CA2433225A1 - Molecules isolees renfermant des epitopes a fractions sulfatees, anticorps vis-a-vis de ces epitopes, et utilisations correspondantes - Google Patents
Molecules isolees renfermant des epitopes a fractions sulfatees, anticorps vis-a-vis de ces epitopes, et utilisations correspondantes Download PDFInfo
- Publication number
- CA2433225A1 CA2433225A1 CA002433225A CA2433225A CA2433225A1 CA 2433225 A1 CA2433225 A1 CA 2433225A1 CA 002433225 A CA002433225 A CA 002433225A CA 2433225 A CA2433225 A CA 2433225A CA 2433225 A1 CA2433225 A1 CA 2433225A1
- Authority
- CA
- Canada
- Prior art keywords
- antibody
- binding fragment
- antigen
- complex
- binding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Heart & Thoracic Surgery (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
L'invention concerne des épitopes propres aux cellules cancéreuses, qui jouent un rôle important dans certains phénomènes physiologiques comme le roulement cellulaire, la métastase et l'inflammation. L'invention concerne également des procédés et des compositions thérapeutiques et diagnostiques faisant intervenir des anticorps capables de se lier avec les épitopes. Les procédés et les compositions en question peuvent s'appliquer au diagnostic et à la thérapie pour une série de maladies, à savoir par exemple: cancer, y compris la croissance tumorale et la métastase, leucémie, maladie auto-immune, et maladie inflammatoire.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25894800P | 2000-12-29 | 2000-12-29 | |
US75118100A | 2000-12-29 | 2000-12-29 | |
US60/258,948 | 2000-12-29 | ||
US09/751,181 | 2000-12-29 | ||
PCT/US2001/049442 WO2002053700A2 (fr) | 2000-12-29 | 2001-12-31 | Molecules isolees renfermant des epitopes a fractions sulfatees, anticorps vis-a-vis de ces epitopes, et utilisations correspondantes |
Publications (1)
Publication Number | Publication Date |
---|---|
CA2433225A1 true CA2433225A1 (fr) | 2002-07-11 |
Family
ID=26946974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002433225A Abandoned CA2433225A1 (fr) | 2000-12-29 | 2001-12-31 | Molecules isolees renfermant des epitopes a fractions sulfatees, anticorps vis-a-vis de ces epitopes, et utilisations correspondantes |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1406930A4 (fr) |
JP (1) | JP2005503756A (fr) |
KR (1) | KR20030091953A (fr) |
CN (1) | CN100347194C (fr) |
BR (1) | BR0116764A (fr) |
CA (1) | CA2433225A1 (fr) |
CZ (1) | CZ20031982A3 (fr) |
HU (1) | HUP0700079A2 (fr) |
IL (1) | IL156689A0 (fr) |
MX (1) | MXPA03005945A (fr) |
PL (1) | PL366223A1 (fr) |
RU (1) | RU2003123101A (fr) |
WO (1) | WO2002053700A2 (fr) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7744888B2 (en) | 2001-08-03 | 2010-06-29 | Abgenomics Cooperatief U.A. | Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies |
US20040116333A1 (en) | 2001-08-03 | 2004-06-17 | Rong-Hwa Lin | Modulators of P-selectin glycoprotein ligand 1 |
CN1678348A (zh) * | 2002-07-01 | 2005-10-05 | 萨文特医药公司 | 用于治疗性治疗的组合物和方法 |
RU2006102571A (ru) * | 2003-06-30 | 2007-08-20 | Био-Текнолоджи Дженерал(Израиль) Лтд. (IL) | Специфические антитела человека |
CA2536644A1 (fr) * | 2003-06-30 | 2005-02-03 | Bio-Technology General (Israel) Ltd. | Anticorps et utilisations de ceux-ci |
ITMI20031714A1 (it) * | 2003-09-05 | 2005-03-06 | Gentium Spa | Formazioni ad azione antitumorale. |
