BRPI0413190A - múltiplas caracterìsticas proteÈmicas séricas de alta resolução para detecção de cáncer de ovário - Google Patents
múltiplas caracterìsticas proteÈmicas séricas de alta resolução para detecção de cáncer de ovárioInfo
- Publication number
- BRPI0413190A BRPI0413190A BRPI0413190-8A BRPI0413190A BRPI0413190A BR PI0413190 A BRPI0413190 A BR PI0413190A BR PI0413190 A BRPI0413190 A BR PI0413190A BR PI0413190 A BRPI0413190 A BR PI0413190A
- Authority
- BR
- Brazil
- Prior art keywords
- high resolution
- ovarian cancer
- sensitivity
- resolution mass
- spectral data
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
- G16B40/10—Signal processing, e.g. from mass spectrometry [MS] or from PCR
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
Landscapes
- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Theoretical Computer Science (AREA)
- Bioinformatics & Computational Biology (AREA)
- Biotechnology (AREA)
- Evolutionary Biology (AREA)
- Signal Processing (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Artificial Intelligence (AREA)
- Bioethics (AREA)
- Analytical Chemistry (AREA)
- Data Mining & Analysis (AREA)
- Databases & Information Systems (AREA)
- Epidemiology (AREA)
- Evolutionary Computation (AREA)
- Public Health (AREA)
- Software Systems (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
"MULTIPLAS CARACTERìSTICAS PROTEÈMICAS SéRICAS DE ALTA RESOLUçãO PARA DETECçãO DE CáNCER DE OVáRIO". A presente invenção refere-se a um conjunto de estudo de soro bem controlado (n = 248) de mulheres, acompanhadas e avaliadas quanto à presença de câncer de ovário foi utilizado para estender a análise do padrão proteómico de soropara uma plataforma de instrumento espectrómetro de massa de alta resolução, para explorar a existência de conjuntos de características diagnósticas altamente precisas distintas múltiplas presentes no mesmo espectro de massa. Conjuntos de características proteómicas diagnósticas altamente precisas existem dentro de espectro de massa de soros humanos. Utilizando dados espectrais de massa de alta resolução, pelo menos 56 diferentes padrões foram descobertos, que alcançam mais de 85% de sensibilidade e especificamente na testagem e avaliação. Quatro dos conjuntos de características apresentaram 100% de sensibilidade e especificidade em validação vendada. A sensibilidade e a especificidade de modelos diagnósticos gerados a partir de dados espectrais de massa de alta resolução foram superiores a (p< 0,00001) àquelas de dados espectrais de massa de baixa resolução utilizando a mesma amostra de entrada.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49152403P | 2003-08-01 | 2003-08-01 | |
US90242704A | 2004-07-30 | 2004-07-30 | |
PCT/US2004/024413 WO2005011474A2 (en) | 2003-08-01 | 2004-07-30 | Multiple high-resolution serum proteomic features for ovarian cancer detection |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0413190A true BRPI0413190A (pt) | 2006-10-03 |
Family
ID=34118868
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0413190-8A BRPI0413190A (pt) | 2003-08-01 | 2004-07-30 | múltiplas caracterìsticas proteÈmicas séricas de alta resolução para detecção de cáncer de ovário |
Country Status (11)
Country | Link |
---|---|
US (1) | US20060064253A1 (pt) |
EP (1) | EP1649281A4 (pt) |
JP (1) | JP2007501380A (pt) |
AU (1) | AU2004261222A1 (pt) |
BR (1) | BRPI0413190A (pt) |
CA (1) | CA2534336A1 (pt) |
EA (1) | EA200600346A1 (pt) |
IL (1) | IL173471A0 (pt) |
MX (1) | MXPA06001170A (pt) |
SG (1) | SG145705A1 (pt) |
WO (1) | WO2005011474A2 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR0111742A (pt) | 2000-06-19 | 2004-02-03 | Correlogic Systems Inc | Método heurìstico de classificação |
