CA2430376A1

CA2430376A1 - Semicarbazides and their uses as cyclin dependent kinase inhibitors

Semicarbazides and their uses as cyclin dependent kinase inhibitors Download PDF

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Publication number: CA2430376A1
Authority: CA; Canada
Prior art keywords: compound according; substituted; phenyl; indeno; methyl
Prior art date: 2000-12-08
Legal status : Abandoned

Application number

CA002430376A

Other languages

English (en)

French (fr)

Inventor

David J. Carini

Current Assignee

Bristol Myers Squibb Pharma Co

Original Assignee

Individual

Priority date

2000-12-08

Filing date

2001-12-07

Publication date

2002-06-13

2001-12-07 Application filed by Individual filed Critical Individual

2002-06-13 Publication of CA2430376A1 publication Critical patent/CA2430376A1/en

Status Abandoned legal-status Critical Current

Links

229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 title description 13
239000002875 cyclin dependent kinase inhibitor Substances 0.000 title description 7
150000003349 semicarbazides Chemical class 0.000 title description 5
150000001875 compounds Chemical class 0.000 claims abstract description 194
150000003839 salts Chemical group 0.000 claims abstract description 96
238000000034 method Methods 0.000 claims abstract description 88
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201000011510 cancer Diseases 0.000 claims abstract description 25
239000003795 chemical substances by application Substances 0.000 claims abstract description 21
GHFDYLOGYDGRHI-UHFFFAOYSA-N 1h-indeno[1,2-c]pyrazol-4-one Chemical class C12=CC=CC=C2C(=O)C2=C1NN=C2 GHFDYLOGYDGRHI-UHFFFAOYSA-N 0.000 claims abstract description 18
230000002062 proliferating effect Effects 0.000 claims abstract description 15
239000003112 inhibitor Substances 0.000 claims abstract description 14
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-1 C4-10cycloalkylalkyl Chemical group 0.000 claims description 107
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239000000203 mixture Substances 0.000 claims description 56
230000002401 inhibitory effect Effects 0.000 claims description 55
229940002612 prodrug Drugs 0.000 claims description 47
239000000651 prodrug Substances 0.000 claims description 47
230000000694 effects Effects 0.000 claims description 46
229910052757 nitrogen Inorganic materials 0.000 claims description 46
229910052717 sulfur Inorganic materials 0.000 claims description 34
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 33
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125000003118 aryl group Chemical group 0.000 claims description 12
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