CA2449190A1 - Use of optical diffraction elements in detection methods - Google Patents

Use of optical diffraction elements in detection methods Download PDF

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Publication number
CA2449190A1
CA2449190A1 CA002449190A CA2449190A CA2449190A1 CA 2449190 A1 CA2449190 A1 CA 2449190A1 CA 002449190 A CA002449190 A CA 002449190A CA 2449190 A CA2449190 A CA 2449190A CA 2449190 A1 CA2449190 A1 CA 2449190A1
Authority
CA
Canada
Prior art keywords
optical
sample
carrier
volume elements
luminescence
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002449190A
Other languages
English (en)
French (fr)
Inventor
Rudolf Rigler
Hans Blom
Mathias Johansson
Sverker Hard
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gnothis Holding SA
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2449190A1 publication Critical patent/CA2449190A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6452—Individual samples arranged in a regular 2D-array, e.g. multiwell plates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N2021/6417—Spectrofluorimetric devices
    • G01N2021/6421—Measuring at two or more wavelengths
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G01N21/6458—Fluorescence microscopy

Landscapes

  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
CA002449190A 2001-05-29 2002-05-28 Use of optical diffraction elements in detection methods Abandoned CA2449190A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10126083A DE10126083A1 (de) 2001-05-29 2001-05-29 Verwendung von optischen Diffraktionselementen in Nachweisverfahren
DE10126083.0 2001-05-29
PCT/EP2002/005866 WO2002097406A1 (de) 2001-05-29 2002-05-28 Verwendung von optischen diffraktionselementen in nachweisverfahren

Publications (1)

Publication Number Publication Date
CA2449190A1 true CA2449190A1 (en) 2002-12-05

Family

ID=7686488

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002449190A Abandoned CA2449190A1 (en) 2001-05-29 2002-05-28 Use of optical diffraction elements in detection methods

Country Status (6)

Country Link
US (1) US7259847B2 (https=)
EP (1) EP1390725B1 (https=)
JP (1) JP2004530137A (https=)
CA (1) CA2449190A1 (https=)
DE (1) DE10126083A1 (https=)
WO (1) WO2002097406A1 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1637871B1 (en) * 2003-05-30 2011-03-23 Olympus Corporation Measuring apparatus including a light-receiving unit
DE10336080A1 (de) * 2003-08-06 2005-03-03 Gnothis Holding Sa Verfahren und Vorrichtung zur Bestimmung von lumineszierenden Molekülen, insbesondere nach der Methode der Fluoreszenzkorrelationsspektroskopie
DE202004012992U1 (de) * 2004-08-19 2005-12-29 Storz Endoskop Produktions Gmbh Endoskopisches Video-Meßsystem
JP2008523383A (ja) 2004-12-10 2008-07-03 コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ マルチスポット調査装置
DE102005000840B4 (de) * 2005-01-05 2007-12-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Verfahren und Vorrichtung zur Elementanalyse mittels Laser-Emissionsspektrometrie
CN100372947C (zh) * 2005-03-03 2008-03-05 华南师范大学 转基因物种的荧光相关光谱检测方法
WO2006128442A1 (de) * 2005-05-31 2006-12-07 W.O.M. World Of Medicine Ag Verfahren und vorrichtung zur optischen charakterisierung von gewebe
US20100167413A1 (en) * 2007-05-10 2010-07-01 Paul Lundquist Methods and systems for analyzing fluorescent materials with reduced autofluorescence
AU2008251861B2 (en) * 2007-05-10 2014-03-20 Pacific Biosciences Of California, Inc. Methods and systems for analyzing fluorescent materials with reduced autofluorescence
US20080277595A1 (en) * 2007-05-10 2008-11-13 Pacific Biosciences Of California, Inc. Highly multiplexed confocal detection systems and methods of using same
DE102010016818A1 (de) * 2010-03-16 2011-09-22 Leica Microsystems Cms Gmbh Verfahren und Vorrichtung zur Durchführung von Multipoint-FCS
US9920364B2 (en) 2012-03-06 2018-03-20 Rudolf Rigler Cyclic single molecule sequencing process
CN106460034B (zh) 2014-01-10 2021-05-07 格诺特斯控股股份公司 具有高准确度的单分子分析
EP3112841A1 (en) 2015-06-30 2017-01-04 Gnothis Holding SA Single molecule analysis in an electrical field
EP3330763A1 (en) 2016-12-05 2018-06-06 Gnothis AB Apparatus for characterizing luminescent entities
DE102017105113B4 (de) 2017-03-10 2021-09-30 Leibniz-Institut für Photonische Technologien e.V. (Engl.Leibniz Institute of Photonic Technology) Anordnung und Verfahren für die Erfassung von Änderungen der optischen Weglänge in einem Nano-Kapillarkanal
CN112912715B (zh) * 2018-10-25 2024-08-09 浜松光子学株式会社 光学测定装置及光学测定方法
EP4379378A1 (en) 2022-11-29 2024-06-05 Gnothis Holding AG Selective-area coated protein resistant surface
WO2024099959A1 (en) 2022-11-07 2024-05-16 Gnothis Holding Ag Selective-area coated protein resistant surface
EP4403643A1 (en) 2023-01-19 2024-07-24 Gnothis Holding AG Multiple molecular binding sites
EP4623095A1 (en) 2022-11-21 2025-10-01 Gnothis Holding AG Multiple molecular binding sites
EP4375644A1 (en) 2022-11-22 2024-05-29 Gnothis Holding AG Fingerprint analysis of single molecule events
EP4379355A1 (en) 2022-11-29 2024-06-05 Gnothis Holding AG High throughput analysis of single molecule events
EP4382614A1 (en) 2022-12-06 2024-06-12 Gnothis Holding AG High yield support

