CA2442329A1 - Imidazo-triazine derivatives as pde 5 inhibitors - Google Patents

Imidazo-triazine derivatives as pde 5 inhibitors Download PDF

Info

Publication number
CA2442329A1
CA2442329A1 CA002442329A CA2442329A CA2442329A1 CA 2442329 A1 CA2442329 A1 CA 2442329A1 CA 002442329 A CA002442329 A CA 002442329A CA 2442329 A CA2442329 A CA 2442329A CA 2442329 A1 CA2442329 A1 CA 2442329A1
Authority
CA
Canada
Prior art keywords
compounds
alkyl
het
formula
aryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002442329A
Other languages
English (en)
French (fr)
Inventor
Charlotte Moira Norfor Allerton
Kevin Neil Dack
Mark Ian Kemp
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2442329A1 publication Critical patent/CA2442329A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Reproductive Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA002442329A 2001-03-28 2002-03-19 Imidazo-triazine derivatives as pde 5 inhibitors Abandoned CA2442329A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0107751.0A GB0107751D0 (en) 2001-03-28 2001-03-28 Pharmaceutically active compounds
GB0107751.0 2001-03-28
PCT/IB2002/000854 WO2002079203A1 (en) 2001-03-28 2002-03-19 Imidazo-triazine derivatives as pde 5 inhibitors

Publications (1)

Publication Number Publication Date
CA2442329A1 true CA2442329A1 (en) 2002-10-10

Family

ID=9911744

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002442329A Abandoned CA2442329A1 (en) 2001-03-28 2002-03-19 Imidazo-triazine derivatives as pde 5 inhibitors

Country Status (8)

Country Link
EP (1) EP1395589A1 (https=)
JP (1) JP2004528320A (https=)
AU (1) AU2002241211A1 (https=)
BR (1) BR0208463A (https=)
CA (1) CA2442329A1 (https=)
GB (1) GB0107751D0 (https=)
MX (1) MXPA03005990A (https=)
WO (1) WO2002079203A1 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7456184B2 (en) 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
CA2462200A1 (en) 2001-08-10 2003-02-20 Palatin Technologies, Inc. Peptidomimetics of biologically active metallopeptides
US7354923B2 (en) 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
DE10229778A1 (de) * 2002-07-03 2004-01-29 Bayer Ag Neue Verwendung von Imidazotriazinonen
JP2006219374A (ja) 2003-06-13 2006-08-24 Daiichi Asubio Pharma Co Ltd Ｐｄｅ７阻害作用を有するイミダゾトリアジノン誘導体
DK1697371T3 (da) * 2003-12-19 2007-09-17 Bristol Myers Squibb Co Azabicykliske heterocykliske forbindelser som cannabinoidreceptormodulatorer
TW200528455A (en) * 2003-12-19 2005-09-01 Bristol Myers Squibb Co Azabicyclic heterocycles as cannabinoid receptor modulators
US7683060B2 (en) 2006-08-07 2010-03-23 Incyte Corporation Triazolotriazines as kinase inhibitors
ME02372B (me) 2006-11-22 2016-06-20 Incyte Holdings Corp Imidazotriazini i imidazopiramidini kao inhibitori kinaze
WO2009143211A2 (en) 2008-05-21 2009-11-26 Incyte Corporation Salts of 2-fluoro-n-methyl-4-[7-(quinolin-6-yl-methyl)- imidazo[1,2-b][1,2,4]triazin-2-yl]benzamide and processes related to preparing the same
EA025304B1 (ru) 2010-02-03 2016-12-30 Инсайт Холдингс Корпорейшн ИМИДАЗО[1,2-b][1,2,4]ТРИАЗИНЫ В КАЧЕСТВЕ c-Met ИНГИБИТОРОВ
CN102372730B (zh) * 2010-08-19 2014-03-26 山东轩竹医药科技有限公司 桥环取代的磷酸二酯酶抑制剂
CN102382129B (zh) * 2010-08-19 2014-02-26 山东轩竹医药科技有限公司 螺环取代的磷酸二酯酶抑制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9114760D0 (en) * 1991-07-09 1991-08-28 Pfizer Ltd Therapeutic agents
GB9311920D0 (en) * 1993-06-09 1993-07-28 Pfizer Ltd Therapeutic agents
US6362178B1 (en) * 1997-11-12 2002-03-26 Bayer Aktiengesellschaft 2-phenyl substituted imidazotriazinones as phosphodiesterase inhibitors
US6503908B1 (en) * 1999-10-11 2003-01-07 Pfizer Inc Pharmaceutically active compounds
DE10010067A1 (de) * 2000-03-02 2001-09-06 Bayer Ag Neue Imidazotriazinone und ihre Verwendung

Also Published As

Publication number Publication date
BR0208463A (pt) 2004-03-02
GB0107751D0 (en) 2001-05-16
JP2004528320A (ja) 2004-09-16
AU2002241211A1 (en) 2002-10-15
MXPA03005990A (es) 2005-02-14
EP1395589A1 (en) 2004-03-10
WO2002079203A1 (en) 2002-10-10
WO2002079203A8 (en) 2002-11-21

Similar Documents

Publication Publication Date Title
EP1372656B1 (en) Pyrazolo[4,3-d]pyrimidinone compounds as cgmp pde inhibitors
US6677335B1 (en) Pharmaceutically active compounds
EP1368352B1 (en) Cyclic guanosine 3',5'-monophosphate phosphodiesterase inhibitors
US6440982B1 (en) Pharmaceutically active compounds
US6770645B2 (en) Pharmaceutically active compounds
US6503908B1 (en) Pharmaceutically active compounds
US6784185B2 (en) Pharmaceutically active compounds
CA2442329A1 (en) Imidazo-triazine derivatives as pde 5 inhibitors
US6794387B2 (en) Pharmaceutically active compounds
US6831074B2 (en) Pharmaceutically active compounds
EP1380293A1 (en) Bone metabolism improving agents
CA2376844A1 (en) Pyrazolo¢4,3-d!pyrimidin-7-ones and pyrazolo¢3,4!pyrimidin-4-ones and purinones which inhibit cgmp pdes
WO2002072586A1 (en) Pyrazolo'4,3-d-pyrimidine for inhibiting cgmp pde
US20020173502A1 (en) Pharmaceutically active compounds

Legal Events

Date Code Title Description
EEER Examination request
FZDE Dead