AR040711A1 (es) * | 2002-07-29 | 2005-04-13 | Us Agriculture | Un metodo para verificacion de calidad/control de calidad para proceso de bioensayo de alto rendimiento |
US7425700B2 (en) | 2003-05-22 | 2008-09-16 | Stults John T | Systems and methods for discovery and analysis of markers |
US20070003996A1 (en) * | 2005-02-09 | 2007-01-04 | Hitt Ben A | Identification of bacteria and spores |
US20080312514A1 (en) * | 2005-05-12 | 2008-12-18 | Mansfield Brian C | Serum Patterns Predictive of Breast Cancer |
US7972802B2 (en) | 2005-10-31 | 2011-07-05 | University Of Washington | Lipoprotein-associated markers for cardiovascular disease |
US7736905B2 (en) | 2006-03-31 | 2010-06-15 | Biodesix, Inc. | Method and system for determining whether a drug will be effective on a patient with a disease |
WO2008037479A1 (en) * | 2006-09-28 | 2008-04-03 | Private Universität Für Gesundheitswissenschaften Medizinische Informatik Und Technik - Umit | Feature selection on proteomic data for identifying biomarker candidates |
CN101932934A (zh) * | 2007-02-01 | 2010-12-29 | 菲诺梅诺米发现公司 | 诊断卵巢癌健康状况和卵巢癌健康状况危险的方法 |
WO2008100941A2 (en) * | 2007-02-12 | 2008-08-21 | Correlogic Systems Inc. | A method for calibrating an analytical instrument |
BRPI0813002A2 (pt) | 2007-06-29 | 2017-05-02 | Correlogic Systems Inc | marcadores preditivos para o câncer ovariano |
US8241861B1 (en) | 2008-07-08 | 2012-08-14 | Insilicos, Llc | Methods and compositions for diagnosis or prognosis of cardiovascular disease |
CN102770760A (zh) * | 2010-02-24 | 2012-11-07 | 佰欧迪塞克斯公司 | 利用质谱分析选择施用治疗剂的癌症患者 |
KR101439975B1 (ko) | 2012-01-03 | 2014-11-21 | 국립암센터 | 대장암 진단 장치 |
KR101439981B1 (ko) | 2012-01-03 | 2014-09-12 | 국립암센터 | 유방암 진단 장치 |
KR101439977B1 (ko) | 2012-01-03 | 2014-09-12 | 국립암센터 | 위암 진단 장치 |
WO2013103197A1 (ko) * | 2012-01-03 | 2013-07-11 | 국립암센터 | 암 진단 장치 |
EP2741224A1 (en) * | 2012-11-20 | 2014-06-11 | Thermo Finnigan LLC | Methods for generating local mass spectral libraries for interpreting multiplexed mass spectra |
CN117169534A (zh) | 2019-08-05 | 2023-12-05 | 禧尔公司 | 用于样品制备、数据生成和蛋白质冠分析的系统和方法 |
Family Cites Families (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3935562A (en) * | 1974-02-22 | 1976-01-27 | Stephens Richard G | Pattern recognition method and apparatus |
US4075475A (en) * | 1976-05-03 | 1978-02-21 | Chemetron Corporation | Programmed thermal degradation-mass spectrometry analysis method facilitating identification of a biological specimen |
US4122518A (en) * | 1976-05-17 | 1978-10-24 | The United States Of America As Represented By The Administrator Of The National Aeronautics & Space Administration | Automated clinical system for chromosome analysis |
US4697242A (en) * | 1984-06-11 | 1987-09-29 | Holland John H | Adaptive computing system capable of learning and discovery |
US4881178A (en) * | 1987-05-07 | 1989-11-14 | The Regents Of The University Of Michigan | Method of controlling a classifier system |
US5697369A (en) * | 1988-12-22 | 1997-12-16 | Biofield Corp. | Method and apparatus for disease, injury and bodily condition screening or sensing |
WO1991014990A1 (en) * | 1990-03-28 | 1991-10-03 | Koza John R | Non-linear genetic algorithms for solving problems by finding a fit composition of functions |
US5210412A (en) * | 1991-01-31 | 1993-05-11 | Wayne State University | Method for analyzing an organic sample |
US5784162A (en) * | 1993-08-18 | 1998-07-21 | Applied Spectral Imaging Ltd. | Spectral bio-imaging methods for biological research, medical diagnostics and therapy |
US5632957A (en) * | 1993-11-01 | 1997-05-27 | Nanogen | Molecular biological diagnostic systems including electrodes |
US6114114A (en) * | 1992-07-17 | 2000-09-05 | Incyte Pharmaceuticals, Inc. | Comparative gene transcript analysis |
