CA2424656A1 - Composition et procede pour liquides injectables stables - Google Patents
Composition et procede pour liquides injectables stables Download PDFInfo
- Publication number
- CA2424656A1 CA2424656A1 CA002424656A CA2424656A CA2424656A1 CA 2424656 A1 CA2424656 A1 CA 2424656A1 CA 002424656 A CA002424656 A CA 002424656A CA 2424656 A CA2424656 A CA 2424656A CA 2424656 A1 CA2424656 A1 CA 2424656A1
- Authority
- CA
- Canada
- Prior art keywords
- composition according
- component
- glass
- microparticles
- sugar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
L'invention concerne une composition destinée à administrer un composé stable et bioactif à un sujet et comportant un premier et un second composant, le premier composant contenant des microparticules d'un verre de glucide ou un verre de phosphate contenant l'agent bioactif. Le verre de glucide ou de phosphate peut comporter un composé facilitant la formation du verre, et le second composant comporte au moins un perfluorocarbone liquide biocompatible, dans lequel le premier composant est insoluble et dispersé. Le perfluocarbone peut comporter un tensio-actif.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2689856A CA2689856C (fr) | 2000-10-13 | 2000-10-13 | Composition et procede pour liquides injectables stables |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2000/028244 WO2002032402A1 (fr) | 2000-10-13 | 2000-10-13 | Composition et procede pour liquides injectables stables |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2689856A Division CA2689856C (fr) | 2000-10-13 | 2000-10-13 | Composition et procede pour liquides injectables stables |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2424656A1 true CA2424656A1 (fr) | 2002-04-25 |
CA2424656C CA2424656C (fr) | 2010-03-23 |
Family
ID=21741883
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2689856A Expired - Lifetime CA2689856C (fr) | 2000-10-13 | 2000-10-13 | Composition et procede pour liquides injectables stables |
CA2424656A Expired - Lifetime CA2424656C (fr) | 2000-10-13 | 2000-10-13 | Composition et procede pour liquides injectables stables |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2689856A Expired - Lifetime CA2689856C (fr) | 2000-10-13 | 2000-10-13 | Composition et procede pour liquides injectables stables |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1328255A1 (fr) |
JP (1) | JP2004513093A (fr) |
KR (1) | KR20030096224A (fr) |
CN (1) | CN100339066C (fr) |
AU (2) | AU2001211986B2 (fr) |
CA (2) | CA2689856C (fr) |
ES (1) | ES2337252T3 (fr) |
MX (1) | MXPA03003236A (fr) |
NO (1) | NO20031706L (fr) |
PL (1) | PL360052A1 (fr) |
PT (1) | PT1452171E (fr) |
WO (1) | WO2002032402A1 (fr) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1559433A4 (fr) * | 2002-10-22 | 2009-11-04 | Dainippon Sumitomo Pharma Co | Composition stabilisee |
JP2007001865A (ja) * | 2003-09-16 | 2007-01-11 | Ltt Bio-Pharma Co Ltd | 脂溶性薬物封入微粒子、その製造法およびそれを含有する製剤 |
GB0408199D0 (en) * | 2004-04-13 | 2004-05-19 | Cambridge Biostability Ltd | Liquids containing suspended sugar glass particles |
WO2005099669A1 (fr) | 2004-04-13 | 2005-10-27 | Cambridge Biostability Limited | Liquides contenant des particules de verre en suspension |
GB2430880A (en) * | 2005-10-04 | 2007-04-11 | Cambridge Biostability Ltd | Pharmaceutical compositions stabilized in glassy particles |
GB0523638D0 (en) * | 2005-11-21 | 2005-12-28 | Cambridge Biostability Ltd | Pharmaceutical device for the administration of substances to patients |
US8946200B2 (en) | 2006-11-02 | 2015-02-03 | Southwest Research Institute | Pharmaceutically active nanosuspensions |
JP5301468B2 (ja) * | 2008-01-18 | 2013-09-25 | 旭化成ファーマ株式会社 | 安定な医薬組成物 |
US8404850B2 (en) | 2008-03-13 | 2013-03-26 | Southwest Research Institute | Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors |
US8722706B2 (en) | 2008-08-15 | 2014-05-13 | Southwest Research Institute | Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts |
US8309134B2 (en) | 2008-10-03 | 2012-11-13 | Southwest Research Institute | Modified calcium phosphate nanoparticle formation |
WO2010146536A1 (fr) | 2009-06-18 | 2010-12-23 | Koninklijke Philips Electronics N.V. | Suspension de particules comprenant un médicament |
WO2011007327A2 (fr) | 2009-07-16 | 2011-01-20 | Koninklijke Philips Electronics N.V. | Suspension pour usage thérapeutique et dispositif d'administration de ladite suspension |
ES2362525B8 (es) | 2009-10-08 | 2013-01-03 | Azurebio, S.L. | Formulación de medicamentos en forma de agujas percutaneas penetrantes. |
