CA2457432A1 - Method and system for profiling biological systems - Google Patents

Method and system for profiling biological systems Download PDF

Info

Publication number
CA2457432A1
CA2457432A1 CA002457432A CA2457432A CA2457432A1 CA 2457432 A1 CA2457432 A1 CA 2457432A1 CA 002457432 A CA002457432 A CA 002457432A CA 2457432 A CA2457432 A CA 2457432A CA 2457432 A1 CA2457432 A1 CA 2457432A1
Authority
CA
Canada
Prior art keywords
analysis
data sets
correlation
sets
cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002457432A
Other languages
English (en)
French (fr)
Inventor
Jan Van Der Greef
Eric K. Neumann
Aram S. Adourian
Noubar B. Afeyan
Matej Oresic
Frederick E. Regnier
Elwin Robbert Verheij
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BG Medicine Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2457432A1 publication Critical patent/CA2457432A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H01J49/0036—Step by step routines describing the handling of the data generated during a measurement
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Physics & Mathematics (AREA)
  • Medical Informatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Software Systems (AREA)
  • Biotechnology (AREA)
  • Data Mining & Analysis (AREA)
  • Databases & Information Systems (AREA)
  • Epidemiology (AREA)
  • Evolutionary Computation (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Bioethics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Artificial Intelligence (AREA)
  • Theoretical Computer Science (AREA)
  • Molecular Biology (AREA)
  • Signal Processing (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CA002457432A 2001-08-13 2002-08-13 Method and system for profiling biological systems Abandoned CA2457432A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US31214501P 2001-08-13 2001-08-13
US60/312,145 2001-08-13
PCT/US2002/025734 WO2003017177A2 (en) 2001-08-13 2002-08-13 Method and system for profiling biological systems

Publications (1)

Publication Number Publication Date
CA2457432A1 true CA2457432A1 (en) 2003-02-27

Family

ID=23210073

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002457432A Abandoned CA2457432A1 (en) 2001-08-13 2002-08-13 Method and system for profiling biological systems

Country Status (6)

Country Link
US (3) US8068987B2 (https=)
EP (1) EP1425695A2 (https=)
JP (2) JP2005500543A (https=)
CA (1) CA2457432A1 (https=)
IL (1) IL160324A0 (https=)
WO (1) WO2003017177A2 (https=)