CA2143633A1 (en) * | 1992-09-01 | 1994-03-17 | James Oliver Normile | Improved vector quantization |
CA2163426C (en) * | 1993-05-28 | 2005-11-01 | T. William Hutchens | Method and apparatus for desorption and ionization of analytes |
US5995645A (en) * | 1993-08-18 | 1999-11-30 | Applied Spectral Imaging Ltd. | Method of cancer cell detection |
US5352613A (en) * | 1993-10-07 | 1994-10-04 | Tafas Triantafillos P | Cytological screening method |
US5553616A (en) * | 1993-11-30 | 1996-09-10 | Florida Institute Of Technology | Determination of concentrations of biological substances using raman spectroscopy and artificial neural network discriminator |
US6025128A (en) * | 1994-09-29 | 2000-02-15 | The University Of Tulsa | Prediction of prostate cancer progression by analysis of selected predictive parameters |
AU1837495A (en) * | 1994-10-13 | 1996-05-06 | Horus Therapeutics, Inc. | Computer assisted methods for diagnosing diseases |
US5848177A (en) * | 1994-12-29 | 1998-12-08 | Board Of Trustees Operating Michigan State University | Method and system for detection of biological materials using fractal dimensions |
GB2301897B (en) * | 1995-06-08 | 1999-05-26 | Univ Wales Aberystwyth The | Composition analysis |
KR100197580B1 (ko) * | 1995-09-13 | 1999-06-15 | 이민화 | 무선 통신망을 이용한 실시간 생체신호모니터링시스템 |
US5716825A (en) * | 1995-11-01 | 1998-02-10 | Hewlett Packard Company | Integrated nucleic acid analysis system for MALDI-TOF MS |
US5687716A (en) * | 1995-11-15 | 1997-11-18 | Kaufmann; Peter | Selective differentiating diagnostic process based on broad data bases |
DE19543020A1 (de) * | 1995-11-18 | 1997-05-22 | Boehringer Mannheim Gmbh | Verfahren und Vorrichtung zur Bestimmung von analytischen Daten über das Innere einer streuenden Matrix |
US5760761A (en) * | 1995-12-15 | 1998-06-02 | Xerox Corporation | Highlight color twisting ball display |
US5839438A (en) * | 1996-09-10 | 1998-11-24 | Neuralmed, Inc. | Computer-based neural network system and method for medical diagnosis and interpretation |
WO1998020459A1 (en) * | 1996-11-04 | 1998-05-14 | 3-Dimensional Pharmaceuticals, Inc. | System, method, and computer program product for the visualization and interactive processing and analysis of chemical data |
US6571227B1 (en) * | 1996-11-04 | 2003-05-27 | 3-Dimensional Pharmaceuticals, Inc. | Method, system and computer program product for non-linear mapping of multi-dimensional data |
EP1164203B1 (en) * | 1996-11-06 | 2007-10-10 | Sequenom, Inc. | DNA Diagnostics based on mass spectrometry |
US6157921A (en) * | 1998-05-01 | 2000-12-05 | Barnhill Technologies, Llc | Enhancing knowledge discovery using support vector machines in a distributed network environment |
IL131843A (en) * | 1997-03-24 | 2004-06-20 | Univ Kingston | A method for detecting coincidences, products and devices |
US5905258A (en) * | 1997-06-02 | 1999-05-18 | Advanced Research & Techology Institute | Hybrid ion mobility and mass spectrometer |
NZ516848A (en) * | 1997-06-20 | 2004-03-26 | Ciphergen Biosystems Inc | Retentate chromatography apparatus with applications in biology and medicine |
US6081797A (en) * | 1997-07-09 | 2000-06-27 | American Heuristics Corporation | Adaptive temporal correlation network |
US5974412A (en) * | 1997-09-24 | 1999-10-26 | Sapient Health Network | Intelligent query system for automatically indexing information in a database and automatically categorizing users |
US6085576A (en) * | 1998-03-20 | 2000-07-11 | Cyrano Sciences, Inc. | Handheld sensing apparatus |
US6723564B2 (en) * | 1998-05-07 | 2004-04-20 | Sequenom, Inc. | IR MALDI mass spectrometry of nucleic acids using liquid matrices |
WO2000025192A2 (en) * | 1998-10-26 | 2000-05-04 | Visionary Medical, Inc. | Prescription-controlled data collection system and method |