MY148646A (en) | 2004-05-10 | 2013-05-15 | Abgenomics Cooperatief Ua | Anti-psgl-1 antibodies |
AR048840A1 (es) * | 2004-05-11 | 2006-05-31 | Boehringer Ingelheim Int | Epitopes inductores de la muerte de las celulas t |
ES2694239T3 (es) | 2010-11-12 | 2018-12-19 | Gentium S.R.L. | Defibrótido para su uso en profilaxis y/o tratamiento de la enfermedad de Injerto contra huésped (GVHD) |
CA2838952C (fr) | 2011-06-13 | 2020-11-24 | Stefan Bassarab | Anticorps anti-psgl-1 et leurs utilisations |
CA2874960C (fr) | 2012-06-22 | 2021-05-18 | Gentium S.P.A. | Procede a base d'euglobuline pour la determination de l'activite biologique de defibrotide |
WO2016013828A1 (fr) * | 2014-07-21 | 2016-01-28 | 연세대학교 산학협력단 | Mutant de domaine extracellulaire 1 de récepteur de chimiokines duffy sulfaté et utilisation associée |
EP3026122A1 (fr) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Procédé à base cellulaire pour déterminer la puissance de défibrotide |
JP2019031486A (ja) * | 2017-08-04 | 2019-02-28 | 公立大学法人福島県立医科大学 | 新規ポリペプチド及びその用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3326693A (en) * | 1991-12-12 | 1993-07-19 | Scripps Research Institute, The | Bifunctional antithrombotic molecules and antithrombotic polypeptides |
EP0833650A4 (fr) * | 1995-06-14 | 2005-01-19 | Gen Hospital Corp | Ligands de p-selectine et procedes et molecules associes--- |
JPH11510543A (ja) * | 1995-08-03 | 1999-09-14 | ボード オブ リージェンツ オブ ザ ユニヴァーシティー オブ オクラホマ | ペプチド及びセレクチン介在炎症のo−グリカン阻害剤 |
US5985833A (en) * | 1996-09-17 | 1999-11-16 | Wisconsin Alumni Research Foundation | Thrombin inhibitor |
WO1999065712A2 (fr) * | 1998-06-16 | 1999-12-23 | The Board Of Regents Of The University Of Oklahoma | Glycosulfopeptide, technique de synthese et utilisation |
-
2001
- 2001-12-31 CZ CZ20031982A patent/CZ20031982A3/cs unknown
- 2001-12-31 KR KR10-2003-7008890A patent/KR20030091953A/ko not_active Application Discontinuation
- 2001-12-31 BR BRPI0116764-2A patent/BR0116764A/pt not_active IP Right Cessation
- 2001-12-31 JP JP2002555211A patent/JP2005503756A/ja active Pending
- 2001-12-31 HU HU0700079A patent/HUP0700079A2/hu unknown
- 2001-12-31 CN CNB018228844A patent/CN100347194C/zh not_active Expired - Fee Related
- 2001-12-31 MX MXPA03005945A patent/MXPA03005945A/es not_active Application Discontinuation
- 2001-12-31 EP EP01994330A patent/EP1406930A4/fr not_active Withdrawn
- 2001-12-31 PL PL01366223A patent/PL366223A1/xx unknown
- 2001-12-31 RU RU2003123101/13A patent/RU2003123101A/ru not_active Application Discontinuation
- 2001-12-31 WO PCT/US2001/049442 patent/WO2002053700A2/fr active Application Filing
- 2001-12-31 CA CA002433225A patent/CA2433225A1/fr not_active Abandoned
- 2001-12-31 IL IL15668901A patent/IL156689A0/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CN1649900A (zh) | 2005-08-03 |
CN100347194C (zh) | 2007-11-07 |
EP1406930A4 (fr) | 2007-01-10 |
EP1406930A2 (fr) | 2004-04-14 |
WO2002053700A2 (fr) | 2002-07-11 |
IL156689A0 (en) | 2004-01-04 |
WO2002053700A3 (fr) | 2004-02-12 |
JP2005503756A (ja) | 2005-02-10 |
RU2003123101A (ru) | 2005-03-10 |
PL366223A1 (en) | 2005-01-24 |
KR20030091953A (ko) | 2003-12-03 |
BR0116764A (pt) | 2007-01-09 |
CZ20031982A3 (cs) | 2004-09-15 |
MXPA03005945A (es) | 2004-10-15 |
HUP0700079A2 (en) | 2007-05-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
FZDE | Discontinued |