BR0116764A - moléculas isoladas compreendendo epitopos contendo porções sulfatadas, anticorpos para os referidos epitopos e seus usos - Google Patents
moléculas isoladas compreendendo epitopos contendo porções sulfatadas, anticorpos para os referidos epitopos e seus usosInfo
- Publication number
- BR0116764A BR0116764A BRPI0116764-2A BR0116764A BR0116764A BR 0116764 A BR0116764 A BR 0116764A BR 0116764 A BR0116764 A BR 0116764A BR 0116764 A BR0116764 A BR 0116764A
- Authority
- BR
- Brazil
- Prior art keywords
- epitopes
- antibodies
- isolated molecules
- present
- containing sulfated
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3061—Blood cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Diabetes (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"MOLéCULAS ISOLADAS COMPREENDENDO EPITOPOS CONTENDO PORçõES SULFATADAS, ANTICORPOS PARA OS REFERIDOS EPITOPOS E SEUS USOS". A presente invenção fornece epitopos presentes em células cancerígenas e é importante no fenómeno fisiológico como o rolamento de células, metástase e inflamação. São fornecidos métodos e compostos terapêuticos e de diagnóstico que usam anticorpos capazes de se ligarem aos epitopos. Os métodos e compostos de acordo com a presente invenção podem ser usados no diagnóstico e na terapia para as referidas doenças como câncer, incluindo crescimento de tumor e metástase, leucemia, doença autoimune e doença inflamatória.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75118100A | 2000-12-29 | 2000-12-29 | |
US25894800P | 2000-12-29 | 2000-12-29 | |
PCT/US2001/049442 WO2002053700A2 (en) | 2000-12-29 | 2001-12-31 | Isolated molecules comprising epitopes containing sulfated moieties, antibodies to such epitopes, and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0116764A true BR0116764A (pt) | 2007-01-09 |
Family
ID=26946974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0116764-2A BR0116764A (pt) | 2000-12-29 | 2001-12-31 | moléculas isoladas compreendendo epitopos contendo porções sulfatadas, anticorpos para os referidos epitopos e seus usos |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1406930A4 (pt) |
JP (1) | JP2005503756A (pt) |
KR (1) | KR20030091953A (pt) |
CN (1) | CN100347194C (pt) |
BR (1) | BR0116764A (pt) |
CA (1) | CA2433225A1 (pt) |
CZ (1) | CZ20031982A3 (pt) |
HU (1) | HUP0700079A2 (pt) |
IL (1) | IL156689A0 (pt) |
MX (1) | MXPA03005945A (pt) |
PL (1) | PL366223A1 (pt) |
RU (1) | RU2003123101A (pt) |
WO (1) | WO2002053700A2 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040116333A1 (en) | 2001-08-03 | 2004-06-17 | Rong-Hwa Lin | Modulators of P-selectin glycoprotein ligand 1 |
US7744888B2 (en) | 2001-08-03 | 2010-06-29 | Abgenomics Cooperatief U.A. | Methods of modulating T cell or natural killer cell activity with anti-P-selectin glycoprotein ligand 1 antibodies |
EP1551452A4 (en) * | 2002-07-01 | 2006-08-30 | Savient Pharmaceuticals Inc | COMPOSITIONS AND METHODS FOR THERAPEUTIC TREATMENT |
MXPA06000252A (es) * | 2003-06-30 | 2006-12-15 | Bio Technology General Israel | Anticuerpos y usos de los mismos. |
WO2005005455A2 (en) * | 2003-06-30 | 2005-01-20 | Bio-Technology General (Israel)Ltd. | Specific human antibodies |
ITMI20031714A1 (it) * | 2003-09-05 | 2005-03-06 | Gentium Spa | Formazioni ad azione antitumorale. |
MY148646A (en) * | 2004-05-10 | 2013-05-15 | Abgenomics Cooperatief Ua | Anti-psgl-1 antibodies |
