CA2440218C - Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use as adenosine receptor-selective ligands - Google Patents

Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use as adenosine receptor-selective ligands Download PDF

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Publication number
CA2440218C
CA2440218C CA2440218A CA2440218A CA2440218C CA 2440218 C CA2440218 C CA 2440218C CA 2440218 A CA2440218 A CA 2440218A CA 2440218 A CA2440218 A CA 2440218A CA 2440218 C CA2440218 C CA 2440218C
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hydrate
salt
substituted
alkoxy
hydroxyl
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French (fr)
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CA2440218A1 (en
Inventor
Ulrich Rosentreter
Thomas Kraemer
Andrea Vaupel
Walter Huebsch
Nicole Diedrichs
Thomas Krahn
Klaus Dembowsky
Johannes Peter Stasch
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Bayer Pharma AG
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Bayer Schering Pharma AG
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • C07—ORGANIC CHEMISTRY
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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C07D213/85—Nitriles in position 3
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
CA2440218A 2001-03-07 2002-02-28 Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use as adenosine receptor-selective ligands Expired - Fee Related CA2440218C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE10110754A DE10110754A1 (de) 2001-03-07 2001-03-07 Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10110754.4 2001-03-07
PCT/EP2002/002121 WO2002070485A1 (de) 2001-03-07 2002-02-28 Substituierte 2-thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre verwendung als adenosinrezeptor-selektive liganden

Publications (2)

Publication Number Publication Date
CA2440218A1 CA2440218A1 (en) 2002-09-12
CA2440218C true CA2440218C (en) 2010-11-30

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CA2440218A Expired - Fee Related CA2440218C (en) 2001-03-07 2002-02-28 Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use as adenosine receptor-selective ligands

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US (1) US7825255B2 (https=)
EP (1) EP1368319B1 (https=)
JP (1) JP4460834B2 (https=)
CA (1) CA2440218C (https=)
DE (2) DE10110754A1 (https=)
ES (1) ES2278003T3 (https=)
WO (1) WO2002070485A1 (https=)

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DE10115922A1 (de) * 2001-03-30 2002-10-10 Bayer Ag Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10238113A1 (de) * 2001-12-11 2003-06-18 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
US7045632B2 (en) * 2003-03-04 2006-05-16 Chevron Phillips Chemical Company, Lp Composition and method for a hexadentate ligand and bimetallic complex for polymerization of olefins

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US7825255B2 (en) 2010-11-02
DE10110754A1 (de) 2002-09-19
CA2440218A1 (en) 2002-09-12
ES2278003T3 (es) 2007-08-01
JP4460834B2 (ja) 2010-05-12
US20060154969A1 (en) 2006-07-13
EP1368319A1 (de) 2003-12-10
EP1368319B1 (de) 2006-12-06
JP2004531490A (ja) 2004-10-14
DE50208895D1 (de) 2007-01-18
WO2002070485A1 (de) 2002-09-12

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