10 1989-12-21 Prutec Ltd Optical test probe and apparatus for optically determining species in solution

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO8801376A1 *

Also Published As

Publication number Publication date
JPH01500928A (ja) 1989-03-30
DK201088A (da) 1988-06-14
WO1988001376A1 (fr) 1988-02-25
DK201088D0 (da) 1988-04-13
GB8619823D0 (en) 1986-09-24
FI881704A0 (fi) 1988-04-13
FI881704A (fi) 1988-04-13

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Legal Events

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