CN1545422A - 通过口服和胃肠道外给予含有肽原料药和其它不易吸收的活性成分的组合物来增强药物活性的组合物和方法 - Google Patents
通过口服和胃肠道外给予含有肽原料药和其它不易吸收的活性成分的组合物来增强药物活性的组合物和方法 Download PDFInfo
- Publication number
- CN1545422A CN1545422A CNA028038320A CN02803832A CN1545422A CN 1545422 A CN1545422 A CN 1545422A CN A028038320 A CNA028038320 A CN A028038320A CN 02803832 A CN02803832 A CN 02803832A CN 1545422 A CN1545422 A CN 1545422A
- Authority
- CN
- China
- Prior art keywords
- peptide
- compositions
- medicament
- oral
- medicament according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title claims abstract description 103
- 238000000034 method Methods 0.000 title claims abstract description 34
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- 102000004196 processed proteins & peptides Human genes 0.000 title claims abstract description 9
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- 230000000144 pharmacologic effect Effects 0.000 title abstract description 6
- 229920001184 polypeptide Polymers 0.000 title abstract 3
- 238000007911 parenteral administration Methods 0.000 title 1
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- YFGBQHOOROIVKG-FKBYEOEOSA-N Met-enkephalin Chemical compound C([C@@H](C(=O)N[C@@H](CCSC)C(O)=O)NC(=O)CNC(=O)CNC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 YFGBQHOOROIVKG-FKBYEOEOSA-N 0.000 claims description 8
- 108010042237 Methionine Enkephalin Proteins 0.000 claims description 8
- 239000004475 Arginine Substances 0.000 claims description 7
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 7
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 7
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 7
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 7
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 7
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 7
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims description 7
- 125000004031 fumaroyl group Chemical group C(\C=C\C(=O)*)(=O)* 0.000 claims description 7
- 229930182817 methionine Natural products 0.000 claims description 7
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims description 7
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 7
- 125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 7
- 239000013543 active substance Substances 0.000 claims description 6
- 125000000539 amino acid group Chemical group 0.000 claims description 5
- 239000002671 adjuvant Substances 0.000 claims description 4
- 230000035479 physiological effects, processes and functions Effects 0.000 claims description 4
- 241000700605 Viruses Species 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 3
- 230000001681 protective effect Effects 0.000 claims description 2
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 description 14
- 238000001990 intravenous administration Methods 0.000 description 7
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- 239000008186 active pharmaceutical agent Substances 0.000 description 5
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- 241000700159 Rattus Species 0.000 description 4
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 4
- 229960002680 enalaprilat Drugs 0.000 description 4
- LZFZMUMEGBBDTC-QEJZJMRPSA-N enalaprilat (anhydrous) Chemical compound C([C@H](N[C@@H](C)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 LZFZMUMEGBBDTC-QEJZJMRPSA-N 0.000 description 4
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- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 2
- 108010007859 Lisinopril Proteins 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
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- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 2
- 229960001680 ibuprofen Drugs 0.000 description 2
- 125000005647 linker group Chemical group 0.000 description 2
- 229960002394 lisinopril Drugs 0.000 description 2
- RLAWWYSOJDYHDC-BZSNNMDCSA-N lisinopril Chemical compound C([C@H](N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(O)=O)C(O)=O)CC1=CC=CC=C1 RLAWWYSOJDYHDC-BZSNNMDCSA-N 0.000 description 2
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- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- 108010049140 Endorphins Proteins 0.000 description 1
- 102000009025 Endorphins Human genes 0.000 description 1
- 108010092674 Enkephalins Proteins 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 101100244562 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) oprD gene Proteins 0.000 description 1
- 241000700157 Rattus norvegicus Species 0.000 description 1
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- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 description 1
- 108091005601 modified peptides Proteins 0.000 description 1
- 229940127240 opiate Drugs 0.000 description 1
- 229940126701 oral medication Drugs 0.000 description 1
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/645—Polycationic or polyanionic oligopeptides, polypeptides or polyamino acids, e.g. polylysine, polyarginine, polyglutamic acid or peptide TAT
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Abstract
Description
时间 | 0小时 | 1小时 | 2小时 | 4小时 | 6小时 | 24小时 |
安慰剂 | 53.2 | 30.6 | 38.4 | 45.0 | 46.6 | 42.0 |
吗啡 | 51.8 | 84.8 | 81.2 | 58.8 | 48.8 | 42.0 |
可待因 | 53.2 | 51.4 | 64.6 | 57.6 | 56.2 | 46.4 |
布洛芬 | 53.2 | 55.0 | 70.4 | 66.0 | 54.0 | 44.2 |
CY5M | 53.6 | 46.2 | 78.8 | 78.2 | 82.6 | 98.8 |
时间 | 0小时 | 1小时 | 2小时 | 4小时 | 6小时 | 24小时 |
安慰剂 | 53.2 | 30.6 | 38.4 | 45.0 | 46.6 | 42.0 |
吗啡 | 51.8 | 118.8 | 86.6 | 63.2 | 45.6 | 40.0 |
CY5M | 51.0 | 57.0 | 114.0 | 88.2 | 106.0 | 86.6 |
Claims (27)
Applications Claiming Priority (9)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26233701P | 2001-01-17 | 2001-01-17 | |
US60/262,337 | 2001-01-17 | ||
US25787201P | 2001-05-01 | 2001-05-01 | |
US28788601P | 2001-05-01 | 2001-05-01 | |
US60/257,872 | 2001-05-01 | ||
US60/287,886 | 2001-05-01 | ||
US33263601P | 2001-11-06 | 2001-11-06 | |
US60/332,636 | 2001-11-06 | ||
PCT/IB2002/000133 WO2002056916A2 (en) | 2001-01-17 | 2002-01-17 | Compositions and methods for enhanced pharmacological activity through oral and parenteral administration of compositions comprising polypeptide drug substances and other poorly absorbed active ingredients |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010102537253A Division CN101979093B (zh) | 2001-01-17 | 2002-01-17 | 含有肽原料药和其它不易吸收的活性成分的组合物及其应用 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1545422A true CN1545422A (zh) | 2004-11-10 |
CN1545422B CN1545422B (zh) | 2010-09-22 |
Family
ID=27500604
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010102537253A Expired - Fee Related CN101979093B (zh) | 2001-01-17 | 2002-01-17 | 含有肽原料药和其它不易吸收的活性成分的组合物及其应用 |
CN028038320A Expired - Fee Related CN1545422B (zh) | 2001-01-17 | 2002-01-17 | 通过口服和胃肠道外给予含有肽原料药和其它不易吸收的活性成分的组合物来增强药物活性的组合物和方法 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2010102537253A Expired - Fee Related CN101979093B (zh) | 2001-01-17 | 2002-01-17 | 含有肽原料药和其它不易吸收的活性成分的组合物及其应用 |
Country Status (4)
Country | Link |
---|---|
JP (2) | JP5057628B2 (zh) |
CN (2) | CN101979093B (zh) |
AU (1) | AU2002228260B2 (zh) |
CA (1) | CA2434831C (zh) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL2427475T3 (pl) * | 2009-05-08 | 2021-07-19 | Techfields Biochem Co., Ltd. | Kompozycje proleku o wysokim przenikaniu peptydów i związków powiązanych z peptydami |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4396606A (en) * | 1979-11-05 | 1983-08-02 | Addiction Research Foundation | Novel polypeptide analgesics |
CA1340588C (en) * | 1988-06-13 | 1999-06-08 | Balraj Krishan Handa | Amino acid derivatives |
JP2001500852A (ja) * | 1996-08-27 | 2001-01-23 | プレーシス ファーマスーティカルズ インコーポレイテッド | D―アミノ酸を含むβ―アミロイドペプチド凝集のモジュレーター |
US6174993B1 (en) * | 1997-05-21 | 2001-01-16 | The Children's Medical Center Corp. | Short peptides which selectively modulate the activity of serine/threonine kinases |
-
2002
- 2002-01-17 JP JP2002557423A patent/JP5057628B2/ja not_active Expired - Fee Related
- 2002-01-17 CA CA2434831A patent/CA2434831C/en not_active Expired - Lifetime
- 2002-01-17 CN CN2010102537253A patent/CN101979093B/zh not_active Expired - Fee Related
- 2002-01-17 AU AU2002228260A patent/AU2002228260B2/en not_active Ceased
- 2002-01-17 CN CN028038320A patent/CN1545422B/zh not_active Expired - Fee Related
-
2009
- 2009-06-08 JP JP2009137059A patent/JP2009235082A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CA2434831A1 (en) | 2002-07-25 |
JP5057628B2 (ja) | 2012-10-24 |
AU2002228260B2 (en) | 2007-02-08 |
CN101979093A (zh) | 2011-02-23 |
JP2005505492A (ja) | 2005-02-24 |
CN101979093B (zh) | 2013-04-24 |
JP2009235082A (ja) | 2009-10-15 |
CA2434831C (en) | 2012-03-06 |
CN1545422B (zh) | 2010-09-22 |
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Owner name: EUREKA CORPORATION S. A. R. L. Free format text: FORMER OWNER: ROBERT H. ZIMMER Effective date: 20150304 |
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