US20060003940A1 (en) * | 2004-05-11 | 2006-01-05 | Rong-Hwa Lin | T-cell death-inducing epitopes |
EP2637672B1 (en) | 2010-11-12 | 2018-08-22 | Gentium S.r.l. | Defibrotide for use in prophylaxis and/or treatment of graft versus host disease (gvhd). |
UA114712C2 (uk) | 2011-06-13 | 2017-07-25 | Абдженомікс Коеператіеф У.А. | Моноклональне антитіло, яке імуноспецифічно зв'язується з людським psgl-1, та його застосування |
CN104619857A (zh) | 2012-06-22 | 2015-05-13 | 真蒂奥姆有限公司 | 用于测定去纤维蛋白多核苷酸的生物活性的基于优球蛋白的方法 |
WO2016013828A1 (ko) * | 2014-07-21 | 2016-01-28 | 연세대학교 산학협력단 | 황산화된 더피 케모카인 수용체의 세포 외 도메인 1 변이체 및 이의 용도 |
EP3026122A1 (en) | 2014-11-27 | 2016-06-01 | Gentium S.p.A. | Cellular-based method for determining the potency of defibrotide |
JP2019031486A (ja) * | 2017-08-04 | 2019-02-28 | 公立大学法人福島県立医科大学 | 新規ポリペプチド及びその用途 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU3326693A (en) * | 1991-12-12 | 1993-07-19 | Scripps Research Institute, The | Bifunctional antithrombotic molecules and antithrombotic polypeptides |
KR19990022954A (ko) * | 1995-06-14 | 1999-03-25 | 어니스트 엠. 해데드 | P-셀렉틴 리간드 및 관련 분자 및 방법 |
EP0850243B1 (en) * | 1995-08-03 | 2003-10-08 | Board Of Regents Of The University Of Oklahoma | o-glycan inhibitors of selectin mediated inflammation |
US5985833A (en) * | 1996-09-17 | 1999-11-16 | Wisconsin Alumni Research Foundation | Thrombin inhibitor |
AU773542B2 (en) * | 1998-06-16 | 2004-05-27 | Board Of Regents Of The University Of Oklahoma, The | Glycosulfopeptides and methods of synthesis and use thereof |
-
2001
- 2001-12-31 KR KR10-2003-7008890A patent/KR20030091953A/ko not_active Application Discontinuation
- 2001-12-31 PL PL01366223A patent/PL366223A1/xx unknown
- 2001-12-31 RU RU2003123101/13A patent/RU2003123101A/ru not_active Application Discontinuation
- 2001-12-31 EP EP01994330A patent/EP1406930A4/en not_active Withdrawn
- 2001-12-31 HU HU0700079A patent/HUP0700079A2/hu unknown
- 2001-12-31 CA CA002433225A patent/CA2433225A1/en not_active Abandoned
- 2001-12-31 BR BRPI0116764-2A patent/BR0116764A/pt not_active IP Right Cessation
- 2001-12-31 IL IL15668901A patent/IL156689A0/xx unknown
- 2001-12-31 CN CNB018228844A patent/CN100347194C/zh not_active Expired - Fee Related
- 2001-12-31 MX MXPA03005945A patent/MXPA03005945A/es not_active Application Discontinuation
- 2001-12-31 JP JP2002555211A patent/JP2005503756A/ja active Pending
- 2001-12-31 WO PCT/US2001/049442 patent/WO2002053700A2/en active Application Filing
- 2001-12-31 CZ CZ20031982A patent/CZ20031982A3/cs unknown
Also Published As
Publication number | Publication date |
---|---|
PL366223A1 (en) | 2005-01-24 |
CA2433225A1 (en) | 2002-07-11 |
CN100347194C (zh) | 2007-11-07 |
JP2005503756A (ja) | 2005-02-10 |
IL156689A0 (en) | 2004-01-04 |
WO2002053700A3 (en) | 2004-02-12 |
HUP0700079A2 (en) | 2007-05-02 |
CN1649900A (zh) | 2005-08-03 |
EP1406930A2 (en) | 2004-04-14 |
KR20030091953A (ko) | 2003-12-03 |
RU2003123101A (ru) | 2005-03-10 |
WO2002053700A2 (en) | 2002-07-11 |
CZ20031982A3 (cs) | 2004-09-15 |
MXPA03005945A (es) | 2004-10-15 |
EP1406930A4 (en) | 2007-01-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 4A ANUIDADE. |
|
B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1962 DE 12/08/2008 POR TER SIDO APRESENTADO PROTOCOLO DE ESCLARECIMENTO NO 420805107402 EM 18/08/2008. |
|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 8A E 9A ANUIDADES. |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE 8.6 DA RPI 2112 DE 28/06/2011. |