CA2454136A1 - 5-aminolevulinic acid and esters, in combination with another photosensitizer, as photosensitizing agents in photochemotherapy, and their uses in_treating wounds - Google Patents
5-aminolevulinic acid and esters, in combination with another photosensitizer, as photosensitizing agents in photochemotherapy, and their uses in_treating wounds Download PDFInfo
- Publication number
- CA2454136A1 CA2454136A1 CA002454136A CA2454136A CA2454136A1 CA 2454136 A1 CA2454136 A1 CA 2454136A1 CA 002454136 A CA002454136 A CA 002454136A CA 2454136 A CA2454136 A CA 2454136A CA 2454136 A1 CA2454136 A1 CA 2454136A1
- Authority
- CA
- Canada
- Prior art keywords
- ala
- wound
- photosensitizer
- ala ester
- ester
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
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- 210000000936 intestine Anatomy 0.000 description 1
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- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
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- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002405 nuclear magnetic resonance imaging agent Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
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- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- FHHPUSMSKHSNKW-SMOYURAASA-M sodium deoxycholate Chemical compound [Na+].C([C@H]1CC2)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 FHHPUSMSKHSNKW-SMOYURAASA-M 0.000 description 1
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 1
- 230000003381 solubilizing effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
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- 238000011200 topical administration Methods 0.000 description 1
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- 150000003751 zinc Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
- A61K41/0061—5-aminolevulinic acid-based PDT: 5-ALA-PDT involving porphyrins or precursors of protoporphyrins generated in vivo from 5-ALA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0118251.8A GB0118251D0 (en) | 2001-07-26 | 2001-07-26 | Method |
| GB0118251.8 | 2001-07-26 | ||
| PCT/GB2002/003386 WO2003011265A2 (en) | 2001-07-26 | 2002-07-25 | 5-aminolevulinic acid and esters, in combination with another phtosensitizer, as photosensitizing agents in photochemotherapy, and their uses in treating wounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA2454136A1 true CA2454136A1 (en) | 2003-02-13 |
Family
ID=9919248
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002454136A Abandoned CA2454136A1 (en) | 2001-07-26 | 2002-07-25 | 5-aminolevulinic acid and esters, in combination with another photosensitizer, as photosensitizing agents in photochemotherapy, and their uses in_treating wounds |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20040259949A1 (https=) |
| EP (1) | EP1414430A2 (https=) |
| JP (1) | JP2005501050A (https=) |
| KR (1) | KR20040030863A (https=) |
| CN (1) | CN1533271A (https=) |
| CA (1) | CA2454136A1 (https=) |
| CZ (1) | CZ2004257A3 (https=) |
| GB (1) | GB0118251D0 (https=) |
| HU (1) | HUP0401192A3 (https=) |
| MX (1) | MXPA04000647A (https=) |
| NO (1) | NO20040321L (https=) |
| RU (1) | RU2004105655A (https=) |
| WO (1) | WO2003011265A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7888526B2 (en) | 2004-03-26 | 2011-02-15 | Photocure Asa | Acid addition salts of 5-aminolevulinic acid or its derivatives |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0018528D0 (en) | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