US9028873B2 (en) | 2010-02-08 | 2015-05-12 | Southwest Research Institute | Nanoparticles for drug delivery to the central nervous system |
CN106132717B (zh) | 2014-03-24 | 2018-09-14 | 精工爱普生株式会社 | 带打印装置和带打印系统 |
CN106102724A (zh) * | 2014-03-27 | 2016-11-09 | 诺华股份有限公司 | 用于吸入活性药物成分的经喷雾干燥的水包油包固体分散系 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR78151B (fr) * | 1982-04-05 | 1984-09-26 | Alcon Lab Inc | |
US5518731A (en) * | 1990-09-27 | 1996-05-21 | Allergan, Inc. | Nonaqueous fluorinated drug delivery vehicle suspensions |
AU3924193A (en) * | 1992-03-19 | 1993-10-21 | Allergan, Inc. | Compositions comprising a drug delivery vehicle suspended in a nonaqueous fluorinated liquid |
GB9705588D0 (en) * | 1997-03-18 | 1997-05-07 | Anglia Research Foundation | Stable particle in liquid formulations |
US6190701B1 (en) * | 1999-03-17 | 2001-02-20 | Peter M. Ronai | Composition and method for stable injectable liquids |
-
2000
- 2000-10-13 MX MXPA03003236A patent/MXPA03003236A/es active IP Right Grant
- 2000-10-13 EP EP00973483A patent/EP1328255A1/fr not_active Withdrawn
- 2000-10-13 ES ES04013422T patent/ES2337252T3/es not_active Expired - Lifetime
- 2000-10-13 PT PT04013422T patent/PT1452171E/pt unknown
- 2000-10-13 WO PCT/US2000/028244 patent/WO2002032402A1/fr active IP Right Grant
- 2000-10-13 CN CNB008199655A patent/CN100339066C/zh not_active Expired - Fee Related
- 2000-10-13 AU AU2001211986A patent/AU2001211986B2/en not_active Ceased
- 2000-10-13 PL PL00360052A patent/PL360052A1/xx unknown
- 2000-10-13 CA CA2689856A patent/CA2689856C/fr not_active Expired - Lifetime
- 2000-10-13 KR KR10-2003-7004941A patent/KR20030096224A/ko active Search and Examination
- 2000-10-13 JP JP2002535640A patent/JP2004513093A/ja not_active Withdrawn
- 2000-10-13 AU AU1198601A patent/AU1198601A/xx active Pending
- 2000-10-13 CA CA2424656A patent/CA2424656C/fr not_active Expired - Lifetime
-
2003
- 2003-04-11 NO NO20031706A patent/NO20031706L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN100339066C (zh) | 2007-09-26 |
MXPA03003236A (es) | 2004-12-03 |
PT1452171E (pt) | 2010-03-08 |
NO20031706D0 (no) | 2003-04-11 |
AU1198601A (en) | 2002-04-29 |
CN1527699A (zh) | 2004-09-08 |
AU2001211986B2 (en) | 2007-04-26 |
KR20030096224A (ko) | 2003-12-24 |
JP2004513093A (ja) | 2004-04-30 |
CA2689856C (fr) | 2013-09-24 |
CA2689856A1 (fr) | 2002-04-25 |
PL360052A1 (en) | 2004-09-06 |
NO20031706L (no) | 2003-04-11 |
CA2424656C (fr) | 2010-03-23 |
WO2002032402A1 (fr) | 2002-04-25 |
EP1328255A1 (fr) | 2003-07-23 |
ES2337252T3 (es) | 2010-04-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CA2424656A1 (fr) | Composition et procede pour liquides injectables stables | |
US6190701B1 (en) | Composition and method for stable injectable liquids | |
EP0909562B1 (fr) | Produits pour injection contenant des analogues de lipides a et procede de preparation correspondant | |
WO2006067608A1 (fr) | Formulations aqueuses a base de hyaluronate de sodium a usage parenteral | |
CA1117417A (fr) | Immunoglobuline serique stabilisee | |
CA1115206A (fr) | Methode de preparation d'injections d'urokinase | |
AU2001211986A1 (en) | Composition and method for stable injectable liquids | |
CA2438108C (fr) | Composition pharmaceutique et methode d'injection a liberation controlee connexe | |
JP2003507388A (ja) | 凍結乾燥したケーキの安定化 | |
CN116650425A (zh) | 糖酯化合物或其盐在冷冻保护、冷冻干燥保护中的应用 | |
CA1214102A (fr) | Preparation pharmaceutique contenant de la fibronectine purifiee | |
Maa et al. | Optimization of an alum-adsorbed vaccine powder formulation for epidermal powder immunization | |
RU2003113537A (ru) | Композиция для доставки стабильных инъецируемых жидкостей и способ доставки | |
EP1007102B1 (fr) | Procede de preparation de milieux de contraste | |
AU2005203369B2 (en) | Pharmaceutical liquid suspensions | |
JP4027881B2 (ja) | 安定注射液用の組成物および方法 | |
KR100743442B1 (ko) | 약제적 액체 현탁액 | |
CN100594937C (zh) | 稳定的注射液组合物和方法 | |
EP1449523A1 (fr) | Composition et procédé pour liquides injectables stables | |
RU2259817C2 (ru) | Композиция для доставки стабильных инъецируемых жидкостей и способ доставки | |
JP4326030B2 (ja) | リピッドa類縁体含有注射用製剤及びその製造方法 | |
JPS6219531A (ja) | 安定なヒト型アンギオテンシン製剤 | |
NZ525026A (en) | A two-component composition comprising particles of sugar glass and a biocompatible liquid perfluorocarbon | |
NZ538681A (en) | A pharmaceutical composition comprising active biological ingredient carried by particles that form a stable suspension in a liquid indefinitely | |
KR20000022502A (ko) | 리피드a 유사체함유 주사용 제제 및 그 제조방법 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20201013 |