CA2452151C - Use of cyclopamine, an inducer of the differentiation and apoptosis of the basal cell carcinoma (bcc) cells, in the treatment of bcc's and other tumors that use the hedgehog/smoothened pathway for proliferation of apoptosis - Google Patents
Use of cyclopamine, an inducer of the differentiation and apoptosis of the basal cell carcinoma (bcc) cells, in the treatment of bcc's and other tumors that use the hedgehog/smoothened pathway for proliferation of apoptosis Download PDFInfo
- Publication number
- CA2452151C CA2452151C CA2452151A CA2452151A CA2452151C CA 2452151 C CA2452151 C CA 2452151C CA 2452151 A CA2452151 A CA 2452151A CA 2452151 A CA2452151 A CA 2452151A CA 2452151 C CA2452151 C CA 2452151C
- Authority
- CA
- Canada
- Prior art keywords
- medicament
- cyclopamine
- bcc
- cells
- apoptosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 206010004146 Basal cell carcinoma Diseases 0.000 title claims abstract description 82
- QASFUMOKHFSJGL-LAFRSMQTSA-N Cyclopamine Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H](CC2=C3C)[C@@H]1[C@@H]2CC[C@@]13O[C@@H]2C[C@H](C)CN[C@H]2[C@H]1C QASFUMOKHFSJGL-LAFRSMQTSA-N 0.000 title claims abstract description 63
- QASFUMOKHFSJGL-UHFFFAOYSA-N cyclopamine Natural products C1C=C2CC(O)CCC2(C)C(CC2=C3C)C1C2CCC13OC2CC(C)CNC2C1C QASFUMOKHFSJGL-UHFFFAOYSA-N 0.000 title claims abstract description 63
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- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
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- 206010061619 Deformity Diseases 0.000 description 1
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- 108090000031 Hedgehog Proteins Proteins 0.000 description 1
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- 238000013115 immunohistochemical detection Methods 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 230000006882 induction of apoptosis Effects 0.000 description 1
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- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
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- 229930003352 steroid alkaloid Natural products 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/TR2001/000027 WO2002078703A1 (en) | 2001-07-02 | 2001-07-02 | Use of cyclopamine in the treatment of basal cell carcinoma and other tumors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2452151A1 CA2452151A1 (en) | 2002-10-10 |
| CA2452151C true CA2452151C (en) | 2012-01-03 |
Family
ID=21619326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2452151A Expired - Fee Related CA2452151C (en) | 2001-07-02 | 2001-07-02 | Use of cyclopamine, an inducer of the differentiation and apoptosis of the basal cell carcinoma (bcc) cells, in the treatment of bcc's and other tumors that use the hedgehog/smoothened pathway for proliferation of apoptosis |
Country Status (14)
| Country | Link |
|---|---|
| EP (4) | EP2862570A1 (enExample) |
| JP (3) | JP2004536045A (enExample) |
| KR (1) | KR20090125833A (enExample) |
| CN (2) | CN1525859B (enExample) |
| AT (2) | ATE305300T1 (enExample) |
| AU (1) | AU2001272892B8 (enExample) |
| BR (1) | BR0117063A (enExample) |
| CA (1) | CA2452151C (enExample) |
| DE (2) | DE60113733T2 (enExample) |
| DK (2) | DK1401438T3 (enExample) |
| ES (3) | ES2534400T3 (enExample) |
| PT (1) | PT1411938E (enExample) |
| RU (1) | RU2312661C2 (enExample) |
| WO (2) | WO2002078703A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8044259B2 (en) | 2000-08-03 | 2011-10-25 | The Regents Of The University Of Michigan | Determining the capability of a test compound to affect solid tumor stem cells |
| US6984522B2 (en) | 2000-08-03 | 2006-01-10 | Regents Of The University Of Michigan | Isolation and use of solid tumor stem cells |
| ES2534400T3 (es) * | 2001-07-02 | 2015-04-22 | Sinan Tas | Uso de ciclopamina en el tratamiento de carcinoma de células basales y otros tumores |
