CA2453110C - System for the separation of magnetically attractable particles - Google Patents
System for the separation of magnetically attractable particles Download PDFInfo
- Publication number
- CA2453110C CA2453110C CA2453110A CA2453110A CA2453110C CA 2453110 C CA2453110 C CA 2453110C CA 2453110 A CA2453110 A CA 2453110A CA 2453110 A CA2453110 A CA 2453110A CA 2453110 C CA2453110 C CA 2453110C
- Authority
- CA
- Canada
- Prior art keywords
- microparticles
- vessel
- magnets
- separation
- ring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 238000000926 separation method Methods 0.000 title claims abstract description 28
- 239000002245 particle Substances 0.000 title description 40
- 239000011859 microparticle Substances 0.000 claims abstract description 42
- 239000007788 liquid Substances 0.000 claims abstract description 26
- 238000000034 method Methods 0.000 claims abstract description 15
- 239000000725 suspension Substances 0.000 claims abstract description 12
- 230000005291 magnetic effect Effects 0.000 claims description 20
- 125000006850 spacer group Chemical group 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 4
- 230000001900 immune effect Effects 0.000 claims description 3
- 238000005406 washing Methods 0.000 description 12
- 239000000523 sample Substances 0.000 description 10
- 239000011159 matrix material Substances 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000008021 deposition Effects 0.000 description 4
- 239000012491 analyte Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000006249 magnetic particle Substances 0.000 description 3
- 230000005389 magnetism Effects 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 230000005294 ferromagnetic effect Effects 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- FGUUSXIOTUKUDN-IBGZPJMESA-N C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 Chemical compound C1(=CC=CC=C1)N1C2=C(NC([C@H](C1)NC=1OC(=NN=1)C1=CC=CC=C1)=O)C=CC=C2 FGUUSXIOTUKUDN-IBGZPJMESA-N 0.000 description 1
- 108010090804 Streptavidin Proteins 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000012295 chemical reaction liquid Substances 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000007885 magnetic separation Methods 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000005298 paramagnetic effect Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000013595 supernatant sample Substances 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/28—Magnetic plugs and dipsticks
- B03C1/288—Magnetic plugs and dipsticks disposed at the outer circumference of a recipient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C1/00—Magnetic separation
- B03C1/02—Magnetic separation acting directly on the substance being separated
- B03C1/035—Open gradient magnetic separators, i.e. separators in which the gap is unobstructed, characterised by the configuration of the gap
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B03—SEPARATION OF SOLID MATERIALS USING LIQUIDS OR USING PNEUMATIC TABLES OR JIGS; MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C—MAGNETIC OR ELECTROSTATIC SEPARATION OF SOLID MATERIALS FROM SOLID MATERIALS OR FLUIDS; SEPARATION BY HIGH-VOLTAGE ELECTRIC FIELDS
- B03C2201/00—Details of magnetic or electrostatic separation
- B03C2201/26—Details of magnetic or electrostatic separation for use in medical or biological applications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/0098—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
Landscapes
- Automatic Analysis And Handling Materials Therefor (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10136060.6 | 2001-07-25 | ||