Families Citing this family (64)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2298181C (en) * 2000-02-02 2006-09-19 Dayan Burke Goodnough Non-targeted complex sample analysis
ATE406627T1 (de) * 2000-06-19 2008-09-15 Correlogic Systems Inc Heuristisches klassifikationsverfahren
EP1386275A2 (en) * 2000-07-18 2004-02-04 Correlogic Systems, Inc. A process for discriminating between biological states based on hidden patterns from biological data
WO2003017177A2 (en) 2001-08-13 2003-02-27 Beyong Genomics, Inc. Method and system for profiling biological systems
AU2003304161A1 (en) * 2002-07-29 2005-01-21 Correlogic Systems, Inc. Quality assurance/quality control for high throughput bioassay process
US9740817B1 (en) 2002-10-18 2017-08-22 Dennis Sunga Fernandez Apparatus for biological sensing and alerting of pharmaco-genomic mutation
WO2004052191A1 (ja) * 2002-12-09 2004-06-24 Ajinomoto Co., Inc. 生体状態情報処理装置、生体状態情報処理方法、生体状態情報管理システム、プログラム、および、記録媒体
US7457708B2 (en) * 2003-03-13 2008-11-25 Agilent Technologies Inc Methods and devices for identifying related ions from chromatographic mass spectral datasets containing overlapping components
AU2003901196A0 (en) * 2003-03-17 2003-04-03 Commonwealth Scientific And Industrial Research Organisation Analysis method
GB0307352D0 (en) 2003-03-29 2003-05-07 Qinetiq Ltd Improvements in and relating to the analysis of compounds
US20040236603A1 (en) * 2003-05-22 2004-11-25 Biospect, Inc. System of analyzing complex mixtures of biological and other fluids to identify biological state information
US7425700B2 (en) 2003-05-22 2008-09-16 Stults John T Systems and methods for discovery and analysis of markers
DE112004000746B4 (de) * 2003-05-29 2014-09-25 Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) Verfahren und Vorrichtung zum Verarbeiten von LC-MS- oder LC-MS-/MS-Daten bei Stoffwechseluntersuchungen
AU2004261222A1 (en) * 2003-08-01 2005-02-10 Correlogic Systems, Inc. Multiple high-resolution serum proteomic features for ovarian cancer detection
AU2004267806A1 (en) * 2003-08-20 2005-03-03 Bg Medicine, Inc. Methods and systems for profiling biological systems
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
EP1512970A1 (en) * 2003-09-05 2005-03-09 Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO Method for determining the impact of a multicomponent mixture on the biological profile of a disease
EP1709442A4 (en) * 2003-12-11 2010-01-20 Correlogic Systems Inc METHOD FOR DIAGNOSING BIOLOGICAL CONDITIONS BY USING A CENTRALIZED ADAPTIVE MODEL AND SAMPLE PREPARATION
CA2501003C (en) 2004-04-23 2009-05-19 F. Hoffmann-La Roche Ag Sample analysis to provide characterization data
US20050244973A1 (en) * 2004-04-29 2005-11-03 Predicant Biosciences, Inc. Biological patterns for diagnosis and treatment of cancer
DE602006018578D1 (de) 2005-01-28 2011-01-13 Childrens Medical Center Diagnose- und prognoseverfahren von blasenkrebs.
WO2007053170A2 (en) * 2005-02-09 2007-05-10 Correlogic Systems, Inc. Identification of bacteria and spores
EP1862797A4 (en) * 2005-03-16 2009-09-16 Ajinomoto Kk DEVICE, METHOD, SYSTEM AND PROGRAM FOR EVALUATING BIOLOGICAL STATES, DEVICE, METHOD AND PROGRAM FOR GENERATING AN EVALUATION FUNCTION AND RECORDING MEDIUM
WO2006124628A2 (en) * 2005-05-12 2006-11-23 Correlogic Systems, Inc. A model for classifying a biological sample in relation to breast cancer based on mass spectral data
KR20080049821A (ko) 2005-09-12 2008-06-04 페노미넘 디스커버리스 인코포레이티드 비타민 ｅ-관련 대사산물의 측정에 의한 결장암 및난소암의 진단방법
US7981399B2 (en) * 2006-01-09 2011-07-19 Mcgill University Method to determine state of a cell exchanging metabolites with a fluid medium by analyzing the metabolites in the fluid medium
WO2007098102A2 (en) 2006-02-17 2007-08-30 Children's Medical Center Corporation Free ngal as a biomarker for cancer
US7736905B2 (en) 2006-03-31 2010-06-15 Biodesix, Inc. Method and system for determining whether a drug will be effective on a patient with a disease
US7571056B2 (en) * 2006-05-25 2009-08-04 Vialogy Corp. Analyzing information gathered using multiple analytical techniques