| NL1020336C2 (nl) * | 2002-04-09 | 2003-10-13 | Photobiochem Leiden N V | Toepassing van een verbinding voor de bereiding van een farmaceutisch preparaat voor het behandelen van brandwonden, en een werkwijze voor het behandelen van brandwonden. |
| NL1022597C2 (nl) * | 2003-02-05 | 2004-08-06 | Photobiochem N V | Toepassing van een fotosensitizerverbinding voor de bereiding van een farmaceutisch preparaat, werkwijze voor het bereiden van een farmaceutisch preparaat en een werkwijze voor het behandelen van een zoogdier. |
| US20050154052A1 (en) * | 2003-03-24 | 2005-07-14 | Hetero Drugs Limited | Novel crystalline forms of (s)-citalopram oxalate |
| GB0420888D0 (en) * | 2004-09-20 | 2004-10-20 | Photopharmica Ltd | Compounds and uses |
| GB0424833D0 (en) * | 2004-11-10 | 2004-12-15 | Photocure Asa | Method |
| WO2008006083A2 (en) | 2006-07-07 | 2008-01-10 | Surmodics, Inc. | Beaded wound spacer device |
| US20090264492A1 (en) * | 2006-08-29 | 2009-10-22 | Stichting Voor De Technische Wetenschappen | Pharmaceutical composition for the treatment of a fungal skin disorder and a method for the preparation thereof |
| AU2008337067A1 (en) * | 2007-12-14 | 2009-06-25 | Photoderma Sa | Novel compounds useful in therapeutic and cosmetic methods |
| EP2268311A4 (en) * | 2008-04-04 | 2014-08-27 | Immunolight Llc | NON-INVASIVE SYSTEMS AND IN SITU PHOTOBIOMODULATION METHODS |
| RU2395315C1 (ru) * | 2008-12-01 | 2010-07-27 | Государственное унитарное предприятие г. Москвы Международный научный и клинический центр "Интермедбиофизхим" (ГУП МНКЦ "Интермедбиофизхим") | Способ фотодинамической терапии гнойных ран и трофических язв |
| GB0823472D0 (en) | 2008-12-23 | 2009-01-28 | Photocure Asa | Product |
| GB0900461D0 (en) * | 2009-01-12 | 2009-02-11 | Photocure Asa | Photodynamic therapy device |
| RU2526803C2 (ru) | 2009-06-11 | 2014-08-27 | ФотоКьюэр АСА | Полутвердые композиции и фармацевтические продукты |
| GB0914287D0 (en) | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
| GB0914286D0 (en) * | 2009-08-14 | 2009-09-30 | Pci Biotech As | Method |
| CA2790827A1 (en) | 2010-03-01 | 2011-09-09 | Photocure Asa | Cosmetic compositions |
| EP2585111A1 (en) | 2010-06-23 | 2013-05-01 | Photocure ASA | Hyperosmotic preparations comprising 5 -amino levulinic acid or derivative as photosensitizing agent |
| JP5991970B2 (ja) | 2010-07-09 | 2016-09-14 | フォトキュア エイエスエイ | 光力学的治療または光力学的診断で使用する乾燥組成物および当該乾燥組成物を含む装置 |
| WO2012012616A1 (en) * | 2010-07-21 | 2012-01-26 | Patty-Fu Giles | Photoactive vitamin nanoparticles for the treatment of chronic wounds |
| CA2819810A1 (en) * | 2010-12-06 | 2012-06-14 | The University Of British Columbia | Granzyme b inhibitor compositions, methods and uses for promoting wound healing |
| WO2012086802A1 (ja) | 2010-12-24 | 2012-06-28 | アークレイ株式会社 | 癌細胞の検出方法 |
| KR101254752B1 (ko) * | 2011-02-28 | 2013-04-15 | 부산대학교 산학협력단 | 광역동치료의 광증감제로 사용하기 위한 구연산을 이용한 아미노레불리닉산 트라이머 |
| KR101254758B1 (ko) * | 2011-02-28 | 2013-04-15 | 부산대학교병원 | 광역동치료의 광증감제로 사용하기 위한 이디티에이를 이용한 아미노레불리닉산 테트라머 |
| CN103717215B (zh) * | 2011-06-16 | 2016-08-17 | 思佰益药业股份有限公司 | 过敏性鼻炎的治疗剂 |
| US20140316534A1 (en) | 2011-10-14 | 2014-10-23 | Photocure Asa | Stent |
| EP2766049A1 (en) | 2011-10-14 | 2014-08-20 | Photocure ASA | Photodynamic diagnosis of abnormalities of the epithelial lining of the oesophagus with the means of a 5-ala ester |
| RU2615870C2 (ru) | 2011-12-19 | 2017-04-11 | ФотоКьюэр АСА | Устройство облучения |
| WO2014062839A1 (en) | 2012-10-16 | 2014-04-24 | Surmodics, Inc. | Wound packing device and methods |
| GB201306369D0 (en) | 2013-04-09 | 2013-05-22 | Photocure As | Irradiation device |
| EP3011972B1 (en) * | 2013-06-19 | 2019-10-23 | SBI Pharmaceuticals Co., Ltd. | Medicinal composition for promoting synthesis of protoporphyrin ix |
| US10201457B2 (en) | 2014-08-01 | 2019-02-12 | Surmodics, Inc. | Wound packing device with nanotextured surface |
| RU2604399C1 (ru) * | 2015-12-01 | 2016-12-10 | Сергей Владимирович Москвин | Способ лазерной терапии больных трофическими язвами |
| RU2661084C1 (ru) * | 2017-07-21 | 2018-07-11 | Федеральное Агентство Научных Организаций Федеральное Государственное Бюджетное Научное Учреждение "Федеральный Научно-Клинический Центр Реаниматологии И Реабилитологии" (Фнкц Рр) | Способ комплексного лечения пролежней у пациентов с длительной иммобилизацией |
| CN109453408A (zh) * | 2018-11-16 | 2019-03-12 | 江南大学 | 抗菌创伤敷料及其制备方法 |
| CN112062713B (zh) * | 2020-08-04 | 2023-03-31 | 浙江工业大学 | 具铁螯合性和pdt活性的ala-hpo杂合衍生物及其制备方法与应用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5234940A (en) * | 1989-07-28 | 1993-08-10 | Queen's University | Photochemotherapeutic method using 5-aminolevulinic acid and precursors thereof |
| US5913884A (en) * | 1996-09-19 | 1999-06-22 | The General Hospital Corporation | Inhibition of fibrosis by photodynamic therapy |
| GB0018528D0 (en) * | 2000-07-27 | 2000-09-13 | Photocure Asa | Compounds |
-
2001
- 2001-07-26 GB GBGB0118251.8A patent/GB0118251D0/en not_active Ceased
-
2002
- 2002-07-25 EP EP02747590A patent/EP1414430A2/en not_active Withdrawn
- 2002-07-25 RU RU2004105655/15A patent/RU2004105655A/ru not_active Application Discontinuation
- 2002-07-25 MX MXPA04000647A patent/MXPA04000647A/es unknown
- 2002-07-25 HU HU0401192A patent/HUP0401192A3/hu unknown
- 2002-07-25 CZ CZ2004257A patent/CZ2004257A3/cs unknown
- 2002-07-25 CN CNA028145801A patent/CN1533271A/zh active Pending
- 2002-07-25 CA CA002454136A patent/CA2454136A1/en not_active Abandoned
- 2002-07-25 WO PCT/GB2002/003386 patent/WO2003011265A2/en not_active Ceased
- 2002-07-25 US US10/484,743 patent/US20040259949A1/en not_active Abandoned
- 2002-07-25 KR KR10-2004-7001165A patent/KR20040030863A/ko not_active Withdrawn
- 2002-07-25 JP JP2003516496A patent/JP2005501050A/ja active Pending
-
2004
- 2004-01-23 NO NO20040321A patent/NO20040321L/no not_active Application Discontinuation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7888526B2 (en) | 2004-03-26 | 2011-02-15 | Photocure Asa | Acid addition salts of 5-aminolevulinic acid or its derivatives |
| US8692014B2 (en) | 2004-03-26 | 2014-04-08 | Photocure Asa | Acid addition salts of 5-aminolevulinic acid or its derivatives |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003011265A3 (en) | 2003-04-24 |
| HUP0401192A3 (en) | 2005-07-28 |
| MXPA04000647A (es) | 2004-05-17 |
| WO2003011265A2 (en) | 2003-02-13 |
| US20040259949A1 (en) | 2004-12-23 |
| GB0118251D0 (en) | 2001-09-19 |
| JP2005501050A (ja) | 2005-01-13 |
| NO20040321L (no) | 2004-03-19 |
| EP1414430A2 (en) | 2004-05-06 |
| CZ2004257A3 (cs) | 2004-08-18 |
| RU2004105655A (ru) | 2005-04-10 |
| KR20040030863A (ko) | 2004-04-09 |
| CN1533271A (zh) | 2004-09-29 |
| HUP0401192A2 (hu) | 2004-12-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FZDE | Discontinued |