| DE10136060A DE10136060A1 (de) | 2001-07-25 | 2001-07-25 | System zur Separation von magnetisch anziehbaren Partikeln |
| PCT/EP2002/008174 WO2003009943A1 (de) | 2001-07-25 | 2002-07-23 | System zur separation von magnetisch anziehbaren partikeln |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2453110A1 CA2453110A1 (en) | 2003-02-06 |
| CA2453110C true CA2453110C (en) | 2010-02-09 |
Family
ID=7692933
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2453110A Expired - Fee Related CA2453110C (en) | 2001-07-25 | 2002-07-23 | System for the separation of magnetically attractable particles |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7326350B2 (enExample) |
| EP (1) | EP1420888B1 (enExample) |
| JP (1) | JP3842784B2 (enExample) |
| AT (1) | ATE297255T1 (enExample) |
| CA (1) | CA2453110C (enExample) |
| DE (2) | DE10136060A1 (enExample) |
| ES (1) | ES2242877T3 (enExample) |
| WO (1) | WO2003009943A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003226075B2 (en) | 2002-04-12 | 2008-09-25 | Instrumentation Laboratory Company | Immunoassay probe |
| US8211386B2 (en) | 2004-06-08 | 2012-07-03 | Biokit, S.A. | Tapered cuvette and method of collecting magnetic particles |
| US7535329B2 (en) * | 2005-04-14 | 2009-05-19 | Makrochem, Ltd. | Permanent magnet structure with axial access for spectroscopy applications |
| US7867765B2 (en) | 2005-12-28 | 2011-01-11 | The General Hospital Corporation | Blood cell sorting methods and systems |
| US8268116B2 (en) * | 2007-06-14 | 2012-09-18 | Lam Research Corporation | Methods of and apparatus for protecting a region of process exclusion adjacent to a region of process performance in a process chamber |
| US8795609B2 (en) * | 2007-02-08 | 2014-08-05 | Biokit, S.A. | Magnetic particle washing station |
| JP2008209330A (ja) * | 2007-02-28 | 2008-09-11 | Hitachi High-Technologies Corp | 磁気分離器およびそれを用いた分析装置 |
| US9199247B2 (en) * | 2007-05-29 | 2015-12-01 | Invitrogen Dynal As | Magnetic separation rack |
| GB0724404D0 (en) * | 2007-05-29 | 2008-01-30 | Invitrogen Dynal As | A sample vessel retaining portion |
| JP4586054B2 (ja) * | 2007-08-31 | 2010-11-24 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| US8723113B2 (en) * | 2008-05-30 | 2014-05-13 | The State of Oregon Acting by and through the State Board of Higher Education of behalf of Oregon State University | Radio-frequency-free hybrid electrostatic/magnetostatic cell for transporting, trapping, and dissociating ions in mass spectrometers |
| EP2306959A2 (en) * | 2008-07-11 | 2011-04-13 | The General Hospital Corporation | Magnetic apparatus for blood separation |
| EP2208531A1 (en) * | 2008-12-30 | 2010-07-21 | Atonomics A/S | Distribution of particles in capillary channel by application of magnetic field |
| EP2246349A1 (en) | 2009-04-20 | 2010-11-03 | BKG Pharma ApS | Treatment of infectious diseases |
| US20120262260A1 (en) * | 2011-04-18 | 2012-10-18 | Exact Sciences Corporation | Magnetic microparticle localization device |
| JP6297546B2 (ja) * | 2012-06-29 | 2018-03-20 | コーニンクレッカ フィリップス エヌ ヴェＫｏｎｉｎｋｌｉｊｋｅ Ｐｈｉｌｉｐｓ Ｎ．Ｖ． | 結合磁性粒子及び未結合磁性粒子の処理 |
| EP2883237B1 (en) | 2012-08-16 | 2020-11-25 | The State Of Oregon Acting By And Through The State Board Of Higher Education On Behalf Of Oregon State University | Electromagnetostatic electron-induced dissociation cell |
| US9803787B2 (en) * | 2012-09-14 | 2017-10-31 | The United States Of America, As Represented By The Secretary Of The Navy | Magnetically attracted fluid transfer system |
| KR101367122B1 (ko) * | 2012-09-20 | 2014-02-26 | 한국원자력연구원 | 영구자석을 이용한 자기 장치 |
| US20150233932A1 (en) * | 2013-02-19 | 2015-08-20 | Ching-Ping Tseng | Methods, Systems, and Compositions for Enrichment of Rare Cells |
