CA2438921C - Streptococcus pyogenes polypeptides and corresponding dna fragments - Google Patents

Info

Publication number

CA2438921C

CA2438921C CA2438921A CA2438921A CA2438921C CA 2438921 C CA2438921 C CA 2438921C CA 2438921 A CA2438921 A CA 2438921A CA 2438921 A CA2438921 A CA 2438921A CA 2438921 C CA2438921 C CA 2438921C

Authority

CA

Canada

Prior art keywords

polypeptide

amino acid

leu

lys

acid sequence

Prior art date

2001-02-21

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Expired - Fee Related

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• 241000193996 Streptococcus pyogenes Species 0.000 title claims abstract description 74
• 102000004196 processed proteins & peptides Human genes 0.000 title claims description 437
• 108090000765 processed proteins & peptides Proteins 0.000 title claims description 437
• 229920001184 polypeptide Polymers 0.000 title claims description 436
• 239000012634 fragment Substances 0.000 title claims description 85
• 108091007433 antigens Proteins 0.000 claims abstract description 21
• 102000036639 antigens Human genes 0.000 claims abstract description 21
• 239000000427 antigen Substances 0.000 claims abstract description 20
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 140
• 108091033319 polynucleotide Proteins 0.000 claims description 69
• 102000040430 polynucleotide Human genes 0.000 claims description 69
• 239000002157 polynucleotide Substances 0.000 claims description 69
• 241000194017 Streptococcus Species 0.000 claims description 40
• 125000000539 amino acid group Chemical group 0.000 claims description 34
• 208000015181 infectious disease Diseases 0.000 claims description 27
• 238000000034 method Methods 0.000 claims description 27
• 239000008194 pharmaceutical composition Substances 0.000 claims description 25
• 239000002671 adjuvant Substances 0.000 claims description 22
• 239000013598 vector Substances 0.000 claims description 22
• 239000000203 mixture Substances 0.000 claims description 20
• 150000001413 amino acids Chemical class 0.000 claims description 18
• 239000012472 biological sample Substances 0.000 claims description 18
• 230000027455 binding Effects 0.000 claims description 17
• 230000014509 gene expression Effects 0.000 claims description 13
• 230000028993 immune response Effects 0.000 claims description 13
• 230000000295 complement effect Effects 0.000 claims description 12
• 239000003085 diluting agent Substances 0.000 claims description 11
• 125000001360 methionine group Chemical group N[C@@H](CCSC)C(=O)* 0.000 claims description 11
• 238000006467 substitution reaction Methods 0.000 claims description 11
• 238000011282 treatment Methods 0.000 claims description 11
• 241000282414 Homo sapiens Species 0.000 claims description 10
• 230000000069 prophylactic effect Effects 0.000 claims description 8
• 230000001225 therapeutic effect Effects 0.000 claims description 8
• 238000002360 preparation method Methods 0.000 claims description 7
• 229960005486 vaccine Drugs 0.000 claims description 7
• 239000003937 drug carrier Substances 0.000 claims description 6
• 239000002773 nucleotide Substances 0.000 claims description 6
• 125000003729 nucleotide group Chemical group 0.000 claims description 6
• 238000012217 deletion Methods 0.000 claims description 5
• 230000037430 deletion Effects 0.000 claims description 5
• 230000008569 process Effects 0.000 claims description 5
• 241000124008 Mammalia Species 0.000 claims description 4
• 238000012258 culturing Methods 0.000 claims description 4
• 238000000338 in vitro Methods 0.000 claims description 4
• 208000031729 Bacteremia Diseases 0.000 claims description 3
• 201000000297 Erysipelas Diseases 0.000 claims description 3
• 206010021531 Impetigo Diseases 0.000 claims description 3
• 206010028885 Necrotising fasciitis Diseases 0.000 claims description 3
• 201000007100 Pharyngitis Diseases 0.000 claims description 3
• 206010039587 Scarlet Fever Diseases 0.000 claims description 3
• 206010040070 Septic Shock Diseases 0.000 claims description 3
• 206010044248 Toxic shock syndrome Diseases 0.000 claims description 3
• 231100000650 Toxic shock syndrome Toxicity 0.000 claims description 3
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• 230000009870 specific binding Effects 0.000 claims description 3
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• 241001505901 Streptococcus sp. 'group A' Species 0.000 abstract description 4
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• WEZNQZHACPSMEF-QEJZJMRPSA-N Ala-Phe-Lys Chemical compound NCCCC[C@@H](C(O)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)C)CC1=CC=CC=C1 WEZNQZHACPSMEF-QEJZJMRPSA-N 0.000 description 13
• JZLFYAAGGYMRIK-BYULHYEWSA-N Asn-Val-Asp Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(O)=O JZLFYAAGGYMRIK-BYULHYEWSA-N 0.000 description 13
• 241000588724 Escherichia coli Species 0.000 description 13
• MXOODARRORARSU-ACZMJKKPSA-N Glu-Ala-Ser Chemical compound C[C@@H](C(=O)N[C@@H](CO)C(=O)O)NC(=O)[C@H](CCC(=O)O)N MXOODARRORARSU-ACZMJKKPSA-N 0.000 description 13
• PMGDADKJMCOXHX-UHFFFAOYSA-N L-Arginyl-L-glutamin-acetat Natural products NC(=N)NCCCC(N)C(=O)NC(CCC(N)=O)C(O)=O PMGDADKJMCOXHX-UHFFFAOYSA-N 0.000 description 13
• DLCOFDAHNMMQPP-SRVKXCTJSA-N Leu-Asp-Leu Chemical compound CC(C)C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(O)=O DLCOFDAHNMMQPP-SRVKXCTJSA-N 0.000 description 13
• JMGJDTNUMAZNLX-RWRJDSDZSA-N Thr-Glu-Ile Chemical compound [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O JMGJDTNUMAZNLX-RWRJDSDZSA-N 0.000 description 13
• 229940024606 amino acid Drugs 0.000 description 13
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• 108010038633 aspartylglutamate Proteins 0.000 description 13
• 108010054155 lysyllysine Proteins 0.000 description 13
• RPWTZTBIFGENIA-VOAKCMCISA-N Lys-Thr-Leu Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(O)=O RPWTZTBIFGENIA-VOAKCMCISA-N 0.000 description 12
• 108091028043 Nucleic acid sequence Proteins 0.000 description 12
• 108010049041 glutamylalanine Proteins 0.000 description 12
• 239000013612 plasmid Substances 0.000 description 12
• KIUYPHAMDKDICO-WHFBIAKZSA-N Ala-Asp-Gly Chemical compound C[C@H](N)C(=O)N[C@@H](CC(O)=O)C(=O)NCC(O)=O KIUYPHAMDKDICO-WHFBIAKZSA-N 0.000 description 11
• 241000880493 Leptailurus serval Species 0.000 description 11
• YBAFDPFAUTYYRW-UHFFFAOYSA-N N-L-alpha-glutamyl-L-leucine Natural products CC(C)CC(C(O)=O)NC(=O)C(N)CCC(O)=O YBAFDPFAUTYYRW-UHFFFAOYSA-N 0.000 description 11
• KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 description 11
• 108010077515 glycylproline Proteins 0.000 description 11
• CYBJZLQSUJEMAS-LFSVMHDDSA-N Ala-Phe-Thr Chemical compound C[C@H]([C@@H](C(=O)O)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)[C@H](C)N)O CYBJZLQSUJEMAS-LFSVMHDDSA-N 0.000 description 10
• JDHOJQJMWBKHDB-CIUDSAMLSA-N Asp-Asn-Lys Chemical compound C(CCN)C[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)N)NC(=O)[C@H](CC(=O)O)N JDHOJQJMWBKHDB-CIUDSAMLSA-N 0.000 description 10
• CHJKEDSZNSONPS-DCAQKATOSA-N Leu-Pro-Ser Chemical compound [H]N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(O)=O CHJKEDSZNSONPS-DCAQKATOSA-N 0.000 description 10
• WRODMZBHNNPRLN-SRVKXCTJSA-N Lys-Leu-Ser Chemical compound [H]N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(O)=O WRODMZBHNNPRLN-SRVKXCTJSA-N 0.000 description 10
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• 108010037850 glycylvaline Proteins 0.000 description 10
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• 210000002966 serum Anatomy 0.000 description 10
• KHCNTVRVAYCPQE-CIUDSAMLSA-N Asn-Lys-Asn Chemical compound [H]N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(O)=O KHCNTVRVAYCPQE-CIUDSAMLSA-N 0.000 description 9
• YKBUCXNNBYZYAY-MNXVOIDGSA-N Glu-Lys-Ile Chemical compound [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(O)=O YKBUCXNNBYZYAY-MNXVOIDGSA-N 0.000 description 9
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• VZKBJNBZMZHKRC-XUXIUFHCSA-N Pro-Ile-Leu Chemical compound [H]N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(O)=O VZKBJNBZMZHKRC-XUXIUFHCSA-N 0.000 description 9
• WQOHKVRQDLNDIL-YJRXYDGGSA-N Tyr-Thr-Ser Chemical compound [H]N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(O)=O WQOHKVRQDLNDIL-YJRXYDGGSA-N 0.000 description 9
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