CA2424656A1 - Composition and method for stable injectable liquids - Google Patents
Composition and method for stable injectable liquids Download PDFInfo
- Publication number
- CA2424656A1 CA2424656A1 CA002424656A CA2424656A CA2424656A1 CA 2424656 A1 CA2424656 A1 CA 2424656A1 CA 002424656 A CA002424656 A CA 002424656A CA 2424656 A CA2424656 A CA 2424656A CA 2424656 A1 CA2424656 A1 CA 2424656A1
- Authority
- CA
- Canada
- Prior art keywords
- composition according
- component
- glass
- microparticles
- sugar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
A composition for delivering a stable, bioactive compound to a subject comprising a first component and a second component, the first component comprises microparticles of sugar glass or a phosphate glass containing the bioactive agent. The sugar glass or phosphate glass optionally includes a glass formation facilitator compound, and the second component comprises at least one biocompatible liquid perfluorocarbon in which the first component is insoluble and dispersed. The liquid perfluorocarbon optionally includes a surfactant.
Claims (3)
1. A composition for delivering a stable, bioactive compound to a subject comprising a first component and a second component, said first component comprising microparticles of sugar glass, metal carboxylate glass or a phosphate glass containing said bioactive agent, wherein said sugar glass, metal carboxylate glass or phosphate glass optionally includes a glass formation facilitator compound, and said second component consisting of at least one biocompatible liquid perfluorocarbon in which said first component is insoluble and dispersed, wherein said liquid perfluorocarbon optionally includes a surfactant.
2. The composition according to claim 1, wherein said sugar glass is formed from a sugar selected from the group consisting of trehalose, sucrose, raffinose, stachyose, glucopyranosyl sorbitol, glucopyranosyl mannitol, palatinit, lactitol, a monosaccharide alcohol or sugar molecules modified by the addition of hydrophobic side chains selected from the group consisting of sucrose octaacetate or trehalose octaacetate.
3. The composition according to claim 1, wherein said phosphate glass or carboxylate glass is produced from mixtures of divalent metal phosphates or metal carboxylates.
5. The composition according to claim 1, wherein said optional glass formation facilitator is selected from the group consisting of a peptide, a protein, dextran, polyvinylpyrollidone, borate ion, calcium lactate, sodium polyphosphate, and silicate or acetate salts.
6. The composition according to claim 1, wherein said sugar glass microparticles are from about 0.1 to about 100 micrometers in diameter.
7. The composition according to claim 6, wherein said diameter range is from 1 to 10 micrometers.
8. The composition according to claim 1, wherein said microparticles have a water content of no more than 4% and preferably less than 2% and ideally less than 1 %.
9. The composition according to claim 1, wherein said first component is monodispersed in said second component.
10. The composition according to claim 1, wherein the concentration of said first component in said second component is from about 1 % to about 40% by weight.
11. The composition according to claim 10, wherein said concentration range is 10% to 15%.
12. The composition according to claim 1, wherein said surfactant concentration in said second component ranges from about 0.01 % to about 10%.
13. The composition according to claim 12, wherein said concentration is about 1 %.
14. The composition according to claim l, further comprising first component microparticles to which is added an inorganic salt in an amount effective to produce in said microparticles a density matching that of said second component liquid phase.
15. The composition according to claim 1, further comprising the incorporation into said microparticles of an excipient that confers upon said microparticles a weak residual electrostatic charge such that said microparticles repel one another.
16. The composition according to claim 15, wherein said excipient is an amino acid.
17. The composition according to claim 1 wherein said perfluorocarbon is selected from a group consisting of perfluorohexane, perfluorodecalin and perfluorophenanthrene.
18. The composition according to claim 1, wherein said bioactive compound is a vaccine, a drug, an enzyme or a diagnostic reagent.
19. A method for delivering a bioactive substance to a subject patient, comprising the steps of:
(a) producing first component microparticles according to claim 1;
(b) suspending said microparticles in said second component perfluorocarbon according to claim 1; and (c) administering said admixture to said patient.
5. The composition according to claim 1, wherein said optional glass formation facilitator is selected from the group consisting of a peptide, a protein, dextran, polyvinylpyrollidone, borate ion, calcium lactate, sodium polyphosphate, and silicate or acetate salts.
6. The composition according to claim 1, wherein said sugar glass microparticles are from about 0.1 to about 100 micrometers in diameter.
7. The composition according to claim 6, wherein said diameter range is from 1 to 10 micrometers.
8. The composition according to claim 1, wherein said microparticles have a water content of no more than 4% and preferably less than 2% and ideally less than 1 %.