US5989824A (en) * | 1998-11-04 | 1999-11-23 | Mesosystems Technology, Inc. | Apparatus and method for lysing bacterial spores to facilitate their identification |
US6631333B1 (en) * | 1999-05-10 | 2003-10-07 | California Institute Of Technology | Methods for remote characterization of an odor |
US7057168B2 (en) * | 1999-07-21 | 2006-06-06 | Sionex Corporation | Systems for differential ion mobility analysis |
US6329652B1 (en) * | 1999-07-28 | 2001-12-11 | Eastman Kodak Company | Method for comparison of similar samples in liquid chromatography/mass spectrometry |
US6615199B1 (en) * | 1999-08-31 | 2003-09-02 | Accenture, Llp | Abstraction factory in a base services pattern environment |
BR0111742A (pt) * | 2000-06-19 | 2004-02-03 | Correlogic Systems Inc | Método heurìstico de classificação |
US6680203B2 (en) * | 2000-07-10 | 2004-01-20 | Esperion Therapeutics, Inc. | Fourier transform mass spectrometry of complex biological samples |
US20020059030A1 (en) * | 2000-07-17 | 2002-05-16 | Otworth Michael J. | Method and apparatus for the processing of remotely collected electronic information characterizing properties of biological entities |
AU2001280581A1 (en) * | 2000-07-18 | 2002-01-30 | Correlogic Systems, Inc. | A process for discriminating between biological states based on hidden patterns from biological data |
WO2002042733A2 (en) * | 2000-11-16 | 2002-05-30 | Ciphergen Biosystems, Inc. | Method for analyzing mass spectra |
CA2436503A1 (en) * | 2001-02-01 | 2002-08-08 | Huw A. Davies | Improved methods for protein identification, characterization and sequencing by tandem mass spectrometry |
KR20040054609A (ko) * | 2001-02-16 | 2004-06-25 | 싸이퍼젠 바이오시스템즈, 인코포레이티드 | 유전자 발현 프로파일을 단백질 발현 프로파일과연관시키는 방법 |
CN1463291A (zh) * | 2001-04-19 | 2003-12-24 | 赛弗根生物系统股份有限公司 | 用质谱法和亲和标记物鉴定生物分子的特性 |
US20040260478A1 (en) * | 2001-08-03 | 2004-12-23 | Schwamm Lee H. | System, process and diagnostic arrangement establishing and monitoring medication doses for patients |
US8068987B2 (en) * | 2001-08-13 | 2011-11-29 | Bg Medicine, Inc. | Method and system for profiling biological systems |
AU2003235749A1 (en) * | 2002-01-07 | 2003-07-24 | John Hopkins University | Biomarkers for detecting ovarian cancer |
US20020193950A1 (en) * | 2002-02-25 | 2002-12-19 | Gavin Edward J. | Method for analyzing mass spectra |
AR040711A1 (es) * | 2002-07-29 | 2005-04-13 | Us Agriculture | Un metodo para verificacion de calidad/control de calidad para proceso de bioensayo de alto rendimiento |
JP4585167B2 (ja) * | 2002-11-29 | 2010-11-24 | 東芝医用システムエンジニアリング株式会社 | X線コンピュータ断層撮影システム |
CA2548842A1 (en) * | 2003-12-11 | 2005-07-07 | Correlogic Systems, Inc. | Method of diagnosing biological states through the use of a centralized, adaptive model, and remote sample processing |
US20070003996A1 (en) * | 2005-02-09 | 2007-01-04 | Hitt Ben A | Identification of bacteria and spores |
-
2004
- 2004-07-30 AU AU2004261222A patent/AU2004261222A1/en not_active Abandoned
- 2004-07-30 SG SG200805721-8A patent/SG145705A1/en unknown
- 2004-07-30 BR BRPI0413190-8A patent/BRPI0413190A/pt not_active Application Discontinuation
- 2004-07-30 EA EA200600346A patent/EA200600346A1/ru unknown
- 2004-07-30 EP EP04779461A patent/EP1649281A4/en not_active Withdrawn
- 2004-07-30 CA CA002534336A patent/CA2534336A1/en not_active Abandoned
- 2004-07-30 WO PCT/US2004/024413 patent/WO2005011474A2/en active Application Filing
- 2004-07-30 MX MXPA06001170A patent/MXPA06001170A/es unknown
- 2004-07-30 JP JP2006522041A patent/JP2007501380A/ja active Pending
-
2005
- 2005-03-30 US US11/093,018 patent/US20060064253A1/en not_active Abandoned
-
2006
- 2006-01-31 IL IL173471A patent/IL173471A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