| US20170326118A1 (en) | 2001-07-02 | 2017-11-16 | Sinan Tas | Drug treatment of tumors wherein hedgehog/smoothened signaling is utilized for inhibition of apoptosis of tumor cells |
| CA2452152A1 (en) | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
| AU2006283040B2 (en) | 2005-08-22 | 2011-08-25 | The Johns Hopkins University | Hedgehog pathway antagonists to treat disease |
| PT2500360E (pt) | 2005-10-31 | 2015-10-15 | Oncomed Pharm Inc | Composições e métodos para diagnóstico e tratamento do cancro |
| US7723477B2 (en) | 2005-10-31 | 2010-05-25 | Oncomed Pharmaceuticals, Inc. | Compositions and methods for inhibiting Wnt-dependent solid tumor cell growth |
| MY181496A (en) * | 2006-10-31 | 2020-12-23 | Government Of The United States Of America Represented By The Sec Dep Of Health And Human Services | Smoothened polypeptides and methods of use |
| TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明（ｃｙｃｌｏｐａｍｉｎｅ）類似物類 |
| EP2106439B1 (en) | 2007-01-24 | 2014-11-12 | The Regents of the University of Michigan | Compositions and methods for treating and diagnosing pancreatic cancer |
| NZ579361A (en) * | 2007-03-07 | 2012-04-27 | Infinity Discovery Inc | Heterocyclic cyclopamine analogs and methods of use thereof |
| US7964590B2 (en) | 2007-03-07 | 2011-06-21 | Infinity Discovery, Inc. | Cyclopamine lactam analogs and methods of use thereof |
| EP3190121B1 (en) | 2007-12-27 | 2019-02-20 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction of cyclopamine 4-en-3-one derivative |
| WO2009099625A2 (en) * | 2008-02-08 | 2009-08-13 | The Board Of Regents Of The University Of Texas System | Cyclopamine tartrate salt and uses thereof |
| MX2011003183A (es) | 2008-09-26 | 2011-04-21 | Oncomed Pharm Inc | Agentes que se unen a receptor encrespado y usos de los mismos. |
| US20110275576A1 (en) * | 2009-01-06 | 2011-11-10 | Utah State University | Carbohydrate-Cyclopamine Conjugates as Anticancer Agents |
| JP2009143963A (ja) * | 2009-03-25 | 2009-07-02 | Sinan Tas | 腫瘍細胞のアポトーシスを阻害するためにヘッジホッグ／スムーズンド信号を使用する腫瘍を治療するための製薬組成物 |
| WO2011017551A1 (en) | 2009-08-05 | 2011-02-10 | Infinity Pharmaceuticals, Inc. | Enzymatic transamination of cyclopamine analogs |
| TWI535445B (zh) | 2010-01-12 | 2016-06-01 | 安可美德藥物股份有限公司 | Ｗｎｔ拮抗劑及治療和篩選方法 |
| KR20130043102A (ko) | 2010-04-01 | 2013-04-29 | 온코메드 파마슈티칼스, 인크. | 프리즐드-결합 작용제 및 그의 용도 |
| WO2012037217A1 (en) | 2010-09-14 | 2012-03-22 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
| HK1212216A1 (en) | 2012-10-23 | 2016-06-10 | Oncomed Pharmaceuticals, Inc. | Methods of treating neuroendocrine tumors using wnt pathway-binding agents |
| HK1211887A1 (en) | 2013-02-04 | 2016-06-03 | Oncomed Pharmaceuticals, Inc. | Methods and monitoring of treatment with a wnt pathway inhibitor |
| US9168300B2 (en) | 2013-03-14 | 2015-10-27 | Oncomed Pharmaceuticals, Inc. | MET-binding agents and uses thereof |
| CN104740633A (zh) * | 2013-12-26 | 2015-07-01 | 中国科学院上海生命科学研究院 | Shh信号通路特异性抑制剂的应用 |
| BR112017026103B1 (pt) | 2015-06-04 | 2023-10-03 | Sol-Gel Technologies Ltd | Composições tópicas com composto inibidor de hedgehog, sistema de entrega tópica e seus usos |
| WO2017139497A1 (en) * | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Hedgehog inhibitor for use in relief of and treatment of pruritus or itching |
| CA3227688A1 (en) | 2021-09-13 | 2023-03-02 | Sinan Tas | Effective interventions with aging and diseases of aging of human and their consequences |
| CN114292279B (zh) * | 2022-01-07 | 2023-05-09 | 吉林省农业科学院 | 一种藜芦抗癌有效成分环杷明提取与分离方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5851993A (en) * | 1994-06-13 | 1998-12-22 | Biotie Therapies Ltd. | Suppression of tumor cell growth by syndecan-1 ectodomain |