9. The composition according to claim 1, wherein said first component is monodispersed in said second component.
10. The composition according to claim 1, wherein the concentration of said first component in said second component is from about 1 % to about 40% by weight.
11. The composition according to claim 10, wherein said concentration range is 10% to 15%.
12. The composition according to claim 1, wherein said surfactant concentration in said second component ranges from about 0.01 % to about 10%.
13. The composition according to claim 12, wherein said concentration is about 1 %.
14. The composition according to claim l, further comprising first component microparticles to which is added an inorganic salt in an amount effective to produce in said microparticles a density matching that of said second component liquid phase.
15. The composition according to claim 1, further comprising the incorporation into said microparticles of an excipient that confers upon said microparticles a weak residual electrostatic charge such that said microparticles repel one another.
16. The composition according to claim 15, wherein said excipient is an amino acid.
17. The composition according to claim 1 wherein said perfluorocarbon is selected from a group consisting of perfluorohexane, perfluorodecalin and perfluorophenanthrene.
18. The composition according to claim 1, wherein said bioactive compound is a vaccine, a drug, an enzyme or a diagnostic reagent.
19. A method for delivering a bioactive substance to a subject patient, comprising the steps of:
(a) producing first component microparticles according to claim 1;
(b) suspending said microparticles in said second component perfluorocarbon according to claim 1; and (c) administering said admixture to said patient.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA2689856A CA2689856C (en) | 2000-10-13 | 2000-10-13 | Composition and method for stable injectable liquids |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2000/028244 WO2002032402A1 (en) | 2000-10-13 | 2000-10-13 | Composition and method for stable injectable liquids |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2689856A Division CA2689856C (en) | 2000-10-13 | 2000-10-13 | Composition and method for stable injectable liquids |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2424656A1 true CA2424656A1 (en) | 2002-04-25 |
CA2424656C CA2424656C (en) | 2010-03-23 |
Family
ID=21741883
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2424656A Expired - Lifetime CA2424656C (en) | 2000-10-13 | 2000-10-13 | Composition and method for stable injectable liquids |
CA2689856A Expired - Lifetime CA2689856C (en) | 2000-10-13 | 2000-10-13 | Composition and method for stable injectable liquids |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA2689856A Expired - Lifetime CA2689856C (en) | 2000-10-13 | 2000-10-13 | Composition and method for stable injectable liquids |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1328255A1 (en) |
JP (1) | JP2004513093A (en) |
KR (1) | KR20030096224A (en) |
CN (1) | CN100339066C (en) |
AU (2) | AU1198601A (en) |
CA (2) | CA2424656C (en) |
ES (1) | ES2337252T3 (en) |
MX (1) | MXPA03003236A (en) |
NO (1) | NO20031706D0 (en) |
PL (1) | PL360052A1 (en) |
PT (1) | PT1452171E (en) |
WO (1) | WO2002032402A1 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20050267222A1 (en) * | 2002-10-22 | 2005-12-01 | Dainippon Pharmaceutical Co. Ltd. | Stabilized composition |
JP2007001865A (en) * | 2003-09-16 | 2007-01-11 | Ltt Bio-Pharma Co Ltd | Fine particle enclosing fat-soluble medicine, method for producing the same and preparation containing the same |
KR20070009639A (en) | 2004-04-13 | 2007-01-18 | 캠브리지 바이오스테빌리티 리미티드 | Liquids containing suspended glass particles |
GB0408199D0 (en) * | 2004-04-13 | 2004-05-19 | Cambridge Biostability Ltd | Liquids containing suspended sugar glass particles |
GB2430880A (en) * | 2005-10-04 | 2007-04-11 | Cambridge Biostability Ltd | Pharmaceutical compositions stabilized in glassy particles |
GB0523638D0 (en) * | 2005-11-21 | 2005-12-28 | Cambridge Biostability Ltd | Pharmaceutical device for the administration of substances to patients |
US8946200B2 (en) | 2006-11-02 | 2015-02-03 | Southwest Research Institute | Pharmaceutically active nanosuspensions |
KR101340129B1 (en) * | 2008-01-18 | 2013-12-10 | 아사히 가세이 파마 가부시키가이샤 | Stable pharmaceutical composition |
US8404850B2 (en) | 2008-03-13 | 2013-03-26 | Southwest Research Institute | Bis-quaternary pyridinium-aldoxime salts and treatment of exposure to cholinesterase inhibitors |
US8722706B2 (en) | 2008-08-15 | 2014-05-13 | Southwest Research Institute | Two phase bioactive formulations of bis-quaternary pyridinium oxime sulfonate salts |
US8309134B2 (en) | 2008-10-03 | 2012-11-13 | Southwest Research Institute | Modified calcium phosphate nanoparticle formation |
WO2010146536A1 (en) | 2009-06-18 | 2010-12-23 | Koninklijke Philips Electronics N.V. | Suspension of particles with drug |
WO2011007327A2 (en) | 2009-07-16 | 2011-01-20 | Koninklijke Philips Electronics N.V. | Suspension for therapeutic use and device for delivering said suspension |
ES2362525B8 (en) | 2009-10-08 | 2013-01-03 | Azurebio, S.L. | Medication formulation in the form of penetrating percutaneous needles. |
US9028873B2 (en) | 2010-02-08 | 2015-05-12 | Southwest Research Institute | Nanoparticles for drug delivery to the central nervous system |
TWI654098B (en) | 2014-03-24 | 2019-03-21 | 日商精工愛普生股份有限公司 | Belt printing device and tape printing system |
RU2016141948A (en) * | 2014-03-27 | 2018-04-27 | Новартис Аг | SPRAY DRIED DISPERSIONS OF SOLID-IN-OIL-IN-WATER OF ACTIVE PHARMACEUTICAL INGREDIENTS FOR INHALATION |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GR78151B (en) * | 1982-04-05 | 1984-09-26 | Alcon Lab Inc | |
US5518731A (en) * | 1990-09-27 | 1996-05-21 | Allergan, Inc. | Nonaqueous fluorinated drug delivery vehicle suspensions |
WO1993018748A1 (en) * | 1992-03-19 | 1993-09-30 | Allergan, Inc. | Compositions comprising a drug delivery vehicle suspended in a nonaqueous fluorinated liquid |
GB9705588D0 (en) * | 1997-03-18 | 1997-05-07 | Anglia Research Foundation | Stable particle in liquid formulations |
US6190701B1 (en) * | 1999-03-17 | 2001-02-20 | Peter M. Ronai | Composition and method for stable injectable liquids |
-
2000
- 2000-10-13 CN CNB008199655A patent/CN100339066C/en not_active Expired - Fee Related
- 2000-10-13 MX MXPA03003236A patent/MXPA03003236A/en active IP Right Grant
- 2000-10-13 PL PL00360052A patent/PL360052A1/en unknown
- 2000-10-13 CA CA2424656A patent/CA2424656C/en not_active Expired - Lifetime
- 2000-10-13 PT PT04013422T patent/PT1452171E/en unknown
- 2000-10-13 AU AU1198601A patent/AU1198601A/en active Pending
- 2000-10-13 EP EP00973483A patent/EP1328255A1/en not_active Withdrawn
- 2000-10-13 JP JP2002535640A patent/JP2004513093A/en not_active Withdrawn
- 2000-10-13 WO PCT/US2000/028244 patent/WO2002032402A1/en active IP Right Grant
- 2000-10-13 AU AU2001211986A patent/AU2001211986B2/en not_active Ceased
- 2000-10-13 KR KR10-2003-7004941A patent/KR20030096224A/en active Search and Examination
- 2000-10-13 ES ES04013422T patent/ES2337252T3/en not_active Expired - Lifetime
- 2000-10-13 CA CA2689856A patent/CA2689856C/en not_active Expired - Lifetime
-
2003
- 2003-04-11 NO NO20031706A patent/NO20031706D0/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
CN100339066C (en) | 2007-09-26 |
CA2689856A1 (en) | 2002-04-25 |
NO20031706L (en) | 2003-04-11 |
NO20031706D0 (en) | 2003-04-11 |
WO2002032402A1 (en) | 2002-04-25 |
CA2689856C (en) | 2013-09-24 |
AU2001211986B2 (en) | 2007-04-26 |
KR20030096224A (en) | 2003-12-24 |
CN1527699A (en) | 2004-09-08 |
PL360052A1 (en) | 2004-09-06 |
PT1452171E (en) | 2010-03-08 |
MXPA03003236A (en) | 2004-12-03 |
AU1198601A (en) | 2002-04-29 |
CA2424656C (en) | 2010-03-23 |
JP2004513093A (en) | 2004-04-30 |
ES2337252T3 (en) | 2010-04-22 |
EP1328255A1 (en) | 2003-07-23 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKEX | Expiry |
Effective date: 20201013 |