US20080201095A1 (en) * 2007-02-12 2008-08-21 Yip Ping F Method for Calibrating an Analytical Instrument
EP2538048B1 (en) 2007-03-30 2015-03-04 Continental Automotive Systems US, Inc. Reductant delivery unit for selective catalytic reduction
WO2011084685A2 (en) 2009-12-17 2011-07-14 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
CA3056116A1 (en) 2007-06-22 2008-12-31 Randolph Watnick Methods and uses thereof of prosaposin
US8664358B2 (en) 2007-06-29 2014-03-04 Vermillion, Inc. Predictive markers for ovarian cancer
JP4983451B2 (ja) * 2007-07-18 2012-07-25 株式会社島津製作所 クロマトグラフ質量分析データ処理装置
US20100099135A1 (en) * 2008-10-22 2010-04-22 Mandy Katz-Jaffe Methods and assays for assessing the quality of embryos in assisted reproduction technology protocols
WO2010064413A1 (ja) * 2008-12-01 2010-06-10 国立大学法人山口大学 薬剤の作用・副作用予測システムとそのプログラム
EP2382466B1 (en) 2008-12-30 2016-03-09 Children's Medical Center Corporation Method of predicting acute appendicitis
WO2010079253A2 (es) 2009-01-09 2010-07-15 Proyecto De Biomedicina Cima, S.L. Biomarcadores para el diagnóstico de fibrosis
KR101149236B1 (ko) * 2010-04-09 2012-05-25 대한민국(농촌진흥청장) 크로마토그래피?질량분석을 이용한 인삼 연근 판별 방법
CN103154742B (zh) * 2010-06-20 2017-11-21 佐拉生物科学公司 用于鉴定高风险冠状动脉疾病患者的脂质组学标志
US20130296183A1 (en) 2010-09-17 2013-11-07 President And Fellows Of Harvard College Functional genomics assay for characterizing pluripotent stem cell utility and safety
DE102010038014B4 (de) * 2010-10-06 2021-10-07 Numares Ag Verwendung spezifischer Substanzen als Marker zur Bestimmung des Risikos einer Nierenabstoßung
CN102478563B (zh) * 2010-11-25 2014-08-13 中国科学院大连化学物理研究所 一种用于研究转基因和非转基因水稻代谢差异的方法
AU2012275841A1 (en) 2011-06-27 2014-01-16 The Jackson Laboratory Methods and compositions for treatment of cancer and autoimmune disease
US10378060B2 (en) 2011-10-14 2019-08-13 Dana-Farber Cancer Institute, Inc. ZNF365/ZFP365 biomarker predictive of anti-cancer response
KR102035877B1 (ko) 2011-11-14 2019-10-23 알파시그마 에스.피.에이. 우울증이 있는 대상체를 위한 치료 양생법 선택을 위한 검정법 및 치료 방법
EP3560509B1 (en) 2011-12-22 2024-01-31 Children's Medical Center Corporation Saposin-a derived peptides and uses thereof
LT2800578T (lt) 2012-01-05 2019-02-11 Boston Medical Center Corporation Slit-robo signalo perdavimas, skirtas inkstų ligos diagnozavimui ir gydymui
AU2012367247B2 (en) 2012-01-24 2018-04-05 Cd Diagnostics, Inc. System for detecting infection in synovial fluid
CN103913698B (zh) * 2014-03-27 2016-07-06 西北工业大学 基于小波分形及核主元特征的开关电流电路故障诊断方法
CA2944903A1 (en) 2014-04-24 2015-10-29 Dana-Farber Cancer Institute, Inc. Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response
SG11201610610YA (en) 2014-06-19 2017-01-27 Sloan Kettering Inst Cancer Biomarkers for response to ezh2 inhibitors
EP3169691B1 (en) 2014-07-17 2020-09-02 The Trustees Of The University Of Pennsylvania Methods for using exosomes to monitor transplanted organ status
CA2994416A1 (en) 2015-08-04 2017-02-09 Cd Diagnostics, Inc. Methods for detecting adverse local tissue reaction (altr) necrosis
WO2017147186A1 (en) 2016-02-22 2017-08-31 Ursure, Inc. System and method for detecting therapeutic agents to monitor adherence to a treatment regimen
CN106022373B (zh) * 2016-05-18 2019-04-23 江南大学 一种基于广义均值典型相关分析的图像识别方法
CN109187614B (zh) * 2018-09-27 2020-03-06 厦门大学 基于核磁共振和质谱的代谢组学数据融合方法及其应用
CN117169534A (zh) 2019-08-05 2023-12-05 禧尔公司 用于样品制备、数据生成和蛋白质冠分析的系统和方法
US12018279B2 (en) 2019-10-18 2024-06-25 The Trustees Of The University Of Pennsylvania Micro-engineered models of the human eye and methods of use
US20230374599A1 (en) 2020-10-19 2023-11-23 Alexander Gusev Germline biomarkers of clinical response and benefit to immune checkpoint inhibitor therapy
US20250076312A1 (en) 2021-02-25 2025-03-06 Lung Therapeutics, Llc Biomarkers for the treatment of interstitial lung disease
EP4074820A1 (en) 2021-04-16 2022-10-19 The Trustees of The University of Pennsylvania Micro-engineered models of the human eye and methods of use
US12553904B2 (en) 2024-05-08 2026-02-17 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of detecting and treating cerebral aneurysms

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6194217B1 (en) 1980-01-14 2001-02-27 Esa, Inc. Method of diagnosing or categorizing disorders from biochemical profiles
US5644503A (en) 1994-03-28 1997-07-01 Hitachi, Ltd. Methods and apparatuses for analyzing multichannel chromatogram
JP3270290B2 (ja) * 1994-04-28 2002-04-02 株式会社日立製作所 マルチチャンネルクロマトグラムの解析方法及びデータ処理装置
US6031232A (en) 1995-11-13 2000-02-29 Bio-Rad Laboratories, Inc. Method for the detection of malignant and premalignant stages of cervical cancer
US6699710B1 (en) 1998-02-25 2004-03-02 The United States Of America As Represented By The Department Of Health And Human Services Tumor tissue microarrays for rapid molecular profiling
US6428956B1 (en) * 1998-03-02 2002-08-06 Isis Pharmaceuticals, Inc. Mass spectrometric methods for biomolecular screening
CA2291889A1 (en) 1998-03-30 1999-10-07 Esa, Inc. Methodology for predicting and/or diagnosing disease
GB2362953A (en) 1999-02-10 2001-12-05 Oxford Natural Products Plc Process for quality control and standardisation of medicinal plant products
US6647341B1 (en) 1999-04-09 2003-11-11 Whitehead Institute For Biomedical Research Methods for classifying samples and ascertaining previously unknown classes
US6743576B1 (en) 1999-05-14 2004-06-01 Cytokinetics, Inc. Database system for predictive cellular bioinformatics
WO2001044269A2 (en) * 1999-12-17 2001-06-21 Large Scale Proteomics Corporation Brain protein markers
JP4798921B2 (ja) 2000-03-06 2011-10-19 バイオシーク インコーポレーティッド 機能相同性スクリーニング
GB0013007D0 (en) 2000-05-30 2000-07-19 Imperial College Characterization system and method
EP1386275A2 (en) 2000-07-18 2004-02-04 Correlogic Systems, Inc. A process for discriminating between biological states based on hidden patterns from biological data
NL1016034C2 (nl) 2000-08-03 2002-02-08 Tno Werkwijze en systeem voor het identificeren en kwantificeren van chemische componenten van een te onderzoeken mengsel van materialen.
AU2001292846A1 (en) 2000-09-20 2002-04-29 Surromed, Inc. Biological markers for evaluating therapeutic treatment of inflammatory and autoimmune disorders
US20030130798A1 (en) 2000-11-14 2003-07-10 The Institute For Systems Biology Multiparameter integration methods for the analysis of biological networks
EP1337845B1 (en) 2000-11-16 2012-01-04 Bio-Rad Laboratories, Inc. Method for analyzing mass spectra
US20020095260A1 (en) * 2000-11-28 2002-07-18 Surromed, Inc. Methods for efficiently mining broad data sets for biological markers
GB0031566D0 (en) 2000-12-22 2001-02-07 Mets Ometrix Methods for spectral analysis and their applications
WO2002057989A2 (en) 2001-01-18 2002-07-25 Basf Aktiengesellschaft Method for metabolic profiling
US20050037515A1 (en) 2001-04-23 2005-02-17 Nicholson Jeremy Kirk Methods for analysis of spectral data and their applications osteoporosis
US20050130321A1 (en) 2001-04-23 2005-06-16 Nicholson Jeremy K. Methods for analysis of spectral data and their applications
CA2445431A1 (en) 2001-04-23 2002-10-31 Metabometrix Limited Methods for the diagnosis and treatment of bone disorders
WO2002099452A1 (en) 2001-06-04 2002-12-12 Metabometrix Limited Methods for spectral analysis and their applications: reliability assessment
US7343247B2 (en) 2001-07-30 2008-03-11 The Institute For Systems Biology Methods of classifying drug responsiveness using multiparameter analysis
WO2003017177A2 (en) 2001-08-13 2003-02-27 Beyong Genomics, Inc. Method and system for profiling biological systems
US6873915B2 (en) 2001-08-24 2005-03-29 Surromed, Inc. Peak selection in multidimensional data
AU2002336504A1 (en) 2001-09-12 2003-03-24 The State Of Oregon, Acting By And Through The State Board Of Higher Education On Behalf Of Oregon S Method and system for classifying a scenario
US20030078739A1 (en) 2001-10-05 2003-04-24 Surromed, Inc. Feature list extraction from data sets such as spectra
US6835927B2 (en) 2001-10-15 2004-12-28 Surromed, Inc. Mass spectrometric quantification of chemical mixture components
US20040023295A1 (en) 2001-11-21 2004-02-05 Carol Hamilton Methods and systems for analyzing complex biological systems
EP1327883A3 (en) 2002-01-10 2003-07-30 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Combined metabolomic, proteomic and transcriptomic analysis from one, single sample and suitable statistical evaluation of data
US7623969B2 (en) 2002-01-31 2009-11-24 The Institute For Systems Biology Gene discovery for the system assignment of gene function
WO2003095978A2 (en) 2002-05-09 2003-11-20 Surromed, Inc. Methods for time-alignment of liquid chromatography-mass spectrometry data
AU2003232406A1 (en) 2002-06-14 2003-12-31 Pfizer Inc. Metabolic phenotyping
US20040096917A1 (en) 2002-11-12 2004-05-20 Becton, Dickinson And Company Diagnosis of sepsis or SIRS using biomarker profiles