| US7098196B1 (en) * | 1999-10-13 | 2006-08-29 | Johns Hopkins University School Of Medicine | Regulators of the hedgehog pathway, compositions and uses related thereto |
| WO1999052534A1 (en) * | 1998-04-09 | 1999-10-21 | Johns Hopkins University School Of Medicine | Use of steroidal alkaloid derivatives as inhibitors of hedgehog signaling pathways |
| ATE466850T1 (de) * | 1998-09-23 | 2010-05-15 | Res Dev Foundation | Tocopherole, tocotrienole, sonstige chroman- und seitenkettenderivate, sowie deren verwendungen |
| US6291516B1 (en) * | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
| AU780358B2 (en) * | 1999-06-08 | 2005-03-17 | Lorantis Limited | Therapeutic use of an inhibitor of a hedgehog or a hedgehog-related signalling pathway |
| EP1646395B8 (en) * | 1999-11-30 | 2014-12-17 | Curis, Inc. | Methods and compositions for regulating lymphocyte activity |
| CU23175A1 (es) * | 2000-07-17 | 2006-09-22 | Ct De Investigacion Y Desarrol | Formulacion liposomica de propionato de clobetasol |
| CA2452152A1 (en) * | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
| ES2534400T3 (es) * | 2001-07-02 | 2015-04-22 | Sinan Tas | Uso de ciclopamina en el tratamiento de carcinoma de células basales y otros tumores |
-
2001
- 2001-07-02 ES ES10163813.8T patent/ES2534400T3/es not_active Expired - Lifetime
- 2001-07-02 CN CN018234429A patent/CN1525859B/zh not_active Expired - Fee Related
- 2001-07-02 ES ES01952097T patent/ES2250434T3/es not_active Expired - Lifetime
- 2001-07-02 CA CA2452151A patent/CA2452151C/en not_active Expired - Fee Related
- 2001-07-02 EP EP20140196071 patent/EP2862570A1/en not_active Withdrawn
- 2001-07-02 DK DK01952097T patent/DK1401438T3/da active
- 2001-07-02 EP EP10163813.8A patent/EP2216022B1/en not_active Expired - Lifetime
- 2001-07-02 DE DE60113733T patent/DE60113733T2/de not_active Expired - Lifetime
- 2001-07-02 JP JP2002576969A patent/JP2004536045A/ja active Pending
- 2001-07-02 EP EP05008758A patent/EP1561464A3/en not_active Withdrawn
- 2001-07-02 AT AT01952097T patent/ATE305300T1/de not_active IP Right Cessation
- 2001-07-02 WO PCT/TR2001/000027 patent/WO2002078703A1/en not_active Ceased
- 2001-07-02 EP EP01952097A patent/EP1401438B1/en not_active Revoked
- 2001-07-02 AU AU2001272892A patent/AU2001272892B8/en not_active Ceased
- 2001-07-02 BR BR0117063-5A patent/BR0117063A/pt active Search and Examination
-
2002
- 2002-04-19 DE DE60204966T patent/DE60204966T2/de not_active Expired - Lifetime
- 2002-04-19 PT PT02736467T patent/PT1411938E/pt unknown
- 2002-04-19 RU RU2004103074/15A patent/RU2312661C2/ru not_active IP Right Cessation
- 2002-04-19 DK DK02736467T patent/DK1411938T3/da active
- 2002-04-19 WO PCT/TR2002/000017 patent/WO2002078704A1/en not_active Ceased
- 2002-04-19 ES ES02736467T patent/ES2246011T3/es not_active Expired - Lifetime
- 2002-04-19 CN CNB02813429XA patent/CN1230169C/zh not_active Expired - Fee Related
- 2002-04-19 AT AT02736467T patent/ATE299022T1/de not_active IP Right Cessation
-
2003
- 2003-03-17 KR KR1020097022024A patent/KR20090125833A/ko not_active Ceased
-
2010
- 2010-02-10 JP JP2010028010A patent/JP5424923B2/ja not_active Expired - Fee Related
-
2013
- 2013-09-18 JP JP2013193304A patent/JP2014028834A/ja not_active Ceased
Also Published As
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| Publication | Publication Date | Title |
|---|---|---|
| CA2452151C (en) | Use of cyclopamine, an inducer of the differentiation and apoptosis of the basal cell carcinoma (bcc) cells, in the treatment of bcc's and other tumors that use the hedgehog/smoothened pathway for proliferation of apoptosis | |
| US7893078B2 (en) | Use of cyclopamine in the treatment of basal cell carcinoma and other tumors | |
| AU2001272892A1 (en) | Use of cyclopamine in the treatment of basal cell carcinoma and other tumors | |
| CA2596759C (en) | Local treatment of neurofibromas | |
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