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU5884394A (en) 1993-01-18 1994-08-15 Evotec Biosystems Gmbh Method and device for assessing the suitability of biopolymers
JP3474652B2 (ja) 1994-11-11 2003-12-08 株式会社モリテックス 多点レーザトラッピング装置及びその方法
DE19748211A1 (de) 1997-10-31 1999-05-06 Zeiss Carl Fa Optisches Array-System und Reader für Mikrotiterplatten
US6055106A (en) * 1998-02-03 2000-04-25 Arch Development Corporation Apparatus for applying optical gradient forces
US6208411B1 (en) * 1998-09-28 2001-03-27 Kla-Tencor Corporation Massively parallel inspection and imaging system
US6455861B1 (en) * 1998-11-24 2002-09-24 Cambridge Research & Instrumentation, Inc. Fluorescence polarization assay system and method
GB9906929D0 (en) 1999-03-26 1999-05-19 Univ Glasgow Assay system
JP2001228756A (ja) * 2000-02-18 2001-08-24 Canon Inc 画像形成装置
US20010033376A1 (en) * 2000-02-25 2001-10-25 Cambridge Reseach & Instrumentation Inc. Automatic G-factor calibration
DE10065632A1 (de) 2000-05-12 2001-11-15 Smtech Biovision Holding Ag Ec Verfahren zum Nachweis von Polynukleotiden
DE10065626A1 (de) 2000-06-30 2002-01-10 Smtech Biovision Holding Ag Ec Einzelmolekül-Sequenzierungsverfahren

Also Published As

Publication number Publication date
DE10126083A1 (de) 2002-12-05
EP1390725B1 (de) 2015-12-23
EP1390725A1 (de) 2004-02-25
US20040126780A1 (en) 2004-07-01
WO2002097406A1 (de) 2002-12-05
JP2004530137A (ja) 2004-09-30
US7259847B2 (en) 2007-08-21

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Legal Events

Date Code Title Description
EEER Examination request
FZDE Discontinued