| US9387486B2 (en) * | 2014-09-30 | 2016-07-12 | Ut-Battelle, Llc | High-gradient permanent magnet apparatus and its use in particle collection |
| JP6472973B2 (ja) * | 2014-10-24 | 2019-02-20 | 日本電子株式会社 | 自動分析装置及び分離洗浄方法 |
| CZ306187B6 (cs) * | 2015-02-26 | 2016-09-14 | Univerzita PalackĂ©ho v Olomouci | Zařízení pro magnetickou separaci feromagnetických částic, sada pro magnetickou separaci částic, způsob separace magnetických částic z roztoku a použití zařízení nebo sady pro magnetickou separaci částic |
| CN108474024B (zh) * | 2016-01-05 | 2022-08-02 | 豪夫迈·罗氏有限公司 | 磁性玻璃颗粒对核酸的连续捕获 |
| US11125365B2 (en) | 2018-02-28 | 2021-09-21 | Kohler Co. | Magnetic joint |
| US11408543B2 (en) | 2018-02-28 | 2022-08-09 | Kohler Co. | Articulating faucet |
| US10890277B2 (en) * | 2018-02-28 | 2021-01-12 | Kohler Co. | Articulating faucet with progressive magnetic joint |
| US11214946B2 (en) | 2018-06-04 | 2022-01-04 | Kohler Co. | Articulating faucet |
| US11242675B2 (en) | 2018-06-04 | 2022-02-08 | Kohler Co. | Articulating faucet |
| EP4614158A1 (en) * | 2022-10-31 | 2025-09-10 | FUJIFILM Corporation | Magnetic collecting unit, and testing device |
| EP4614157A1 (en) * | 2022-10-31 | 2025-09-10 | FUJIFILM Corporation | Magnetic collecting unit and test device |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6253714A (ja) * | 1985-08-30 | 1987-03-09 | Kamata Bio Eng Kk | 流体の磁化浄化装置 |
| JPS6295371A (ja) | 1985-10-22 | 1987-05-01 | Agency Of Ind Science & Technol | 粉末状吸湿架橋性ホツトメルト接着剤の製造方法 |
| EP0479448A3 (en) | 1990-10-02 | 1992-12-23 | Beckman Instruments, Inc. | Magnetic separation device |
| US5897783A (en) | 1992-09-24 | 1999-04-27 | Amersham International Plc | Magnetic separation method |
| US5599501A (en) | 1994-11-10 | 1997-02-04 | Ciba Corning Diagnostics Corp. | Incubation chamber |
| EP0810905B1 (en) * | 1995-02-21 | 1998-11-04 | Iqbal W. Dr. Siddiqi | Apparatus and method for mixing and separation employing magnetic particles |
| US5888835A (en) | 1996-05-10 | 1999-03-30 | Chiron Diagnostics Corporation | Method and apparatus for wash, resuspension, recollection and localization of magnetizable particles in assays using magnetic separation technology |
| US6451207B1 (en) * | 1997-06-04 | 2002-09-17 | Dexter Magnetic Technologies, Inc. | Magnetic cell separation device |
| AU1778701A (en) * | 1999-11-17 | 2001-05-30 | University Of Virginia Patent Foundation | Sperm cell selection system |
-
2001
- 2001-07-25 DE DE10136060A patent/DE10136060A1/de not_active Withdrawn
-
2002
- 2002-07-23 CA CA2453110A patent/CA2453110C/en not_active Expired - Fee Related
- 2002-07-23 WO PCT/EP2002/008174 patent/WO2003009943A1/de not_active Ceased
- 2002-07-23 ES ES02767249T patent/ES2242877T3/es not_active Expired - Lifetime
- 2002-07-23 DE DE50203361T patent/DE50203361D1/de not_active Expired - Lifetime
- 2002-07-23 JP JP2003515326A patent/JP3842784B2/ja not_active Expired - Fee Related
- 2002-07-23 EP EP02767249A patent/EP1420888B1/de not_active Expired - Lifetime
- 2002-07-23 AT AT02767249T patent/ATE297255T1/de active
- 2002-07-23 US US10/484,110 patent/US7326350B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003009943A8 (de) | 2005-03-03 |
| ATE297255T1 (de) | 2005-06-15 |
| DE10136060A1 (de) | 2003-02-13 |
| JP3842784B2 (ja) | 2006-11-08 |
| ES2242877T3 (es) | 2005-11-16 |
| JP2004535591A (ja) | 2004-11-25 |
| EP1420888B1 (de) | 2005-06-08 |
| DE50203361D1 (de) | 2005-07-14 |
| US7326350B2 (en) | 2008-02-05 |
| US20040265903A1 (en) | 2004-12-30 |
| EP1420888A1 (de) | 2004-05-26 |
| WO2003009943A1 (de) | 2003-02-06 |
| CA2453110A1 (en) | 2003-02-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20170724 |