Also Published As

Publication number Publication date
EP1425695A2 (en) 2004-06-09
US20030134304A1 (en) 2003-07-17
WO2003017177A2 (en) 2003-02-27
US20050283320A1 (en) 2005-12-22
JP2009133867A (ja) 2009-06-18
US20050273275A1 (en) 2005-12-08
WO2003017177A3 (en) 2004-04-08
US8068987B2 (en) 2011-11-29
IL160324A0 (en) 2004-07-25
JP2005500543A (ja) 2005-01-06

Similar Documents

Publication Publication Date Title
US8068987B2 (en) Method and system for profiling biological systems
Collins et al. Current challenges and recent developments in mass spectrometry–based metabolomics
Witting et al. Current status of retention time prediction in metabolite identification
Tan et al. Metabolomics study of stepwise hepatocarcinogenesis from the model rats to patients: potential biomarkers effective for small hepatocellular carcinoma diagnosis
Peckner et al. Specter: linear deconvolution for targeted analysis of data-independent acquisition mass spectrometry proteomics
Hill et al. Mass spectral metabonomics beyond elemental formula: chemical database querying by matching experimental with computational fragmentation spectra
Theodoridis et al. Mass spectrometry‐based holistic analytical approaches for metabolite profiling in systems biology studies
Milman General principles of identification by mass spectrometry
Lu et al. LC–MS-based metabonomics analysis
Lindon et al. Metabonomics in pharmaceutical R & D
Southam et al. A complete workflow for high-resolution spectral-stitching nanoelectrospray direct-infusion mass-spectrometry-based metabolomics and lipidomics
Kuhl et al. CAMERA: an integrated strategy for compound spectra extraction and annotation of liquid chromatography/mass spectrometry data sets
Barnes et al. Training in metabolomics research. II. Processing and statistical analysis of metabolomics data, metabolite identification, pathway analysis, applications of metabolomics and its future
Wishart Computational approaches to metabolomics
Gika et al. Sample preparation prior to the LC–MS-based metabolomics/metabonomics of blood-derived samples
Mazzone et al. Metabolite profiles of the serum of patients with non–small cell carcinoma
Song et al. Technological advances in current metabolomics and its application in tradition Chinese medicine
WO2004089972A2 (en) Mass spectrometry data analysis techniques
Jiang et al. An automated data analysis pipeline for GC− TOF− MS metabonomics studies
van der Greef et al. The role of metabolomics in systems biology: a new vision for drug discovery and development
Alsaleh et al. Mass spectrometry: a guide for the clinician
Jansen et al. PARAFASCA: ASCA combined with PARAFAC for the analysis of metabolic fingerprinting data
Crockford et al. Statistical search space reduction and two-dimensional data display approaches for UPLC− MS in biomarker discovery and pathway analysis
Furlani et al. Liquid chromatography-mass spectrometry for clinical metabolomics: an overview
Wong et al. Multidimensional gas chromatography methods for bioanalytical research

Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued