CA2434641A1 - Preparations de microemulsion chimiotherapeutique de paclitaxel presentant une meilleure biodisponibilite orale - Google Patents
Preparations de microemulsion chimiotherapeutique de paclitaxel presentant une meilleure biodisponibilite orale Download PDFInfo
- Publication number
- CA2434641A1 CA2434641A1 CA002434641A CA2434641A CA2434641A1 CA 2434641 A1 CA2434641 A1 CA 2434641A1 CA 002434641 A CA002434641 A CA 002434641A CA 2434641 A CA2434641 A CA 2434641A CA 2434641 A1 CA2434641 A1 CA 2434641A1
- Authority
- CA
- Canada
- Prior art keywords
- composition
- paclitaxel
- cellulosic polymer
- group
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nanotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biophysics (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
L'invention concerne des préparations pharmaceutiques adaptées pour l'administration orale contenant du paclitaxel, un solvant, un surfactant, un polymère cellulosique substitué et éventuellement mais de préférence un inhibiteur P-glycoprotéine. Cette préparation peut également contenir un diglycéride ou un mélange de diglycéride et de monoglycéride. La préparation produit une microémulsion de paclitaxel sursaturée lors du contact avec l'eau, ce qui procure une meilleure biodisponibilité de paclitaxel.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US26255501P | 2001-01-18 | 2001-01-18 | |
US60/262,555 | 2001-01-18 | ||
PCT/US2002/000497 WO2002064132A2 (fr) | 2001-01-18 | 2002-01-14 | Preparations de microemulsion chimiotherapeutique de paclitaxel presentant une meilleure biodisponibilite orale |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2434641A1 true CA2434641A1 (fr) | 2002-08-22 |
Family
ID=22998000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002434641A Abandoned CA2434641A1 (fr) | 2001-01-18 | 2002-01-14 | Preparations de microemulsion chimiotherapeutique de paclitaxel presentant une meilleure biodisponibilite orale |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1365759A2 (fr) |
JP (1) | JP2004520398A (fr) |
AR (1) | AR032642A1 (fr) |
CA (1) | CA2434641A1 (fr) |
MX (1) | MXPA03006404A (fr) |
NZ (1) | NZ539046A (fr) |
PE (1) | PE20020833A1 (fr) |
WO (1) | WO2002064132A2 (fr) |
ZA (1) | ZA200305086B (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6750246B1 (en) | 2000-02-03 | 2004-06-15 | Bristol-Myers Squibb Company | C-4 carbonate taxanes |
FR2838349B1 (fr) * | 2002-04-15 | 2004-06-25 | Laurence Paris | Compositions liquides pour capsules molle a liberation prolongee et leur procede de fabrication |
KR100533458B1 (ko) | 2002-07-20 | 2005-12-07 | 대화제약 주식회사 | 파클리탁셀의 가용화용 조성물 및 그의 제조 방법 |
EP1498120A1 (fr) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Formulation semi-solide pour l'administration orale du taxol |
EP1498143A1 (fr) * | 2003-07-18 | 2005-01-19 | Aventis Pharma S.A. | Formulations auto-émulsifiantes et auto-microémulsifiantes pour l'administration orale de taxoides |
US20050123602A1 (en) * | 2003-09-25 | 2005-06-09 | Michaelis Arthur F. | Rifalazil formulations |
EP1904052A4 (fr) * | 2005-06-17 | 2008-12-10 | Hospira Australia Pty Ltd | Compositions pharmaceutiques liquides de docétaxel |
US20100168410A1 (en) * | 2006-10-27 | 2010-07-01 | Pfizer Products Inc. | Hydroxypropyl Methyl Cellulose Hard Capsules and Process of Manufacture |
US20090088393A1 (en) * | 2007-09-28 | 2009-04-02 | Zomanex, Llc | Methods and formulations for converting intravenous and injectable drugs into oral dosage forms |