AU2004261222A2 (en) | 2005-02-10 |
WO2005011474A2 (en) | 2005-02-10 |
IL173471A0 (en) | 2006-06-11 |
EA200600346A1 (ru) | 2006-08-25 |
JP2007501380A (ja) | 2007-01-25 |
US20060064253A1 (en) | 2006-03-23 |
CA2534336A1 (en) | 2005-02-10 |
MXPA06001170A (es) | 2006-05-15 |
WO2005011474A3 (en) | 2005-06-09 |
EP1649281A4 (en) | 2007-11-07 |
AU2004261222A1 (en) | 2005-02-10 |
SG145705A1 (en) | 2008-09-29 |
EP1649281A2 (en) | 2006-04-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BRPI0413190A (pt) | múltiplas caracterìsticas proteÈmicas séricas de alta resolução para detecção de cáncer de ovário | |
Hu et al. | Technical advances in proteomics: new developments in data-independent acquisition | |
Witjes et al. | Recently introduced biomarkers for screening of hepatocellular carcinoma: a systematic review and meta-analysis | |
Vivas et al. | Age-related differences in celiac disease: Specific characteristics of adult presentation | |
Tenori et al. | Exploration of serum metabolomic profiles and outcomes in women with metastatic breast cancer: a pilot study | |
CA2619732A1 (en) | Methods for the diagnosis of colorectal cancer and ovarian cancer health states | |
Zhou et al. | Metabolomic profiling of mice serum during toxoplasmosis progression using liquid chromatography-mass spectrometry | |
Ramus et al. | Spiked proteomic standard dataset for testing label-free quantitative software and statistical methods | |
Spencer et al. | Matrix-assisted laser desorption/ionization–time of flight-mass spectrometry profiling of trace constituents of condom lubricants in the presence of biological fluids | |
Monneret et al. | How clinical flow cytometry rebooted sepsis immunology | |
Yusof et al. | Metabolomics profiling on different stages of colorectal cancer: a systematic review | |
Wang et al. | Development and validation of a highly sensitive urine-based test to identify patients with colonic adenomatous polyps | |
de Oliveira Ferreira et al. | Lymphoma subtype incidence rates in children and adolescents: first report from Brazil | |
Liu et al. | Detection of endometriosis with the use of plasma protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry | |
Rich | Epidemiology of thymoma | |
Adachi et al. | Association between plasma α‐aminobutyric acid and depressive symptoms in older community‐dwelling adults in Japan | |
VanBeek et al. | Anti-PLA2R-associated membranous nephropathy: a review with emphasis on diagnostic testing methods | |
Deng et al. | Profiling of polar urine metabolite extracts from Chinese colorectal cancer patients to screen for potential diagnostic and adverse-effect biomarkers | |
Song et al. | A population pharmacokinetic model for individualised dosage regimens of vancomycin in Chinese neonates and young infants | |
Saleh et al. | Profile shift in latex sensitization over the last 20 years | |
Chen et al. | Identification of circulating biomarkers in sera of Plasmodium knowlesi-infected malaria patients–comparison against Plasmodium vivax infection | |
Zhao et al. | Positivity of both plasma Epstein–Barr virus DNA and serum Epstein–Barr virus capsid specific immunoglobulin A is a better prognostic biomarker for nasopharyngeal carcinoma | |
Nannini et al. | Fecal metabolomic profiles: A comparative study of patients with colorectal cancer vs adenomatous polyps | |
El Jamal et al. | MEF2B is a member of the BCL6 gene transcriptional complex and induces its expression in diffuse large B-cell lymphoma of the germinal center B-cell-like type | |
Perzanowska et al. | An MRM‐Based Cytokeratin Marker Assay as a Tool for Cancer Studies: Application to Lung Cancer Pleural Effusions |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |