WO1993009421A1 - Appareil pour la mesure ex-vivo des niveaux de sucre dans le sang - Google Patents

Appareil pour la mesure ex-vivo des niveaux de sucre dans le sang Download PDF

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Publication number
WO1993009421A1
WO1993009421A1 PCT/DK1992/000317 DK9200317W WO9309421A1 WO 1993009421 A1 WO1993009421 A1 WO 1993009421A1 DK 9200317 W DK9200317 W DK 9200317W WO 9309421 A1 WO9309421 A1 WO 9309421A1
Authority
WO
WIPO (PCT)
Prior art keywords
light
substance
sample
attenuated total
reflection device
Prior art date
Application number
PCT/DK1992/000317
Other languages
English (en)
Inventor
Vaughan Clift
Original Assignee
Novo Nordisk A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk A/S filed Critical Novo Nordisk A/S
Publication of WO1993009421A1 publication Critical patent/WO1993009421A1/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/55—Specular reflectivity
    • G01N21/552—Attenuated total reflection
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light

Definitions

  • the invention concerns an apparatus for measuring ex vivo blood sugar levels, and especially a portable apparatus for measuring the glucose concentration in the blood.
  • Persons suffering from diabetes must frequently check the glucose concentration in their blood to be able to adjust their insulin treatment so that a close to normal glucose concentration is maintained.
  • the concentration should be measured once a day and a profile involving several measurements within 24 hours should be taken once a fortnight.
  • a device is wanted which the patient may carry in his pocket and use to make a measurement when and where he should want to without being dependent on outer installations.
  • an apparatus must have dimensions making it portable and it must permit measurements on samples of unprepared blood, the needed size of the sample should not exceed 25 ⁇ l corresponding to a drop of blood which may be provided by pricking a finger or an earlobe, and the apparatus should be able to perform a great number of measurements without needing any services.
  • Portable glucose sensors are known which are based on colouring a strip when the glucose in a sample placed on the strip is oxidized using an enzyme. The colouring is evaluated by visual inspection or using a miniaturized photometer.
  • glucose sensors are based on the use of amperometric sensors measuring oxygen consumption or hydrogen peroxide production when glucose is oxidized in the presence of glucose oxidase.
  • amperometric sensors measuring oxygen consumption or hydrogen peroxide production when glucose is oxidized in the presence of glucose oxidase.
  • the use of amperometric sensors causes problems such as large drift, short lifetime, difficulties with calibration, lack of accuracy, and various interferences.
  • the enzyme based methods are based on a timed reaction and in order to attain sufficient accuracy it usually takes at least one minute to make the measurement. Consequently, it is the object of the invention to provide an apparatus which provides a simple, rapid, robust method for intermittent glucose assay of a blood sample, and which requires no other reagents or extra components to be purchased and which is, therefore, always ready for use.
  • a light aggregate able to provide single or pairs of narrow light bands in the wavelength range of 1-40 ⁇ m whereof at least one band lies in the range of 3-10 ⁇ m,
  • a computer for calculating the concentration of the substance by unvariate analysis directly comparing the pairs of wavelengths for each substance, the substances being the analyte in question and the major interfering substances, and correcting for the error produced by the light absorption due to each specific interfering substance.
  • Such an apparatus can, by virtue of its design, use smaller and more varied sample volumes permitting the user to make fewer painful blood extractions. Further, the blood may be smeared onto the window surface as the device is not affected by direct contact of a finger onto the test area, and being based on measurement of light absorption the apparatus may reduce the measurement time to seconds.
  • the apparatus is confined by a housing 10 and comprises a light source 1 from which light the chosen wavelengths are led to an ATR crystal 2 having a surface 3, which is accessible from the outside of the housing and acts as the window onto which the sample should be placed.
  • the light from the light source 1 is by a mirror 4 led to the ATR crystal, and in the beam leaving the crystal 2 a detector 5 is placed, which detector converts the light signals to electric signals, which through electrical leads 6 are led to a computer 7, which on the basis of the electric signals calculates the wanted concentrations.
  • the results may be displayed on a not shown display.
  • a power supply 8 is provided to supply the light source and the computer.

Abstract

Un appareil pour la mesure ex-vivo des niveaux de sucre dans le sang comprend un agrégat léger (1) fournissant une seule ou une paire de bandes lumineuses étroites dans une plage de longueurs d'ondes de 1 à 40 νm avec au minimum une bande dans la plage de 3 à 10 νm. La lumière est transmise à un dispositif de reflexion interne totale atténuée (2). L'échantillon avec la substance à mesurer est placé sur la surface (3) dudit dispositif (2) devant être traversé par la lumière qui est plus ou moins absorbée par la substance. Un détecteur (5) convertit l'intensité de la lumière émanant du dispositif de reflexion totale attenuée (2) en un signal électrique qui est traité par un ordinateur (7) qui calcule la concentration de la substance par analyse uniforme en comparant directement les paires de longueurs d'ondes pour chaque substance.
PCT/DK1992/000317 1991-11-04 1992-11-03 Appareil pour la mesure ex-vivo des niveaux de sucre dans le sang WO1993009421A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK911811A DK181191D0 (da) 1991-11-04 1991-11-04 Apparat
DK1811/91 1991-11-04

Publications (1)

Publication Number Publication Date
WO1993009421A1 true WO1993009421A1 (fr) 1993-05-13

Family

ID=8108233

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DK1992/000317 WO1993009421A1 (fr) 1991-11-04 1992-11-03 Appareil pour la mesure ex-vivo des niveaux de sucre dans le sang

Country Status (3)

Country Link
AU (1) AU2941792A (fr)
DK (1) DK181191D0 (fr)
WO (1) WO1993009421A1 (fr)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999044493A1 (fr) * 1998-03-06 1999-09-10 Dittel Rudolf H Systeme de determination qualitative et quantitative, non invasive, indirecte, a haute specificite et quasiment sans retard de temps permettant de detecter des substances du sang par la mesure de signatures spectrales
US6226082B1 (en) 1998-06-25 2001-05-01 Amira Medical Method and apparatus for the quantitative analysis of a liquid sample with surface enhanced spectroscopy
US7221440B2 (en) 2004-07-22 2007-05-22 Eastman Kodak Company System and method for controlling ink concentration using a refractometer
US7254429B2 (en) 2004-08-11 2007-08-07 Glucolight Corporation Method and apparatus for monitoring glucose levels in a biological tissue
US7356365B2 (en) 2003-07-09 2008-04-08 Glucolight Corporation Method and apparatus for tissue oximetry
US7375813B2 (en) 2004-10-21 2008-05-20 Eastman Kodak Company Method and system for diffusion attenuated total reflection based concentration sensing
US7510849B2 (en) 2004-01-29 2009-03-31 Glucolight Corporation OCT based method for diagnosis and therapy
US9060721B2 (en) 2008-03-04 2015-06-23 Glt Acquisition Corp. Flowometry in optical coherence tomography for analyte level estimation
US9078560B2 (en) 2004-08-11 2015-07-14 Glt Acquisition Corp. Method for data reduction and calibration of an OCT-based physiological monitor
US9554737B2 (en) 2004-08-11 2017-01-31 Masimo Corporation Noninvasively measuring analyte levels in a subject

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3902807A (en) * 1973-10-25 1975-09-02 Du Pont Method for operating an attenuated total reflection infrared system
US4169676A (en) * 1976-02-20 1979-10-02 Nils Kaiser Method for determining the contents of metabolic products in the blood
GB2192070A (en) * 1986-06-27 1987-12-31 Secr Defence Optical attenuator
WO1990001697A1 (fr) * 1988-08-05 1990-02-22 Red Kite Technology Limited Controle de la glycemie
DE4124920A1 (de) * 1990-07-27 1992-02-06 Hitachi Ltd Biochemischer analysator und in dem analysator verwendete prismazelle fuer abgeschwaechte totalreflektion

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3902807A (en) * 1973-10-25 1975-09-02 Du Pont Method for operating an attenuated total reflection infrared system
US4169676A (en) * 1976-02-20 1979-10-02 Nils Kaiser Method for determining the contents of metabolic products in the blood
GB2192070A (en) * 1986-06-27 1987-12-31 Secr Defence Optical attenuator
WO1990001697A1 (fr) * 1988-08-05 1990-02-22 Red Kite Technology Limited Controle de la glycemie
DE4124920A1 (de) * 1990-07-27 1992-02-06 Hitachi Ltd Biochemischer analysator und in dem analysator verwendete prismazelle fuer abgeschwaechte totalreflektion

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, Vol. 37, No. 5, May 1990, Y. MENDELSON, A.C. CLERMONT, R.A. PEURA, B-C LIN: "Blood Glucose Measurement by Multiple Attenuated Total Reflection and Infrared Absorption Spectroscopy". *

Cited By (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999044493A1 (fr) * 1998-03-06 1999-09-10 Dittel Rudolf H Systeme de determination qualitative et quantitative, non invasive, indirecte, a haute specificite et quasiment sans retard de temps permettant de detecter des substances du sang par la mesure de signatures spectrales
US6226082B1 (en) 1998-06-25 2001-05-01 Amira Medical Method and apparatus for the quantitative analysis of a liquid sample with surface enhanced spectroscopy
US6313914B1 (en) 1998-06-25 2001-11-06 Amira Medical Method and apparatus for the quantitative analysis of a liquid sample with surface enhanced spectroscopy
US7356365B2 (en) 2003-07-09 2008-04-08 Glucolight Corporation Method and apparatus for tissue oximetry
US7510849B2 (en) 2004-01-29 2009-03-31 Glucolight Corporation OCT based method for diagnosis and therapy
US7221440B2 (en) 2004-07-22 2007-05-22 Eastman Kodak Company System and method for controlling ink concentration using a refractometer
US9078560B2 (en) 2004-08-11 2015-07-14 Glt Acquisition Corp. Method for data reduction and calibration of an OCT-based physiological monitor
US10791971B2 (en) 2004-08-11 2020-10-06 Masimo Corporation Method for data reduction and calibration of an OCT-based physiological monitor
US11426104B2 (en) 2004-08-11 2022-08-30 Masimo Corporation Method for data reduction and calibration of an OCT-based physiological monitor
US10130291B2 (en) 2004-08-11 2018-11-20 Masimo Corporation Method for data reduction and calibration of an OCT-based physiological monitor
US7254429B2 (en) 2004-08-11 2007-08-07 Glucolight Corporation Method and apparatus for monitoring glucose levels in a biological tissue
US9554737B2 (en) 2004-08-11 2017-01-31 Masimo Corporation Noninvasively measuring analyte levels in a subject
US9668679B2 (en) 2004-08-11 2017-06-06 Masimo Corporation Method for data reduction and calibration of an OCT-based physiological monitor
US7375813B2 (en) 2004-10-21 2008-05-20 Eastman Kodak Company Method and system for diffusion attenuated total reflection based concentration sensing
US7593107B2 (en) 2004-10-21 2009-09-22 Eastman Kodak Company Method and system for diffusion attenuated total reflection based concentration sensing
US9833180B2 (en) 2008-03-04 2017-12-05 Masimo Corporation Multispot monitoring for use in optical coherence tomography
US9060721B2 (en) 2008-03-04 2015-06-23 Glt Acquisition Corp. Flowometry in optical coherence tomography for analyte level estimation
US10368787B2 (en) 2008-03-04 2019-08-06 Masimo Corporation Flowometry in optical coherence tomography for analyte level estimation
US11033210B2 (en) 2008-03-04 2021-06-15 Masimo Corporation Multispot monitoring for use in optical coherence tomography
US11426105B2 (en) 2008-03-04 2022-08-30 Masimo Corporation Flowometry in optical coherence tomography for analyte level estimation
US11660028B2 (en) 2008-03-04 2023-05-30 Masimo Corporation Multispot monitoring for use in optical coherence tomography

Also Published As

Publication number Publication date
AU2941792A (en) 1993-06-07
DK181191D0 (da) 1991-11-04

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