KR101053780B1 (ko) * | 2008-02-29 | 2011-08-02 | 동아제약주식회사 | 도세탁셀을 함유하는 단일액상의 안정한 약제학적 조성물 |
US9345683B2 (en) * | 2010-11-08 | 2016-05-24 | Cadila Pharmaceuticals Limited | Pharmaceutical composition of taxoids |
CN103110581B (zh) * | 2013-02-26 | 2015-07-22 | 西南大学 | 一种紫杉醇微乳药物组合物及其制备方法 |
KR101542364B1 (ko) * | 2014-10-31 | 2015-08-07 | 대화제약 주식회사 | 탁산을 포함하는 경구 투여용 약학 조성물 |
CN108136030B (zh) * | 2015-07-30 | 2021-01-26 | 大化制药株式会社 | 含有高浓度紫杉烷的用于口服给药的药物组合物 |
CN107028931A (zh) * | 2016-02-04 | 2017-08-11 | 上海宣泰医药科技有限公司 | 一种紫杉醇药物组合物及其药物制剂、制备方法和用途 |
EP3701943A1 (fr) * | 2019-02-26 | 2020-09-02 | CAPNOMED GmbH | Administration retardée de médicaments anticancer |
WO2023220109A1 (fr) * | 2022-05-11 | 2023-11-16 | Eli Lilly And Company | Compositions pharmaceutiques à base de glp1 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6964946B1 (en) * | 1995-10-26 | 2005-11-15 | Baker Norton Pharmaceuticals, Inc. | Oral pharmaceutical compositions containing taxanes and methods of treatment employing the same |
WO1998013359A1 (fr) * | 1996-09-24 | 1998-04-02 | Marigen S.A. | Ultramicroemulsions constituees de concentres pouvant etre disperses de façon spontanne, renfermant des esters de composes de baccatine-iii a effet antitumoral et antiviral |
CH688504A5 (de) * | 1997-03-26 | 1997-10-31 | Marigen Sa | Ultramikroemulsionen aus spontan dispergierbaren Konzentraten mit antitumoral wirksamem Taxol und mit Taxol-analogen Verbindungen. |
JP2002500667A (ja) * | 1997-05-27 | 2002-01-08 | ベーカー ノートン ファーマシューティカルズ インコーポレイテッド | 人間の患者に対して経口的にタキサン類を投薬するための方法及び組成物 |
AU3574097A (en) * | 1997-06-20 | 1999-01-04 | Baker Norton Pharmaceuticals, Inc. | Soluble prodrugs of paclitaxel |
IL131217A0 (en) * | 1998-03-10 | 2001-01-28 | Napro Biotherapeutics Inc | Novel methods and compositions for delivery of taxanes |
IL143580A0 (en) * | 1998-12-11 | 2002-04-21 | Pharmasolutions Inc | Pharmaceutical compositions containing lipophilic drugs and methods for the preparation thereof |
CA2371836C (fr) * | 1999-05-27 | 2006-01-31 | Acusphere, Inc. | Matrices medicamenteuses poreuses et procedes de fabrication associes |
US6136846A (en) * | 1999-10-25 | 2000-10-24 | Supergen, Inc. | Formulation for paclitaxel |
WO2002043765A2 (fr) * | 2000-11-28 | 2002-06-06 | Transform Pharmaceuticals, Inc. | Formulations pharmaceutiques contenant du paclitaxel, ses derives et ses sels pharmaceutiquement acceptables |
-
2002
- 2002-01-14 EP EP02718808A patent/EP1365759A2/fr not_active Withdrawn
- 2002-01-14 CA CA002434641A patent/CA2434641A1/fr not_active Abandoned
- 2002-01-14 NZ NZ539046A patent/NZ539046A/en unknown
- 2002-01-14 WO PCT/US2002/000497 patent/WO2002064132A2/fr not_active Application Discontinuation
- 2002-01-14 JP JP2002563926A patent/JP2004520398A/ja active Pending
- 2002-01-14 MX MXPA03006404A patent/MXPA03006404A/es unknown
- 2002-01-17 PE PE2002000030A patent/PE20020833A1/es not_active Application Discontinuation
- 2002-01-17 AR ARP020100158A patent/AR032642A1/es unknown
-
2003
- 2003-06-30 ZA ZA200305086A patent/ZA200305086B/en unknown
Also Published As
Publication number | Publication date |
---|---|
PE20020833A1 (es) | 2002-09-19 |
MXPA03006404A (es) | 2004-12-02 |
ZA200305086B (en) | 2004-06-30 |
NZ539046A (en) | 2006-11-30 |
EP1365759A2 (fr) | 2003-12-03 |
AR032642A1 (es) | 2003-11-19 |
WO2002064132A2 (fr) | 2002-08-22 |
WO2002064132A3 (fr) | 2003-05-30 |
JP2004520398A (ja) | 2004-07-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FZDE | Discontinued | ||
FZDE | Discontinued |
Effective date: 20080114 |