CA2434831A1 - Drogues a base de polypeptide - Google Patents
Drogues a base de polypeptide Download PDFInfo
- Publication number
- CA2434831A1 CA2434831A1 CA002434831A CA2434831A CA2434831A1 CA 2434831 A1 CA2434831 A1 CA 2434831A1 CA 002434831 A CA002434831 A CA 002434831A CA 2434831 A CA2434831 A CA 2434831A CA 2434831 A1 CA2434831 A1 CA 2434831A1
- Authority
- CA
- Canada
- Prior art keywords
- pharmaceutical agent
- peptide
- species
- composition
- moiety
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract 21
- 229920001184 polypeptide Polymers 0.000 title claims abstract 11
- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract 11
- 229940088679 drug related substance Drugs 0.000 title claims abstract 5
- 239000008177 pharmaceutical agent Substances 0.000 claims abstract 18
- 238000000034 method Methods 0.000 claims abstract 9
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 8
- 239000000203 mixture Substances 0.000 claims abstract 6
- -1 cinnamoyl Chemical group 0.000 claims 10
- 229940002612 prodrug Drugs 0.000 claims 3
- 239000000651 prodrug Substances 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- YQTCQNIPQMJNTI-UHFFFAOYSA-N 2,2-dimethylpropan-1-one Chemical group CC(C)(C)[C]=O YQTCQNIPQMJNTI-UHFFFAOYSA-N 0.000 claims 2
- 239000008186 active pharmaceutical agent Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 2
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 2
- 125000004031 fumaroyl group Chemical group C(\C=C\C(=O)*)(=O)* 0.000 claims 2
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 2
- 230000004962 physiological condition Effects 0.000 claims 2
- YFGBQHOOROIVKG-FKBYEOEOSA-N Met-enkephalin Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 YFGBQHOOROIVKG-FKBYEOEOSA-N 0.000 claims 1
- 108010042237 Methionine Enkephalin Proteins 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000007515 enzymatic degradation Effects 0.000 claims 1
- 230000001747 exhibiting effect Effects 0.000 claims 1
- 238000001727 in vivo Methods 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002458 infectious effect Effects 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 230000003278 mimic effect Effects 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne de nouveaux agents et de nouvelles compostions pharmaceutiques ainsi que de nouvelles méthodes qui améliorent l'absorption de substances médicamenteuses à base de polypeptides qui, normalement, présentent une absorbabilité faible ou inexistante si elles sont administrées par voie orale. Cette invention concerne également de nouvelles compositions et de nouvelles méthodes qui améliorent significativement la biodisponibilité et l'efficacité pharmacologique de substances médicamenteuses à base de polypeptides, qu'elles soient administrées par voie orale ou par voie parentérale.
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26233701P | 2001-01-17 | 2001-01-17 | |
| US60/262,337 | 2001-01-17 | ||
| US28788601P | 2001-05-01 | 2001-05-01 | |
| US25787201P | 2001-05-01 | 2001-05-01 | |
| US60/257,872 | 2001-05-01 | ||
| US60/287,886 | 2001-05-01 | ||
| US33263601P | 2001-11-06 | 2001-11-06 | |
| US60/332,636 | 2001-11-06 | ||
| PCT/IB2002/000133 WO2002056916A2 (fr) | 2001-01-17 | 2002-01-17 | Compositions et methodes assurant une activite pharmacologique accrue au moyen de l'administration par voie orale et parenterale de compositions renfermant des substances medicamenteuses a base de polypeptides et d'autres ingredients actifs presentant une faible absorption |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2434831A1 true CA2434831A1 (fr) | 2002-07-25 |
| CA2434831C CA2434831C (fr) | 2012-03-06 |
Family
ID=27500604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2434831A Expired - Lifetime CA2434831C (fr) | 2001-01-17 | 2002-01-17 | Drogues a base de polypeptide |
Country Status (4)
| Country | Link |
|---|---|
| JP (2) | JP5057628B2 (fr) |
| CN (2) | CN1545422B (fr) |
| AU (1) | AU2002228260B2 (fr) |
| CA (1) | CA2434831C (fr) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180110187A (ko) * | 2009-05-08 | 2018-10-08 | 테크필즈 바이오켐 코., 엘티디. | 펩티드 및 펩티드관련 화합물의 고침투성 전구약물 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4396606A (en) * | 1979-11-05 | 1983-08-02 | Addiction Research Foundation | Novel polypeptide analgesics |
| CA1340588C (fr) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Derive d'aminoacides |
| ES2245003T3 (es) * | 1996-08-27 | 2005-12-16 | Praecis Pharmaceuticals Incorporated | Moduladores de la agregacion de peptidos beta-amiloides que comprenden d-aminoacidos. |
| US6174993B1 (en) * | 1997-05-21 | 2001-01-16 | The Children's Medical Center Corp. | Short peptides which selectively modulate the activity of serine/threonine kinases |
-
2002
- 2002-01-17 CA CA2434831A patent/CA2434831C/fr not_active Expired - Lifetime
- 2002-01-17 CN CN028038320A patent/CN1545422B/zh not_active Expired - Fee Related
- 2002-01-17 JP JP2002557423A patent/JP5057628B2/ja not_active Expired - Fee Related
- 2002-01-17 AU AU2002228260A patent/AU2002228260B2/en not_active Ceased
- 2002-01-17 CN CN2010102537253A patent/CN101979093B/zh not_active Expired - Fee Related
-
2009
- 2009-06-08 JP JP2009137059A patent/JP2009235082A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN1545422A (zh) | 2004-11-10 |
| CN101979093A (zh) | 2011-02-23 |
| CA2434831C (fr) | 2012-03-06 |
| CN101979093B (zh) | 2013-04-24 |
| CN1545422B (zh) | 2010-09-22 |
| JP2009235082A (ja) | 2009-10-15 |
| JP5057628B2 (ja) | 2012-10-24 |
| JP2005505492A (ja) | 2005-02-24 |
| AU2002228260B2 (en) | 2007-02-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |